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Comments on strand breaks calculated from average doses to the DNA from incorporated isotopes.

Author(s): Charlton DE

Radiat Res. 1988 Apr;114(1):192-7 Authors: Charlton DE

Article GUID: 3353505
Cell survival from single passages for high-LET track-segment experiments with cell monolayers.

Author(s): Charlton DE, Turner MS

Radiat Res. 1993 Nov;136(2):297 Authors: Charlton DE, Turner MS PMID: 8248489 [PubMed - indexed for MEDLINE]

Article GUID: 8248489
The minimum Do for cell killing for alpha-particle emitters uniformly distributed in an extended medium.

Author(s): Charlton DE

Radiat Res. 1998 Jun;149(6):646-8 Authors: Charlton DE

Article GUID: 9611104
The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.

Author(s): Charlton DE

Radiat Res. 1999 Jun;151(6):750-3 Authors: Charlton DE

Article GUID: 10360796
Title:The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.
Authors:Charlton DE
Link:https://www.ncbi.nlm.nih.gov/pubmed/10360796?dopt=Abstract
Category:Radiat Res
PMID:10360796
Dept Affiliation: PHYSICS
1 Physics Department, Concordia University, Montreal, Quebec, Canada.

Description:

The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.

Radiat Res. 1999 Jun;151(6):750-3

Authors: Charlton DE

Abstract

A model of cell survival is described for the case of closely packed clusters of cells growing in monolayers. For alpha-particle decays on the cell surfaces, it is shown that cross-firing between cells produces nonuniform dose distributions within the cluster and that cells in larger clusters are exposed on average to greater doses. The model is used to simulate the survival of SK-MEL-28 human melanoma cells labeled with different radiolabeled monoclonal antibodies. The survival data suggest that this cell line is more sensitive to high-LET radiation than previously thought.

PMID: 10360796 [PubMed - indexed for MEDLINE]