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Resources and Methods for Engineering "Designer" Glycan-Binding Proteins.

Author(s): Warkentin R, Kwan DH

This review provides information on available methods for engineering glycan-binding proteins (GBP). Glycans are involved in a variety of physiological functions and are found in all domains of life and viruses. Due to their wide range of functions, GBPs ha...

Article GUID: 33450899
Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.

Author(s): Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacem...

Article GUID: 33238462
Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review.

Author(s): Badilescu S, Raju D, Bathini S, Packirisamy M

Nano-islands are entities (droplets or other shapes) that are formed by spontaneous dewetting (agglomeration, in the early literature) of thin and very thin metallic (especially gold) films on a substrate, done by post-deposition heating or by using other s...

Article GUID: 33066088
Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from Angelica decursiva.

Author(s): Ali MY, Seong SH, Jung HA, Choi JS

Molecules. 2019 Oct 31;24(21): Authors: Ali MY, Seong SH, Jung HA, Choi JS

Article GUID: 31683604
Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.

Author(s): Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R

Molecules. 2017 Mar 17;22(3): Authors: Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R

Article GUID: 28304349
Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein.

Author(s): Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ

Molecules. 2017 Nov 11;22(11): Authors: Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ

Article GUID: 29137116
Title:Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.
Authors:Said Fatahala S,  Hasabelnaby S,  Goudah A,  Mahmoud GI,  Helmy Abd-El Hameed R
Link:https://www.ncbi.nlm.nih.gov/pubmed/28304349?dopt=Abstract
Category:Molecules
PMID:28304349
Dept Affiliation: CHEMBIOCHEM
1 Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt. samarradwan1@yahoo.com.
2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt. sherifajanaa@yahoo.com.
3 Department of Chemistry and Biochemistry, Concordia University, 7141 rue Sherbrooke O., Montréal, H4Bm1R6 QC, Canada. sherifajanaa@yahoo.com.
4 Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza/Egypt, Giza 12211, Egypt. aymangouda@yahoo.com.
5 Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza/Egypt, Giza 12211, Egypt. ssfathallah@yahoo.com.
6 Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt. zeiadomar@yahoo.com.

Description:

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.

Molecules. 2017 Mar 17;22(3):

Authors: Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R

Abstract

A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, ¹H-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site.

PMID: 28304349 [PubMed - indexed for MEDLINE]