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On-chip integration of droplet microfluidics and nanostructure-initiator mass spectrometry for enzyme screening

Author(s): Joshua Heinemann

Biological assays often require expensive reagents and tedious manipulations. These shortcomings can be overcome using digitally operated microfluidic devices that require reduced sample volumes to automate assays. One particular challenge is integrating bi...

Article GUID: 27957569
An automated microfluidic gene-editing platform for deciphering cancer genes.

Author(s): Sinha H, Quach ABV, Vo PQN, Shih SCC

Lab Chip. 2018 07 24;18(15):2300-2312 Authors: Sinha H, Quach ABV, Vo PQN, Shih SCC

Article GUID: 29989627
An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting.

Author(s): Ahmadi F, Samlali K, Vo PQN, Shih SCC

Lab Chip. 2019 01 29;19(3):524-535 Authors: Ahmadi F, Samlali K, Vo PQN, Shih SCC

Article GUID: 30633267
Title:On-chip integration of droplet microfluidics and nanostructure-initiator mass spectrometry for enzyme screening
Authors:Joshua Heinemann
Link:https://pubmed.ncbi.nlm.nih.gov/27957569/
DOI:10.1039/c6lc01182a
Category:Lab Chip
PMID:27957569
Dept Affiliation: MASSSPEC
1 Joint Bioenergy Institute, Emeryville, California 94608, USA and Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. trnorthen@lbl.gov.
2 Joint Bioenergy Institute, Emeryville, California 94608, USA and Sandia National Laboratories, Livermore, California 94551, USA.
3 Department of Electrical and Computer Engineering, Concordia University, Montreal, Quebec, Canada.
4 Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. trnorthen@lbl.gov.
5 Joint Bioenergy Institute, Emeryville, California 94608, USA and Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. trnorthen@lbl.gov and Department of Bioengineering, University of California, Berkeley, California, 94720, USA.
6 Joint Bioenergy Institute, Emeryville, California 94608, USA and Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. trnorthen@lbl.gov and Joint Genome Institute, Walnut creek, California, 94598, USA.

Description:

Biological assays often require expensive reagents and tedious manipulations. These shortcomings can be overcome using digitally operated microfluidic devices that require reduced sample volumes to automate assays. One particular challenge is integrating bioassays with mass spectrometry based analysis. Towards this goal we have developed µNIMS, a highly sensitive and high throughput technique that integrates droplet microfluidics with nanostructure-initiator mass spectrometry (NIMS). Enzyme...