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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Author(s): Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Neuron. 2019 Aug 26;: Authors: Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Article GUID: 31522764
Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption.

Author(s): Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP

Neuron. 2018 Sep 19;99(6):1260-1273.e4 Authors: Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP

Article GUID: 30146308
Title:Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption.
Authors:Reed SJ,  Lafferty CK,  Mendoza JA,  Yang AK,  Davidson TJ,  Grosenick L,  Deisseroth K,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/30146308?dopt=Abstract
Category:Neuron
PMID:30146308
Dept Affiliation: PSYCHOLOGY
1 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
2 Department of Psychology, McGill University, Montreal, QC, Canada.
3 Department of Physiology and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
4 Department of Statistics, Columbia University Medical Center, New York, NY, USA.
5 Department of Bioengineering, Stanford University, Stanford, CA, USA.
6 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Department of Psychology, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption.

Neuron. 2018 Sep 19;99(6):1260-1273.e4

Authors: Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP

Abstract

Reward-seeking behavior is regulated by a diverse collection of inputs to the nucleus accumbens (NAc). The information encoded in each excitatory afferent to the NAc is unknown, in part because it is unclear when these pathways are active in relation to behavior. Here we compare the activity profiles of amygdala, hippocampal, and thalamic inputs to the NAc shell in mice performing a cued reward-seeking task using GCaMP-based fiber photometry. We find that the rostral and caudal ends of the NAc shell are innervated by distinct but intermingled populations of forebrain neurons that exhibit divergent feeding-related activity. In the rostral NAc shell, a coordinated network-wide reduction in excitatory drive correlates with feeding, and reduced input from individual pathways is sufficient to promote it. Overall, the data suggest that pathway-specific input activity at a population level may vary more across the NAc than between pathways.

PMID: 30146308 [PubMed - in process]