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Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits.

Author(s): Farooqi NAI, Scotti M, Yu A, Lew J, Monnier P, Botteron KN, Campbell BC, Booij L, Herba CM, Séguin JR, Castellanos-Ryan N, McCracken JT, Nguyen TV

J Neuroendocrinol. 2019 Feb;31(2):e12682 Authors: Farooqi NAI, Scotti M, Yu A, Lew J, Monnier P, Botteron KN, Campbell BC, Booij L, Herba CM, Séguin JR, Castellanos-Ryan N, McCracken JT, Nguyen TV

Article GUID: 30597689
Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.

Author(s): Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier...

J Neuroendocrinol. 2019 Apr;31(4):e12698 Authors: Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier P, Du...

Article GUID: 30776161
High Oestradiol Replacement Reverses Response Memory Bias in Ovariectomised Female Rats Regardless of Dopamine Levels in the Dorsal Striatum.

Author(s): Hussain D, Cossette MP, Brake WG

J Neuroendocrinol. 2016 05;28(5): Authors: Hussain D, Cossette MP, Brake WG

Article GUID: 26929121
Title:Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.
Authors:Nguyen TV,  Jones SL,  Gower T,  Lew J,  Albaugh MD,  Botteron KN,  Hudziak JJ,  Fonov VS,  Louis Collins D,  Campbell BC,  Booij L,  Herba CM,  Monnier P,  Ducharme S,  Waber D,  McCracken JT
Link:https://www.ncbi.nlm.nih.gov/pubmed/30776161?dopt=Abstract
Category:J Neuroendocrinol
PMID:30776161
Dept Affiliation: PSYCHOLOGY
1 Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
2 Department of Obstetrics-Gynecology, McGill University Health Center, Montreal, Quebec, Canada.
3 Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
4 Department of Psychology, McGill University, Montreal, Quebec, Canada.
5 Douglas Mental Health University Institute, Verdun, Quebec, Canada.
6 Department of Psychology, University of Vermont, College of Medicine, Burlington, Vermont, Canada.
7 Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri.
8 Brain Development Cooperative Group.
9 McConnell Brain imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada.
10 Department of Anthropology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
11 Department of Psychology, Concordia University, Montreal, Quebec, Canada.
12 CHU Sainte Justine Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.
13 Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
14 Department of Neurology & Neurosurgery, McGill University, Montreal, Quebec, Canada.
15 Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
16 Department of Child and Adolescent Psychiatry, University of California in Los Angeles, Los Angeles, California.

Description:

Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.

J Neuroendocrinol. 2019 Apr;31(4):e12698

Authors: Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier P, Ducharme S, Waber D, McCracken JT

Abstract

Oestradiol is known to play an important role in the developing human brain, although little is known about the entire network of potential regions that might be affected and how these effects may vary from childhood to early adulthood, which in turn can explain sexually differentiated behaviours. In the present study, we examined the relationships between oestradiol, cortico-amygdalar structural covariance, and cognitive or behavioural measures typically showing sex differences (verbal/spatial skills, anxious-depressed symptomatology) in 152 children and adolescents (aged 6-22 years). Cortico-amygdalar structural covariance shifted from positive to negative across the age range. Oestradiol was found to diminish the impact of age on cortico-amygdalar covariance for the pre-supplementary motor area/frontal eye field and retrosplenial cortex (across the age range), as well as for the posterior cingulate cortex (in older children). Moreover, the influence of oestradiol on age-related cortico-amygdalar networks was associated with higher word identification and spatial working memory (across the age range), as well as higher reading comprehension (in older children), although it did not impact anxious-depressed symptoms. There were no significant sex effects on any of the above relationships. These findings confirm the importance of developmental timing on oestradiol-related effects and hint at the non-sexually dimorphic role of oestradiol-related cortico-amygdalar structural networks in aspects of cognition distinct from emotional processes.

PMID: 30776161 [PubMed - in process]