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Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.

Author(s): Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Nat Neurosci. 2020 Jan 20;: Authors: Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Article GUID: 31959935
Best practices in data analysis and sharing in neuroimaging using MRI.

Author(s): Nichols TE, Das S, Eickhoff SB, Evans AC, Glatard T, Hanke M, Kriegeskorte N, Milham MP, Poldrack RA, Poline JB, Proal E, Thirion B, Van Ess...

Nat Neurosci. 2017 Feb 23;20(3):299-303 Authors: Nichols TE, Das S, Eickhoff SB, Evans AC, Glatard T, Hanke M, Kriegeskorte N, Milham MP, Poldrack RA, Poline JB, Proal E, Thirion B, Van Essen DC, ...

Article GUID: 28230846
Practice makes plasticity.

Author(s): Steele CJ, Zatorre RJ

Nat Neurosci. 2018 12;21(12):1645-1646 Authors: Steele CJ, Zatorre RJ

Article GUID: 30482944
Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Author(s): Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Nat Neurosci. 2015 Jun;18(6):855-62 Authors: Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Article GUID: 25915475
Title:Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
Authors:Cao R,  Gkogkas CG,  de Zavalia N,  Blum ID,  Yanagiya A,  Tsukumo Y,  Xu H,  Lee C,  Storch KF,  Liu AC,  Amir S,  Sonenberg N
Link:https://www.ncbi.nlm.nih.gov/pubmed/25915475?dopt=Abstract
Category:Nat Neurosci
PMID:25915475
Dept Affiliation: CSBN
1 Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Canada.
2 Patrick Wild Centre, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Canada.
4 Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
5 Department of Biological Sciences, University of Memphis, Memphis, Tennessee, USA.
6 Department of Biomedical Sciences, Neuroscience Program, College of Medicine, Florida State University, Tallahassee, Florida, USA.

Description:

Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Nat Neurosci. 2015 Jun;18(6):855-62

Authors: Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Abstract

The circadian (~24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. Light-induced gene expression is thought to be the molecular mechanism underlying clock entrainment. mRNA translation is a key step of gene expression, but the manner in which clock entrainment is controlled at the level of mRNA translation is not well understood. We found that a light- and circadian clock-regulated MAPK/MNK pathway led to phosphorylation of the cap-binding protein eIF4E in the mouse suprachiasmatic nucleus of the hypothalamus, the locus of the master circadian clock in mammals. Phosphorylation of eIF4E specifically promoted translation of Period 1 (Per1) and Period 2 (Per2) mRNAs and increased the abundance of basal and inducible PER proteins, which facilitated circadian clock resetting and precise timekeeping. Together, these results highlight a critical role for light-regulated translational control in the physiology of the circadian clock.

PMID: 25915475 [PubMed - indexed for MEDLINE]