Keyword search (3,448 papers available)


Physical health problems, depressive mood, and cortisol secretion in old age: buffer effects of health engagement control strategies.

Author(s): Wrosch C, Schulz R, Miller GE, Lupien S, Dunne E

Health Psychol. 2007 May;26(3):341-9 Authors: Wrosch C, Schulz R, Miller GE, Lupien S, Dunne E

Article GUID: 17500621
Diurnal cortisol secretion and 2-year changes in older adults' physical symptoms: the moderating roles of negative affect and sleep.

Author(s): Wrosch C, Miller GE, Lupien S, Pruessner JC

Health Psychol. 2008 Nov;27(6):685-93 Authors: Wrosch C, Miller GE, Lupien S, Pruessner JC

Article GUID: 19025263
Goal disengagement, functional disability, and depressive symptoms in old age.

Author(s): Dunne E, Wrosch C, Miller GE

Health Psychol. 2011 Nov;30(6):763-70 Authors: Dunne E, Wrosch C, Miller GE

Article GUID: 21604877
Relationship between antidepressant therapy and risk for cardiovascular events in patients with and without cardiovascular disease.

Author(s): Lavoie KL, Paine NJ, Pelletier R, Arsenault A, Diodati JG, Campbell TS, Pilote L, Bacon SL

Health Psychol. 2018 Nov;37(11):989-999 Authors: Lavoie KL, Paine NJ, Pelletier R, Arsenault A, Diodati JG, Campbell TS, Pilote L, Bacon SL

Article GUID: 30247064
Title:Relationship between antidepressant therapy and risk for cardiovascular events in patients with and without cardiovascular disease.
Authors:Lavoie KL,  Paine NJ,  Pelletier R,  Arsenault A,  Diodati JG,  Campbell TS,  Pilote L,  Bacon SL
Link:https://www.ncbi.nlm.nih.gov/pubmed/30247064?dopt=Abstract
Category:Health Psychol
PMID:30247064
Dept Affiliation: HKAP
1 Department of Psychology, University of Québec at Montréal.
2 Montreal Behavioural Medicine Centre, Research Center, CIUSSS-NIM, Hôpital du Sacré-Coeur de Montréal.
3 Department of Psychology, University of Calgary.
4 Division of Clinical Epidemiology, McGill University Health Centre.
5 Department of Health, Kinesiology and Applied Physiology, Concordia University.

Description:

Relationship between antidepressant therapy and risk for cardiovascular events in patients with and without cardiovascular disease.

Health Psychol. 2018 Nov;37(11):989-999

Authors: Lavoie KL, Paine NJ, Pelletier R, Arsenault A, Diodati JG, Campbell TS, Pilote L, Bacon SL

Abstract

OBJECTIVE: The American Heart Association has endorsed depression as a cardiac risk factor and recommends screening as part of routine practice. This has been met with controversy due to inconsistencies in the data linking depression treatment to better cardiovascular outcomes. Our objective was to prospectively assess the association between depression treatment (defined as being prescribed antidepressant medication) and major adverse cardiovascular events (MACE) in patients referred for exercise stress tests.

METHOD: Two thousand three hundred eighty-five consecutive patients presenting for myocardial perfusion exercise stress tests underwent a sociodemographic, medical, and psychiatric interview (Primary Care Evaluation of Mental Disorders [PRIME-MD]) and completed the Beck Depression Inventory (BDI). History of cardiovascular disease (CVD) and antidepressant use was self-reported and verified via chart review. Participants followed over an 8.8-year follow up, and information regarding MACE incidence (including cardiac mortality, nonfatal myocardial infarction, revascularization procedures, cerebrovascular events) was obtained from provincial administrative databases.

RESULTS: 8% (n = 190) of the sample were taking antidepressants at baseline, 41% (n = 916) had a history of CVD, and 38.7% (n = 921) had depression according to the PRIME-MD or BDI. Antidepressant treatment was associated with a 30% reduced risk of MACE (Hazard ratio [HR] = 0.697; 95% confidence interval [CI] = [0.504, 0.964]; p = .029). A 46% reduction in risk was associated with antidepressant treatment among those without CVD (HR = 0.542; 95% CI [0.299, 0.981]; p = .043). In depressed patients, a 33% reduction in risk of MACE associated with antidepressant use was seen (adjusted HR = 0.674; 95% CI [0.440, 1.033]; p = .07).

CONCLUSIONS: Antidepressants may be cardio-protective among patients presenting for stress testing independent of risk factors including CVD and depression. Results support treating depression with antidepressants in this population to reduce risk of MACE. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

PMID: 30247064 [PubMed - indexed for MEDLINE]