Keyword search (3,619 papers available)


Benchmarking macaque brain gene expression for horizontal and vertical translation

Author(s): Luppi AI; Liu ZQ; Hansen JY; Cofre R; Niu M; Kuzmin E; Froudist-Walsh S; Palomero-Gallagher N; Misic B;...

The spatial patterning of gene expression shapes cortical organization and function. The macaque is a fundamental model organism in neuroscience, but the translational potential of macaque gene exp...

Article GUID: 40020056
Genomics-Enabled Mixed-Stock Analysis Uncovers Intraspecific Migratory Complexity and Detects Unsampled Populations in a Harvested Fish

Author(s): Gibelli J; Won H; Michaelides S; Jeon HB; Fraser DJ;

The contributions of distinct populations to annual harvests provide key insights to conservation, especially in migratory species that return to specific reproductive areas. In this context, genetic stock identification (GSI) requires reference samples fro...

Article GUID: 39995301
Performance and functional assessment of the Kimera P-IV point-of-care plasmonic qPCR prototype for ultra rapid pathogen detection of chlamydia trachomatis

Author(s): Hayes J; Lee SS; Carnevale J; Shamir D; Bohbot M; Kirk AG; Paliouras M; Trifiro MA;

Current standard microbiological techniques are generally very time consuming, usually requiring 24-72 h to establish a diagnosis. Consequentially, contemporary clinical practices implement broad-spectrum antibiotic administration prior to pathogen detectio...

Article GUID: 39881625
Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance

Author(s): Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; ...

Background: Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the inter...

Article GUID: 39920830
Human recreational activity does not influence open cup avian nest survival in urban green spaces

Author(s): Cull CA; Guest MJ; Frei B; Ziter CD;

The breeding period of birds is a critical and sensitive portion of the annual cycle. Understanding how human use of urban green spaces affects nest survival can improve our understanding of conserving breeding bird populations in cities and support science...

Article GUID: 39897430
The temperate forest phyllosphere and rhizosphere microbiome: a case study of sugar maple

Author(s): Enea M; Beauregard J; De Bellis T; Faticov M; Laforest-Lapointe I;

The interactions between sugar maple (Acer saccharum, Marshall) and its microbial communities are important for tree fitness, growth, and establishment. Despite recent progress in our understanding of the rhizosphere and phyllosphere microbial communities o...

Article GUID: 39881993
Water Quality and Land Use Shape Bacterial Communities Across 621 Canadian Lakes

Author(s): Onana VE; Beisner BE; Walsh DA;

Human activities such as agriculture and urban development are linked to water quality degradation. Canada represents a large and heterogeneous landscape of freshwater lakes, where variations in climate, geography and geology interact with land cover altera...

Article GUID: 39868666
Landscapes-a lens for assessing sustainability

Author(s): Dade MC; Bonn A; Eigenbrod F; Felipe-Lucia MR; Fisher B; Goldstein B; Holland RA; Hopping KA; Lavorel S; Lede Polain Waroux Y; MacDonald GK;...

Context: There are urgent calls to transition society to more sustainable trajectories, at scales ranging from local to global. Landscape sustainability (LS), or the capacity for landscapes to prov...

Article GUID: 39867571
Ingestion of polyethylene microplastics impacts cichlid behaviour despite having low retention time

Author(s): Felismino MEL; Chevallier Rufigny S; Gonzalez-Fleurant SE; Brown GE;

Microplastics, particles between 0.001 and 5 mm in diameter, are ubiquitous in the environment and their consumption by aquatic organisms is known to lead to a variety of adverse effects. However, studies on the effects of microplastics on prey fish have no...

Article GUID: 39862685
Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA

Author(s): He S; Singh D; Helfield B;

Gene therapy targeting ischemic heart disease is a promising therapeutic avenue, but it is mostly restricted to viral-based delivery approaches which are limited due to off-target immunological responses. Focused ultrasound presents a non-viral, image-guide...

Article GUID: 39850318
De novo evolution of antibiotic resistance to Oct-TriA1

Author(s): Chowdhury FR; Mercado LD; Kharitonov K; Findlay BL;

The rise of antimicrobial resistance as a global health concern has led to a strong interest in compounds able to inhibit the growth of bacteria without detectable levels of resistance evolution. A number of these compounds have been reported in recent year...

Article GUID: 39832423
Focused Ultrasound and Microbubble-Mediated Delivery of CRISPR-Cas9 Ribonucleoprotein to Human Induced Pluripotent Stem Cells

Author(s): Hazel K; Singh D; He S; Guertin Z; Husser MC; Helfield B;

CRISPR-Cas9 ribonucleoproteins (RNPs) have been heavily considered for gene therapy due to their high on-target efficiency, rapid activity and lack of insertional mutagenesis relative to other CRISPR-Cas9 delivery formats. Genetic diseases such as hypertrop...

Article GUID: 39797397
Beyond the Illusion of Controlled Environments: How to Embrace Ecological Pertinence in Research?

Author(s): Cassandre Vielle

Through the lens of preclinical research on substance use disorders (SUD), I propose a reflection aimed at re-evaluating animal models in neuroscience, with a focus on ecological relevance. While rodent models have provided valuable insights into the neurob...

Article GUID: 39777969
Widespread admixture blurs population structure and confounds Lake Trout (Salvelinus namaycush) conservation even in the genomic era

Author(s): Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ;...

Intraspecific variation is important for species' long-term persistence in changing environments. Conservation strategies targeting intraspecific variation often rely on the identification of m...

Article GUID: 39730611
The effect of micro-vessel viscosity on the resonance response of a two-microbubble system

Author(s): Yusefi H; Helfield B;

Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1-8 µm in diameter, with a volume-weighted mean size of 2-3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing suc...

Article GUID: 39705920
Variation in flower morphology associated with higher bee diversity in urban green spaces

Author(s): Sinno S; MacInnis G; Lessard JP; Ziter CD;

Urbanization is a leading threat to biodiversity, but scientifically informed management of urban ecosystems can mitigate negative impacts. For wild bees, which are declining worldwide, careful consideration of flower choice in public and private green spac...

Article GUID: 39609370
Temporal Variability in Effective Size ( [Formula] ) Identifies Potential Sources of Discrepancies Between Mark Recapture and Close Kin Mark Recapture Estimates of Population Abundance

Author(s): Ruzzante DE; McCracken GR; Fraser DJ; MacMillan J; Buhariwalla C; Flemming JM;

Although efforts to estimate effective population size, census size and their ratio in wild populations are expanding, few empirical studies investigate interannual changes in these parameters. Hence, we do not know how repeatable or representative many est...

Article GUID: 39582254
Vulnerability of Arctic Ocean microbial eukaryotes to sea ice loss

Author(s): Jackson VLN; Grevesse T; Kilias ES; Onda DFL; Young KF; Allen MJ; Walsh DA; Lovejoy C; Monier A;...

The Arctic Ocean (AO) is changing at an unprecedented rate, with ongoing sea ice loss, warming and freshening impacting the extent and duration of primary productivity over summer months. Surface m...

Article GUID: 39572565
Development of SNP Panels from Low-Coverage Whole Genome Sequencing (lcWGS) to Support Indigenous Fisheries for Three Salmonid Species in Northern Canada

Author(s): Beemelmanns A; Bouchard R; Michaelides S; Normandeau E; Jeon HB; Chamlian B; Babin C; Hénault P; Perrot O; Harris LN; Zhu X; Fraser D; Berna...

Single nucleotide polymorphism (SNP) panels are powerful tools for assessing the genetic population structure and dispersal of fishes and can enhance management practices for commercial, recreation...

Article GUID: 39552382
Design, manufacturing, and multi-modal imaging of stereolithography 3D printed flexible intracranial aneurysm phantoms

Author(s): Yalman A; Jafari A; Léger É; Mastroianni MA; Teimouri K; Savoji H; Collins DL; Kadem L; Xiao Y;...

Background: Physical vascular phantoms are instrumental in studying intracranial aneurysms and testing relevant imaging tools and training systems to provide improved clinical care. Current vascula...

Article GUID: 39546636
Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles

Author(s): Rezaei M; Liang M; Yalcin Z; Martin JH; Kazemi P; Bareke E; Ge ZJ; Fardaei M; Benadiva C; Hemida R; Hassan A; Maher GJ; Abdalla E; Buckett W...

To identify novel genes responsible for recurrent hydatidiform moles (HMs), we performed exome sequencing on 75 unrelated patients who were negative for mutations in the known genes. We identified ...

Article GUID: 39545410
Immunomodulation of human T cells by microbubble-mediated focused ultrasound

Author(s): Baez A; Singh D; He S; Hajiaghayi M; Gholizadeh F; Darlington PJ; Helfield B;

While met with initial and ground-breaking success targeting blood borne cancers, cellular immunotherapy remains significantly hindered in the context of solid tumors by the tumor microenvironment. Focused ultrasound, in conjunction with microbubbles, has f...

Article GUID: 39502696
A global dataset of salmonid biomass in streams

Author(s): Foote KJ; Grant JWA; Biron PM;

Salmonid fishes are arguably one of the most studied fish taxa on Earth, but little is known about their biomass range in many parts of the world. We created a dataset of estimated salmonid biomass using published material of over 1000 rivers, covering 27 c...

Article GUID: 39472611
The β2-adrenergic biased agonist nebivolol inhibits the development of Th17 and the response of memory Th17 cells in an NF-κB-dependent manner

Author(s): Hajiaghayi M; Gholizadeh F; Han E; Little SR; Rahbari N; Ardila I; Lopez Naranjo C; Tehranimeh K; Shih SCC; Darlington PJ;...

Introduction: Adrenergic receptors regulate metabolic, cardiovascular, and immunological functions in response to the sympathetic nervous system. The effect of ß2-adrenergic receptor (AR) as a high...

Article GUID: 39445009
What can optimized cost distances based on genetic distances offer? A simulation study on the use and misuse of ResistanceGA

Author(s): Daniel A; Savary P; Foltête JC; Vuidel G; Faivre B; Garnier S; Khimoun A;

Modelling population connectivity is central to biodiversity conservation and often relies on resistance surfaces reflecting multi-generational gene flow. ResistanceGA (RGA) is a common optimization framework for parameterizing these surfaces by maximizing ...

Article GUID: 39417711
Existing evidence on the effect of urban forest management in carbon solutions and avian conservation: a systematic literature map

Author(s): Hutt-Taylor K; Bassett CG; Kinnunen RP; Frei B; Ziter CD;

Background: Urgent solutions are needed in cities to mitigate twin crises of global climate change and biodiversity loss. Urban nature-based solutions (actions that protect, sustainably manage, and restore ecosystems while simultaneously providing human wel...

Article GUID: 39363382
Testing the predictions of reinforcement: long-term empirical data from a damselfly mottled hybrid zone

Author(s): Arce-Valdés LR; Ballén-Guapacha AV; Rivas-Torres A; Chávez-Ríos JR; Wellenreuther M; Hansson B; Guillén RAS;...

Theoretical work suggests that reinforcement can cause the strengthening of prezygotic isolation in sympatry by mitigating the costs of maladaptive hybridization. However, only a handful of studies...

Article GUID: 39325673
Sphingolipids containing very long-chain fatty acids regulate Ypt7 function during the tethering stage of vacuole fusion

Author(s): Zhang C; Calderin JD; Hurst LR; Gokbayrak ZD; Hrabak MR; Balutowski A; Rivera-Kohr DA; Kazmirchuk TDD; Brett CL; Fratti RA;...

Sphingolipids are essential in membrane trafficking and cellular homeostasis. Here, we show that sphingolipids containing very long-chain fatty acids (VLCFAs) promote homotypic vacuolar fusion in S...

Article GUID: 39307308
A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome

Author(s): Zykaj E; Abboud C; Asadi P; Warsame S; Almousa H; Milev MP; Greco BM; López-Sánchez M; Bratkovic D; Kachroo AH; Pérez-Jurado LA; Sacher M;...

Variants in membrane trafficking proteins are known to cause rare disorders with severe symptoms. The highly conserved transport protein particle (TRAPP) complexes are key membrane trafficking regu...

Article GUID: 39273027
Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans

Author(s): Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y;

Candidiasis, which presents a substantial risk to human well-being, is frequently treated with azoles. However, drug-drug interactions caused by azoles inhibiting the human CYP3A4 enzyme, together with increasing resistance of Candida species to azoles, rep...

Article GUID: 38995235
pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings

Author(s): Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK;...

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompat...

Article GUID: 38989606
Shear stress preconditioning and microbubble flow pattern modulate ultrasound-assisted plasma membrane permeabilization

Author(s): Memari E; Helfield B;

The recent and exciting success of anti-inflammatory therapies for ischemic heart disease (e.g. atherosclerosis) is hindered by the lack of site-specific and targeted therapeutic deposition. Microbubble-mediated focused ultrasound, which uses circulating, l...

Article GUID: 38988819
Cardiac gene delivery using ultrasound: State of the field

Author(s): Singh D; Memari E; He S; Yusefi H; Helfield B;

Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explo...

Article GUID: 38983873
Measuring what matters to older persons for active living: part I content development for the OPAL measure across four countries

Author(s): Mayo NE; Auais M; Barclay R; Branin J; Dawes H; Korfage IJ; Sawchuk K; Tal E; White CL; Ayoubi Z; Chowdhury F; Henderson J; Mansoubi M; Mate...

Aims: Many older persons do not think of themselves as "patients" but as persons wishing to live as actively as possible for as long as possible. However, most health-related quality of life (HRQL)...

Article GUID: 38967870
Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Author(s): Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y;

Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it. Consequently, converting FLC into a...

Article GUID: 38929106
Modelling reindeer rut activity using on-animal acoustic recorders and machine learning

Author(s): Boucher AJ; Weladji RB; Holand Ø; Kumpula J;

For decades, researchers have employed sound to study the biology of wildlife, with the aim to better understand their ecology and behaviour. By utilizing on-animal recorders to capture audio from freely moving animals, scientists can decipher the vocalizat...

Article GUID: 38932958
A genome catalogue of mercury-methylating bacteria and archaea from sediments of a boreal river facing human disturbances

Author(s): Lawruk-Desjardins C; Storck V; Ponton DE; Amyot M; Walsh DA;

Methyl mercury, a toxic compound, is produced by anaerobic microbes and magnifies in aquatic food webs, affecting the health of animals and humans. The exploration of mercury methylators based on genomes is still limited, especially in the context of river ...

Article GUID: 38922750
The biotic and abiotic contexts of ecological selection mediate the dominance of distinct dispersal strategies in competitive metacommunities

Author(s): Khattar G; Savary P; Peres-Neto PR;

While the influence of dispersal on ecological selection is the subject of intense research, we still lack a thorough understanding of how ecological selection operates to favour distinct dispersal strategies in metacommunities. To address this issue, we de...

Article GUID: 38913058
Exposure to humans and task difficulty levels affect wild raccoons (Procyon lotor) learning

Author(s): Lazure L; Weladji RB;

Cognition helps wildlife exploit novel resources and environments. Raccoons (Procyon lotor) have successfully adapted to human presence, in part due to their cognitive abilities. However, interactions between humans and wildlife can create conflict. A bette...

Article GUID: 38912327
When population growth intensifies intergroup competition, female colobus monkeys free-ride less

Author(s): Arseneau-Robar TJ; Teichroeb JA; Macintosh AJJ; Saj TL; Glotfelty E; Lucci S; Sicotte P; Wikberg EC;...

Intergroup aggression often results in the production of public goods, such as a safe and stable social environment and a home range containing the resources required to survive and reproduce. We i...

Article GUID: 38906888
A systematic review and meta-analysis on prevalence of gastrointestinal helminthic infections in rodents of Iran: An emphasis on zoonotic aspects

Author(s): Hamzavi Y; Khodayari MT; Davari A; Shiee MR; Karamati SA; Raeghi S; Jabarmanesh H; Bashiri H; Bozorgomid A;...

Rodents are the largest group of mammals that adapt to different ecosystems and may act as the potential reservoirs of significant pathogens including gastrointestinal (GI) helminths. Rodent-borne ...

Article GUID: 38845951
TANGO2 deficiency disease is predominantly caused by a lipid imbalance

Author(s): Sacher M; DeLoriea J; Mehranfar M; Casey C; Naaz A; Gamberi C;

TANGO2 deficiency disease (TDD) is a rare genetic disorder estimated to affect ~8000 individuals worldwide. It causes neurodegeneration often accompanied by potentially lethal metabolic crises that are triggered by diet or illness. Recent work has demonstra...

Article GUID: 38836374
Natural history of TANGO2 deficiency disorder: Baseline assessment of 73 patients

Author(s): Miyake CY; Lay EJ; Soler-Alfonso C; Glinton KE; Houck KM; Tosur M; Moran NE; Stephens SB; Scaglia F; Howard TS; Kim JJ; Pham TD; Valdes SO; ...

Purpose: TANGO2 deficiency disorder (TDD), an autosomal recessive disease first reported in 2016, is characterized by neurodevelopmental delay, seizures, intermittent ataxia, hypot...

Article GUID: 36473599
Measuring prion propagation in single bacteria elucidates mechanism of loss

Author(s): Jager K; Orozco-Hidalgo MT; Springstein BL; Joly-Smith E; Papazotos F; McDonough E; Fleming E; McCallum G; Hilfinger A; Hochschild A; Potvin...

Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathi...

Article GUID: 36712035
Cumulative Effects of Watershed Disturbances and Run-of-river Dams on Mercury Cycling: Case Study and Recommendations for Environmental Managers

Author(s): Amyot M; Bilodeau F; Tremblay A; Planas D; Walsh D; Ponton DE;

Run-of-river power plants (ROR) represent the majority of hydroelectric plants worldwide. Their environmental impacts are not well documented and are believed to be limited, particularly regarding the contamination of food webs by methylmercury (MeHg), a ne...

Article GUID: 38775830
Social network dynamics, infant loss, and gut microbiota composition in female Colobus vellerosus during time periods with alpha male challenges

Author(s): Samartino S; Christie D; Penna A; Sicotte P; Ting N; Wikberg E;

The gut microbiota of group-living animals is strongly influenced by their social interactions, but it is unclear how it responds to social instability. We investigated whether social instability associated with the arrival of new males and challenges to th...

Article GUID: 38735025
Integrating microfluidics and synthetic biology: advancements and diverse applications across organisms

Author(s): Leal-Alves C; Deng Z; Kermeci N; Shih SCC;

Synthetic biology is the design and modification of biological systems for specific functions, integrating several disciplines like engineering, genetics, and computer science. The field of synthetic biology is to understand biological processes within host...

Article GUID: 38712893
Thermotolerance in S. cerevisiae as a model to study extracellular vesicle biology

Author(s): Logan CJ; Staton CC; Oliver JT; Bouffard J; Kazmirchuk TDD; Magi M; Brett CL;

The budding yeast Saccharomyces cerevisiae is a proven model organism for elucidating conserved eukaryotic biology, but to date its extracellular vesicle (EV) biology is understudied. Here, we show yeast transmit information through the extracellular medium...

Article GUID: 38711329
Chloroplast biogenesis involves spatial coordination of nuclear and organellar gene expression in Chlamydomonas

Author(s): Sun Y; Bakhtiari S; Valente-Paterno M; Wu Y; Nishimura Y; Shen W; Law C; Dhaliwal J; Dai D; Bui KH; Zerges W;...

The localization of translation can direct the polypeptide product to the proper intracellular compartment. Our results reveal translation by cytosolic ribosomes on a domain of the chloroplast enve...

Article GUID: 38709497
Functional and structural characterization of an IclR family transcription factor for the development of dicarboxylic acid biosensors

Author(s): Pham C; Nasr MA; Skarina T; Di Leo R; Kwan DH; Martin VJJ; Stogios PJ; Mahadevan R; Savchenko A;...

Prokaryotic transcription factors (TFs) regulate gene expression in response to small molecules, thus representing promising candidates as versatile small molecule-detecting biosensors valuable for...

Article GUID: 38696354
All together now: Assessing variation in maternal and nonmaternal handling of wild Colobus vellerosus infants

Author(s): King AG; Rissling T; Cote S; Sicotte P;

Primatologists have a long-standing interest in the study of maternal care and nonmaternal handling (NH) of infants stemming from recognition that early social relationships can have enduring consequences. Though maternal care and NH often include expressio...

Article GUID: 38654439
Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies

Author(s): Husser MC; Pham NP; Law C; Araujo FRB; Martin VJJ; Piekny A;

Endogenous tags have become invaluable tools to visualize and study native proteins in live cells. However, generating human cell lines carrying endogenous tags is difficult due to the low efficiency of homology-directed repair. Recently, an engineered spli...

Article GUID: 38652106
Global assessment of effective population sizes: Consistent taxonomic differences in meeting the 50/500 rule

Author(s): Clarke SH; Lawrence ER; Matte JM; Gallagher BK; Salisbury SJ; Michaelides SN; Koumrouyan R; Ruzzante DE; Grant JWA; Fraser DJ;...

Effective population size (Ne) is a particularly useful metric for conservation as it affects genetic drift, inbreeding and adaptive potential within populations. Current guidelines recommend a min...

Article GUID: 38613250
Recruitment dynamics of juvenile salmonids: Comparisons among populations and with classic case studies

Author(s): Matte JO; Fraser DJ; Grant JWA;

Understanding recruitment, the process by which individuals are added to a population or to a fishery, is critical for understanding population dynamics and facilitating sustainable fisheries management. Important variation in recruitment dynamics is observ...

Article GUID: 38599588
Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains com...

Article GUID: 38596311
Spatial versus spatio-temporal approaches for studying metacommunities: a multi-taxon analysis in Mediterranean and tropical temporary ponds

Author(s): Gálvez Á; Peres-Neto PR; Castillo-Escrivà A; Bonilla F; Camacho A; García-Roger EM; Iepure S; Miralles J; Monrós JS; Olmo C; Picazo A; Rojo ...

Prior research on metacommunities has largely focused on snapshot surveys, often overlooking temporal dynamics. In this study, our aim was to compare the insights obtained from metacommunity analys...

Article GUID: 38565154
Limited Differences in Insect Herbivory on Young White Spruce Growing in Small Open Plantations and under Natural Canopies in Boreal Mixed Forests

Author(s): Yataco AP; Noor S; Girona MM; Work T; Despland E;

In managed boreal forests, both plantations and natural regeneration are used to re-establish a cohort of conifer trees following harvest or disturbance. Young trees in open plantations generally grow more rapidly than under forest canopies, but more rapid ...

Article GUID: 38535391
BioCloneBot: A versatile, low-cost, and open-source automated liquid handler

Author(s): Wells KC; Kharma N; Jaunky BB; Nie K; Aguiar-Tawil G; Berry D;

Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automate...

Article GUID: 38524156
Alternative Oxidase: From Molecule and Function to Future Inhibitors

Author(s): Li J; Yang S; Wu Y; Wang R; Liu Y; Liu J; Ye Z; Tang R; Whiteway M; Lv Q; Yan L;

In the respiratory chain of the majority of aerobic organisms, the enzyme alternative oxidase (AOX) functions as the terminal oxidase and has important roles in maintaining metabolic and signaling homeostasis in mitochondria. AOX endows the respiratory syst...

Article GUID: 38524433
Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring

Author(s): Kuzmin E; Baker TM; Lesluyes T; Monlong J; Abe KT; Coelho PP; Schwartz M; Del Corpo J; Zou D; Morin G; Pacis A; Yang Y; Martinez C; Barber J...

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromoso...

Article GUID: 38517886
Exploring the effects of anthropogenic disturbance on predator inspection activity in Trinidadian guppies

Author(s): Brusseau AJP; Feyten LEA; Crane AL; Brown GE;

No abstract available

Article GUID: 38476138
Marine fishes experiencing high-velocity range shifts may not be climate change winners

Author(s): Chaikin S; Riva F; Marshall KE; Lessard JP; Belmaker J;

Climate change is driving the global redistribution of species. A common assumption is that rapid range shifts occur in tandem with overall stable or positive abundance trends throughout the range and thus these species may be considered as climate change &...

Article GUID: 38459374
An Automated Single-Cell Droplet-Digital Microfluidic Platform for Monoclonal Antibody Discovery

Author(s): Ahmadi F; Tran H; Letourneau N; Little SR; Fortin A; Moraitis AN; Shih SCC;

Monoclonal antibody (mAb) discovery plays a prominent role in diagnostic and therapeutic applications. Droplet microfluidics has become a standard technology for high-throughput screening of antibody-producing cells due to high droplet single-cell confineme...

Article GUID: 38441226
Connectivity of stormwater ponds impacts Odonata abundance and species richness

Author(s): Richmond IC; Perron MC; Boyle SP; Pick FR;

Context: The successful dispersal of an animal depends, partly, on landscape connectivity. Urbanization poses risks to dispersal activities by increasing hostile land cover types. Objectives: We investigated how connectivity of urban ponds impacted Odonata...

Article GUID: 38435963
Cone allometry and seed protection from fire are similar in serotinous and nonserotinous conifers

Author(s): Greene DF; Kane JM; Pounden E; Michaletz ST;

Serotiny is an adaptive trait that allows certain woody plants to persist in stand-replacing fire regimes. However, the mechanisms by which serotinous cones avoid seed necrosis and nonserotinous species persist in landscapes with short fire cycles and serot...

Article GUID: 38375897
The effect of Wharton's jelly-derived stem cells seeded/boron-loaded acellular scaffolds on the healing of full-thickness burn wounds in the rat model

Author(s): Nikzad S; Same S; Safiri S; Dolati S; Roushangar Zineh B; Meshgi S; Roshangar L; Sahin F;

Burn wounds are the most destructive and complicated type of skin or underlying soft tissue injury that are exacerbated by a prolonged inflammatory response. Several cell-based therapeutic systems through the culturing of potent stem cells on modified scaff...

Article GUID: 38364284
Variation the in relationship between urban tree canopy and air temperature reduction under a range of daily weather conditions

Author(s): Locke DH; Baker M; Alonzo M; Yang Y; Ziter CD; Murphy-Dunning C; O' Neil-Dunne JPM;

Mitigating heat is a vital ecosystem service of trees, particularly with climate change. Land surface temperature measures captured at a single time of day (in the morning) dominate the urban heat island literature. Less is known about how local tree canopy...

Article GUID: 38352758
A multiyear time series (2004-2012) of bacterial and archaeal community dynamics in a changing Arctic Ocean

Author(s): Kraemer SA; Ramachandran A; Onana VE; Li WKW; Walsh DA;

Climate change is profoundly impacting the Arctic, leading to a loss of multiyear sea ice and a warmer, fresher upper Arctic Ocean. The response of microbial communities to these climate-mediated changes is largely unknown. Here, we document the interannual...

Article GUID: 38282643
Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer

Author(s): Memari E; Khan D; Alkins R; Helfield B;

Focused ultrasound (FUS) combined with intravascularly circulating microbubbles can transiently increase the permeability of the blood-brain barrier (BBB) to enable targeted therapeutic delivery to the brain, the clinical testing of which is currently under...

Article GUID: 38266715
Subharmonic resonance of phospholipid coated ultrasound contrast agent microbubbles

Author(s): Yusefi H; Helfield B;

Phospholipid encapsulated ultrasound contrast agents have proven to be a powerful addition in diagnostic imaging and show emerging applications in targeted therapy due to their resonant and nonlinear scattering. Microbubble response is affected by their int...

Article GUID: 38217906
Trans-regulatory variant network contributes to missing heritability

Author(s): Pereira V; Kuzmin E;

In a recent Cell Genomics article, Tsouris et al.1 analyze the transcriptomes of a large diallel panel of hybrids from Saccharomyces cerevisiae natural isolates to study cis- and trans-regulatory changes underlying gene expression variation. Vanessa Pereira...

Article GUID: 38216282
Reciprocal inhibition and competitive hierarchy cause negative biodiversity-ecosystem function relationships

Author(s): D' Andrea R; Khattar G; Koffel T; Frans VF; Bittleston LS; Cuellar-Gempeler C;

The relationship between biodiversity and ecosystem function (BEF) captivates ecologists, but the factors responsible for the direction of this relationship remain unclear. While higher ecosystem functioning at higher biodiversity levels ('positive BEF&...

Article GUID: 38193391
Morphological and Habitat Quality of Salmonid Streams and their Relationship with Fish-Based Indices in Aotearoa New Zealand and Ontario (Canada)

Author(s): Foote KJ; Biron PM; Grant JWA;

Habitat degradation is one of the major reasons for freshwater species decline. Hydrogeomorphological processes (such as sediment transport, bank erosion, and flooding) operate at the catchment scale and determine habitat features in river reaches. However,...

Article GUID: 38172273
Erratum: Correction Notice: Single-step Precision Genome Editing in Yeast Using CRISPR-Cas9

Author(s): Akhmetov A; Laurent JM; Gollihar J; Gardner EC; Garge RK; Ellington AD; Kachroo AH; Marcotte EM;

[This corrects the article .].

Article GUID: 38161732
Discovery of an adjuvant that resensitizes polymyxin B-resistant bacteria

Author(s): Mahdavi M; Findlay BL;

Infections caused by antibiotic-resistant bacteria are a major threat to health, increasing mortality rates and straining health systems worldwide. Adjuvants targeted to beta-lactamase function are able to resensitize bacteria to beta-lactam antibiotics, bu...

Article GUID: 38096681
Evidence suggesting that reindeer mothers allonurse according to the direct reciprocity and generalized reciprocity decision rules

Author(s): Engelhardt SC; Weladji RB; Holand Ø; Røed KH; Nieminen M;

Allonursing is the nursing of the offspring of other mothers. Cooperation is an emergent property of evolved decision rules. Cooperation can be explained by at least three evolved decision rules: 1) direct reciprocity, i.e. help someone who previously helpe...

Article GUID: 38096314
Single-cell imaging of protein dynamics of paralogs reveals mechanisms of gene retention

Author(s): Dandage R; Papkov M; Greco BM; Fishman D; Friesen H; Wang K; Styles E; Kraus O; Grys B; Boone C; Andrews B; Parts L; Kuzmin E;...

Gene duplication is common across the tree of life, including yeast and humans, and contributes to genomic robustness. In this study, we examined changes in the subcellular localization and abundan...

Article GUID: 38045359
Microgeographic variation in demography and thermal regimes stabilize regional abundance of a widespread freshwater fish

Author(s): Gallagher BK; Fraser DJ;

Predicting the persistence of species under climate change is an increasingly important objective in ecological research and management. However, biotic and abiotic heterogeneity can drive asynchrony in population responses at small spatial scales, complica...

Article GUID: 38071739
Condition-dependent survival and movement behavior in an endangered endemic damselfly

Author(s): Mahdjoub H; Zebsa R; Kahalerras A; Amari H; Bensouilah S; Samways MJ; Khelifa R;

Movement is essential for the maintenance of populations in their natural habitats, particularly for threatened species living in fluctuating environments. Empirical evidence suggests that the probability and distance of movement in territorial species are ...

Article GUID: 38071197
Decoding human genetic variation using a synthetic paradigm

Author(s): Aashiq H Kachroo

No abstract available

Article GUID: 38057547
17β-Estradiol-Loaded Exosomes for Targeted Drug Delivery in Osteoporosis: A Comparative Study of Two Loading Methods

Author(s): Gholami Farashah MS; Javadi M; Soleimani Rad J; Shakouri SK; Asnaashari S; Dastmalchi S; Nikzad S; Roshangar L;...

Purpose: Exosomes are natural nanoparticles that participate in intercellular communication through molecular transport. Recently, due to their membrane vesicular structure and surface proteins, ex...

Article GUID: 38022800
Variation in a Darwin Wasp (Hymenoptera: Ichneumonidae) Community along an Elevation Gradient in a Tropical Biodiversity Hotspot: Implications for Ecology and Conservation

Author(s): Flinte V; Pádua DG; Durand EM; Hodgin C; Khattar G; da Silveira LFL; Fernandes DRR; Sääksjärvi IE; Monteiro RF; Macedo MV; Mayhew PJ;...

Understanding how biodiversity varies from place to place is a fundamental goal of ecology and an important tool for halting biodiversity loss. Parasitic wasps (Hymenoptera) are a diverse and funct...

Article GUID: 37999060
Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections

Author(s): Feng Y; Lu H; Whiteway M; Jiang Y;

Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) cause...

Article GUID: 37918789
Heterogeneous dispersal networks to improve biodiversity science

Author(s): Savary P; Lessard JP; Peres-Neto PR;

Dispersal has a key role in shaping spatial patterns of biodiversity, yet its spatial heterogeneity is often overlooked in biodiversity analyses and management strategies. Properly parameterised heterogeneous dispersal networks capture the complex interplay...

Article GUID: 37891075
Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

Author(s): Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett M...

Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least ...

Article GUID: 37888959
Olfaction and reaction: The role of olfactory and hypothalamic investment in the antipredator responses to chemical alarm cues by northern redbelly dace

Author(s): Joyce BJ; Brown GE;

Neuroplasticity enables teleosts to promote or downregulate the growth of their brains regionally. To compensate for the effects of predation pressure, teleosts may alter their brain morphology and behavioral responses to mitigate its impact on individual f...

Article GUID: 37876646
Uncertainty about predation risk: a conceptual review

Author(s): Crane AL; Feyten LEA; Preagola AA; Ferrari MCO; Brown GE;

Uncertainty has long been of interest to economists and psychologists and has more recently gained attention among ecologists. In the ecological world, animals must regularly make decisions related to finding resources and avoiding threats. Here, we describ...

Article GUID: 37839808
How can we apply decision-making theories to wild animal behavior? Predictions arising from dual process theory and Bayesian decision theory

Author(s): Teichroeb JA; Smeltzer EA; Mathur V; Anderson KA; Fowler EJ; Adams FV; Vasey EN; Tamara Kumpan L; Stead SM; Arseneau-Robar TJM;...

Our understanding of decision-making processes and cognitive biases is ever increasing, thanks to an accumulation of testable models and a large body of research over the last several decades. The ...

Article GUID: 37839050
Publisher Correction: A genome catalogue of lake bacterial diversity and its drivers at continental scale

Author(s): Garner RE; Kraemer SA; Onana VE; Fradette M; Varin MP; Huot Y; Walsh DA;

No abstract

Article GUID: 37821571
The caleosin RD20/CLO3 regulates lateral root development in response to abscisic acid and regulates flowering time in conjunction with the caleosin CLO7

Author(s): Brunetti SC; Arseneault MKM; Gulick PJ;

The caleosins are encoded by multi-gene families in Arabidopsis thaliana and other plant species. This work investigates the role of two family members, RD20/CLO3 and CLO7, in flowering transition and in root development in response to ABA treatment. Gene e...

Article GUID: 37812854
The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans

Author(s): Shrivastava M; Kouyoumdjian GS; Kirbizakis E; Ruiz D; Henry M; Vincent AT; Sellam A; Whiteway M;...

Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans. We found that activation of the transcr...

Article GUID: 37791798
Interplay between male quality and male-female compatibility across episodes of sexual selection

Author(s): Mahdjoub H; Khelifa R; Roy J; Sbilordo SH; Zeender V; Perdigón Ferreira J; Gourgoulianni N; Lüpold S;...

The processes underlying mate choice profoundly influence the dynamics of sexual selection and the evolution of male sexual traits. Consistent preference for certain phenotypes may erode genetic va...

Article GUID: 37774022
Microhabitat conditions drive uncertainty of risk and shape neophobic responses in Trinidadian guppies, Poecilia reticulata

Author(s): Feyten LEA; Ramnarine IW; Brown GE;

In response to uncertain risks, prey may rely on neophobic phenotypes to reduce the costs associated with the lack of information regarding local conditions. Neophobia has been shown to be driven by information reliability, ambient risk and predator diversi...

Article GUID: 37753307
Genome sequencing of 15 acid-tolerant yeasts

Author(s): Bagley JA; Pyne ME; Exley K; Kevvai K; Wang Q; Whiteway M; Martin VJJ;

We report draft genome sequences for 15 non-conventional Saccharomycotina yeast strains obtained from public culture repositories. Included in our collection are eight strains of Pichia with broad tolerance to dicarboxylic acids. The genome sequences of the...

Article GUID: 37747226
Fitness Costs of Antibiotic Resistance Impede the Evolution of Resistance to Other Antibiotics

Author(s): Chowdhury FR; Findlay BL;

Antibiotic resistance is a major threat to global health, claiming the lives of millions every year. With a nearly dry antibiotic development pipeline, novel strategies are urgently needed to combat resistant pathogens. One emerging strategy is the use of s...

Article GUID: 37726252
TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions

Author(s): Almousa H; Lewis SA; Bakhtiari S; Nordlie SH; Pagnozzi A; Magee H; Efthymiou S; Heim JA; Cornejo P; Zaki MS; Anwar N; Maqbool S; Rahman F; N...

Highly conserved transport protein particle (TRAPP) complexes regulate subcellular trafficking pathways. Accurate protein trafficking has been increasingly recognized to be critically important for...

Article GUID: 37713627
Screening non-conventional yeasts for acid tolerance and engineering Pichia occidentalis for production of muconic acid

Author(s): Pyne ME; Bagley JA; Narcross L; Kevvai K; Exley K; Davies M; Wang Q; Whiteway M; Martin VJJ;...

Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism's prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipula...

Article GUID: 37652930
Mismatch between calf paternity and observed copulations between male and female reindeer: Multiple mating in a polygynous ungulate?

Author(s): Coombs KR; Weladji RB; Holand Ø; Røed KH;

In polygynous systems, such as that exhibited by reindeer Rangifer tarandus, mate choice can be difficult to disentangle from male intrasexual competition because male behavior may constrain female choice. Multiple mating may provide an avenue for female ma...

Article GUID: 37614915
Alleviative Effects of Adipose Tissue-derived Stem Cells and α-NETA on Metabolic, Biochemical, and Endocrine Parameters in a Letrozole-induced Rat Model of PCOS

Author(s): Nejabati HR; Nikzad S; Roshangar L;

Background: Polycystic ovary syndrome (PCOS), the most prevalent reproductive disorder, is accompanied by hyperandrogenism (HA), ovulatory dysfunction (OD), and insulin resistance (IR). A number of reports indicate that adipokines play a vital role in the p...

Article GUID: 37584355
CRAPS: Chromosomal-Repair-Assisted Pathway Shuffling in Yeast

Author(s): Dykstra CB; Pyne ME; Martin VJJ;

A fundamental challenge of metabolic engineering involves assembling and screening vast combinations of orthologous enzymes across a multistep biochemical pathway. Current pathway assembly workflows involve combining genetic parts ex vivo and assembling one...

Article GUID: 37584634
Global meta-analysis of urbanization stressors on insect abundance, richness, and traits

Author(s): Vaz S; Manes S; Khattar G; Mendes M; Silveira L; Mendes E; de Morais Rodrigues E; Gama-Maia D; Lorini ML; Macedo M; Paiva PC;...

Anthropic stressors are among the greatest concerns in nature conservation. Among these, deforestation and urban expansion are major drivers of habitat loss, which is a major threat to biodiversity...

Article GUID: 37543317
Kaempferol: A Dietary Flavonol in Alleviating Obesity

Author(s): Nejabati HR; Nikzad S; Roshangar L;

Obesity is considered as a chronic and high-prevalence disease on a global scale which affects all genders and ages. Although various drugs have been confirmed for the treatment of obesity, these medications have been shown to have a number of adverse effec...

Article GUID: 37537778
A genome catalogue of lake bacterial diversity and its drivers at continental scale

Author(s): Garner RE; Kraemer SA; Onana VE; Fradette M; Varin MP; Huot Y; Walsh DA;

Lakes are heterogeneous ecosystems inhabited by a rich microbiome whose genomic diversity is poorly defined. We present a continental-scale study of metagenomes representing 6.5 million km2 of the most lake-rich landscape on Earth. Analysis of 308 Canadian ...

Article GUID: 37524802
Monkeys who experience more feeding competition utilize social information to learn foraging skills faster

Author(s): Arseneau-Robar TJM; Anderson KA; Sicotte P; Teichroeb JA;

Animals must learn foraging skills to successfully survive and reproduce but the sources of interindividual variation in learning are poorly understood. For example, there is little consensus on the role motivation plays, even though it is a key factor impa...

Article GUID: 37468534
Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

Author(s): Mansur A; Joseph R; Kim ES; Jean-Beltran PM; Udeshi ND; Pearce C; Jiang H; Iwase R; Milev MP; Almousa HA; McNamara E; Widrick J; Perez C; Ra...

Ubiquitin-proteasome system (UPS) dysfunction is associated with the pathology of a wide range of human diseases, including myopathies and muscular atrophy. However, the mechanistic understanding o...

Article GUID: 37432316
Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger

Author(s): Sgro M; Chow N; Olyaei F; Arentshorst M; Geoffrion N; Ram AFJ; Powlowski J; Tsang A;

Bacteria and fungi catabolize plant-derived aromatic compounds by funneling into one of seven dihydroxylated aromatic intermediates, which then undergo ring fission and conversion to TCA cycle intermediates. Two of these intermediates, protocatechuic acid a...

Article GUID: 37399977
Divergent directed evolution of a TetR-type repressor towards aromatic molecules

Author(s): Nasr MA; Martin VJJ; Kwan DH;

Reprogramming cellular behaviour is one of the hallmarks of synthetic biology. To this end, prokaryotic allosteric transcription factors (aTF) have been repurposed as versatile tools for processing small molecule signals into cellular responses. Expanding t...

Article GUID: 37377432
Macrogenetics reveals multifaceted influences of environmental variation on vertebrate population genetic diversity across the Americas

Author(s): Lawrence ER; Pedersen EJ; Fraser DJ;

The broad scale distribution of population-specific genetic diversity (GDP ) across taxa remains understudied relative to species diversity gradients, despite its relevance for systematic conservation planning. We used nuclear DNA data collected from 3678 v...

Article GUID: 37365672
Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast

Author(s): Sultana S; Abdullah M; Li J; Hochstrasser M; Kachroo AH;

Yeast and humans share thousands of genes despite a billion years of evolutionary divergence. While many human genes can functionally replace their yeast counterparts, nearly half of the tested shared genes cannot. For example, most yeast proteasome subunit...

Article GUID: 37364278
Rapid, scalable, combinatorial genome engineering by marker-less enrichment and recombination of genetically engineered loci in yeast

Author(s): Abdullah M; Greco BM; Laurent JM; Garge RK; Boutz DR; Vandeloo M; Marcotte EM; Kachroo AH;

A major challenge to rationally building multi-gene processes in yeast arises due to the combinatorics of combining all of the individual edits into the same strain. Here, we present a precise and multi-site genome editing approach that combines all edits w...

Article GUID: 37323580
Candidiasis: from cutaneous to systemic, new perspectives of potential targets and therapeutic strategies

Author(s): Lu H; Hong T; Jiang Y; Whiteway M; Zhang S;

Candidiasis is an infection caused by fungi from a Candida species, most commonly Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on human skin and mucous membranes of the mouth, intestines or vagina. It can cause a wide...

Article GUID: 37307922
Ratiometric Sensing of Glyphosate in Water Using Dual Fluorescent Carbon Dots

Author(s): Clermont-Paquette A; Mendoza DA; Sadeghi A; Piekny A; Naccache R;

Glyphosate is a broad-spectrum pesticide used in crops and is found in many products used by industry and consumers. Unfortunately, glyphosate has been shown to have some toxicity toward many organisms found in our ecosystems and has been reported to have c...

Article GUID: 37299928
Effects of Herbicides and the Chytrid Fungus Batrachochytrium dendrobatidis on the growth, development and survival of Larval American Toads (Anaxyrus americanus)

Author(s): Paetow LJ; Cue RI; Pauli BD; Marcogliese DJ;

Pesticides and pathogens adversely affect amphibian health, but their interactive effects are not well known. We assessed independent and combined effects of two agricultural herbicides and the fungal pathogen Batrachochytrium dendrobatidis (Bd) on the grow...

Article GUID: 37216860
Pushed to the edge: Spatial sorting can slow down invasions

Author(s): Shaw AK; Lutscher F; Popovic L;

Our ability to understand population spread dynamics is complicated by rapid evolution, which renders simple ecological models insufficient. If dispersal ability evolves, more highly dispersive individuals may arrive at the population edge than less dispers...

Article GUID: 37198882
Therapeutic Potential of Mesenchymal Stem Cells in PCOS

Author(s): Nejabati HR; Nikzad S; Roshangar L;

Polycystic ovary syndrome (PCOS) is a major reproductive endocrine disorder affecting different facets of a woman's life, comprising reproduction, metabolism, and mental health. Recently, several research groups have brought attention to the therapeutic...

Article GUID: 37198984
The evolution of plasticity at geographic range edges

Author(s): Usui T; Lerner D; Eckert I; Angert AL; Garroway CJ; Hargreaves A; Lancaster LT; Lessard JP; Riva F; Schmidt C; van der Burg K; Marshall KE;...

Phenotypic plasticity enables rapid responses to environmental change, and could facilitate range shifts in response to climate change. What drives the evolution of plasticity at range edges, and t...

Article GUID: 37183152
Reproducibility in ecology and evolution: Minimum standards for data and code

Author(s): Jenkins GB; Beckerman AP; Bellard C; Benítez-López A; Ellison AM; Foote CG; Hufton AL; Lashley MA; Lortie CJ; Ma Z; Moore AJ; Narum SR; Nils...

We call for journals to commit to requiring open data be archived in a format that will be simple and clear for readers to understand and use. If applied consistently, these requirements will allow...

Article GUID: 37181203
Functional Synthetic Biology

Author(s): Aldulijan I; Beal J; Billerbeck S; Bouffard J; Chambonnier G; Ntelkis N; Guerreiro I; Holub M; Ross P; Selvarajah V; Sprent N; Vidal G; Vign...

Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of funct...

Article GUID: 37073284
Ecological strategies of (pl)ants: Towards a world-wide worker economic spectrum for ants

Author(s): Gibb H; Bishop TR; Leahy L; Parr CL; Lessard JP; Sanders NJ; Shik JZ; Ibarra-Isassi J; Narendra A; Dunn RR; Wright IJ;...

Current global challenges call for a rigorously predictive ecology. Our understanding of ecological strategies, imputed through suites of measurable functional traits, comes from decades of work th...

Article GUID: 37056633
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)

Author(s): Pyne ME; Gold ND; Martin VJJ;

Sacred lotus (Nelumbo nucifera) has been utilized as a food, medicine, and spiritual symbol for nearly 3000 years. The medicinal properties of lotus are largely attributed to its unique profile of benzylisoquinoline alkaloids (BIAs), which includes potentia...

Article GUID: 37004909
A metagenomic-based study of two sites from the Barbadian reef system

Author(s): Simpson S; Bettauer V; Ramachandran A; Kraemer S; Mahon S; Medina M; Vallès Y; Dumeaux V; Vallès H; Walsh D; Hallett MT;...

We study the microbiome of sea water collected from two locations of the Barbadian coral reefs. The two sites differ in several environmental and ecological variables including their endogenous ben...

Article GUID: 37009568
Decoupled responses of biodiversity facets driven from anuran vulnerability to climate and land-use changes

Author(s): Ceron K; Sales LP; Santana DJ; Pires MM;

Biodiversity loss not only implies the loss of species but also entails losses in other dimensions of biodiversity, such as functional, phylogenetic and interaction diversity. Yet, each of those facets of biodiversity may respond differently to extinctions....

Article GUID: 36967645
Identifying climate change refugia for South American biodiversity

Author(s): Sales LP; Pires MM;

Refugia-based conservation strategies offer long-term effectiveness and minimize uncertainty on strategies for climate change adaptation. Here, we use distribution modelling to identify climate change refugia for 617 terrestrial mammals and quantify the rol...

Article GUID: 36919472
Non-Reproductive Sexual Behavior in Wild White-Thighed Colobus Monkeys (Colobus vellerosus)

Author(s): Teichroeb JA; Fox SA; Samartino S; Wikberg EC; Sicotte P;

Rare behaviors are often missing from published papers, hampering phylogenetic analyses. Here, we report, for the first time, masturbation and same-sex sexual behavior (SSB) in both male and female black-and-white colobus monkeys. We recorded these behavior...

Article GUID: 36849676
A shift to English in Algerian education

Author(s): Rassim Khelifa

No abstract

Article GUID: 36795832
Single Digit Index Finger Amputation-To Replant or Not?

Author(s): Thibedeau M; Ramji M; McKenzie M; Yeung J; Nickerson DA;

ackground: Single index finger replantation is often listed as a contraindication due to its hindrance of hand function when replanted. Recent studies demonstrate comparable subjective and global functional outcomes for index flexor zone II finger replants ...

Article GUID: 36755823
Decline in wild bee species richness associated with honey bee (Apis mellifera L.) abundance in an urban ecosystem

Author(s): MacInnis G; Normandin E; Ziter CD;

The spatial heterogeneity of urban landscapes, relatively low agrochemical use, and species-rich floral communities often support a surprising diversity of wild pollinators in cities. However, the management of Western honey bees (Apis mellifera L.) in urba...

Article GUID: 36755869
Can species naming drive scientific attention? A perspective from plant-feeding arthropods

Author(s): Mlynarek JJ; Cull C; Parachnowitsch AL; Vickruck JL; Heard SB;

How do researchers choose their study species? Some choices are based on ecological or economic importance, some on ease of study, some on tradition-but could the name of a species influence researcher decisions? We asked whether phytophagous arthropod spec...

Article GUID: 36750196
Converting antimicrobial into targeting peptides reveals key features governing protein import into mitochondria and chloroplasts

Author(s): Caspari OD; Garrido C; Law CO; Choquet Y; Wollman FA; Lafontaine I;

We asked what peptide features govern targeting to the mitochondria versus the chloroplast using antimicrobial peptides as a starting point. This approach was inspired by the endosymbiotic hypothesis that organelle-targeting peptides derive from antimicrobi...

Article GUID: 36733255
Geospatial analysis reveals a hotspot of fecal bacteria in Canadian prairie lakes linked to agricultural non-point sources

Author(s): Oliva A; Onana VE; Garner RE; Kraemer SA; Fradette M; Walsh DA; Huot Y;

Lakes are sentinels of environmental changes within their watersheds including those induced by a changing climate and anthropogenic activities. In particular, contamination originating from point or non-point sources (NPS) within watersheds might be reflec...

Article GUID: 36653256
Mutualistic coevolution and community diversity favour persistence in metacommunities under environmental changes

Author(s): Cosmo LG; Sales LP; Guimarães PR; Pires MM;

Linking local to regional ecological and evolutionary processes is key to understand the response of Earth's biodiversity to environmental changes. Here we integrate evolution and mutualistic coevolution in a model of metacommunity dynamics and use nume...

Article GUID: 36629106
Degradation pathways for organic matter of terrestrial origin are widespread and expressed in Arctic Ocean microbiomes

Author(s): Grevesse T; Guéguen C; Onana VE; Walsh DA;

Background: The Arctic Ocean receives massive freshwater input and a correspondingly large amount of humic-rich organic matter of terrestrial origin. Global warming, permafrost melt, and a changing hydrological cycle will contribute to an intensification of...

Article GUID: 36566218
An electrochemical aptasensor for Δ9-tetrahydrocannabinol detection in saliva on a microfluidic platform

Author(s): Kékedy-Nagy L; Perry JM; Little SR; Llorens OY; Shih SCC;

We present a novel "on-off", cost-effective, rapid electrochemical aptasensor combined with a microfluidics cartridge system for the detection of ?9-THC (?9-tetrahydrocannabinol) in human saliva via differential pulse voltammetry. The assay relied on the co...

Article GUID: 36549107
Stable Cavitation-Mediated Delivery of miR-126 to Endothelial Cells

Author(s): He S; Singh D; Yusefi H; Helfield B;

In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia. Novel ultrasound-stimulated microbubbles offer a means to deli...

Article GUID: 36559150
The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum

Author(s): Li J; Chroumpi T; Garrigues S; Kun RS; Meng J; Salazar-Cerezo S; Aguilar-Pontes MV; Zhang Y; Tejomurthula S; Lipzen A; Ng V; Clendinen CS; T...

Fungi play a critical role in the global carbon cycle by degrading plant polysaccharides to small sugars and metabolizing them as carbon and energy sources. We mapped the well-established sugar met...

Article GUID: 36547648
Polarization and cell-fate decision facilitated by the adaptor Ste50p in Saccharomyces cerevisiae

Author(s): Sharmeen N; Law C; Wu C;

In response to pheromone, many proteins localize on the plasma membrane of yeast cell to reform it into a polarized shmoo structure. The adaptor protein Ste50p, known as a pheromone signal enhancer critical for shmoo polarization, has never been explored sy...

Article GUID: 36538537
Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells

Author(s): Asadi P; Milev MP; Saint-Dic D; Gamberi C; Sacher M;

Mutations in the Transport and Golgi Organization 2 (TANGO2) gene are associated with intellectual deficit, neurodevelopmental delay and regression. Individuals can also present with an acute metabolic crisis that includes rhabdomyolysis, cardiomyopathy and...

Article GUID: 36502486
A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

Author(s): Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y;...

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungici...

Article GUID: 36475771
Droplet digital microfluidic system for screening filamentous fungi based on enzymatic activity

Author(s): Samlali K; Alves CL; Jezernik M; Shih SCC;

Fungal cell-wall-degrading enzymes have great utility in the agricultural and food industries. These cell-wall-degrading enzymes are known to have functions that can help defend against pathogenic organisms. The existing methods used to discover these enzym...

Article GUID: 36438986
Demographic resilience of brook trout populations subjected to experimental size-selective harvesting

Author(s): Clarke SH; McCracken GR; Humphries S; Ruzzante DE; Grant JWA; Fraser DJ;

Sustainable management of exploited populations benefits from integrating demographic and genetic considerations into assessments, as both play a role in determining harvest yields and population persistence. This is especially important in populations subj...

Article GUID: 36426123
Diversity is the spice of life: An overview of how cytokinesis regulation varies with cell type

Author(s): Ozugergin I; Piekny A;

Cytokinesis is required to physically cleave a cell into two daughters at the end of mitosis. Decades of research have led to a comprehensive understanding of the core cytokinesis machinery and how it is regulated in animal cells, however this knowledge was...

Article GUID: 36420142
Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA

Author(s): Husser MC; Ozugergin I; Resta T; Martin VJJ; Piekny AJ;

Cytokinesis is required to physically separate the daughter cells at the end of mitosis. This crucial process requires the assembly and ingression of an actomyosin ring, which must occur with high fidelity to avoid aneuploidy and cell fate changes. Most of ...

Article GUID: 36416720
An RNA granule for translation quality control in Saccharomyces cerevisiae

Author(s): Dhaliwal JS; Panozzo C; Benard L; Zerges W;

Cytoplasmic RNA granules compartmentalize phases of the translation cycle in eukaryotes. We previously reported the localization of oxidized RNA to cytoplasmic foci called oxidized RNA bodies (ORBs) in human cells. We show here that ORBs are RNA granules in...

Article GUID: 36373798
A Synthetic Biosensor for Detecting Putrescine in Beef Samples

Author(s): Selim AS; Perry JM; Nasr MA; Pimprikar JM; Shih SCC;

Biogenic amines (BAs) are toxicological risks present in many food products. Putrescine is the most common foodborne BA and is frequently used as a quality control marker. Currently, there is a lack of regulation concerning safe putrescine limits in food as...

Article GUID: 36356104
Patient and family engagement in patient care and research in Canadian intensive care units: a national survey

Author(s): Burns KEA; McDonald E; Debigaré S; Zamir N; Vasquez M; Piche-Ayotte M; Oczkowski S;

Purpose: While patient and family engagement may improve clinical care and research, current practices for engagement in Canadian intensive care units (ICUs) are unknown. Methods: We developed and administered a cross-sectional questionnaire to ICU leaders...

Article GUID: 36344874
A resistome survey across hundreds of freshwater bacterial communities reveals the impacts of veterinary and human antibiotics use

Author(s): Kraemer SA; Barbosa da Costa N; Oliva A; Huot Y; Walsh DA;

Our decreasing ability to fight bacterial infections is a major health concern. It is arising due to the evolution of antimicrobial resistance (AMR) in response to the mis- and overuse of antibiotics in both human and veterinary medicine. Lakes integrate wa...

Article GUID: 36338036
The caleosin CLO7 and its role in the heterotrimeric G-protein signalling network

Author(s): Brunetti SC; Arseneault MKM; Gulick PJ;

The investigation of the caleosin CLO7 in relation to heterotrimeric G-protein signalling in Arabidopsis showed that the gene plays a role in seed germination and embryo viability. The caleosin CLO7 belongs to a multi-gene family of calcium-binding proteins...

Article GUID: 36334585
Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications

Author(s): Allard P; Papazotos F; Potvin-Trottier L;

Cells are inherently dynamic, whether they are responding to environmental conditions or simply at equilibrium, with biomolecules constantly being made and destroyed. Due to their small volumes, the chemical reactions inside cells are stochastic, such that ...

Article GUID: 36312536
We're building it up to burn it down: fire occurrence and fire-related climatic patterns in Brazilian biomes

Author(s): Diele Viegas LM; Sales L; Hipólito J; Amorim C; Johnson de Pereira E; Ferreira P; Folta C; Ferrante L; Fearnside P; Mendes Malhado AC; Frede...

Background: Terrestrial biomes in South America are likely to experience a persistent increase in environmental temperature, possibly combined with moisture reduction due to climat...

Article GUID: 36312759
Recommendations for making editorial boards diverse and inclusive

Author(s): Mahdjoub H; Maas B; Nuñez MA; Khelifa R;

Lack of diversity in editorial boards hinders multifaceted perspectives in fields such as ecology, evolution, and conservation. We outline ten key actions for editorial boards to promote equity, diversity, and inclusion, benefiting the journal in attracting...

Article GUID: 36280401
The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles

Author(s): Yusefi H; Helfield B;

Ultrasound-driven microbubbles, typically between 1 and 8 µm in diameter, are resonant scatterers that are employed as diagnostic contrast agents and emerging as potentiators of targeted therapies. Microbubbles are administered in populations whereby their ...

Article GUID: 36223708
A two-tiered system for selective receptor and transporter protein degradation

Author(s): Golden CK; Kazmirchuk TDD; McNally EK; El Eissawi M; Gokbayrak ZD; Richard JD; Brett CL;

Diverse physiology relies on receptor and transporter protein down-regulation and degradation mediated by ESCRTs. Loss-of-function mutations in human ESCRT genes linked to cancers and neurological disorders are thought to block this process. However, when h...

Article GUID: 36215320
Inconsistent response of taxonomic groups to space and environment in mediterranean and tropical pond metacommunities

Author(s): Gálvez Á; Peres-Neto PR; Castillo-Escrivà A; Bonilla F; Camacho A; García-Roger EM; Iepure S; Miralles-Lorenzo J; Monrós JS; Olmo C; Picazo ...

The metacommunity concept provides a theoretical framework that aims at explaining organism distributions by a combination of environmental filtering, dispersal, and drift. However, few works have ...

Article GUID: 36199222
A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies

Author(s): Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT;...

We present deep learning-based approaches for exploring the complex array of morphologies exhibited by the opportunistic human pathogen Candida albicans. Our system, entitled Candescence, automatic...

Article GUID: 35972285
Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast

Author(s): Leonov A; Feldman R; Piano A; Arlia-Ciommo A; Junio JAB; Orfanos E; Tafakori T; Lutchman V; Mohammad K; Elsaser S; Orfali S; Rajen H; Titore...

We propose a hypothesis of a mechanism linking cellular aging to cellular quiescence in chronologically aging budding yeast. Our hypothesis posits that this mechanism integrates four different proc...

Article GUID: 35937500
Assessing effects of predator density and diversity on neophobia in Trinidadian guppies

Author(s): Feyten LEA; Demers EEM; Ramnarine IW; Brown GE;

Neophobic predator avoidance, where prey actively avoid novel stimuli, is thought to allow prey to cope with the inability to predict predation risk (i.e. uncertainty) while reducing the costs associated with learning. Recent studies suggest that neophobia ...

Article GUID: 35907447
Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate

Author(s): Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J;

The infection of a mammalian host by the pathogenic fungus Candida albicans involves fungal resistance to reactive oxygen species (ROS)-induced DNA damage stress generated by the defending macrophages or neutrophils. Thus, the DNA damage response in C. albi...

Article GUID: 35886903
Gold Nano-Bio-Interaction to Modulate Mechanobiological Responses for Cancer Therapy Applications

Author(s): Sohrabi Kashani A; Larocque K; Piekny A; Packirisamy M;

In the present study, we investigate the mechanobiological responses of human lung cancer that may occur through their interactions with two different types of gold nanoparticles: nanostars and nanospheres. Hyperspectral images of nanoparticle-treated cells...

Article GUID: 35839330
Acetate and hypertonic stress stimulate vacuole membrane fission using distinct mechanisms

Author(s): Gokbayrak ZD; Patel D; Brett CL;

Vacuoles in plants and fungi play critical roles in cell metabolism and osmoregulation. To support these functions, vacuoles change their morphology, e.g. they fragment when these organisms are challenged with draught, high salinity or metabolic stress (e.g...

Article GUID: 35834522
Pattern and Visual Prognostic Factors of Behcet's Uveitis in Northwest Iran

Author(s): Alizadeh Ghavidel L; Bagheri M; Mousavi F; Rezaei L; Hazeri S; Hashemi HS;

Purpose: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. Methods: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the Inter...

Article GUID: 35765637
Population demography maintains biogeographic boundaries

Author(s): Schmidt C; Muñoz G; Lancaster LT; Lessard JP; Marske KA; Marshall KE; Garroway CJ;

Global biodiversity is organised into biogeographic regions that comprise distinct biotas. The contemporary factors maintaining differences in species composition between regions are poorly understood. Given evidence that populations with sufficient genetic...

Article GUID: 35753949
The MyLo CRISPR-Cas9 Toolkit: A Markerless Yeast Localization and Overexpression CRISPR-Cas9 Toolkit

Author(s): Bean BDM; Whiteway M; Martin VJJ;

The genetic tractability of the yeast Saccharomyces cerevisiae has made it a key model organism for basic research and a target for metabolic engineering. To streamline the introduction of tagged genes and compartmental markers with powerful CRISPR-Cas9-bas...

Article GUID: 35708612
The aesthetic value of reef fishes is globally mismatched to their conservation priorities

Author(s): Langlois J; Guilhaumon F; Baletaud F; Casajus N; De Almeida Braga C; Fleuré V; Kulbicki M; Loiseau N; Mouillot D; Renoult JP; Stahl A; Stuar...

Reef fishes are closely connected to many human populations, yet their contributions to society are mostly considered through their economic and ecological values. Cultural and intrinsic values of ...

Article GUID: 35671265
Humanized yeast to model human biology, disease and evolution

Author(s): Kachroo AH; Vandeloo M; Greco BM; Abdullah M;

For decades, budding yeast, a single-cellular eukaryote, has provided remarkable insights into human biology. Yeast and humans share several thousand genes despite morphological and cellular differences and over a billion years of separate evolution. These ...

Article GUID: 35661208
The importance of eco-evolutionary dynamics for predicting and managing insect range shifts

Author(s): Wellenreuther M; Dudaniec RY; Neu A; Lessard JP; Bridle J; Carbonell JA; Diamond SE; Marshall KE; Parmesan C; Singer MC; Swaegers J; Thomas ...

Evolutionary change impacts the rate at which insect pests, pollinators, or disease vectors expand or contract their geographic ranges. Although evolutionary changes, and their ecological feedbacks...

Article GUID: 35644339
Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols

Author(s): Bean BDM; Mulvihill CJ; Garge RK; Boutz DR; Rousseau O; Floyd BM; Cheney W; Gardner EC; Ellington AD; Marcotte EM; Gollihar JD; Whiteway M; ...

The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. However, some receptors, including the mu opioid receptor...

Article GUID: 35610225
Characterization and Expression of the Pirin Gene Family in Triticum aestivum

Author(s): Brunetti SC; Arseneault MKM; Gulick PJ;

Pirins are nuclear bicupin proteins, encoded by genes that are one of several gene families that comprise the Cupin superfamily in plants. Pirin genes have been implicated in stress response pathways studied in Arabidopsis and At-Pirin1 has been shown to in...

Article GUID: 35504035
Characterization of the heterotrimeric G protein gene families in Triticum aestivum and related species

Author(s): Gawande ND; Hamiditabar Z; Brunetti SC; Gulick PJ;

This study characterizes the heterotrimeric G protein gene families in Triticum aestivum, their tissue-specific expression patterns during development and in response to biotic and abiotic stress conditions. There are three Ga genes, three Gß and 12 G? gene...

Article GUID: 35463045
An Overview of Cell Membrane Perforation and Resealing Mechanisms for Localized Drug Delivery

Author(s): He S; Singh D; Helfield B;

Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease. Indeed, the plasma membrane represents a significant barrier to successful del...

Article GUID: 35456718
Phylogeography of the Korean endemic Coreoleuciscus (Cypriniformes: Gobionidae): the genetic evidence of colonization through Eurasian continent to the Korean Peninsula during Late Plio-Pleistocene

Author(s): Jeon HB; Song HY; Suk HY; Bang IC;

Background: Freshwater endemism is thought to have been formed through the vicariance of connected water systems or the process by which ancestral populations colonized specific areas. The Korean Peninsula is well recognized for its high level of freshwater...

Article GUID: 35438462
Regional variation drives differences in microbial communities associated with sugar maple across a latitudinal range

Author(s): De Bellis T; Laforest-Lapointe I; Solarik KA; Gravel D; Kembel SW;

Climate change is prompting plants to migrate and establish novel interactions in new habitats. Because of the pivotal roles microbes have on plant health and function, it is important to understand the ecological consequences of these shifts in host-microb...

Article GUID: 35412652
SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation

Author(s): Rashid S; Correia-Mesquita TO; Godoy P; Omran RP; Whiteway M;

SAGA (Spt-Ada-Gcn5-acetyltransferase) is a highly conserved, multiprotein co-activator complex that consists of five distinct modules. It has two enzymatic functions, a histone acetyltransferase (HAT) and a deubiquitinase (DUB) and plays a central role in p...

Article GUID: 35350439
Global urban environmental change drives adaptation in white clover

Author(s): Santangelo JS; Ness RW; Cohan B; Fitzpatrick CR; Innes SG; Koch S; Miles LS; Munim S; Peres-Neto PR; Prashad C; Tong AT; Aguirre WE; Akinwol...

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6...

Article GUID: 35298255
Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice

Author(s): Rawlins LE; Almousa H; Khan S; Collins SC; Milev MP; Leslie J; Saint-Dic D; Khan V; Hincapie AM; Day JO; McGavin L; Rowley C; Harlalka GV; V...

The highly evolutionarily conserved transport protein particle (TRAPP) complexes (TRAPP II and III) perform fundamental roles in subcellular trafficking pathways. Here we identified biallelic seque...

Article GUID: 35298461
Comparing microscopy and DNA metabarcoding techniques for identifying cyanobacteria assemblages across hundreds of lakes

Author(s): MacKeigan PW; Garner RE; Monchamp MÈ; Walsh DA; Onana VE; Kraemer SA; Pick FR; Beisner BE; Agbeti MD; da Costa NB; Shapiro BJ; Gregory-Eaves...

Accurately identifying the species present in an ecosystem is vital to lake managers and successful bioassessment programs. This is particularly important when monitoring cyanobacteria, as numerous...

Article GUID: 35287928
The effect of past defaunation on ranges, niches, and future biodiversity forecasts

Author(s): Sales LP; Galetti M; Carnaval A; Monsarrat S; Svenning JC; Pires MM;

Humans have reshaped the distribution of biodiversity across the globe, extirpating species from regions otherwise suitable and restricting populations to a subset of their original ranges. Here, we ask if anthropogenic range contractions since the Late Ple...

Article GUID: 35246902
Cryptic eco-evolutionary feedback in the city

Author(s): Carly D Ziter

Research Highlight: Brans, K. I., Tüzün, N., Sentis, A., De Meester, L., & Stoks, R. (2021). Cryptic eco-evolutionary feedback in the city: Urban evolution of prey dampens the effect of urban evolution of the predator. Journal of Animal Ecology. https:/...

Article GUID: 35238028
Games researchers play: conceptual advancement versus validation strategies

Author(s): Dubois F; R Peres-Neto P;

Conceptual advances and validation are critical to research, yet at odds. Using a game theoretical perspective, we show that a mixed strategy combining advances and validation, leads to increases in both individual researchers' and societal gains. This ...

Article GUID: 35193771
Viral Generation, Packaging, and Transduction on a Digital Microfluidic Platform

Author(s): Quach ABV; Little SR; Shih SCC;

Viral-based systems are a popular delivery method for introducing exogenous genetic material into mammalian cells. Unfortunately, the preparation of lentiviruses containing the machinery to edit the cells is labor-intensive, with steps requiring optimizatio...

Article GUID: 35192339
Neutral and adaptive drivers of genomic change in introduced brook trout (Salvelinus fontinalis) populations revealed by pooled sequencing

Author(s): Brookes B; Jeon HB; Derry AM; Post JR; Rogers SM; Humphries S; Fraser DJ;

Understanding the drivers of successful species invasions is important for conserving native biodiversity and for mitigating the economic impacts of introduced species. However, whole-genome resolution investigations of the underlying contributions of neutr...

Article GUID: 35154655
Warm and arid regions of the world are hotspots of superorganism complexity

Author(s): La Richelière F; Muñoz G; Guénard B; Dunn RR; Economo EP; Powell S; Sanders NJ; Weiser MD; Abouheif E; Lessard JP;...

Biologists have long been fascinated by the processes that give rise to phenotypic complexity of organisms, yet whether there exist geographical hotspots of phenotypic complexity remains poorly exp...

Article GUID: 35135345
Disturbance cues function as a background risk cue but not as an associative learning cue in tadpoles

Author(s): Rivera-Hernández IAE; Crane AL; Pollock MS; Ferrari MCO;

Chemical information has an important role in the sensory ecology of aquatic species. For aquatic prey, chemical cues are a vital source of information related to predator avoidance and risk assessment. For instance, alarm cues are released by prey that hav...

Article GUID: 35099624
Diverse mechanisms regulate contractile ring assembly for cytokinesis in the two-cell C. elegans embryo

Author(s): Ozugergin I; Mastronardi K; Law C; Piekny A;

Cytokinesis occurs at the end of mitosis due to the ingression of a contractile ring that cleaves the daughter cells. The core machinery regulating this crucial process is conserved among metazoans. Multiple pathways control ring assembly, but their contrib...

Article GUID: 35022791
Detection of Fusobacterium nucleatum subspecies in the saliva of pre-colorectal cancer patients, using tandem mass spectrometry

Author(s): Morsi H; Golizeh M; Brosseau N; Janati AI; Emami E; Ndao M; Tran SD;

Objective: Rising evidence links Fusobacterium nucleatum (F. nucleatum) with its four subspecies; nucleatum, polymorphum, animalis, and vincentii, with the development of colorectal cancer (CRC) and its precursor colorectal adenoma (CRA). This study aims to...

Article GUID: 34929558
Joint intergroup aggression in female colobus monkeys (Colobus vellerosus) is associated with grooming bonds, male participation, and group size

Author(s): Wikberg EC; Gonzalez S; Rodriguez C; Sicotte P;

Cooperative home range defense is common in primates, despite a collective action problem that arises when group members benefit from winning the intergroup encounter regardless of whether they participate. The costs associated with this collective action p...

Article GUID: 34927751
The occurrence of potentially pathogenic fungi and protists in Canadian lakes predicted using geomatics, in situ and satellite-derived variables: Towards a tele-epidemiological approach

Author(s): Oliva A; Garner RE; Walsh D; Huot Y;

Eukaryotic pathogens including fungi and enteroparasites infect humans, animals and plants. As integrators of landscape catchment, lakes can reflect and record biological and geochemical events or anthropogenic changes and provide useful knowledge to formul...

Article GUID: 34915335
Species compositions mediate biomass conservation: the case of lake fish communities

Author(s): Arranz I; Fournier B; Lester NP; Shuter BJ; Peres-Neto PR;

Environmental and geographical factors are known to influence the number, distribution and combination of species that coexist within ecological communities. This, in turn, should influence ecosystem functions such as biomass conservation, or the ability of...

Article GUID: 34905222
Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells

Author(s): Jaunky DB; Larocque K; Husser MC; Liu JT; Forgione P; Piekny A;

We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification. Previously we found that sub micromolar concentrations of C75 caused cytoto...

Article GUID: 34880347
Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast

Author(s): Mohammad K; Orfanos E; Titorenko VI;

After budding yeast cells cultured in a nutrient-rich liquid medium with 0.2% glucose (under caloric restriction conditions) or 2% glucose (under non-caloric restriction conditions), ferment glucose to ethanol and then consume ethanol, they enter the statio...

Article GUID: 34853658
Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast

Author(s): Garge RK; Cha HJ; Lee C; Gollihar JD; Kachroo AH; Wallingford JB; Marcotte EM;

Thiabendazole (TBZ) is an FDA-approved benzimidazole widely used for its antifungal and antihelminthic properties. We showed previously that TBZ is also a potent vascular disrupting agent and inhibits angiogenesis at the tissue level by dissociating vascula...

Article GUID: 34849907
What can be learned from fishers' perceptions for fishery management planning? Case study insights from Sainte-Marie, Madagascar

Author(s): Bernos TA; Travouck C; Ramasinoro N; Fraser DJ; Mathevon B;

Local support is critical to the success and longevity of fishery management initiatives. Previous research suggests that how resource users perceive ecological changes, explain them, and cope with them, influences local support. The objectives of this stud...

Article GUID: 34780489
Engineering Yeast for De Novo Synthesis of the Insect Repellent Nepetalactone

Author(s): Davies ME; Tsyplenkov D; Martin VJJ;

While nepetalactone, the active ingredient in catnip, is a potent insect repellent, its low in planta accumulation limits its commercial viability as an alternative repellent. Here we describe for the first time de novo nepetalactone synthesis in Saccharomy...

Article GUID: 34748704
Exploratory decisions of Trinidadian guppies when uncertain about predation risk

Author(s): Crane AL; Demers EE; Feyten LEA; Ramnarine IW; Brown GE;

Animals can reduce their uncertainty of predation risk by gathering new information via exploration behaviour. However, a decision to explore may also be costly due to increased predator exposure. Here, we found contextual effects of predation risk on the e...

Article GUID: 34741669
Empowering Melatonin Therapeutics with Drosophila Models

Author(s): Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C;

Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacol...

Article GUID: 34698120
Location and Species Matters: Variable Influence of the Environment on the Gene Flow of Imperiled, Native and Invasive Cottontails

Author(s): McGreevy TJ; Michaelides S; Djan M; Sullivan M; Beltrán DM; Buffum B; Husband T;

The environment plays an important role in the movement of individuals and their associated genes among populations, which facilitates gene flow. Gene flow can help maintain the genetic diversity both within and between populations and counter the negative ...

Article GUID: 34659333
Changes in selection pressure can facilitate hybridization during biological invasion in a Cuban lizard

Author(s): Bock DG; Baeckens S; Pita-Aquino JN; Chejanovski ZA; Michaelides SN; Muralidhar P; Lapiedra O; Park S; Menke DB; Geneva AJ; Losos JB; Kolbe ...

Hybridization is among the evolutionary mechanisms most frequently hypothesized to drive the success of invasive species, in part because hybrids are common in invasive populations. One explanation...

Article GUID: 34654747
TRAPPC11-related muscular dystrophy with hypoglycosylation of alpha-dystroglycan in skeletal muscle and brain

Author(s): Munot P; McCrea N; Torelli S; Manzur A; Sewry C; Chambers D; Feng L; Ala P; Zaharieva I; Ragge N; Roper H; Marton T; Cox P; Milev MP; Liang ...

Aims: TRAPPC11, a subunit of the transport protein particle (TRAPP) complex is important for complex integrity and anterograde membrane transport from the endoplasmic reticulum (ER) to the ER-Golgi...

Article GUID: 34648194
Curcumin inhibition of bleomycin-induced changes in lung collagen synthesis, deposition and assembly

Author(s): Durairaj P; Venkatesan S; Narayanan V; Babu M;

Background: Idiopathic pulmonary fibrosis is characterized by progressive lung tissue remodeling and disproportionate deposition of collagenous proteins with limited therapeutic interventions. The purpose of this study was to determine whether curcumin inhi...

Article GUID: 34643929
The stress induced caleosin, RD20/CLO3, acts as a negative regulator of GPA1 in Arabidopsis

Author(s): Brunetti SC; Arseneault MKM; Wright JA; Wang Z; Ehdaeivand MR; Lowden MJ; Rivoal J; Khalil HB; Garg G; Gulick PJ;...

A stress induced calcium-binding protein, RD20/CLO3 interacts with the alpha subunit of the heterotrimeric G-protein complex in Arabidopsis and affects etiolation and leaf morphology. Heterotrimeri...

Article GUID: 34599731
Digital Microfluidics Chips for the Execution and Real-Time Monitoring of Multiple Ribozymatic Cleavage Reactions

Author(s): Davis AN; Samlali K; Kapadia JB; Perreault J; Shih SCC; Kharma N;

In this paper, we describe the design and performance of two digital microfluidics (DMF) chips capable of executing multiple ribozymatic reactions, with proper controls, in response to short single-stranded DNA inducers. Since the fluorescence output of a r...

Article GUID: 34514224
A Pathfinder in High-Pressure Bioscience: In Memoriam of Gaston Hui Bon Hoa

Author(s): Davydov DR; Jung C; Petsko GA; Sligar SG; Kornblatt JA;

On 26 July 2020, our colleague and friend Dr [...].

Article GUID: 34440010
Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent

Author(s): Liu JT; Jaunky DB; Larocque K; Chen F; Mckibbon K; Sirouspour M; Taylor S; Shafeii A; Campbell D; Braga H; Piekny A; Forgione P;...

Several derivatives of a series that share a thienoisoquinoline scaffold have demonstrated potent anti-cancer activity against cancer cell lines A549, HeLa, HCT-116 in the submicromolar concentrati...

Article GUID: 34416378
Seeing is believing: tools to study the role of Rho GTPases during cytokinesis

Author(s): Koh SP; Pham NP; Piekny A;

Cytokinesis is required to cleave the daughter cells at the end of mitosis and relies on the spatiotemporal control of RhoA GTPase. Cytokinesis failure can lead to changes in cell fate or aneuploidy, which can be detrimental during development and/or can le...

Article GUID: 34405757
Expanding the limits towards 'one-pot' DNA assembly and transformation on a rapid-prototype microfluidic device

Author(s): Perry JM; Soffer G; Jain R; Shih SCC;

DNA assembly and transformation are crucial to the building process in synthetic biology. These steps are significant roadblocks when engineering increasingly complex biological systems. To address this, recent development of widespread 'biofoundry'...

Article GUID: 34369550
Defensive Traits during White Spruce (Picea glauca) Leaf Ontogeny

Author(s): Antoine-Olivier Lirette

Changes during leaf ontogeny affect palatability to herbivores, such that many insects, including the eastern spruce budworm (Choristoneura fumiferana (Clem.)), are specialist feeders on growing conifer leaves and buds. Developmental constraints imply lower...

Article GUID: 34357304
Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations

Author(s): Won H; Jeon HB; Kim DY; Suk HY;

Given the fact that threatened species are often composed of isolated small populations, spatial continuity or demography of the populations may be major factors that have shaped the species' genetic diversity. Thus, neutral loci have been the most comm...

Article GUID: 34354168
Environmental and anthropogenic effects on the nesting patterns of Nigeria-Cameroon chimpanzees in North-West Cameroon

Author(s): Fotang C; Bröring U; Roos C; Enoguanbhor EC; Dutton P; Tédonzong LRD; Willie J; Yuh YG; Birkhofer K;...

Environmental conditions and human activity influence the selection of nest sites by chimpanzees and may have serious conservation implications. We examined the characteristics of nesting trees pre...

Article GUID: 34343361
Duplicated antagonistic EPF peptides optimize grass stomatal initiation

Author(s): Jangra R; Brunetti SC; Wang X; Kaushik P; Gulick PJ; Foroud NA; Wang S; Lee JS;

Peptide signaling has emerged as a key component of plant growth and development, including stomatal patterning, which is critical for plant productivity and survival. Although exciting progress has been made in understanding EPIDERMAL PATTERNING FACTOR (EP...

Article GUID: 34328169
Advancing Undergraduate Synthetic Biology Education: Insights from a Canadian iGEM Student Perspective

Author(s): Diep P; Boucinha A; Kell BJ; Yeung BA; Chen XA; Tsyplenkov D; Serra D; Escobar A; Gnanapragasam A; Emond CA; Sajtovich VA; Mahadevan R; Kilk...

The last two decades have seen vigorous activity in synthetic biology research and ever-increasing applications of its technologies. However, pedagogical research pertaining to teaching synthetic b...

Article GUID: 34237221
Interrogation of Bacillus anthracis SrtA active site loop forming open/close lid conformations through extensive MD simulations for understanding binding selectivity of SrtA inhibitors

Author(s): Selvaraj C; Selvaraj G; Mohamed Ismail R; Vijayakumar R; Baazeem A; Wei DQ; Singh SK;

Bacillus anthracis is a gram positive, deadly spore forming bacteria causing anthrax and these bacteria having the complex mechanism in the cell wall envelope, which can adopt the changes in environmental conditions. In this, the membrane bound cell wall pr...

Article GUID: 34220215
Mixtures of rare earth elements show antagonistic interactions in Chlamydomonas reinhardtii

Author(s): Morel E; Cui L; Zerges W; Wilkinson KJ;

In order to better understand the environmental risks of the rare earth elements (REEs), it is necessary to determine their fate and biological effects under environmentally relevant conditions (e.g. at low concentrations, REE mixtures). Here, the unicellul...

Article GUID: 34175518
Varying genetic imprints of road networks and human density in North American mammal populations

Author(s): Habrich AK; Lawrence ER; Fraser DJ;

Road networks and human density are major factors contributing to habitat fragmentation and loss, isolation of wildlife populations, and reduced genetic diversity. Terrestrial mammals are particularly sensitive to road networks and encroachment by human pop...

Article GUID: 34178111
Rethinking microbial infallibility in the metagenomics era

Author(s): O' Malley MA; Walsh DA;

The 'principle of microbial infallibility' was a mainstay of microbial physiology and environmental microbiology in earlier decades. This principle asserts that wherever there is an energetic gain to be made from environmental resources, microorgani...

Article GUID: 34160589
A Novel Freshwater to Marine Evolutionary Transition Revealed within Methylophilaceae Bacteria from the Arctic Ocean

Author(s): Ramachandran A; McLatchie S; Walsh DA;

Bacteria inhabiting polar oceans, particularly the Arctic Ocean, are less studied than those at lower latitudes. Discovering bacterial adaptations to Arctic Ocean conditions is essential for understanding responses to the accelerated environmental changes o...

Article GUID: 34154421
Resampling the pool of genotypic possibilities: an adaptive function of sexual reproduction

Author(s): Hickey DA; Golding GB;

Background: Natural populations harbor significant levels of genetic variability. Because of this standing genetic variation, the number of possible genotypic combinations is many orders of magnitude greater than the population size. This means that any giv...

Article GUID: 34118864
Disturbance-induced emigration: an overlooked mechanism that reduces metapopulation extinction risk

Author(s): Mestre A; Barfield M; Peniston JH; Peres-Neto PR; Mesquita-Joanes F; Holt RD;

Emigration propensity (i.e., the tendency to leave undisturbed patches) is a key life-history trait of organisms in metapopulations with local extinctions and colonizations. Metapopulation models of dispersal evolution typically assume that patch disturbanc...

Article GUID: 34086976
Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics

Author(s): Evdokias G; Semper C; Mora-Ochomogo M; Di Falco M; Nguyen TTM; Savchenko A; Tsang A; Benoit-Gelber I;...

Previously, DNA microarrays analysis showed that, in co-culture with Bacillus subtilis, a biosynthetic gene cluster anchored with a nonribosomal peptides synthetase of Aspergillus niger is downregu...

Article GUID: 34064722
Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors

Author(s): Mohammad K; Titorenko VI;

Caloric restriction and the tor1? mutation are robust geroprotectors in yeast and other eukaryotes. Lithocholic acid is a potent geroprotector in Saccharomyces cerevisiae. Here, we used liquid chromatography coupled with tandem mass spectrometry method of n...

Article GUID: 33868583
Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target

Author(s): Li W; Shrivastava M; Lu H; Jiang Y;

Increased morbidity and mortality of candidiasis are a notable threat to the immunocompromised patients. At present, the types of drugs available to treat C. albicans infection are relatively limited. Moreover, the emergence of antifungal drug resistance of...

Article GUID: 33989979
Role of organic matter and microbial communities in mercury retention and methylation in sediments near run-of-river hydroelectric dams.

Author(s): Millera Ferriz L, Ponton DE, Storck V, Leclerc M, Bilodeau F, Walsh DA, Amyot M

Run-of-river power plants (RoRs) are expected to triple in number over the next decades in Canada. These structures are not anticipated to considerably promote the mobilization and transport of mercury (Hg) and its subsequent microbial transformation to met...

Article GUID: 33609815
Candida albicans targets that potentially synergize with fluconazole.

Author(s): Lu H, Shrivastava M, Whiteway M, Jiang Y

Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazol...

Article GUID: 33587857
Real-Time Optogenetics System for Controlling Gene Expression Using a Model-Based Design.

Author(s): Soffer G, Perry JM, Shih SCC

Optimization of engineered biological systems requires precise control over the rates and timing of gene expression. Optogenetics is used to dynamically control gene expression as an alternative to conventional chemical-based methods since it provides a mor...

Article GUID: 33543619
Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Author(s): Mohammad K; Jiang H; Titorenko VI;

Metabolomics is a methodology used for the identification and quantification of many low-molecular-weight intermediates and products of metabolism within a cell, tissue, organ, biological fluid, or organism. Metabolomics traditionally focuses on water-solub...

Article GUID: 33491678
The Biology of Vasopressin.

Author(s): Sparapani S, Millet-Boureima C, Oliver J, Mu K, Hadavi P, Kalostian T, Ali N, Avelar CM, Bardies M, Barrow B, Benedikt M, Biancardi G, Bindr...

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrest...

Article GUID: 33477721
Potential Movement Corridors and High Road-Kill Likelihood do not Spatially Coincide for Felids in Brazil: Implications for Road Mitigation.

Author(s): Cerqueira RC, Leonard PB, da Silva LG, Bager A, Clevenger AP, Jaeger JAG, Grilo C

The negative effects of roads on wildlife populations are a growing concern. Movement corridors and road-kill data are typically used to prioritize road segments for mitigation measures. Some research suggests that locations where animals move across roads ...

Article GUID: 33469694
Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes.

Author(s): Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Piere...

Horizontal gene transfer (HGT) is an important source of novelty in eukaryotic genomes. This is particularly true for the ochrophytes, a diverse and important group of algae. Previous studies have ...

Article GUID: 33419955
Using Models to (Re-)Design Synthetic Circuits.

Author(s): McCallum G, Potvin-Trottier L

Mathematical models play an important role in the design of synthetic gene circuits, by guiding the choice of biological components and their assembly into novel gene networks. Here, we present a guide for biologists to build and utilize models of gene netw...

Article GUID: 33405217
Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans.

Author(s): Yao S, Feng Y, Islam A, Shrivastava M, Gu H, Lu Y, Sheng J, Whiteway M, Feng J

The polymorphous cellular shape of Candida albicans, in particular the transition from a yeast to a filamentous form, is crucial for either commensalism or life-threatening infections of the host. Various external or internal stimuli, including serum and nu...

Article GUID: 33363697
Using intracellular plasmonics to characterize nanomorphology in human cells.

Author(s): Sohrabi Kashani A, Piekny A, Packirisamy M

Determining the characteristics and localization of nanoparticles inside cells is crucial for nanomedicine design for cancer therapy. Hyperspectral imaging is a fast, straightforward, reliable, and accurate method to study the interactions of nanoparticles ...

Article GUID: 33365137
Multi-tissue patterning drives anterior morphogenesis of the C. elegans embryo.

Author(s): Grimbert S, Mastronardi K, Richard V, Christensen R, Law C, Zardoui K, Fay D, Piekny A

Complex structures derived from multiple tissue types are challenging to study in vivo, and our knowledge of how cells from different tissues are coordinated is limited. Model organisms have proven invaluable for improving our understanding of how chemical ...

Article GUID: 33309948
Evaluating the correlation between genome-wide diversity and the release of plastic phenotypic variation in experimental translocations to novel natural environments.

Author(s): Yates MC, Fraser DJ

Phenotypic reaction norms are often shaped and constrained by selection and are important for allowing organisms to respond to environmental change. However, selection cannot constrain reaction norms for environmental conditions that populations have not ex...

Article GUID: 33274531
Genome Sequence Resource of Bacillus velezensis EB14, a native endophytic bacterial strain with biocontrol potential against the poplar stem canker causative pathogen, Sphaerulina musiva.

Author(s): Naik S, Tsang A, Ramanan US, Dayanandan S

Bacillus velezensis EB14, isolated from a leaf of Populus ? jackii, possesses antagonistic activity against Sphaerulina musiva, a fungal pathogen of Populus sp. that causes leaf spots and stem cankers on Poplars limiting the utility of hybrid poplars as pla...

Article GUID: 33263425
Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.

Author(s): Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacem...

Article GUID: 33238462
Publisher Correction: Characterization of three TRAPPC11 variants suggests a critical role for the extreme carboxy terminus of the protein.

Author(s): Milev MP; Stanga D; Schänzer A; Nascimento A; Saint-Dic D; Ortez C; Natera-de Benito D; Barrios DG; Colomer J; Badosa C; Jou C; Gallano P; Gonzalez-Quereda L; Töpf A; Johnson K; Straub V; Hahn A; S...

An amendment to this paper has been published and can be accessed via a link at the top of the paper.PMID: 33173071 [PubMed]

Article GUID: 33173071
Sediment Metagenomes as Time Capsules of Lake Microbiomes.

Author(s): Garner RE; Gregory-Eaves I; Walsh DA;

The reconstruction of ecological time series from lake sediment archives can retrace the environmental impact of human activities. Molecular genetic approaches in paleolimnology have provided unprecedented access to DNA time series, which record evidence of...

Article GUID: 33148818
Early-life and parental predation risk shape fear acquisition in adult minnows.

Author(s): Crane AL, Meuthen D, Thapa H, Ferrari MCO, Brown GE

Exposure to predation risk can induce a fearful baseline state, as well as fear reactions toward novel situations (i.e., neophobia). Some research indicates that risk exposure during sensitive periods makes adults more prone to acquiring long-term fearful p...

Article GUID: 33125574
The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.

Author(s): Milev MP, Saint-Dic D, Zardoui K, Klopstock T, Law C, Distelmaier F, Sacher M

TANGO2 variants result in a complex disease phenotype consisting of recurrent crisis-induced rhabdomyolysis, encephalopathy, seizures, lactic acidosis, hypoglycemia, and cardiac arrhythmias. Although first described in a fruit fly model as a protein necessa...

Article GUID: 32909282
Anillin Controls the Rho Zone.

Author(s): Piekny A

Bioessays. 2020 Sep 06; :e2000193 Authors: Piekny A PMID: 32893380 [PubMed - as supplied by publisher]

Article GUID: 32893380
Support transgender scientists post-COVID-19.

Author(s): Turney S, Carvalho MM, Sousa ME, Birrer C, Cordeiro TEF, Diele-Viegas LM, Hipólito J, Sales LP, Santos-Silva R, Souza L

Science. 2020 Sep 04; 369(6508):1171-1172 Authors: Turney S, Carvalho MM, Sousa ME, Birrer C, Cordeiro TEF, Diele-Viegas LM, Hipólito J, Sales LP, Santos-Silva R, Souza L PMID: 32883854 [PubMed - in process]

Article GUID: 32883854
Exploring the threat-sensitive predator avoidance hypothesis on mate competition in two wild populations of Trinidadian guppies.

Author(s): Chuard PJC, Grant JWA, Ramnarine IW, Brown GE

The intensity of mate competition is often influenced by predation pressure. The threat-sensitive predator avoidance hypothesis predicts that prey should precisely adjust their fitness-related activities to the level of perceived acute predation risk and th...

Article GUID: 32860863
Temperature drives caste-specific morphological clines in ants.

Author(s): Brassard F, Francoeur A, Lessard JP

1. The morphology of organisms relates to most aspects of their life history and autecology. As such, elucidating the drivers of morphological variation along environmental gradients might give insight into processes limiting species distributions. In eusoc...

Article GUID: 32858759
A novel homozygous variant in TRAPPC2L results in a neurodevelopmental disorder and disrupts TRAPP complex function.

Author(s): Al-Deri N, Okur V, Ahimaz P, Milev M, Valivullah Z, Hagen J, Sheng Y, Chung W, Sacher M, Ganapathi M...

BACKGROUND: Next-generation sequencing has facilitated the diagnosis of neurodevelopmental disorders with variable and non-specific clinical findings. Recently, a homozygous missense p.(Asp37Tyr) v...

Article GUID: 32843486
Ontogenetic shift from aposematism and gregariousness to crypsis in a Romaleid grasshopper.

Author(s): Despland E

Traits of chemically-defended animals can change as an individual grows and matures, and both theoretical and empirical evidence favour a direction of change from crypsis to aposematism. This study examines the suite of traits involved in an unusual opposit...

Article GUID: 32817631
A large-scale assessment of lakes reveals a pervasive signal of land use on bacterial communities.

Author(s): Kraemer SA, Barbosa da Costa N, Shapiro BJ, Fradette M, Huot Y, Walsh DA

ISME J. 2020 Aug 07;: Authors: Kraemer SA, Barbosa da Costa N, Shapiro BJ, Fradette M, Huot Y, Walsh DA

Article GUID: 32770118
Zoo soundscape: Daily variation of low-to-high-frequency sounds.

Author(s): Pelletier C, Weladji RB, Lazure L, Paré P

Zoo Biol. 2020 Jul 31;: Authors: Pelletier C, Weladji RB, Lazure L, Paré P

Article GUID: 32735724
Investigating the Accumulation of Submicron Phase-Change Droplets in Tumors.

Author(s): Helfield BL, Yoo K, Liu J, Williams R, Sheeran PS, Goertz DE, Burns PN

Ultrasound Med Biol. 2020 Jul 27;: Authors: Helfield BL, Yoo K, Liu J, Williams R, Sheeran PS, Goertz DE, Burns PN

Article GUID: 32732167
Response of reindeer mating time to climatic variability.

Author(s): Paoli A, Weladji RB, Holand Ø, Kumpula J

BMC Ecol. 2020 Jul 29;20(1):44 Authors: Paoli A, Weladji RB, Holand Ø, Kumpula J

Article GUID: 32727535
The Canadian Fungal Research Network: current challenges and future opportunities.

Author(s): Horianopoulos LC, Gluck-Thaler E, Benoit Gelber I, Cowen LE, Geddes-McAlister J, Landry CR, Schwartz IS, Scott JA, Sellam A, Sheppard DC, Sp...

Can J Microbiol. 2020 Jul 27;: Authors: Horianopoulos LC, Gluck-Thaler E, Benoit Gelber I, Cowen LE, Geddes-McAlister J, Landry CR, Schwartz IS, Scott JA, Sellam A, Sheppard DC, Spribille T, Subra...

Article GUID: 32717148
One Cell, One Drop, One Click: Hybrid Microfluidics for Mammalian Single Cell Isolation.

Author(s): Samlali K, Ahmadi F, Quach ABV, Soffer G, Shih SCC

Small. 2020 Jul 23;:e2002400 Authors: Samlali K, Ahmadi F, Quach ABV, Soffer G, Shih SCC

Article GUID: 32705796
Temporal clustering of prey in wildlife passages provides no evidence of a prey-trap.

Author(s): Martinig AR, Riaz M, St Clair CC

Sci Rep. 2020 Jul 13;10(1):11489 Authors: Martinig AR, Riaz M, St Clair CC

Article GUID: 32661272
Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.

Author(s): Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Int J Mol Sci. 2020 Jul 02;21(13): Authors: Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Article GUID: 32630624
A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids.

Author(s): Pyne ME, Kevvai K, Grewal PS, Narcross L, Choi B, Bourgeois L, Dueber JE, Martin VJJ

Nat Commun. 2020 Jul 03;11(1):3337 Authors: Pyne ME, Kevvai K, Grewal PS, Narcross L, Choi B, Bourgeois L, Dueber JE, Martin VJJ

Article GUID: 32620756
Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast.

Author(s): Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard ...

Oncotarget. 2020 Jun 09;11(23):2182-2203 Authors: Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard É...

Article GUID: 32577164
Drug discovery and chemical probing in Drosophila.

Author(s): Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Genome. 2020 Jun 18;: Authors: Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Article GUID: 32551911
The propensity for re-triggered predation fear in a prey fish.

Author(s): Crane AL, Feyten LEA, Ramnarine IW, Brown GE

Sci Rep. 2020 Jun 09;10(1):9253 Authors: Crane AL, Feyten LEA, Ramnarine IW, Brown GE

Article GUID: 32518253
Short-term Captivity Drives Hypothalamic Plasticity and Asymmetry in Wild-Caught Northern Red Bellied Dace (Chrosomus eos).

Author(s): Joyce BJ, Brown GE

J Fish Biol. 2020 May 23;: Authors: Joyce BJ, Brown GE

Article GUID: 32447778
The onset in spring and the end in autumn of the thermal and vegetative growing season affect calving time and reproductive success in reindeer.

Author(s): Paoli A, Weladji RB, Holand Ø, Kumpula J

Curr Zool. 2020 Apr;66(2):123-134 Authors: Paoli A, Weladji RB, Holand Ø, Kumpula J

Article GUID: 32440272
Sender and receiver experience alters the response of fish to disturbance cues.

Author(s): Goldman JA, Feyten LEA, Ramnarine IW, Brown GE

Curr Zool. 2020 Jun;66(3):255-261 Authors: Goldman JA, Feyten LEA, Ramnarine IW, Brown GE

Article GUID: 32440286
Modelling Free-Living and Particle-Associated Bacterial Assemblages across the Deep and Hypoxic Lower St. Lawrence Estuary.

Author(s): Cui TT, Dawson TJ, McLatchie S, Dunn K, Bielawski J, Walsh DA

mSphere. 2020 May 20;5(3): Authors: Cui TT, Dawson TJ, McLatchie S, Dunn K, Bielawski J, Walsh DA

Article GUID: 32434843
Humanization of yeast genes with multiple human orthologs reveals functional divergence between paralogs.

Author(s): Laurent JM, Garge RK, Teufel AI, Wilke CO, Kachroo AH, Marcotte EM

PLoS Biol. 2020 May 18;18(5):e3000627 Authors: Laurent JM, Garge RK, Teufel AI, Wilke CO, Kachroo AH, Marcotte EM

Article GUID: 32421706
Editorial: RNA Regulation in Development and Disease.

Author(s): Chartrand P, Jaramillo M, Gamberi C

Front Genet. 2020;11:430 Authors: Chartrand P, Jaramillo M, Gamberi C PMID: 32411184 [PubMed]

Article GUID: 32411184
Early Life History of Coreoperca herzi in Han River, Korea.

Author(s): Park JM, Jeon HB, Suk HY, Cho SJ, Han KH

Dev Reprod. 2020 Mar;24(1):63-70 Authors: Park JM, Jeon HB, Suk HY, Cho SJ, Han KH

Article GUID: 32411919
The dark cloud with a silver lining: Assessing the impact of the SARS COVID-19 pandemic on the global environment.

Author(s): Lal P, Kumar A, Kumar S, Kumari S, Saikia P, Dayanandan A, Adhikari D, Khan ML

Sci Total Environ. 2020 May 08;732:139297 Authors: Lal P, Kumar A, Kumar S, Kumari S, Saikia P, Dayanandan A, Adhikari D, Khan ML

Article GUID: 32408041
Transendothelial Perforations and the Sphere of Influence of Single-Site Sonoporation.

Author(s): Helfield B, Chen X, Watkins SC, Villanueva FS

Ultrasound Med Biol. 2020 May 10;: Authors: Helfield B, Chen X, Watkins SC, Villanueva FS

Article GUID: 32402675
Late-spring frost risk between 1959 and 2017 decreased in North America but increased in Europe and Asia.

Author(s): Zohner CM, Mo L, Renner SS, Svenning JC, Vitasse Y, Benito BM, Ordonez A, Baumgarten F, Bastin JF, Sebald V, Reich PB, Liang J, Nabuurs GJ, ...

Late-spring frosts (LSFs) affect the performance of plants and animals across the world's temperate and boreal zones, but despite their ecological and economic impact on agriculture and forestr...

Article GUID: 32393624
Protective effects of curcumin on bleomycin-induced changes in lung glycoproteins.

Author(s): Durairaj P, Venkatesan S, Narayanan V, Babu M

Mol Cell Biochem. 2020 Apr 29;: Authors: Durairaj P, Venkatesan S, Narayanan V, Babu M

Article GUID: 32350681
High-risk environments promote chemical disturbance signalling among socially familiar Trinidadian guppies.

Author(s): Crane AL, Feyten LEA, Ramnarine IW, Brown GE

Oecologia. 2020 Apr 15;: Authors: Crane AL, Feyten LEA, Ramnarine IW, Brown GE

Article GUID: 32296954
Importin-binding mediates the intramolecular regulation of anillin during cytokinesis.

Author(s): Beaudet D, Pham N, Skaik N, Piekny A

Mol Biol Cell. 2020 Apr 02;:mbcE20010006 Authors: Beaudet D, Pham N, Skaik N, Piekny A

Article GUID: 32238082
Genotoxicity of cisplatin and carboplatin in cultured human lymphocytes: a comparative study.

Author(s): Azab B, Alassaf A, Abu-Humdan A, Dardas Z, Almousa H, Alsalem M, Khabour O, Hammad H, Saleh T, Awidi A

Interdiscip Toxicol. 2019 Oct;12(2):93-97 Authors: Azab B, Alassaf A, Abu-Humdan A, Dardas Z, Almousa H, Alsalem M, Khabour O, Hammad H, Saleh T, Awidi A

Article GUID: 32206030
Top-down and bottom-up controls on an herbivore on a native and introduced plant in a tropical agricultural landscape.

Author(s): Despland E, Santacruz PG

PeerJ. 2020;8:e8782 Authors: Despland E, Santacruz PG

Article GUID: 32206453
Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Author(s): Mohammad K; Jiang H; Hossain MI; Titorenko VI;

Lipids are structurally diverse amphipathic molecules that are insoluble in water. Lipids are essential contributors to the organization and function of biological membranes, energy storage and production, cellular signaling, vesicular transport of proteins...

Article GUID: 32202524
TRAPPing a neurological disorder: from yeast to humans.

Author(s): Lipatova Z, Van Bergen N, Stanga D, Sacher M, Christodoulou J, Segev N

Autophagy. 2020 Mar 02;: Authors: Lipatova Z, Van Bergen N, Stanga D, Sacher M, Christodoulou J, Segev N

Article GUID: 32116085
Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans.

Author(s): Feng J, Yao S, Dong Y, Hu J, Whiteway M, Feng J

mSphere. 2020 Feb 19;5(1): Authors: Feng J, Yao S, Dong Y, Hu J, Whiteway M, Feng J

Article GUID: 32075883
Complementary functions for the Ran gradient during division.

Author(s): Ozugergin I, Piekny A

Small GTPases. 2020 Feb 03;: Authors: Ozugergin I, Piekny A

Article GUID: 32013678
Evidence of an ancient connectivity and biogeodispersal of a bitterling species, Rhodeus notatus, across the Korean Peninsula.

Author(s): Won H; Jeon HB; Suk HY;

The modern-day distribution of freshwater fishes throughout multiple rivers is likely the result of past migration during times when currently separate drainages were once connected. Here, we used mitochondrial and microsatellite analyses for 248 individual...

Article GUID: 31974505
Effects of chronic exposure to selenomethionine on social learning outcomes in zebrafish (Danio rerio): serotonergic dysregulation and oxidative stress in the brain.

Author(s): Attaran A, Salahinejad A, Naderi M, Crane AL, Niyogi S, Chivers DP

Chemosphere. 2020 Jan 11;247:125898 Authors: Attaran A, Salahinejad A, Naderi M, Crane AL, Niyogi S, Chivers DP

Article GUID: 31972490
Giant virus diversity and host interactions through global metagenomics.

Author(s): Schulz F, Roux S, Paez-Espino D, Jungbluth S, Walsh D, Denef VJ, McMahon KD, Konstantinidis KT, Eloe-Fadrosh EA, Kyrpides N, Woyke T

Nature. 2020 Jan 22;: Authors: Schulz F, Roux S, Paez-Espino D, Jungbluth S, Walsh D, Denef VJ, McMahon KD, Konstantinidis KT, Eloe-Fadrosh EA, Kyrpides N, Woyke T

Article GUID: 31968354
Hof1 plays a checkpoint related role in MMS induced DNA damage response in Candida albicans.

Author(s): Feng J, Islam A, Bean B, Feng J, Sparapani S, Shrivastava M, Goyal A, Omran RP, Mallick J, Whiteway M

Mol Biol Cell. 2020 Jan 15;:mbcE19060316 Authors: Feng J, Islam A, Bean B, Feng J, Sparapani S, Shrivastava M, Goyal A, Omran RP, Mallick J, Whiteway M

Article GUID: 31940254
RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans.

Author(s): Xu H, Fang T, Omran RP, Whiteway M, Jiang L

Cell Commun Signal. 2020 Jan 03;18(1):1 Authors: Xu H, Fang T, Omran RP, Whiteway M, Jiang L

Article GUID: 31900175
Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities.

Author(s): Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG

Proc Natl Acad Sci U S A. 2019 Dec 17;: Authors: Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG PMID: 31848251 [PubMed - as supplied by publisher]

Article GUID: 31848251
The interplay of nested biotic interactions and the abiotic environment regulates populations of a hypersymbiont.

Author(s): Mestre A, Poulin R, Holt RD, Barfield M, Clamp JC, Fernandez-Leborans G, Mesquita-Joanes F

J Anim Ecol. 2019 12;88(12):1998-2010 Authors: Mestre A, Poulin R, Holt RD, Barfield M, Clamp JC, Fernandez-Leborans G, Mesquita-Joanes F

Article GUID: 31408529
Limited initial impacts of biomass harvesting on composition of wood-inhabiting fungi within residual stumps.

Author(s): Boué C, DeBellis T, Venier LA, Work TT, Kembel SW

PeerJ. 2019;7:e8027 Authors: Boué C, DeBellis T, Venier LA, Work TT, Kembel SW

Article GUID: 31844564
Diversity, evolution, and classification of virophages uncovered through global metagenomics.

Author(s): Paez-Espino D, Zhou J, Roux S, Nayfach S, Pavlopoulos GA, Schulz F, McMahon KD, Walsh D, Woyke T, Ivanova NN, Eloe-Fadrosh EA, Tringe SG, Kyrpides NC

Microbiome. 2019 Dec 10;7(1):157 Authors: Paez-Espino D, Zhou J, Roux S, Nayfach S, Pavlopoulos GA, Schulz F, McMahon KD, Walsh D, Woyke T, Ivanova NN, Eloe-Fadrosh EA, Tringe SG, Kyrpides NC

Article GUID: 31823797
In-Silico Evaluation of a New Gene From Wheat Reveals the Divergent Evolution of the CAP160 Homologous Genes Into Monocots.

Author(s): Zayed M, Badawi MA

J Mol Evol. 2019 Dec 10;: Authors: Zayed M, Badawi MA

Article GUID: 31820048
Metabolic networks of the human gut microbiota.

Author(s): Selber-Hnatiw S, Sultana T, Tse W, Abdollahi N, Abdullah S, Al Rahbani J, Alazar D, Alrumhein NJ, Aprikian S, Arshad R, Azuelos JD, Bernadot...

Metabolic networks of the human gut microbiota.

Microbiology. 2019 Dec 04;:

Authors: Selber-Hnatiw S, Sultana T, Tse W, Abdollahi N, Abdullah S, Al Rahbani J, Alazar D, Alrumhei...

Article GUID: 31799915
Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability.

Author(s): Van Bergen NJ, Guo Y, Al-Deri N, Lipatova Z, Stanga D, Zhao S, Murtazina R, Gyurkovska V, Pehlivan D, Mitani T, Gezdirici A, Antony J, Colli...

The conserved transport protein particle (TRAPP) complexes regulate key trafficking events and are required for autophagy. TRAPPC4, like its yeast Trs23 orthologue, is a core component of the TRAPP...

Article GUID: 31794024
Small population size and low genomic diversity have no effect on fitness in experimental translocations of a wild fish.

Author(s): Yates MC, Bowles E, Fraser DJ

Proc Biol Sci. 2019 Dec 04;286(1916):20191989 Authors: Yates MC, Bowles E, Fraser DJ

Article GUID: 31771476
Isolating live cells after high-throughput, long-term, time-lapse microscopy.

Author(s): Luro S, Potvin-Trottier L, Okumus B, Paulsson J

Nat Methods. 2019 Nov 25;: Authors: Luro S, Potvin-Trottier L, Okumus B, Paulsson J

Article GUID: 31768062
The spatial frequency of climatic conditions affects niche composition and functional diversity of species assemblages: the case of Angiosperms.

Author(s): Fournier B, Vázquez-Rivera H, Clappe S, Donelle L, Braga PHP, Peres-Neto PR

Ecol Lett. 2019 Nov 21;: Authors: Fournier B, Vázquez-Rivera H, Clappe S, Donelle L, Braga PHP, Peres-Neto PR

Article GUID: 31749270
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Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

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Diversity from genes to ecosystems: A unifying framework to study variation across biological metrics and scales.

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Evol Appl. 2018 Aug;11(7):1176-1193 Authors: Gaggiotti OE, Chao A, Peres-Neto P, Chiu CH, Edwards C, Fortin MJ, Jost L, Richards CM, Selkoe KA

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Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts.

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TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins.

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Traffic. 2019 01;20(1):5-26 Authors: Sacher M, Shahrzad N, Kamel H, Milev MP

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Correlated evolution of flower size and seed number in flowering plants (monocotyledons).

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Rab-Effector-Kinase Interplay Modulates Intralumenal Fragment Formation during Vacuole Fusion.

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A Cell-Free Content Mixing Assay for SNARE-Mediated Multivesicular Body-Vacuole Membrane Fusion.

Author(s): Karim MA, Samyn DR, Brett CL

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Visualization of SNARE-Mediated Organelle Membrane Hemifusion by Electron Microscopy.

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Competition for food in 2 populations of a wild-caught fish.

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Curr Zool. 2018 Oct;64(5):615-622 Authors: Chuard PJC, Brown GE, Grant JWA

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A Highly Characterized Synthetic Landing Pad System for Precise Multicopy Gene Integration in Yeast.

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Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.

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The Many Nuanced Evolutionary Consequences of Duplicated Genes.

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Mol Biol Evol. 2019 02 01;36(2):304-314 Authors: Teufel AI, Johnson MM, Laurent JM, Kachroo AH, Marcotte EM, Wilke CO

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Embracing an interdisciplinary approach to plastics pollution awareness and action.

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Road mortality locations of small and medium-sized mammals along a partly-fenced highway in Quebec, Canada, 2012-2015.

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Ideal despotic distributions in convict cichlids (Amatitlania nigrofasciata)? Effects of predation risk and personality on habitat preference.

Author(s): Church KDW, Grant JWA

Behav Processes. 2019 Jan;158:163-171 Authors: Church KDW, Grant JWA

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Characterization of the Esi3/RCI2/PMP3 gene family in the Triticeae.

Author(s): Brunetti SC, Arseneault MKM, Gulick PJ

BMC Genomics. 2018 Dec 11;19(1):898 Authors: Brunetti SC, Arseneault MKM, Gulick PJ

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The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation.

Author(s): McNally EK, Brett CL

Nat Commun. 2018 12 18;9(1):5358 Authors: McNally EK, Brett CL

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Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in Candida albicans.

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Genetics. 2019 02;211(2):637-650 Authors: Chaillot J, Tebbji F, Mallick J, Sellam A

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Functional divergence of a global regulatory complex governing fungal filamentation.

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Functional divergence of a global regulatory complex governing fungal filamentation.

PLoS Genet. 2019 01;15(1):e1007901

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Chronic exposure to dietary selenomethionine dysregulates the genes involved in serotonergic neurotransmission and alters social and antipredator behaviours in zebrafish (Danio rerio).

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Environ Pollut. 2019 Mar;246:837-844 Authors: Attaran A, Salahinejad A, Crane AL, Niyogi S, Chivers DP

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The adaptor protein Ste50 directly modulates yeast MAPK signaling specificity through differential connections of its RA domain.

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Aegilops tauschii Genome Sequence: A Framework for Meta-analysis of Wheat QTLs.

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Biodiversity Observations Miner: A web application to unlock primary biodiversity data from published literature.

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Predation risk assessment based on uncertain information: interacting effects of known and unknown cues.

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Curr Zool. 2019 Feb;65(1):75-76 Authors: Feyten LEA, Demers EEM, Ramnarine IW, Brown GE PMID: 30697241 [PubMed]

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Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing.

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Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.

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Oncotarget. 2019 Jan 08;10(3):313-338 Authors: Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI

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Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5.

Author(s): Song Z, Yang H, Peckham EM, Becker JB

Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5.

eNeuro. 2019 Jan-Feb;6(1):

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MAP Kinase Regulation of the Candida albicans Pheromone Pathway.

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mSphere. 2019 02 20;4(1): Authors: Rastghalam G, Omran RP, Alizadeh M, Fulton D, Mallick J, Whiteway M

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A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host.

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The evolutionary rewiring of the ribosomal protein transcription pathway modifies the interaction of transcription factor heteromer Ifh1-Fhl1 (interacts with forkhead 1-forkhead-like 1) with the DNA-binding specificity element.

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J Biol Chem. 2013 Jun 14;288(24):17508-19 Authors: Mallick J, Whiteway M

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Genetic structure and diversity of indigenous rice (Oryza sativa) varieties in the Eastern Himalayan region of Northeast India.

Author(s): Choudhury B, Khan ML, Dayanandan S

Springerplus. 2013 Dec;2(1):228 Authors: Choudhury B, Khan ML, Dayanandan S

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Development of a pyrG mutant of Aspergillus oryzae strain S1 as a host for the production of heterologous proteins.

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ScientificWorldJournal. 2013;2013:634317 Authors: Ling SO, Storms R, Zheng Y, Rodzi MR, Mahadi NM, Illias RM, Abdul Murad AM, Abu Bakar FD

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Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae.

Author(s): Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ

Nat Commun. 2014;5:3283 Authors: Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ

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Functional androdioecy in critically endangered Gymnocladus assamicus (Leguminosae) in the Eastern Himalayan Region of Northeast India.

Author(s): Choudhury BI, Khan ML, Dayanandan S

PLoS One. 2014;9(2):e87287 Authors: Choudhury BI, Khan ML, Dayanandan S

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Transcriptome and exoproteome analysis of utilization of plant-derived biomass by Myceliophthora thermophila.

Author(s): Kolbusz MA, Di Falco M, Ishmael N, Marqueteau S, Moisan MC, Baptista CDS, Powlowski J, Tsang A

Fungal Genet Biol. 2014 Nov;72:10-20 Authors: Kolbusz MA, Di Falco M, Ishmael N, Marqueteau S, Moisan MC, Baptista CDS, Powlowski J, Tsang A

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Patterns of nucleotide diversity and phenotypes of two domestication related genes (OsC1 and Wx) in indigenous rice varieties in Northeast India.

Author(s): Choudhury BI, Khan ML, Dayanandan S

BMC Genet. 2014 Jun 16;15:71 Authors: Choudhury BI, Khan ML, Dayanandan S

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Phylogeny reconstruction and hybrid analysis of populus (Salicaceae) based on nucleotide sequences of multiple single-copy nuclear genes and plastid fragments.

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PLoS One. 2014;9(8):e103645 Authors: Wang Z, Du S, Dayanandan S, Wang D, Zeng Y, Zhang J

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Inter-simple sequence repeat data reveals high genetic diversity in wild populations of the narrowly distributed endemic Lilium regale in the Minjiang River Valley of China.

Author(s): Wu ZH, Shi J, Xi ML, Jiang FX, Deng MW, Dayanandan S

PLoS One. 2015;10(3):e0118831 Authors: Wu ZH, Shi J, Xi ML, Jiang FX, Deng MW, Dayanandan S

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Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae.

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PLoS One. 2015;10(4):e0124459 Authors: Fossati E, Narcross L, Ekins A, Falgueyret JP, Martin VJ

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An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose.

Author(s): DeLoache WC, Russ ZN, Narcross L, Gonzales AM, Martin VJ, Dueber JE

Nat Chem Biol. 2015 Jul;11(7):465-71 Authors: DeLoache WC, Russ ZN, Narcross L, Gonzales AM, Martin VJ, Dueber JE

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The Energetics of Streptococcal Enolase Octamer Formation: The Quantitative Contributions of the Last Eight Amino Acids at the Carboxy-Terminus.

Author(s): Kornblatt JA, Quiros V, Kornblatt MJ

PLoS One. 2015;10(8):e0135754 Authors: Kornblatt JA, Quiros V, Kornblatt MJ

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Microbial Factories for the Production of Benzylisoquinoline Alkaloids.

Author(s): Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ

Trends Biotechnol. 2016 Mar;34(3):228-241 Authors: Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ

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Seamless site-directed mutagenesis of the Saccharomyces cerevisiae genome using CRISPR-Cas9.

Author(s): Biot-Pelletier D, Martin VJ

J Biol Eng. 2016;10:6 Authors: Biot-Pelletier D, Martin VJ

Article GUID: 27134651
Mining Enzyme Diversity of Transcriptome Libraries through DNA Synthesis for Benzylisoquinoline Alkaloid Pathway Optimization in Yeast.

Author(s): Narcross L, Bourgeois L, Fossati E, Burton E, Martin VJ

ACS Synth Biol. 2016 12 16;5(12):1505-1518 Authors: Narcross L, Bourgeois L, Fossati E, Burton E, Martin VJ

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The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.

Author(s): Busby M, Hallett MT, Plante I

Int J Mol Sci. 2018 Feb 28;19(3): Authors: Busby M, Hallett MT, Plante I

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Evolutionary Adaptation to Generate Mutants.

Author(s): de Vries RP, Lubbers R, Patyshakuliyeva A, Wiebenga A, Benoit-Gelber I

Methods Mol Biol. 2018;1775:133-137 Authors: de Vries RP, Lubbers R, Patyshakuliyeva A, Wiebenga A, Benoit-Gelber I

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Ant community response to disturbance: A global synthesis.

Author(s): Lessard JP

J Anim Ecol. 2019 Mar;88(3):346-349 Authors: Lessard JP

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Annual nitrification dynamics in a seasonally ice-covered lake.

Author(s): Massé S, Botrel M, Walsh DA, Maranger R

PLoS One. 2019;14(3):e0213748 Authors: Massé S, Botrel M, Walsh DA, Maranger R

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MKP1 acts as a key modulator of stomatal development.

Author(s): Jangra R, Damen H, Lee JS

MKP1 acts as a key modulator of stomatal development.
Plant Signal Behav. 2019 Apr 13;:1-3
Authors: Jangra R, Damen H, Lee JS
Abstract
The MAPK signaling cascade is universal among eukaryotes and mediates a variety of environmental and devel...

Article GUID: 30983545
Activity budget and spatial distribution of Bennett's wallabies (Macropus rufogriseus) in open versus closed exhibit designs.

Author(s): Beaudin-Judd J, Weladji RB, Lazure L, Paré P

Zoo Biol. 2019 May;38(3):258-265 Authors: Beaudin-Judd J, Weladji RB, Lazure L, Paré P

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No Hot Spot Mutations CHRNE c.1327 delG, CHAT c.914T>C, and RAPSN c.264C>A in Iranian Patients with Congenital Myasthenic Syndrome.

Author(s): Parvizi Omran S, Houshmand M, Dominic D, Farjami Z, Karimzadeh P

Iran J Child Neurol. 2019;13(2):135-143 Authors: Parvizi Omran S, Houshmand M, Dominic D, Farjami Z, Karimzadeh P

Article GUID: 31037086
Mapping the fly Malpighian tubule lipidome by imaging mass spectrometry

Author(s): Yang E; Gamberi C; Chaurand P;

Matrix-assisted laser/desorption ionization imaging mass spectrometry (MALDI IMS) is an analytical technique for understanding the spatial distribution of biomolecules across a sample surface. Originally employed for mammalian tissues, this technology has b...

Article GUID: 31038251
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Author(s): Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2019 May 01;20(9): Authors: Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

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Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla.

Author(s): Dakik P, Medkour Y, Mohammad K, Titorenko VI

Front Physiol. 2019;10:461 Authors: Dakik P, Medkour Y, Mohammad K, Titorenko VI

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Time-dependent latent inhibition of predator-recognition learning.

Author(s): Crane AL, Chivers DP, Ferrari MCO

Biol Lett. 2019 May 31;15(5):20190183 Authors: Crane AL, Chivers DP, Ferrari MCO

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Detoxification of host plant phenolic aglycones by the spruce budworm.

Author(s): Donkor D, Mirzahosseini Z, Bede J, Bauce E, Despland E

PLoS One. 2019;14(5):e0208288 Authors: Donkor D, Mirzahosseini Z, Bede J, Bauce E, Despland E

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Evaluating a 5-year metal contamination remediation and the biomonitoring potential of a freshwater gastropod along the Xiangjiang River, China.

Author(s): Li D, Pi J, Zhang T, Tan X, Fraser DJ

Environ Sci Pollut Res Int. 2018 Jul;25(21):21127-21137 Authors: Li D, Pi J, Zhang T, Tan X, Fraser DJ

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The tricarboxylic acid cycle, cell wall integrity pathway, cytokinesis and intracellular pH homeostasis are involved in the sensitivity of Candida albicans cells to high levels of extracellular calcium.

Author(s): Xu H, Whiteway M, Jiang L

Genomics. 2018 Aug 10;: Authors: Xu H, Whiteway M, Jiang L

Article GUID: 30102968
Author Correction: A compendium of geochemical information from the Saanich Inlet water column.

Author(s): Torres-Beltrán M, Hawley AK, Capelle D, Zaikova E, Walsh DA, Mueller A, Scofield M, Payne C, Pakhomova L, Kheirandish S, Finke J, Bhatia M, ...

Sci Data. 2019 01 15;6(1):1 Authors: Torres-Beltrán M, Hawley AK, Capelle D, Zaikova E, Walsh DA, Mueller A, Scofield M, Payne C, Pakhomova L, Kheirandish S, Finke J, Bhatia M, Shevchuk O, Gi...

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RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement.

Author(s): Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA

Mol Ther Nucleic Acids. 2019 Apr 15;15:12-25 Authors: Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA

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Geo-referenced population-specific microsatellite data across American continents, the MacroPopGen Database.

Author(s): Lawrence ER, Benavente JN, Matte JM, Marin K, Wells ZRR, Bernos TA, Krasteva N, Habrich A, Nessel GA, Koumrouyan RA, Fraser DJ

Sci Data. 2019 04 03;6(1):14 Authors: Lawrence ER, Benavente JN, Matte JM, Marin K, Wells ZRR, Bernos TA, Krasteva N, Habrich A, Nessel GA, Koumrouyan RA, Fraser DJ

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Dispersal limitations and historical factors determine the biogeography of specialized terrestrial protists.

Author(s): Singer D, Mitchell EAD, Payne RJ, Blandenier Q, Duckert C, Fernández LD, Fournier B, Hernández CE, Granath G, Rydin H, Bragazza L, Koronatov...

Mol Ecol. 2019 May 04;: Authors: Singer D, Mitchell EAD, Payne RJ, Blandenier Q, Duckert C, Fernández LD, Fournier B, Hernández CE, Granath G, Rydin H, Bragazza L, Koronatova NG, Goia I,...

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Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.

Author(s): Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Front Syst Neurosci. 2014;8:145 Authors: Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

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Rewiring of the Ppr1 Zinc Cluster Transcription Factor from Purine Catabolism to Pyrimidine Biogenesis in the Saccharomycetaceae.

Author(s): Tebung WA, Choudhury BI, Tebbji F, Morschhäuser J, Whiteway M

Curr Biol. 2016 07 11;26(13):1677-1687 Authors: Tebung WA, Choudhury BI, Tebbji F, Morschhäuser J, Whiteway M

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Persistence of Escherichia coli in batch and continuous vermicomposting systems.

Author(s): Hénault-Ethier L, Martin VJ, Gélinas Y

Waste Manag. 2016 Oct;56:88-99 Authors: Hénault-Ethier L, Martin VJ, Gélinas Y

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Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29.

Author(s): Shekhar-Guturja T, Tebung WA, Mount H, Liu N, Köhler JR, Whiteway M, Cowen LE

Antimicrob Agents Chemother. 2016 12;60(12):7468-7480 Authors: Shekhar-Guturja T, Tebung WA, Mount H, Liu N, Köhler JR, Whiteway M, Cowen LE

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Put3 Positively Regulates Proline Utilization in Candida albicans.

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mSphere. 2017 Nov-Dec;2(6): Authors: Tebung WA, Omran RP, Fulton DL, Morschhäuser J, Whiteway M

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The influence of truncating the carboxy-terminal amino acid residues of streptococcal enolase on its ability to interact with canine plasminogen.

Author(s): Deshmukh SS, Kornblatt MJ, Kornblatt JA

PLoS One. 2019;14(1):e0206338 Authors: Deshmukh SS, Kornblatt MJ, Kornblatt JA

Article GUID: 30653526
Title:Alleviative Effects of Adipose Tissue-derived Stem Cells and α-NETA on Metabolic, Biochemical, and Endocrine Parameters in a Letrozole-induced Rat Model of PCOS
Authors:Nejabati HR,  Nikzad S,  Roshangar L, 
Link:https://pubmed.ncbi.nlm.nih.gov/37584355/
DOI:10.2174/1381612829666230816100641
Category:
PMID:37584355
Dept Affiliation: BIOLOGY

Description:

Background: Polycystic ovary syndrome (PCOS), the most prevalent reproductive disorder, is accompanied by hyperandrogenism (HA), ovulatory dysfunction (OD), and insulin resistance (IR). A number of reports indicate that adipokines play a vital role in the pathophysiology of PCOS. One of these adipokines is chemerin, which is engaged in metabolic disorders, especially obesity, diabetes, and PCOS. Based on the data, the circulating levels of chemerin and the expression of chemokine-like receptor-1 (CMKLR1) in white adipose tissue (WAT) of women with PCOS are significantly higher than in healthy ones. Currently, several scholars have emphasized the therapeutic capacities of stem cells, notably mesenchymal stem cells (MSCs), for the treatment of PCOS.

Objective: In this study, for the first time, the impacts of 2-(a-naphthoyl) ethyltrimethylammonium iodide (a-NETA), an antagonist of CMKLR1, adipose-derived stem cells (ADSCs), and their combinations on metabolic and endocrine aberrancies were assessed in the WAT and ovarian tissues of the letrozole (LET)-induced PCOS rats.

Methods: In the current study, 30 Wistar rats were randomly divided into five groups: control (n = 6), LET-induced PCOS (1.5 mg/kg p.o., n=6), LET + ADSCs (106 ADSCs i.v., n=6), LET + a-NETA (10 mg/kg p.o., n=6), and LET + ADSCs + a-NETA (n=6). The blood samples and adipose and ovarian tissues were obtained to evaluate the effects of ADSCs and a-NETA on hormonal and metabolic parameters in the PCOS rats.

Results: Our findings showed that the administration of a-NETA, ADSCs, and the combination of both favorably restored the irregular estrus cycle and considerably modulated the endocrine parameters in PCOS rats. In addition, these therapeutic factors remarkably regulated steroidogenic and adipogenic gene expressions, as well as the genes related to glucose metabolism and brown adipose tissue (BAT) markers in these animals.

Conclusion: These findings indicate that the combination of ADSCs and a-NETA can successfully ameliorate metabolic and endocrine dysfunction in LET-induced PCOS rats, and this strategy could be a new therapeutic choice for patients with PCOS.