Keyword search (3,448 papers available)


Enzymatic assay for GHB determination in forensic matrices.

Author(s): Grenier V, Huppé G, Lamarche M, Mireault P

J Anal Toxicol. 2012 Sep;36(7):523-8 Authors: Grenier V, Huppé G, Lamarche M, Mireault P

Article GUID: 22722059
Procedure for the Selection and Validation of a Calibration Model I-Description and Application

Author(s): Brigitte Desharnais

Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selectio...

Article GUID: 28137730
Procedure for the Selection and Validation of a Calibration Model II-Theoretical Basis

Author(s): Brigitte Desharnais

In the first part of this paper (I-Description and application), an automated, stepwise and analyst-independent process for the selection and validation of calibration models was put forward and applied to two model analytes. This second part presents the m...

Article GUID: 28158619
Challenges Related to Three Cases of Fatal Intoxication to Multiple Novel Synthetic Opioids.

Author(s): Garneau B, Desharnais B, Beauchamp-Doré A, Lavallée C, Mireault P, Lajeunesse A

J Anal Toxicol. 2019 Mar 30;: Authors: Garneau B, Desharnais B, Beauchamp-Doré A, Lavallée C, Mireault P, Lajeunesse A

Article GUID: 30927001
A Tool for Automatic Correction of Endogenous Concentrations: Application to BHB Analysis by LC-MS-MS and GC-MS

Author(s): Desharnais B; Lajoie MJ; Laquerre J; Savard S; Mireault P; Skinner CD;

Several substances relevant for forensic toxicology purposes have an endogenous presence in biological matrices: beta-hydroxybutyric acid (BHB), gamma-hydroxybutyric acid (GHB), steroids and human insulin, to name only a few. The presence of significant amo...

Article GUID: 31141151
Title:Procedure for the Selection and Validation of a Calibration Model I-Description and Application
Authors:Brigitte Desharnais
Link:https://pubmed.ncbi.nlm.nih.gov/28137730/
Category:J Anal Toxicol
PMID:28137730
Dept Affiliation: CHEMBIOCHEM
1 Department of Toxicology, Laboratoire de sciences judiciaires et de médecine légale, 1701 rue Parthenais, Montréal, Québec, Canada H2K 3S7.
2 Department of Chemistry & Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montréal, Québec, Canada H4B 1R6.
3 Department of Mathematics, Université de Sherbrooke, 2500 boulevard de l'Université, Sherbrooke, Québec, CanadaJ1K 2R1.
4 Department of Toxicology, Laboratoire de sciences judiciaires et de médecine légale, 1701 rue Parthenais, Montréal, Québec, CanadaH2K 3S7.
5 Department of Chemistry & Biochemistry,Concordia University, 7141 Sherbrooke Street West, Montréal, Québec, CanadaH4B 1R6.

Description:

Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control (QC) accuracy, with an error up to 154%. Unfortunately, simple tools to perform this selection and tests to validate the resulting model are lacking. We present a stepwise,...