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Do Mammalian Cells Really Need to Export and Import Heme?

Author(s): Prem Ponka

Heme is a cofactor that is essential to almost all forms of life. The production of heme is a balancing act between the generation of the requisite levels of the end-product and protection of the cell and/or organism against any toxic substrates, intermedia...

Article GUID: 28254242
Title:Do Mammalian Cells Really Need to Export and Import Heme?
Authors:Prem Ponka
Link:https://pubmed.ncbi.nlm.nih.gov/28254242/
DOI:10.1016/j.tibs.2017.01.006
Category:Trends Biochem Sci
PMID:28254242
Dept Affiliation: CERMM
1 Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, H3T 1E2, Canada; Department of Physiology, McGill University, Montréal, QC, H3G 1Y6, Canada. Electronic address: prem.ponka@mcgill.ca.
2 Spartan Bioscience Inc., Ottawa, ON, K2H 1B2, Canada; High Impact Editing, Ottawa, ON, K1B 3Y6, Canada.
3 Department of Chemistry and Biochemistry, Centre for Research in Molecular Modeling and PROTEO, Concordia University, Montréal, QC, H4B 1R, Canada.
4 Department of Chemistry, McGill University, Montréal, QC, H3A 0B8, Canada.
5 Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, H3T 1E2, Canada; Department of Physiology, McGill University, Montréal, QC, H3G 1Y6, Canada.

Description:

Heme is a cofactor that is essential to almost all forms of life. The production of heme is a balancing act between the generation of the requisite levels of the end-product and protection of the cell and/or organism against any toxic substrates, intermediates and, in this case, end-product. In this review, we provide an overview of our understanding of the formation and regulation of this metallocofactor and discuss new research on the cell biology of heme homeostasis, with a focus on putative...