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J Cereb Blood Flow Metab. 2019 Jul 25;:271678X19862873 Authors: Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

Article GUID: 31342831
Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.

Author(s): Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

J Cereb Blood Flow Metab. 2019 Feb 07;:271678X19827944 Authors: Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

Article GUID: 30732551
Title:Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.
Authors:Fan AP,  Khalil AA,  Fiebach JB,  Zaharchuk G,  Villringer A,  Villringer K,  Gauthier CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/30732551?dopt=Abstract
Category:J Cereb Blood Flow Metab
PMID:30732551
Dept Affiliation: PHYSICS
1 Department of Radiology, Stanford University, Stanford, CA, USA.
2 Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.
3 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
4 Berlin School of Mind and Brain, Humboldt-Universitaet zu Berlin, Berlin, Germany.
5 Department of Physics, Concordia University, Montreal, Canada.
6 Montreal Heart Institute, Montreal, Canada.

Description:

Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.

J Cereb Blood Flow Metab. 2019 Feb 07;:271678X19827944

Authors: Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

Abstract

Recent clinical trials of new revascularization therapies in acute ischemic stroke have highlighted the importance of physiological imaging to identify optimal treatments for patients. Oxygen extraction fraction (OEF) is a hallmark of at-risk tissue in stroke, and can be quantified from the susceptibility effect of deoxyhemoglobin molecules in venous blood on MRI phase scans. We measured OEF within cerebral veins using advanced quantitative susceptibility mapping (QSM) MRI reconstructions in 20 acute stroke patients. Absolute OEF was elevated in the affected (29.3?±?3.4%) versus the contralateral hemisphere (25.5?±?3.1%) of patients with large diffusion-perfusion lesion mismatch ( P?=?0.032). In these patients, OEF negatively correlated with relative CBF measured by dynamic susceptibility contrast MRI ( P?=?0.004), suggesting compensation for reduced flow. Patients with perfusion-diffusion match or no hypo-perfusion showed less OEF difference between hemispheres. Nine patients received longitudinal assessment and showed OEF ratio (affected to contralateral) of 1.2?±?0.1 at baseline that normalized (decreased) to 1.0?±?0.1 at follow-up three days later ( P?=?0.03). Our feasibility study demonstrates that QSM MRI can non-invasively quantify OEF in stroke patients, relates to perfusion status, and is sensitive to OEF changes over time. Clinical trial registration: Longitudinal MRI examinations of patients with brain ischemia and blood brain barrier permeability; clinicaltrials.org : NCT02077582.

PMID: 30732551 [PubMed - as supplied by publisher]