| Keyword search (3,448 papers available) | |
Author(s): Fatoki TH; Balogun TC; Ojewuyi AE; Omole AC; Olukayode OV; Adewumi AP; Umesi AJ; Ijeoma NP; Apooyin AE; Chinedu CP; Idowu IE; Isah MJ;...
Introduction: Oritavancin is a semi-synthetic lipoglycopeptide antibiotic primarily used to treat serious infections caused by Gram-positive bacteria. The aim of this study was to elucidate possibl...
Article GUID: 39439008
Author(s): Benlatreche T; Bensegueni MA; Dénès G; Golhen S; Merazig H;
The title compound, [Sn(C6H5)Cl3(C12H8N2)], which was obtained by the reaction between 1,10-phenanthroline and phenyl-tin trichloride in methanol, exhibits intra-molecular hydrogen-bonding inter-actions involving the chlorine and hydrogen atoms. Crystal coh...
Article GUID: 39372187
Author(s): Zhang X; Li L; Xie Z; Ma J; Li YF; Cai M; Ren NQ; Kallenborn R; Zhang ZF; Zhang X; C G Muir D;...
Global monitoring of persistent organic pollutants (POPs) has intensified following regulatory efforts aimed at reducing their release. In this context, we compiled over 10,000 POP measurements, re...
Article GUID: 39321284
Author(s): Adeola AO; Paramo L; Fuoco G; Naccache R;
Emerging contaminants can be natural or synthetic materials, as well as materials of a chemical, or biological origin; these materials are typically not controlled or monitored in the environment. Canada is home to nearly 7 % of the world's renewable wa...
Article GUID: 39278485
Author(s): Tomar R; Ghodke PP; Patra A; Smyth E; Pontarelli A; Copp W; Guengerich FP; Chaput JJ; Wilds CJ; Stone MP; Egli M;...
a-l-(3'-2')-Threofuranosyl nucleic acid (TNA) pairs with itself, cross-pairs with DNA and RNA, and shows promise as a tool in synthetic genetics, diagnostics, and oligonucleotide therapeuti...
Article GUID: 39259676
Author(s): Singh Z; Chiong JD; Ricardo-Noordberg JF; Kamal S; Majewski MB;
A copper(I) donor-chromophore-acceptor triad bearing 1,8-napthalenemonoimide as the electron acceptor and triphenylamine as the electron donor was synthesized. Photophysical and electrochemical characterization suggest stepwise photoinduced charge separatio...
Article GUID: 39258478
Author(s): Mirzaei Y; Gélinas Y;
Coastal sediments are the main deposition center for allochthonous and autochthonous organic carbon (OC). The discharge of terrestrial biomass, anthropogenic activities, oceanic primary productivity, and natural events contribute to this carbon pool. The OC...
Article GUID: 39117203
Author(s): Bicalho HA; Copeman C; Barbosa HP; Donnarumma PR; Davis Z; Quezada-Novoa V; Velazquez-Garcia JJ; Liu N; Hemmer E; Howarth AJ;...
In this work, nine new rare-earth metal-organic frameworks (RE-MOFs, where RE = Lu(III), Yb(III), Tm(III), Er(III), Ho(III), Dy(III), Tb(III), Gd(III), and Eu(III)) isostructural to Zr-MOF-808 are ...
Article GUID: 39105655
Author(s): Bin X; Pawelek PD;
Enterobactin is a high-affinity iron chelator produced and secreted by Escherichia coli and Salmonella typhimurium to scavenge scarce extracellular Fe3+ as a micronutrient. EntC and EntB are the first two enzymes in the enterobactin biosynthetic pathway. Is...
Article GUID: 39031458
Author(s): Kozlov G; Jiang J; Rutherford T; Noronha AM; Wilds CJ; Gehring K;
La-related proteins (LARPs) are a family of RNA-binding proteins that share a conserved La motif (LaM) domain. LARP1 plays a role in regulating ribosomal protein synthesis and stabilizing mRNAs and has a unique structure without an RNA binding RRM domain ad...
Article GUID: 39016322
Author(s): Mosley JD; Dunn WB; Kuligowski J; Lewis MR; Monge ME; Ulmer Holland C; Vuckovic D; Zanetti KA; Schock TB;...
Introduction: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a QA/QC workshop for LC-MS-based untargeted metabolomics. ...
Article GUID: 38980450
Author(s): Hamzehpoor E; Effaty F; Borchers TH; Stein RS; Wahrhaftig-Lewis A; Ottenwaelder X; Frišcic T; Perepichka DF;...
We report a rapid, room-temperature mechanochemical synthesis of 2- and 3-dimensional boroxine covalent organic frameworks (COFs), enabled by using trimethylboroxine as a dehydrating additive to ov...
Article GUID: 38970305
Author(s): Ricardo-Noordberg J; Kamal S; Majewski M;
Dye-sensitized photoelectrochemical cells can enable the production of molecules currently accessible through energetically demanding syntheses. Copper(I)-based dyes represent electronically tunable charge transfer and separation systems. Herein, we report ...
Article GUID: 38932662
Author(s): Lavertu JD; Bawa KK; Hrapovic S; Fu D; Oh JK; Hemraz UD;
A process employing extrusion was used to produce multicore microcapsules composed of multiple beads. The inner beads were made from ?-carrageenan (?-c), a thermo-responsive linear sulphated polymer whose gelling temperature ranges at 40-60 °C, depending on...
Article GUID: 38915334
Author(s): Duarte MP; Adeola AO; Fuoco G; Jargaille TJ; Naccache R;
Rapid global urbanization and population growth have ignited an alarming surge in emerging contaminants in water bodies, posing health risks, even at trace concentrations. To address this challenge, novel water treatment and reuse technologies are required ...
Article GUID: 38909946
Author(s): Cigana B; Lapointe V; Majewski MB; Forgione P;
A library of 2,5-furan-based phenylene/thiophene oligomers were synthesized starting from 5-bromofurfural, a derivative of biomass-derived furfural. Varied electronic groups are coupled onto the furan motif, followed by the installation of a phenylene or th...
Article GUID: 38808994
Author(s): Lei Zhang
Vertical excitation energies for electronic transitions from the ground state to the first two excited states of phenol, mono- and disubstituted methoxyphenols and methyl-substituted phenols have been characterized with the Time-Dependent Density Functional...
Article GUID: 16313201
Author(s): Grygoriy Dolgonos
The potential stabilization of normally unstable C20, the smallest fullerene, via its encapsulation inside a tetraureacalix[4]arene dimer has been analyzed using molecular mechanics calculations with different force fields, the self-consistent-charge densit...
Article GUID: 16869690
Author(s): Elena V Ivanova
A comparative study of the concerted hydrolysis of H-, CF3-, CH3-, and Ph-substituted N-sulfinylamines (R-NSO) and isocyanates (R-NCO) was performed using B3LYP/6-31+G(2d,2p). The "two-water-molecule" model was found to be sufficient for a proper descriptio...
Article GUID: 17915846
Author(s): Robert C Mawhinney
The 13C chemical shifts in selected nitrilimines, nitriles, acetylenes, allenes, and singlet carbenes have been calculated using density-functional theory [PBE0/6-311++G(2df,pd)] and the gauge including atomic orbital (GIAO) method. The effects of substitut...
Article GUID: 18062684
Author(s): Denise M Koch
Sodium iodide has long been a paradigm for ionic and covalent curve crossing and ultrafast nonadiabatic dynamics, and our interest lies in the influence of solvation on this process. The NaI(H2O)n photodissociation dynamics are simulated with the molecular ...
Article GUID: 18183959
Author(s): Qadir K Timerghazin
High-level ab initio calculations employing the CCSD and CCSD(T) coupled cluster methods with a series of systematically convergent correlation-consistent basis sets have been performed to obtain accurate molecular geometry and energetic properties of the s...
Article GUID: 18327309
Author(s): Heidi M Muchall
We are presenting a computational study on the isotropic shielding, charge, and orbital contributions to the shielding of oxygen in benzaldehydes (Ar-CHO), nitrobenzenes (Ar-NO2), phenyl isocyanates (Ar-NCO), anilides (Ar-NHCOCH3), and N-sulfinylamines (Ar-...
Article GUID: 18754608
Author(s): Kamya PR; Muchall HM;
We have evaluated the performance of three (TD-)DFT functionals with the 6-31+G(d,p) basis set for the reproduction of experimental geometries, vertical ionization potentials, and low excitation energies of a selection of [2.2] and [3.3]paracyclophanes. Ove...
Article GUID: 19055395
Author(s): Varadwaj PR; Varadwaj A; Marques HM;
A density functional theory study of the structure of the title compounds with the divalent metal ions in their high-spin ground state, obtained using B3LYP/6-311++G(d,p) in vacuo and in aqueous solution simulated using a polarized continuum medium, is repo...
Article GUID: 21568260
Author(s): Kamya PR; Muchall HM;
Calculated electron densities from PBE0/6-31+G(d,p) were analyzed with respect to the hydrogen bonding within a nucleic acid base pair and the p-stacking between sets of base pairs. From published X-ray crystallographic data, base pairs were isolated from a...
Article GUID: 21721560
Author(s): Heidi M Muchall
Nitrilimines (R-CNN-R) can be described through a carbenic valence bond structure, and although intermolecular carbenic reactions from nitrilimines are unknown, intramolecular reaction products from ortho-vinyl MeCOO-CNN-Ph (1) and Ph-CNN-Ph (2) that seem t...
Article GUID: 21974693
Author(s): Mak CC; Timerghazin QK; Peslherbe GH;
Upon photoexcitation of iodide-water clusters, I(-)(H(2)O)(n), an electron is transferred from iodide to a diffuse cluster-supported, dipole-bound orbital. Recent femtosecond photoelectron spectroscopy experiments have shown that, for photoexcited I(-)(H(2)...
Article GUID: 22466252
Author(s): Zhang L; Muchall HM; Peslherbe GH;
The ground-state equilibrium geometries, electronic structures and vertical excitation energies of methyl- and methoxyl-substituted phenol radical cations and phenoxyl radicals have been investigated using time-dependent density-functional theory (namely TD...
Article GUID: 23216064
Author(s): Jahangiri S; Mercer SM; Jessop PG; Peslherbe GH;
The solvation behavior of alkyl diammonium chlorides of varying alkyl chain length and the molecular details of their effect on the salting-out of organic molecules in aqueous phase have been investigated by classical molecular dynamics simulations. More sp...
Article GUID: 23789929
Author(s): Mak CC; Timerghazin QK; Peslherbe GH;
Photoexcitation of iodide-acetonitrile clusters, I(-)(CH3CN)n, to the charge-transfer-to-solvent (CTTS) state and subsequent cluster relaxation could result in the possible formation of cluster analogues of the bulk solvated electron. In this work, the rela...
Article GUID: 23819756
Author(s): Mak CC; Peslherbe GH;
Upon photoexcitation of iodide-methanol clusters, I(-)(CH3OH)n, to a charge-transfer-to-solvent (CTTS) excited state, extensive relaxation was found to occur, accompanied by a convoluted modulation of the stability of the excited electron, which ultimately ...
Article GUID: 24922343
Author(s): Bilkiss B Issack
While it has long been known that cholesterol reduces the permeability of biological membranes to water, the exact mechanism by which cholesterol influences transmembrane permeation is still unclear. The thermodynamic and kinetic contributions to the transp...
Article GUID: 25679811
Author(s): Soran Jahangiri
Parameter sets of the self-consistent-charge density-functional tight-binding model with and without its third-order extension have been developed to describe the interatomic interactions of halogen elements (X = Cl, Br, I) with hydrogen and oxygen, with th...
Article GUID: 26584090
Author(s): Maria S Shadrina
Standard molecular dynamics (MD) simulations of gas diffusion consume considerable computational time and resources even for small proteins. To combat this, temperature-controlled locally enhanced sampling (TLES) examines multiple diffusion trajectories per...
Article GUID: 26938707
Author(s): Nazeer N; Kooner N; Ghimire A; Rainey JK; Lubell WD; Meneksedag-Erol D; Ahmed M;
Lactam cross-links have been employed to stabilize the helical secondary structure and enhance the activity and physiological stability of antimicrobial peptides; however, stabilization of ß-sheets via lactamization has not been observed. In the present stu...
Article GUID: 38771638
Author(s): López-Peña G; Ortiz-Mansilla E; Arranz A; Bogdan N; Manso-Silván M; Martín Rodríguez E;
Today, diabetes mellitus is one of the most common diseases that affects the population on a worldwide scale. Patients suffering from this disease are required to control their blood-glucose levels several times a day through invasive methods such as pierci...
Article GUID: 38729020
Author(s): Ayan S; Rotaru AM; Kaye EG; Juneau G; Das S; Wilds CJ; Beharry AA;
Fluorescent chemosensors offer a direct means of measuring enzyme activity for cancer diagnosis, predicting drug resistance, and aiding in the discovery of new anticancer drugs. O6-methylguanine DNA methyltransferase (MGMT) is a predictor of resistance towa...
Article GUID: 38502038
Author(s): Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK;
Smart nanoassemblies degradable through the cleavage of acid-labile linkages have attracted significant attention because of their biological relevance found in tumor tissues. Despite their high potential to achieve controlled/enhanced drug release, a syste...
Article GUID: 38499007
Author(s): Joshani A; Mirzaei Y; Barber A; Balind K; Gobeil C; Gélinas Y;
The biogeochemical cycles of iron and organic carbon (OC) are closely interconnected in terrestrial and aquatic systems. In ocean waters, the concentration of reactive Fe is tightly controlled by soluble organic ligands. In soils, Fe stabilizes OC by formin...
Article GUID: 38499107
Author(s): Singh Z; Chiong JD; Kamal S; Majewski MB;
Dye-sensitized photoelectrodes may be used as heterogeneous components for fuel-forming reactions in photoelectrochemical cells. There has been increasing interest in developing Earth-abundant cheaper photosensitizers based on first-row transition metals. W...
Article GUID: 38497406
Author(s): Rodgers TFM; Spraakman S; Wang Y; Johannessen C; Scholes RC; Giang A;
Stormwater rapidly moves trace organic contaminants (TrOCs) from the built environment to the aquatic environment. Bioretention cells reduce loadings of some TrOCs, but they struggle with hydrophilic compounds. Herein, we assessed the potential to enhance T...
Article GUID: 38483320
Author(s): Sasikumar DSN; Thiruselvam P; Sundararajan V; Ravindran R; Gunasekaran S; Madathil D; Kaliamurthi S; Peslherbe GH; Selvaraj G; Sudhakaran SL...
Parkinson's disease (PD) is a complex neurological disease associated with the degeneration of dopaminergic neurons. Oxidative stress is a key player in instigating apoptosis in dopaminergic ne...
Article GUID: 38460310
Author(s): Taktikakis P; Côté M; Subramaniam N; Kroeger K; Youssef H; Badia A; DeWolf C;
Deviations from the normal physicochemical and functional properties of pulmonary surfactants are associated with the incidence of lung injury and other respiratory disorders. This study aims to evaluate the alteration of the 2D molecular organization and m...
Article GUID: 38437623
Author(s): Mosley JD; Schock TB; Beecher CW; Dunn WB; Kuligowski J; Lewis MR; Theodoridis G; Ulmer Holland CZ; Vuckovic D; Wilson ID; Zanetti KA;...
Background: Quality assurance (QA) and quality control (QC) practices are key tenets that facilitate study and data quality across all applications of untargeted metabolomics. These important pract...
Article GUID: 38345679
Author(s): Van Houten J; Dosajh A; Gulati S; Bhullar G; Copeman C; Ogata AF;
Low-cost analytical assays enable accessible detection of clinically and environmentally important analytes; however, common enzyme-based assays suffer from high production and storage costs. Catalytically active synthetic materials serve as replacements fo...
Article GUID: 38320270
Author(s): Mena-Giraldo P; Kaur M; Maurizio SL; Mandl GA; Capobianco JA;
External stimuli can trigger changes in temperature, concentration, and momentum between micromotors and the medium, causing their propulsion and enabling them to perform different tasks with improved kinetic efficiencies. Light-activated micromotors are at...
Article GUID: 38197400
Author(s): Wei D; Peslherbe GH; Selvaraj G; Wang Y;
Building on our 2021-2022 Special Issue, "Advances in Drug Design and Development for Human Therapeutics Using Artificial Intelligence [...].
Article GUID: 38136606
Author(s): Leone F; Imfeld A; Mirzaei Y; Gélinas Y;
Vapour-phase fumigation with HCl is routinely used to remove inorganic carbon in preparation for the measurement of the concentration and d13C value of organic carbon in a sample using elemental analysis coupled to an isotope ratio mass spectrometer. Acidif...
Article GUID: 38097918
Author(s): Broeckling CD; Beger RD; Cheng LL; Cumeras R; Cuthbertson DJ; Dasari S; Davis WC; Dunn WB; Evans AM; Fernández-Ochoa A; Gika H; Goodacre R; ...
Untargeted metabolomics is an analytical approach with numerous applications serving as an effective metabolic phenotyping platform to characterize small molecules within a biological system. Data ...
Article GUID: 38055671
Author(s): Orabi MAA; Orabi EA; Awadh AAA; Alshahrani MM; Abdel-Wahab BA; Sakagami H; Hatano T;
Polyphenols have a variety of phenolic hydroxyl and carbonyl functionalities that enable them to scavenge many oxidants, thereby preserving the human redox balance and preventing a number of oxidative stress-related chronic degenerative diseases. In our ong...
Article GUID: 38001804
Author(s): Dunn WB; Kuligowski J; Lewis M; Mosley JD; Schock T; Ulmer Holland C; Zanetti KA; Vuckovic D;...
Introduction: The Metabolomics Quality Assurance and Quality Control Consortium (mQACC) organized a workshop during the Metabolomics 2022 conference. Objectives: The goal of the workshop was to di...
Article GUID: 37940740
Author(s): Lomboni DJ; Ozgun A; de Medeiros TV; Staines W; Naccache R; Woulfe J; Variola F;
Neuronal disorders are characterized by the loss of functional neurons and disrupted neuroanatomical connectivity, severely impacting the quality of life of patients. This study investigates a novel electroconductive nanocomposite consisting of glycine-deri...
Article GUID: 37922888
Author(s): Sindhoo A; Sipy S; Khan A; Selvaraj G; Alshammari A; Casida ME; Wei DQ;
'Esophageal cancer' (EC) is a highly aggressive and deadly complex disease. It comprises two types, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), with Barrett's esophagus (BE) being the only known precursor. Rece...
Article GUID: 37815872
Author(s): Adeola AO; Clermont-Paquette A; Piekny A; Naccache R;
Carbon dots (CDs) have garnered significant interest for their potential use in multiple applications due to their size, fluorescent properties, high photostability, low toxicity and biocompatibility. CDs can be tailored for specific needs, as they can be s...
Article GUID: 37757783
Author(s): Pontarelli A; Wilds CJ;
The clinical success of the antisense approach for the treatment of genetic disorders is indisputably the result of chemical modifications along the oligonucleotide (ON) scaffold, which impart desirable properties including high RNA affinity, nuclease stabi...
Article GUID: 37667655
Author(s): Kaur M; Maurizio SL; Mandl GA; Capobianco JA;
Dye sensitization is a promising approach to enhance the luminescence of lanthanide-doped upconverting nanoparticles. However, the poor photostability of near-infrared dyes hampers their use in practical applications. To address this, commercial IR820 was m...
Article GUID: 37552506
Author(s): García de la Concepción J; Flores-Jiménez M; Cuccia LA; Light ME; Viedma C; Cintas P;
This paper documents and reinvestigates the solid-state and crystal structures of 4,4'-azobis-4-cyanopentanoic acid (ACPA), a water-soluble azobis-nitrile of immense utility as a radical initiator in living polymerizations and a labile mechanophore that...
Article GUID: 37547876
Author(s): Zarei Ghobadi M; Teymoori-Rad M; Selvaraj G; Wei DQ;
No abstract available
Article GUID: 37475870
Author(s): Lander AJ; Mercado LD; Li X; Taily IM; Findlay BL; Jin Y; Luk LYP;
Tryptophan is frequently found on the surface of membrane-associated proteins that interact with the lipid membrane. However, because of their multifaceted interactions, it is difficult to pinpoint the structure-activity relationship of each tryptophan resi...
Article GUID: 37464011
Author(s): Rodgers TFM; Wang Y; Humes C; Jeronimo M; Johannessen C; Spraakman S; Giang A; Scholes RC;
Road runoff to streams and rivers exposes aquatic organisms to complex mixtures of chemical contaminants. In particular, the tire-derived chemical 6PPD-quinone (N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone) is acutely toxic to several spec...
Article GUID: 37455862
Author(s): Tessitore G; Mandl GA; Maurizio SL; Kaur M; Capobianco JA;
Our society is indebted to the numerous inventors and scientists who helped bring about the incredible technological advances in modern society that we all take for granted. The importance of knowing the history of these inventions is often underestimated, ...
Article GUID: 37323462
Author(s): Mandl GA; Vettier F; Tessitore G; Maurizio SL; Bietar K; Stochaj U; Capobianco JA;
Glioblastoma multiforme is an aggressive type of brain cancer with high recurrence rates due to the presence of radioresistant cells remaining after tumor resection. Here, we report the development of an X-ray-mediated photodynamic therapy (X-PDT) system us...
Article GUID: 37267436
Author(s): Charoughchi S; Liu JT; Berteau-Rainville M; Hase H; Askari MS; Bhagat S; Forgione P; Salzmann I;...
Molecular p-dopants designed to undergo electron transfer with organic semiconductors are typically planar molecules with high electron affinity. However, their planarity can promote the formation ...
Article GUID: 37220083
Author(s): Quezada-Novoa V; Titi HM; Villanueva FY; Wilson MWB; Howarth AJ;
The tetratopic linker, 1,3,6,8-tetrakis(p-benzoic acid)pyrene (H4 TBAPy) along with rare-earth (RE) ions is used for the synthesis of 9 isostructures of a metal-organic framework (MOF) with shp topology, named RE-CU-10 (RE = Y(III), Gd(III), Tb(III), Dy(III...
Article GUID: 37116124
Author(s): Nayak SS; Naidu A; Sudhakaran SL; Vino S; Selvaraj G;
Acute respiratory distress syndrome (ARDS) is intricately linked with SARS-CoV-2-associated disease severity and mortality, especially in patients with co-morbidities. Lung tissue injury caused as a consequence of ARDS leads to fluid build-up in the alveola...
Article GUID: 37109050
Author(s): de Medeiros TV; Macina A; Bicalho HA; Naccache R;
Biodiesel remains one of the most promising alternatives to replace fossil fuel-derived petrodiesel. Nonetheless, conventional biodiesel synthesis relies on homogeneous alkali-based catalysts that involve long and tedious purification steps , increasing bio...
Article GUID: 37058095
Author(s): Pontarelli A; Wilds CJ;
The introduction of chemical modifications on the nucleic acid scaffold has allowed for the progress of antisense oligonucleotides (ASOs) in the clinic for the treatment of a variety of disorders. In contribution to the repertoire of gene-silencing nucleic ...
Article GUID: 36857293
Author(s): Pontarelli A; Liu JT; Oh JK; Wilds CJ;
The protocols described in this article provide details regarding the synthesis and characterization of a disulfide containing linker phosphoramidite for terminal functionalization of synthetic oligonucleotides. The linker is first synthesized from 6-mercap...
Article GUID: 36840706
Author(s): Keramatnejad M; DeWolf C;
Ozone exposure from environmental smog has been implicated as a risk factor for developing dry eye disease (DED). The tear film lipid layer (TFLL), which is the outermost layer of the tear film and responsible for surface tension reduction while blinking, i...
Article GUID: 36837668
Author(s): Copeman C; Bicalho HA; Terban MW; Troya D; Etter M; Frattini PL; Wells DM; Howarth AJ;
A Zr6-based metal-organic framework (MOF), MOF-808, is investigated for the adsorptive removal of IO3- from aqueous solutions, due to its high surface area and abundance of open metal sites. The uptake kinetics, adsorption capacity and binding mode are stud...
Article GUID: 36753325
Author(s): Aminzare M; Jiang J; Mandl GA; Mahshid S; Capobianco JA; Dorval Courchesne NM;
Halide perovskite nanocrystals (HPNCs) have emerged at the forefront of nanomaterials research over the past two decades. The physicochemical and optoelectronic properties of these inorganic semiconductor nanoparticles can be modulated through the introduct...
Article GUID: 36722934
Author(s): Mohideen FI; Kwan DH;
The sugar moieties of many glycosylated small molecule natural products are essential for their biological activity. Glycosyltransferases (GTs) are the enzymes responsible for installing these sugar moieties on a variety of biomolecules. Several GTs that ar...
Article GUID: 36682498
Author(s): Golizeh M; Nam J; Chatelain E; Jackson Y; Ohlund LB; Rasoolizadeh A; Camargo FV; Mahrouche L; Furtos A; Sleno L; Ndao M;...
The causative agent of Chagas disease (CD), Trypanosoma cruzi, claims thousands of lives each year. Current diagnostic tools are insufficient to ensure parasitological detection in chronically infe...
Article GUID: 36590505
Author(s): Wei D; Peslherbe GH; Selvaraj G; Wang Y;
Artificial intelligence (AI) has emerged as a key player in modern healthcare, especially in the pharmaceutical industry for the development of new drugs and vaccine candidates [...].
Article GUID: 36551273
Author(s): Effaty F; Gonnet L; Koenig SG; Nagapudi K; Ottenwaelder X; Frišcic T;
Resonant acoustic mixing (RAM) enables mechanoredox catalysis with BaTiO3 as the piezoelectric catalyst on model diazonium coupling reactions. RAM proceeds without formal grinding or impact media, is faster than the analogous ball-milling strategy, and is r...
Article GUID: 36546478
Author(s): Ali DA; Domínguez Mercado L; Findlay BL; Badia A; DeWolf C;
Antimicrobial peptides, such as GL13K, have a high binding selectivity toward bacterial membranes, while not affecting healthy mammalian cells at therapeutic concentrations. However, delivery of these peptides is challenging since they are susceptible to pr...
Article GUID: 36525622
Author(s): Orabi MAA; Orabi EA; Abdel-Sattar ES; English AM; Hatano T; Elimam H;
An ellagitannin monomer, lythracin M (1), and a dimer, lythracin D (2), along with eight known monomers (3-10) were isolated from Lawsonia inermis (Lythraceae) leaves. Lythracin M (1) is a C-glycosidic ellagitannin with a flavogallonyl dilactone moiety that...
Article GUID: 36423882
Author(s): Yu LH; Cai ZF; Verstraete L; Xia Y; Fang Y; Cuccia L; Ivasenko O; De Feyter S;
Herein we report the impact of covalent modification (grafting), inducing lateral nanoconfinement conditions, on the self-assembly of a quinonoid zwitterion derivative into self-assembled molecular networks at the liquid/solid interface. At low concentratio...
Article GUID: 36425498
Author(s): Johannessen C; Saini A; Zhang X; Harner T;
Pollution from vehicle tires has received world-wide research attention due to its ubiquity and toxicity. In this study, we measured various tire-derived contaminants semi-quantitatively in archived extracts of passive air samplers deployed in 18 major citi...
Article GUID: 36152723
Author(s): Ibrahim UH; Devnarain N; Mohammed M; Omolo CA; Gafar MA; Salih M; Pant A; Shunmugam L; Mocktar C; Khan R; Oh JK; Govender T;...
The incidence and of bacterial infections, and resulting mortality, among cancer patients is growing dramatically, worldwide. Several therapeutics have been reported to have dual anticancer and ant...
Article GUID: 36150574
Author(s): Bicalho HA; Saraci F; Velazquez-Garcia JJ; Titi HM; Howarth AJ;
Y-CU-45, an analogue of Zr-MOF-808, is synthesized for the first time. Several reaction conditions are tested demonstrating that two fluorinated modulators are required for a reproducible synthesis yielding high quality material. Y-CU-45 shows high crystall...
Article GUID: 36065793
Author(s): Kozlov G; Mattijssen S; Jiang J; Nyandwi S; Sprules T; Iben JR; Coon SL; Gaidamakov S; Noronha AM; Wilds CJ; Maraia RJ; Gehring K;...
La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA-binding domains, ...
Article GUID: 35979957
Author(s): Ouellette S; Pakarian P; Bin X; Pawelek PD;
Siderophores are high-affinity small-molecule chelators employed by bacteria to acquire iron from the extracellular environment. The Gram-negative bacterium Escherichia coli synthesizes and secretes enterobactin, a tris-catechol siderophore. Enterobactin is...
Article GUID: 35952947
Author(s): Pontarelli A; Liu JT; Movasat H; Ménard S; Oh JK; Wilds CJ;
The synthesis and incorporation of a tosylated phosphoramidite linker containing a disulfide bond is described. Incorporation of the linker into short DNA and RNA oligomers proceeded efficiently using automated solid phase synthesis. Treatment of the suppor...
Article GUID: 35863757
Author(s): LaBrie R; Péquin B; Fortin St-Gelais N; Yashayaev I; Cherrier J; Gélinas Y; Guillemette F; Podgorski DC; Spencer RGM; Tremblay L; Maranger R...
The microbial carbon pump (MCP) hypothesis suggests that successive transformation of labile dissolved organic carbon (DOC) by prokaryotes produces refractory DOC (RDOC) and contributes to the long...
Article GUID: 35857452
Author(s): Martínez RF; Cuccia LA; Viedma C; Cintas P;
By paraphrasing one of Kipling's most amazing short stories (How the Leopard Got His Spots), this article could be entitled "How Sugars Became Homochiral". Obviously, we have no answer to this still unsolved mystery, and this perspective simply brings r...
Article GUID: 35796896
Author(s): Choi M; Jazani AM; Oh JK; Noh SM;
Nitric oxide (NO) plays a critical role as an important signaling molecule for a variety of biological functions, particularly inhibiting cell proliferation or killing target pathogens. To deliver active radical NO gaseous molecule whose half-life is a few ...
Article GUID: 35683912
Author(s): Chacón-Huete F; Messina C; Cigana B; Forgione P;
This Review summarizes recent efforts to capitalize on 5-hydroxymethylfurfural (HMF) and related furans as emerging building blocks for the synthesis of fine chemicals and materials, with a focus on advanced applications within medicinal and polymer chemist...
Article GUID: 35652539
Author(s): Zhao Z; Li J; Zhang X; Wang L; Wang J; Lin T;
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been frequently detected in groundwater globally. With the phase-out of perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) due to their risk to the ecosystem and human population, various...
Article GUID: 35593984
Author(s): Victoria F; Manioudakis J; Zaroubi L; Findlay B; Naccache R;
Chirality remains a critical consideration in drug development and design, as well as in applications of enantioselective recognition and sensing. However, the preparation of chiral nanomaterials requires extensive post synthetic modifications with a chiral...
Article GUID: 35518167
Author(s): Zhang X; Zhang ZF; Zhang X; Zhu FJ; Li YF; Cai M; Kallenborn R;
The spatial variability of polycyclic aromatic hydrocarbons (PAHs) in the marine atmosphere contributes to the understanding of the global sources, fate, and impact of this contaminant. Few studies conducted to measure PAHs in the oceanic atmosphere have co...
Article GUID: 35476391
Author(s): Li Z; Zhang X; Wang B; Shen G; Zhang Q; Zhu Y;
Indoor exposure to organic flame retardants (FRs) has raised extensive concern due to associated adverse health effects. Indoor-exposure induced daily intakes of six widely used FRs individually ranged 0.002-611 ng/day and 0.02-463 ng/day, respectively, for...
Article GUID: 35461943
Author(s): Pontarelli A; Wilds CJ;
The promise of the antisense approach to treat a variety of diseases with oligonucleotides and solutions to challenges that have been encountered in their development is attributable to chemical modification of the nucleic acid scaffold. Herein, we describe...
Article GUID: 35452799
Author(s): Zhang X; Zhang X; Zhang ZF; Yang PF; Li YF; Cai M; Kallenborn R;
The global oceans are known as terminal sink or secondary source for diffusive emission of organochlorine pesticides (OCPs) and selected current used pesticides (CUPs) into the overlaying atmosphere. Many pesticides have been widely produced worldwide, subs...
Article GUID: 35452973
Author(s): Hernandez R RA; Burchell-Reyes K; Braga APCA; Lopez JK; Forgione P;
Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a ...
Article GUID: 35424611
Author(s): Nellepalli P; Kim MP; Park J; Noh SM; Ye Z; Jung HW; Ko H; Oh JK;
Triboelectric nanogenerators (TENGs), a newly developed energy harvesting device that converts surrounding environmental mechanical stimuli into electricity, have been significantly explored as an ideal long-term power source for electrical devices. Despite...
Article GUID: 35385641
Author(s): Nasr MA; Timmins LR; Martin VJJ; Kwan DH;
Allosteric transcription factor (aTF) biosensors are valuable tools for engineering microbes toward a multitude of applications in metabolic engineering, biotechnology, and synthetic biology. One of the challenges toward constructing functional and diverse ...
Article GUID: 35316041
Author(s): Liczner C; Hanna CC; Payne RJ; Wilds CJ;
A breadth of strategies are needed to efficiently modify oligonucleotides with peptides or lipids to capitalize on their therapeutic and diagnostic potential, including the modulation of in vivo chemical stability and for applications in cell-targeting and ...
Article GUID: 35126973
Author(s): Huang HY; Skripka A; Zaroubi L; Findlay BL; Vetrone F; Skinner C; Oh JK; Cuccia LA;
Chronic wounds present a high risk of infection due to delayed and incomplete healing, leading to increased health risks and financial burden to health-care systems. Numerous approaches to promote wound healing have been extensively explored, especially the...
Article GUID: 35019380
Author(s): Liu Q; Li L; Zhang X; Saini A; Li W; Hung H; Hao C; Li K; Lee P; Wentzell JJB; Huo C; Li SM; Harner T; Liggio J;...
Commercial chemicals are used extensively across urban centres worldwide1, posing a potential exposure risk to 4.2 billion people2. Harmful chemicals are often assessed on the basis of their enviro...
Article GUID: 34912090
Author(s): Lennox CB; Do JL; Crew JG; Arhangelskis M; Titi HM; Howarth AJ; Farha OK; Frišcic T;
Mechanochemistry enables rapid access to boron imidazolate frameworks (BIFs), including ultralight materials based on Li and Cu(i) nodes, as well as new, previously unexplored systems based on Ag(i) nodes. Compared to solution methods, mechanochemistry is f...
Article GUID: 34881001
Author(s): Corminboeuf A; Montero-Serrano JC; St-Louis R; Dalpé A; Gélinas Y;
The concentrations of 23 polycyclic aromatic hydrocarbons (PAHs; 16 parent PAHs and 7 alkyl-PAHs) were determined in 45 surface sediment and 7 basal sediment box core samples retrieved from the Estuary and Gulf of St. Lawrence in eastern Canada. The concent...
Article GUID: 34871900
Author(s): Raab ME; Maurizio SL; Capobianco JA; Prasad PN;
Emission bands from thermally coupled states in lanthanide-doped nanoparticles have been studied for ratiometric nanothermometry in biological applications. Unfortunately certain factors such as water absorption distort the intensity, limiting the accuracy ...
Article GUID: 34813703
Author(s): Mohideen FI; Nguyen LH; Richard JD; Ouadhi S; Kwan DH;
Many small molecule natural products are decorated with sugar moieties that are essential for their biological activity. A considerable number of natural product glycosides and their derivatives are clinically important therapeutics. Anthracyclines like dau...
Article GUID: 34751552
Author(s): Zhang X; Sun X; Jiang R; Zeng EY; Sunderland EM; Muir DCG;
No abstract
Article GUID: 34694120
Author(s): Gravel-Tatta L; DeWolf C; Badia A;
Nanoparticle carriers show promise for drug delivery, including by inhalation, where the first barrier for uptake in the lungs is the monolayer pulmonary surfactant membrane that coats the air/alveoli interface and is critical to breathing. It is imperative...
Article GUID: 34644076
Author(s): Singh H; MacKay A; Sheibany N; Chen F; Mosser M; Rouet PÉ; Rousseau F; Askari MS; Ottenwaelder X;...
Primary hydroxylamines, RNHOH, decompose readily in the presence of transition metal ions. We show that this reactivity can be arrested by ligand design via an intramolecular hydrogen bond. Six met...
Article GUID: 34545379
Author(s): Messina C; Ottenwaelder X; Forgione P;
Herein, we report a modular synthetic route to access tetra-arylated thiophene compounds with four different substituents with programmed chemical control provided by an ester activating/directing group. This method enables the functionalization of individu...
Article GUID: 34506149
Author(s): Nellepalli P; Patel T; Oh JK;
Polyurethane (PU) has not only been widely used in our daily lives, but also extensively explored as an important class of the essential polymers for various applications. In recent years significant efforts have been made on the development of self-healabl...
Article GUID: 34418209
Author(s): Li Z; Zhu Y; Wang D; Zhang X; Jones KC; Ma J; Wang P; Yang R; Li Y; Pei Z; Zhang Q; Jiang G;...
Novel flame retardants (FRs) are of increasing concern, given growing evidence of health effects and use to replace polybrominated diphenyl ethers (PBDEs). This study modeled combined effects of us...
Article GUID: 34410710
Author(s): Sun X; Zhang X; Wang L; Li Y; Muir DCG; Zeng EY;
Deep convolutional neural network (DCNN) has proved to be a promising tool for identifying organic chemicals of environmental concern. However, the uncertainty associated with DCNN predictions remains to be quantified. The training process contains many ran...
Article GUID: 34388923
Author(s): Yan X; Kumar K; Miclette Lamarche R; Youssef H; Shaw GS; Marcotte I; DeWolf CE; Warschawski DE; Boisselier E;...
Protein S100A10 participates in different cellular mechanisms and has different functions, especially at the membrane. Among those, it forms a ternary complex with annexin A2 and the C-terminal of ...
Article GUID: 34339205
Author(s): Bicalho HA; Donnarumma PR; Quezada-Novoa V; Titi HM; Howarth AJ;
Postsynthetic modification of metal-organic frameworks (MOFs) is an important strategy for accessing MOF analogues that cannot be easily synthesized de novo. In this work, the rare-earth (RE) cluster-based MOF Y-CU-10 with shp topology was modified through ...
Article GUID: 34314164
Author(s): Liu X; Vadiyar MM; Oh JK; Ye Z;
The present work demonstrates the efficient design of ultrasmall porous carbon nanospheres with tailored sizes (5-40 nm in diameter) and optimized intrasphere textural properties for high-rate high-energy supercapacitor application. The carbon nanospheres a...
Article GUID: 34229427
Author(s): Kaliamurthi S; Selvaraj G; Selvaraj C; Singh SK; Wei DQ; Peslherbe GH;
Coronavirus disease (COVID)-19 is the leading global health threat to date caused by a severe acute respiratory syndrome coronavirus (SARS-CoV-2). Recent clinical trials reported that the use of Bruton's tyrosine kinase (BTK) inhibitors to treat COVID-1...
Article GUID: 34209188
Author(s): Scott BM; Gutiérrez-Vázquez C; Sanmarco LM; da Silva Pereira JA; Li Z; Plasencia A; Hewson P; Cox LM; O' Brien M; Chen SK; Moraes-Vieira...
Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host ...
Article GUID: 34183837
Author(s): Michno W; Stringer KM; Enzlein T; Passarelli MK; Escrig S; Vitanova K; Wood J; Blennow K; Zetterberg H; Meibom A; Hopf C; Edwards FA; Hanrie...
ß-Amyloid (Aß) plaque formation is the major pathological hallmark of Alzheimer's disease (AD) and constitutes a potentially critical, early inducer driving AD pathogenesis as it precedes other...
Article GUID: 34134980
Author(s): Titi HM; Do JL; Howarth AJ; Nagapudi K; Frišcic T;
We present a rapid and readily scalable methodology for the mechanosynthesis of diverse metal-organic frameworks (MOFs) in the absence of milling media typically required for other types of mechanochemical syntheses. We demonstrate the use of liquid-assiste...
Article GUID: 34094134
Author(s): Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK;
Acid-degradable (or acid-cleavable) polymeric nanoassemblies have witnessed significant progress in anti-cancer drug delivery. However, conventional nanoassemblies designed with acid-cleavable linkages at a single location have several challenges, such as, ...
Article GUID: 34050688
Author(s): Donnarumma PR; Frojmovic S; Marino P; Bicalho HA; Titi HM; Howarth AJ;
Rare-earth (RE) analogues of UiO-66 with non-functionalised 1,4-benzenedicarboxylate linkers are synthesised for the first time, and a series of synthetic approaches is provided to troubleshoot the synthesis. RE-UiO-66 analogues are fully characterised, and...
Article GUID: 34027524
Author(s): Selvaraj G; Kaliamurthi S; Peslherbe GH; Wei DQ;
The Food and Drug Administration (FDA) has recently authorized the two messenger RNA (mRNA) vaccines BNT162b2 and mRNA-1273 for emergency use against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the COVID-19 coronavirus disease. ...
Article GUID: 34021862
Author(s): Liczner C; Duke K; Juneau G; Egli M; Wilds CJ;
Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their sc...
Article GUID: 33981365
Author(s): Zhang G; Patel T; Nellepalli P; Bhagat S; Hase H; Jazani AM; Salzmann I; Ye Z; Oh JK;
The development of heterogeneous covalent adaptable networks (CANs) embedded with carbon nanotubes (CNTs) that undergo reversible dissociation/recombination through thermoreversibility has been significantly explored. However, the carbon nanotube (CNT)-inco...
Article GUID: 33988899
Author(s): Yan X, Noël F, Marcotte I, DeWolf CE, Warschawski DE, Boisselier E
The dysferlin membrane repair complex contains a small complex, S100A10-annexin A2, which initiates membrane repair by recruiting the protein AHNAK to the membrane, where it interacts via binding sites in the C-terminal region. However, no molecular data ar...
Article GUID: 31825630
Author(s): Copp W, Pontarelli A, Wilds CJ
The chemical and self-assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli-responsive devices for a diverse array of applications. Amongst the various three-dimensional assemblies, DNA tetrahedra are o...
Article GUID: 33506614
Author(s): Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG
We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of ...
Article GUID: 33455300
Author(s): Warkentin R, Kwan DH
This review provides information on available methods for engineering glycan-binding proteins (GBP). Glycans are involved in a variety of physiological functions and are found in all domains of life and viruses. Due to their wide range of functions, GBPs ha...
Article GUID: 33450899
Author(s): Reyes-Garcés N; Boyaci E; Gómez-Ríos GA; Olkowicz M; Monnin C; Bojko B; Vuckovic D; Pawliszyn J;...
This work presents an evaluation of solid-phase microextraction (SPME) SPME in combination with liquid chromatography-high resolution mass spectrometry (LC-HRMS) as an analytical approach for untar...
Article GUID: 33433374
Author(s): Wölk C, Youssef H, Guttenberg T, Marbach H, Vizcay-Barrena G, Shen C, Brezesinski G, Harvey RD...
Ion pairing between the major phospholipids of the Staphylococcus aureus plasma membrane (phosphatidylglycerol - PG and lysyl-phosphatidylglycerol - LPG) confers resistance to antimicrobial peptide...
Article GUID: 32065707
Author(s): Orabi EA; English AM;
Long associated with cell death, hydrogen peroxide (H2O2) is now known to perform many physiological roles. Unraveling its biological mechanisms of action requires atomic-level knowledge of its association with proteins and lipids, which we address here. Hi...
Article GUID: 33356279
Author(s): Chacón-Huete F, Lasso JD, Szavay P, Covone J, Forgione P
Biomass-derived commodity chemical 5-hydroxymethyl furfural is an underutilized C6-platform chemical derived from cellulose that is ideal to prepare next-generation value-added products. We have developed an efficient synthetic strategy to access 2,5-diaryl...
Article GUID: 33253575
Author(s): Zsombor-Pindera J; Effaty F; Escomel L; Patrick B; Kennepohl P; Ottenwaelder X;
Redox noninnocent ligands enhance the reactivity of the metal they complex, a strategy used by metalloenzymes and in catalysis. Herein, we report a series of copper complexes with the same ligand framework, but with a pendant nitrogen group that spans five ...
Article GUID: 33124796
Author(s): Martins D, McKay GA, English AM, Nguyen D
Stressors and environmental cues shape the physiological state of bacteria, and thus how they subsequently respond to antibiotic toxicity. To understand how superoxide stress can modulate survival to bactericidal antibiotics, we examined the effect of intra...
Article GUID: 33101252
Author(s): Huang S; Wei YK; Kaliamurthi S; Cao Y; Nangraj AS; Sui X; Chu D; Wang H; Wei DQ; Peslherbe GH; Selvaraj G; Shi J;...
Analysis of circulating miRNAs (cmiRNAs) before surgical operation (BSO) and after the surgical operation (ASO) has been informative for lung adenocarcinoma (LUAD) diagnosis, progression, and outco...
Article GUID: 33050659
Author(s): Desharnais B; Lajoie MJ; Laquerre J; Mireault P; Skinner CD;
A study of impaired driving rates in the province of Québec is currently planned following the legalization of recreational cannabis in Canada. Oral fluid (OF) samples are to be collected with a Quantisal® device and sent to the laboratory for analysis. In ...
Article GUID: 33035929
Author(s): Wang Q, Chen MT, Franco-Cañellas A, Shen B, Geiger T, F Bettinger H, Schreiber F, Salzmann I, Gerlach A, Duhm S...
We studied the structural and electronic properties of 2,3,9,10-tetrafluoropentacene (F4PEN) on Ag(111) via X-ray standing waves (XSW), low-energy electron diffraction (LEED) as well as ultraviolet...
Article GUID: 32974114
Author(s): Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG
Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. O...
Article GUID: 31820915
Author(s): Hu X, Oh JK
The development of effective approaches to synthesize smart amphiphilic block copolymers (ABPs) exhibiting acid-responsive degradation through the cleavage of acid-labile imine bonds is extensively explored for controlled release of encapsulated biomolecule...
Article GUID: 32964550
Author(s): Bicalho HA, Rios RDF, Binatti I, Ardisson JD, Howarth AJ, Lago RM, Teixeira APC
In this work, the potential to use an iron mining waste (IW), rich in a-Fe2O3 and a-FeOOH, for the development of composites based on graphitic carbon nitride (CN) is demonstrated. These materials were synthesized through a simple thermal treatment at 550?°...
Article GUID: 32947712
Author(s): Patel T, Kim MP, Park J, Lee TH, Nellepalli P, Noh SM, Jung HW, Ko H, Oh JK
In recent years, the advent of highly deformable and healable electronics is exciting and promising for next-generation electronic devices. In particular, self-healable triboelectric nanogenerators (SH-TENGs) serve as promising candidates based on the combi...
Article GUID: 32840992
Author(s): Ghallab R, Boutebdja M, Dénès G, Merazig H
In the title mol-ecular salt, (C5H7N2)2[SnCl6], the cation is protonated at the pyridine N atom and the complete dianion is generated by a crystallographic centre of symmetry. In the crystal, N-H?Cl hydrogen bonds link the components into a three-dimensiona...
Article GUID: 32844014
Author(s): Saraci F, Quezada-Novoa V, Donnarumma PR, Howarth AJ
Chem Soc Rev. 2020 Jul 13;: Authors: Saraci F, Quezada-Novoa V, Donnarumma PR, Howarth AJ
Article GUID: 32658241
Author(s): Copp W, Wilds CJ
Chemistry. 2020 Jun 16;: Authors: Copp W, Wilds CJ
Article GUID: 32543755
Author(s): Camirand Lemyre F; Desharnais B; Laquerre J; Morel MA; Côté C; Mireault P; Skinner CD;
Qualitative methods hold an important place in drug testing, filling central needs in screening and analyses, among others, linked to per se legislation. Nevertheless, the bioanalytical method validation guidelines do not discuss this type of method or desc...
Article GUID: 32476284
Author(s): Soroko M, Kwan DH
Biochemistry. 2020 Jun 01;: Authors: Soroko M, Kwan DH
Article GUID: 32441090
Author(s): Dong J, Breitenborn H, Piccoli R, Besteiro LV, You P, Caraffini D, Wang ZM, Govorov AO, Naccache R, Vetrone F, Razzari L, Morandotti R
Biomed Opt Express. 2020 Apr 01;11(4):2254-2267 Authors: Dong J, Breitenborn H, Piccoli R, Besteiro LV, You P, Caraffini D, Wang ZM, Govorov AO, Naccache R, Vetrone F, Razzari L, Morandotti R
Article GUID: 32341881
Author(s): Behmand B; Noronha AM; Wilds CJ; Marignier JL; Mostafavi M; Wagner JR; Hunting DJ; Sanche L;...
Double-stranded oligonucleotides containing cisplatin adducts, with and without a mismatched region, were exposed to hydrated electrons generated by gamma-rays. Gel electrophoresis analysis demonst...
Article GUID: 32211848
Author(s): Maruya-Li K, Shetty C, Moini Jazani A, Arezi N, Oh JK
ACS Omega. 2020 Feb 25;5(7):3734-3742 Authors: Maruya-Li K, Shetty C, Moini Jazani A, Arezi N, Oh JK
Article GUID: 32118189
Author(s): Askari MS, Effaty F, Gennarini F, Orio M, Le Poul N, Ottenwaelder X
Inorg Chem. 2020 Feb 19;: Authors: Askari MS, Effaty F, Gennarini F, Orio M, Le Poul N, Ottenwaelder X
Article GUID: 32073833
Author(s): Dahabiyeh LA; Malkawi AK; Wang X; Colak D; Mujamammi AH; Sabi EM; Li L; Dasouki M; Abdel Rahman AM;...
Dexamethasone (Dex) is a synthetic glucocorticoid (GC) drug commonly used clinically for the treatment of several inflammatory and immune-mediated diseases. Despite its broad range of indications, ...
Article GUID: 31973046
Author(s): Liu JT; Hase H; Taylor S; Salzmann I; Forgione P;
A library of symmetrical linear oligothiophene was prepared employing decarboxylative cross-coupling reaction as the key transformation. Thiophene potassium carboxylate salts were used as cross-coupling partners without the need of co-catalyst, base, or add...
Article GUID: 31961982
Author(s): Napylov A; Reyes-Garces N; Gomez-Rios G; Olkowicz M; Lendor S; Monnin C; Bojko B; Hamani C; Pawliszyn J; Vuckovic D;...
Oxylipins are key lipid mediators of important brain processes, including pain, sleep, oxidative stress, and inflammation. For the first time, an in-depth profile of up to 52 oxylipins can be obtai...
Article GUID: 31697450
Author(s): Jones AOF, Resel R, Schrode B, Machado-Charry E, Röthel C, Kunert B, Salzmann I, Kontturi E, Reishofer D, Spirk S
Biomacromolecules. 2019 Dec 12;: Authors: Jones AOF, Resel R, Schrode B, Machado-Charry E, Röthel C, Kunert B, Salzmann I, Kontturi E, Reishofer D, Spirk S
Article GUID: 31774663
Author(s): Ali MY, Seong SH, Jung HA, Choi JS
Molecules. 2019 Oct 31;24(21): Authors: Ali MY, Seong SH, Jung HA, Choi JS
Article GUID: 31683604
Author(s): Seong SH, Ali MY, Jung HA, Choi JS
Bioorg Chem. 2019 Sep 18;92:103293 Authors: Seong SH, Ali MY, Jung HA, Choi JS
Article GUID: 31557622
Author(s): Liang Y, Manioudakis J, Macairan JR, Askari MS, Forgione P, Naccache R
ACS Omega. 2019 Sep 17;4(12):14955-14961 Authors: Liang Y, Manioudakis J, Macairan JR, Askari MS, Forgione P, Naccache R
Article GUID: 31552336
Author(s): Eskola M, Kos G, Elliott CT, Hajšlová J, Mayar S, Krska R
Crit Rev Food Sci Nutr. 2019 Sep 03;:1-17 Authors: Eskola M, Kos G, Elliott CT, Hajšlová J, Mayar S, Krska R
Article GUID: 31478403
Author(s): Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK
ACS Omega. 2018 Aug 31;3(8):8980-8991 Authors: Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK
Article GUID: 31459031
Author(s): Sonnenberg RA; Naz S; Cougnaud L; Vuckovic D;
To increase metabolome coverage in global LC-MS metabolomics, often both reversed-phase liquid chromatography (RPLC) and hydrophilic-interaction liquid chromatography (HILIC) are implemented in parallel. However, there is a lack of consensus in the literatu...
Article GUID: 31439439
Author(s): Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, John...
Nat Commun. 2019 Jul 11;10(1):3132 Authors: Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR,...
Article GUID: 31296848
Author(s): Orabi EA; Peslherbe GH;
S-Sulfhydration of cysteine to the Cys-SSH persulfide is an oxidative post-translational modification that plays an important regulatory role in many physiological systems. Though hydrogen persulfide (H2S2) has recently been established as a signaling and c...
Article GUID: 31297500
Author(s): Malkawi AK; Masood A; Shinwari Z; Jacob M; Benabdelkamel H; Matic G; Almuhanna F; Dasouki M; Alaiya AA; Rahman AMA;...
Prolonged dexamethasone (Dex) administration leads to serious adverse and decrease brain and heart size, muscular atrophy, hemorrhagic liver, and presence of kidney cysts. Herein, we used an untarg...
Article GUID: 31247941
Author(s): Martins D, Nguyen D, English AM
Sci Rep. 2019 Jun 24;9(1):9185 Authors: Martins D, Nguyen D, English AM
Article GUID: 31235707
Author(s): Fox T, English AM, Gibbs BF
Derivatization of yeast cytochrome c peroxidase with pentaammineruthenium(III).
Bioconjug Chem. 1994 Jan-Feb;5(1):14-20
Authors: Fox T, English AM, Gibbs BF
Abstract
Cytochrome c peroxidase (CCP) was derivatized using aquopentaamminerutheniu...
Article GUID: 8199229
Author(s): Christendat D, Turnbull J
Identification of active site residues of chorismate mutase-prephenate dehydrogenase from Escherichia coli.
Biochemistry. 1996 Apr 09;35(14):4468-79
Authors: Christendat D, Turnbull J
Abstract
Chemical modification studies...
Article GUID: 8605196
Author(s): Cadieux E, Powlowski J
Biochemistry. 1999 Aug 17;38(33):10714-22 Authors: Cadieux E, Powlowski J
Article GUID: 10451366
Author(s): Lin T, Kornblatt MJ
Biochim Biophys Acta. 2000 Feb 09;1476(2):279-86 Authors: Lin T, Kornblatt MJ
Article GUID: 10669792
Author(s): Filosa A, English AM
J Biol Chem. 2001 Jun 15;276(24):21022-7 Authors: Filosa A, English AM
Article GUID: 11262405
Author(s): Romeo AA, Capobianco JA, English AM
J Biol Chem. 2002 Jul 05;277(27):24135-41 Authors: Romeo AA, Capobianco JA, English AM
Article GUID: 11970954
Author(s): Tao L, Murphy ME, English AM
Biochemistry. 2002 May 14;41(19):6185-92 Authors: Tao L, Murphy ME, English AM
Article GUID: 11994015
Author(s): Kornblatt MJ, Zheng SX, Lamandé N, Lazar M
Biochim Biophys Acta. 2002 Jun 03;1597(2):311-9 Authors: Kornblatt MJ, Zheng SX, Lamandé N, Lazar M
Article GUID: 12044909
Author(s): Tsaprailis G, English AM
J Biol Inorg Chem. 2003 Feb;8(3):248-55 Authors: Tsaprailis G, English AM
Article GUID: 12589560
Author(s): Tao L, English AM
Biochemistry. 2003 Mar 25;42(11):3326-34 Authors: Tao L, English AM
Article GUID: 12641465
Author(s): Jiang H, English AM
J Proteome Res. 2002 Jul-Aug;1(4):345-50 Authors: Jiang H, English AM
Article GUID: 12645890
Author(s): Wright PJ, English AM
J Am Chem Soc. 2003 Jul 16;125(28):8655-65 Authors: Wright PJ, English AM
Article GUID: 12848573
Author(s): Papp R, Ekiel I, English AM
Biochem Cell Biol. 2003 Apr;81(2):71-80 Authors: Papp R, Ekiel I, English AM
Article GUID: 12870871
Author(s): Harvey MD, Banks PR
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Aug 05;793(1):115-25 Authors: Harvey MD, Banks PR
Article GUID: 12880859
Author(s): Romeo AA, Capobianco JA, English AM
J Am Chem Soc. 2003 Nov 26;125(47):14370-8 Authors: Romeo AA, Capobianco JA, English AM
Article GUID: 14624585
Author(s): Tao L, English AM
Biochemistry. 2004 Apr 06;43(13):4028-38 Authors: Tao L, English AM
Article GUID: 15049710
Author(s): Bandilla D, Skinner CD
J Chromatogr A. 2004 Jul 30;1044(1-2):113-29 Authors: Bandilla D, Skinner CD
Article GUID: 15354432
Author(s): Shen B, English AM
Biochemistry. 2005 Oct 25;44(42):14030-44 Authors: Shen B, English AM
Article GUID: 16229492
Author(s): Laterreur J, English AM
J Inorg Biochem. 2007 Nov;101(11-12):1827-35 Authors: Laterreur J, English AM
Article GUID: 17889368
Author(s): Ouellet A, Catana D, Plouhinec JB, Lucotte M, Gélinas Y
Environ Sci Technol. 2008 Apr 01;42(7):2490-5 Authors: Ouellet A, Catana D, Plouhinec JB, Lucotte M, Gélinas Y
Article GUID: 18504986
Author(s): Lei Y, Pawelek PD, Powlowski J
Biochemistry. 2008 Jul 01;47(26):6870-82 Authors: Lei Y, Pawelek PD, Powlowski J
Article GUID: 18537268
Author(s): Lin W, Skinner CD
J Sep Sci. 2009 Aug;32(15-16):2642-52 Authors: Lin W, Skinner CD
Article GUID: 19575382
Author(s): Boisvert MR, Koski KG, Skinner CD
Anal Chem. 2010 Feb 01;82(3):1133-7 Authors: Boisvert MR, Koski KG, Skinner CD
Article GUID: 20063865
Author(s): Susanto D, English AM, Sharma R, Kwong E
J Mass Spectrom. 2011 May;46(5):508-16 Authors: Susanto D, English AM, Sharma R, Kwong E
Article GUID: 21520348
Author(s): McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ
Org Biomol Chem. 2012 Sep 21;10(35):7078-90 Authors: McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ
Article GUID: 22850722
Author(s): McManus FP, Khaira A, Noronha AM, Wilds CJ
Bioconjug Chem. 2013 Feb 20;24(2):224-33 Authors: McManus FP, Khaira A, Noronha AM, Wilds CJ
Article GUID: 23347328
Author(s): Martins D, English AM
Redox Biol. 2014;2:632-9 Authors: Martins D, English AM
Article GUID: 24936435
Author(s): Kathiresan M, English AM
Metallomics. 2016 Apr;8(4):434-43 Authors: Kathiresan M, English AM
Article GUID: 26980054
Author(s): O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ
Biochemistry. 2015 Dec 29;54(51):7449-56 Authors: O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ
Article GUID: 26624500
Author(s): Bouaoud Y, Setifi Z, Buvailo A, Potaskalov VA, Merazig H, Dénés G
Acta Crystallogr E Crystallogr Commun. 2016 Jan 01;72(Pt 1):21-4 Authors: Bouaoud Y, Setifi Z, Buvailo A, Potaskalov VA, Merazig H, Dénés G
Article GUID: 26870577
Author(s): Pakarian P, Pawelek PD
Biochimie. 2016 Aug;127:1-9 Authors: Pakarian P, Pawelek PD
Article GUID: 27086082
Author(s): Assi HA, Harkness RW, Martin-Pintado N, Wilds CJ, Campos-Olivas R, Mittermaier AK, González C, Damha MJ
Nucleic Acids Res. 2016 06 20;44(11):4998-5009 Authors: Assi HA, Harkness RW, Martin-Pintado N, Wilds CJ, Campos-Olivas R, Mittermaier AK, González C, Damha MJ
Article GUID: 27166371
Author(s): Orabi EA; English AM;
Oxidation and protonation/deprotonation strongly impact intermolecular noncovalent interactions. For example, S-aromatic interactions are stabilized up to three-fold in the gas phase on oxidation of the sulfur ligand or protonation/deprotonation of the arom...
Article GUID: 31214677
Author(s): Balhara V, Deshmukh SS, Kálmán L, Kornblatt JA
PLoS One. 2014;9(2):e88395 Authors: Balhara V, Deshmukh SS, Kálmán L, Kornblatt JA
Article GUID: 24520380
Author(s): Carter AR, Seaberg MH, Fan HF, Sun G, Wilds CJ, Li HW, Perkins TT
Nucleic Acids Res. 2016 07 08;44(12):5849-60 Authors: Carter AR, Seaberg MH, Fan HF, Sun G, Wilds CJ, Li HW, Perkins TT
Article GUID: 27220465
Author(s): Hébert M, Petiot P, Benoit E, Dansereau J, Ahmad T, Le Roch A, Ottenwaelder X, Gagnon A
J Org Chem. 2016 07 01;81(13):5401-16 Authors: Hébert M, Petiot P, Benoit E, Dansereau J, Ahmad T, Le Roch A, Ottenwaelder X, Gagnon A
Article GUID: 27231755
Author(s): Pinti DL, Gelinas Y, Moritz AM, Larocque M, Sano Y
Sci Total Environ. 2016 Oct 01;566-567:1329-1338 Authors: Pinti DL, Gelinas Y, Moritz AM, Larocque M, Sano Y
Article GUID: 27267724
Author(s): Shlaifer I, Turnbull JL
Extremophiles. 2016 Jul;20(4):503-14 Authors: Shlaifer I, Turnbull JL
Article GUID: 27290727
Author(s): Mangas I, Estevez J, Vilanova E, França TC
Toxicology. 2017 Feb 01;376:30-43 Authors: Mangas I, Estevez J, Vilanova E, França TC
Article GUID: 27311923
Author(s): Chaloner L, Khomutovskaya A, Thomas F, Ottenwaelder X
Dalton Trans. 2016 Jul 05;45(27):11109-19 Authors: Chaloner L, Khomutovskaya A, Thomas F, Ottenwaelder X
Article GUID: 27328176
Author(s): Pakarian P, Pawelek PD
Biochem Biophys Res Commun. 2016 09 09;478(1):25-32 Authors: Pakarian P, Pawelek PD
Article GUID: 27470582
Author(s): O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ
Chem Sci. 2016 Aug 01;7(8):4896-4904 Authors: O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ
Article GUID: 27574558
Author(s): O'Flaherty DK, Wilds CJ
Curr Protoc Nucleic Acid Chem. 2016 09 01;66:5.17.1-5.17.24 Authors: O'Flaherty DK, Wilds CJ
Article GUID: 27584704
Author(s): Pakarian P, Pawelek PD
BMC Biotechnol. 2016 09 13;16(1):68 Authors: Pakarian P, Pawelek PD
Article GUID: 27619907
Author(s): Herascu N, Hunter MS, Shafiei G, Najafi M, Johnson TW, Fromme P, Zazubovich V
J Phys Chem B. 2016;120(40):10483-10495 Authors: Herascu N, Hunter MS, Shafiei G, Najafi M, Johnson TW, Fromme P, Zazubovich V
Article GUID: 27661089
Author(s): Portail M, Olu K, Dubois SF, Escobar-Briones E, Gelinas Y, Menot L, Sarrazin J
PLoS One. 2016;11(9):e0162263 Authors: Portail M, Olu K, Dubois SF, Escobar-Briones E, Gelinas Y, Menot L, Sarrazin J
Article GUID: 27683216
Author(s): Viedma C, Cuccia LA, McTaggart A, Kahr B, Martin AT, McBride JM, Cintas P
Chem Commun (Camb). 2016 Sep 22;52(78):11673-11676 Authors: Viedma C, Cuccia LA, McTaggart A, Kahr B, Martin AT, McBride JM, Cintas P
Article GUID: 27722508
Author(s): de Souza FR, Guimarães AP, Cuya T, de Freitas MP, Gonçalves ADS, Forgione P, Costa França TC
J Biomol Struct Dyn. 2017 Oct;35(13):2975-2986 Authors: de Souza FR, Guimarães AP, Cuya T, de Freitas MP, Gonçalves ADS, Forgione P, Costa França TC
Article GUID: 27726597
Author(s): Nguyen TP, Cheung PS, Werber L, Gagnon J, Sivakumar R, Lennox C, Sossin A, Mastai Y, Cuccia LA
Chem Commun (Camb). 2016 Oct 18;52(85):12626-12629 Authors: Nguyen TP, Cheung PS, Werber L, Gagnon J, Sivakumar R, Lennox C, Sossin A, Mastai Y, Cuccia LA
Article GUID: 27722259
Author(s): Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L
Chem Res Toxicol. 2016 11 21;29(11):1872-1882 Authors: Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L
Article GUID: 27768841
Author(s): O'Flaherty DK, Wilds CJ
Org Biomol Chem. 2016 Dec 20;15(1):189-196 Authors: O'Flaherty DK, Wilds CJ
Article GUID: 27886318
Author(s): Shlaifer I, Quashie PK, Kim HY, Turnbull JL
Biochim Biophys Acta Proteins Proteom. 2017 Mar;1865(3):312-320 Authors: Shlaifer I, Quashie PK, Kim HY, Turnbull JL
Article GUID: 28025081
Author(s): Brigitte Desharnais
Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selectio...
Article GUID: 28137730
Author(s): Brigitte Desharnais
In the first part of this paper (I-Description and application), an automated, stepwise and analyst-independent process for the selection and validation of calibration models was put forward and applied to two model analytes. This second part presents the m...
Article GUID: 28158619
Author(s): Biswas D, An SY, Li Y, Wang X, Oh JK
Mol Pharm. 2017 08 07;14(8):2518-2528 Authors: Biswas D, An SY, Li Y, Wang X, Oh JK
Article GUID: 28207270
Author(s): An SY, Noh SM, Oh JK
Macromol Rapid Commun. 2017 Apr;38(8): Authors: An SY, Noh SM, Oh JK
Article GUID: 28221703
Author(s): Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R
Molecules. 2017 Mar 17;22(3): Authors: Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R
Article GUID: 28304349
Author(s): Barber A, Brandes J, Leri A, Lalonde K, Balind K, Wirick S, Wang J, Gélinas Y
Sci Rep. 2017 03 23;7(1):366 Authors: Barber A, Brandes J, Leri A, Lalonde K, Balind K, Wirick S, Wang J, Gélinas Y
Article GUID: 28336935
Author(s): Kalhapure RS, Sikwal DR, Rambharose S, Mocktar C, Singh S, Bester L, Oh JK, Renukuntla J, Govender T
Nanomedicine. 2017 Aug;13(6):2067-2077 Authors: Kalhapure RS, Sikwal DR, Rambharose S, Mocktar C, Singh S, Bester L, Oh JK, Renukuntla J, Govender T
Article GUID: 28434930
Author(s): Kathiresan M, English AM
Chem Sci. 2017 Feb 01;8(2):1152-1162 Authors: Kathiresan M, English AM
Article GUID: 28451256
Author(s): Bawa KK, Oh JK
Mol Pharm. 2017 08 07;14(8):2460-2474 Authors: Bawa KK, Oh JK
Article GUID: 28493712
Author(s): Desharnais B, Dazé Y, Huppertz LM, Mireault P, Skinner CD
Forensic Sci Med Pathol. 2017 Sep;13(3):350-354 Authors: Desharnais B, Dazé Y, Huppertz LM, Mireault P, Skinner CD
Article GUID: 28668987
Author(s): Van der Heggen D, Joos JJ, Rodríguez Burbano DC, Capobianco JA, Smet PF
Materials (Basel). 2017 Jul 28;10(8): Authors: Van der Heggen D, Joos JJ, Rodríguez Burbano DC, Capobianco JA, Smet PF
Article GUID: 28773228
Author(s): Oh JK
Mol Pharm. 2017 08 07;14(8):2459 Authors: Oh JK PMID: 28780874 [PubMed - indexed for MEDLINE]
Article GUID: 28780874
Author(s): Denisov AY, McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ
Org Biomol Chem. 2017 Oct 11;15(39):8361-8370 Authors: Denisov AY, McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ
Article GUID: 28937154
Author(s): Copp W, Denisov AY, Xie J, Noronha AM, Liczner C, Safaee N, Wilds CJ, Gehring K
Nucleic Acids Res. 2017 Sep 29;45(17):10321-10331 Authors: Copp W, Denisov AY, Xie J, Noronha AM, Liczner C, Safaee N, Wilds CJ, Gehring K
Article GUID: 28973475
Author(s): O'Flaherty DK, Wilds CJ
Chembiochem. 2017 12 05;18(23):2351-2357 Authors: O'Flaherty DK, Wilds CJ
Article GUID: 28980757
Author(s): Monnin C; Ramrup P; Daigle-Young C; Vuckovic D;
Rationale: Mobile-phase additives in liquid chromatography/mass spectrometry (LC/MS) are used to improve peak shape, analyte ionization efficiency and method coverage. Both basic and acidic mobile phases have been used successfully for negative electrospray...
Article GUID: 29105990
Author(s): Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ
Molecules. 2017 Nov 11;22(11): Authors: Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ
Article GUID: 29137116
Author(s): Mal S, Pietraszkiewicz M, Pietraszkiewicz O
Luminescence. 2018 Mar;33(2):370-375 Authors: Mal S, Pietraszkiewicz M, Pietraszkiewicz O
Article GUID: 29178666
Author(s): Jung S, Patel T, Oh JK
Macromol Rapid Commun. 2018 Mar;39(5): Authors: Jung S, Patel T, Oh JK
Article GUID: 29210490
Author(s): Wang JJ, Lafrenière MJ, Lamoureux SF, Simpson AJ, Gélinas Y, Simpson MJ
Environ Sci Technol. 2018 Feb 06;52(3):1062-1071 Authors: Wang JJ, Lafrenière MJ, Lamoureux SF, Simpson AJ, Gélinas Y, Simpson MJ
Article GUID: 29301070
Author(s): Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L
ACS Appl Mater Interfaces. 2018 Feb 07;10(5):4910-4920 Authors: Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L
Article GUID: 29336139
Author(s): Leibovitch M, Hanic-Joyce PJ, Joyce PBM
Biochim Biophys Acta Proteins Proteom. 2018 Apr;1866(4):527-540 Authors: Leibovitch M, Hanic-Joyce PJ, Joyce PBM
Article GUID: 29454993
Author(s): Shahina Z, El-Ganiny AM, Minion J, Whiteway M, Sultana T, Dahms TES
Fungal Biol Biotechnol. 2018;5:3 Authors: Shahina Z, El-Ganiny AM, Minion J, Whiteway M, Sultana T, Dahms TES
Article GUID: 29456868
Author(s): Hong SH, Patel T, Ip S, Garg S, Oh JK
Langmuir. 2018 03 13;34(10):3316-3325 Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK
Article GUID: 29485889
Author(s): Bastos LDC, de Souza FR, Pereira Souza LM, Forgione P, Cuya T, de Alencastro RB, Pimentel AS, Celmar Costa França T
J Biomol Struct Dyn. 2019 Mar;37(5):1170-1176 Authors: Bastos LDC, de Souza FR, Pereira Souza LM, Forgione P, Cuya T, de Alencastro RB, Pimentel AS, Celmar Costa França T PMID: 29542379 [PubMed - in process]
Article GUID: 29542379
Author(s): Clarke C, Liu D, Wang F, Liu Y, Chen C, Ton-That C, Xu X, Jin D
Nanoscale. 2018 Apr 05;10(14):6270-6276 Authors: Clarke C, Liu D, Wang F, Liu Y, Chen C, Ton-That C, Xu X, Jin D
Article GUID: 29560984
Author(s): Slobodchikova I; Vuckovic D;
Mycotoxins are secondary metabolites produced by filamentous fungi. Primary route of human exposure to mycotoxins is the intake of the contaminated food. Minimizing mycotoxin exposure is important for population health, as their chronic toxic effects have b...
Article GUID: 29576275
Author(s): Dajana Vuckovic
This Feature Article highlights some of the key challenges within the field of metabolomics and examines what role separation and analytical sciences can play to improve the use of metabolomics in biomarker discovery and personalized medicine. Recent progre...
Article GUID: 29888773
Author(s): Simbrunner J, Simbrunner C, Schrode B, Röthel C, Bedoya-Martinez N, Salzmann I, Resel R
Acta Crystallogr A Found Adv. 2018 Jul 01;74(Pt 4):373-387 Authors: Simbrunner J, Simbrunner C, Schrode B, Röthel C, Bedoya-Martinez N, Salzmann I, Resel R
Article GUID: 29978847
Author(s): Ali MY, Seong SH, Jung HA, Jannat S, Choi JS
Arch Pharm Res. 2018 Jul;41(7):753-764 Authors: Ali MY, Seong SH, Jung HA, Jannat S, Choi JS
Article GUID: 30047040
Author(s): Fang Y, Cibian M, Hanan GS, Perepichka DF, De Feyter S, Cuccia LA, Ivasenko O
Nanoscale. 2018 Aug 09;10(31):14993-15002 Authors: Fang Y, Cibian M, Hanan GS, Perepichka DF, De Feyter S, Cuccia LA, Ivasenko O
Article GUID: 30052249
Author(s): Gilles H Peslherbe
No abstract available
Article GUID: 30131561
Author(s): Kathiresan M; English AM;
LC-MS/MS profiling reveals that the proteoforms of cytochrome c peroxidase (Ccp1) isolated from respiring yeast mitochondria are oxidized at numerous Met, Trp, and Tyr residues. In vitro oxidation of recombinant Ccp1 by H2O2 in the absence of its reducing s...
Article GUID: 30145880
Author(s): Orabi EA; English AM;
Noncovalent interactions between Met and aromatic residues define a common Met-aromatic motif in proteins. Met oxidation to MetOn (n = 1 sulfoxide, n = 2 sulfone) alters protein stability and function. To predict the chemical and physical consequences of su...
Article GUID: 30168822
Author(s): Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D
Proc Natl Acad Sci U S A. 2018 09 25;115(39):9797-9802 Authors: Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D
Article GUID: 30201715
Author(s): Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK
Colloids Surf B Biointerfaces. 2018 Dec 01;172:608-617 Authors: Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK
Article GUID: 30223243
Author(s): Bawa KK, Jazani AM, Shetty C, Oh JK
Macromol Rapid Commun. 2018 Dec;39(24):e1800477 Authors: Bawa KK, Jazani AM, Shetty C, Oh JK
Article GUID: 30286258
Author(s): Copp W, O'Flaherty DK, Wilds CJ
Org Biomol Chem. 2018 11 28;16(46):9053-9058 Authors: Copp W, O'Flaherty DK, Wilds CJ
Article GUID: 30430154
Author(s): Culham DE; Marom D; Boutin R; Garner J; Ozturk TN; Sahtout N; Tempelhagen L; Lamoureux G; Wood JM;...
ProP is a member of the major facilitator superfamily, a proton-osmolyte symporter, and an osmosensing transporter. ProP proteins share extended cytoplasmic carboxyl terminal domains (CTDs) implica...
Article GUID: 30448037
Author(s): Ghaddar N, Hashemidahaj M, Findlay BL
Sci Rep. 2018 Nov 19;8(1):17023 Authors: Ghaddar N, Hashemidahaj M, Findlay BL
Article GUID: 30451932
Author(s): Reid NE, Ngou JS, Joyce PBM
Biochem Biophys Res Commun. 2019 Jan 15;508(3):785-790 Authors: Reid NE, Ngou JS, Joyce PBM
Article GUID: 30528393
Author(s): Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D
ACS Nano. 2019 Jan 22;13(1):408-420 Authors: Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D
Article GUID: 30604607
Author(s): Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, Modaresi V, Karimi M, Ordooei M, Vakili M, Pakseresht B
Probiotics Antimicrob Proteins. 2019 Jan 09;: Authors: Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, Modaresi V, Karimi M, Ordooei M, Vakili M, Pakseresht B
Article GUID: 30627885
Author(s): Xin X, Huang G, An C, Raina-Fulton R, Weger H
Environ Sci Technol. 2019 Feb 19;53(4):2189-2198 Authors: Xin X, Huang G, An C, Raina-Fulton R, Weger H
Article GUID: 30673261
Author(s): Jannat S, Balupuri A, Ali MY, Hong SS, Choi CW, Choi YH, Ku JM, Kim WJ, Leem JY, Kim JE, Shrestha AC, Ham HN, Lee KH, Kim DM, Kang NS, Park GH
Exp Mol Med. 2019 02 12;51(2):12 Authors: Jannat S, Balupuri A, Ali MY, Hong SS, Choi CW, Choi YH, Ku JM, Kim WJ, Leem JY, Kim JE, Shrestha AC, Ham HN, Lee KH, Kim DM, Kang NS, Park GH
Article GUID: 30755593
Author(s): Garneau B, Desharnais B, Beauchamp-Doré A, Lavallée C, Mireault P, Lajeunesse A
J Anal Toxicol. 2019 Mar 30;: Authors: Garneau B, Desharnais B, Beauchamp-Doré A, Lavallée C, Mireault P, Lajeunesse A
Article GUID: 30927001
Author(s): Ali MY, Zaib S, Rahman MM, Jannat S, Iqbal J, Park SK, Chang MS
Chem Biol Interact. 2019 May 25;305:180-194 Authors: Ali MY, Zaib S, Rahman MM, Jannat S, Iqbal J, Park SK, Chang MS
Article GUID: 30928401
Author(s): Leibovitch M, Reid NE, Victoria J, Hanic-Joyce PJ, Joyce PBM
Biochim Biophys Acta Proteins Proteom. 2019 Jun;1867(6):616-626 Authors: Leibovitch M, Reid NE, Victoria J, Hanic-Joyce PJ, Joyce PBM
Article GUID: 30959222
Author(s): Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Jo...
Nat Commun. 2019 05 09;10(1):2040 Authors: Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR...
Article GUID: 31068573
Author(s): Desharnais B; Lajoie MJ; Laquerre J; Savard S; Mireault P; Skinner CD;
Several substances relevant for forensic toxicology purposes have an endogenous presence in biological matrices: beta-hydroxybutyric acid (BHB), gamma-hydroxybutyric acid (GHB), steroids and human insulin, to name only a few. The presence of significant amo...
Article GUID: 31141151
| Title: | A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers |
| Authors: | Nasr MA, Timmins LR, Martin VJJ, Kwan DH, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/35316041/ |
| DOI: | 10.1021/acssynbio.2c00063 |
| Category: | |
| PMID: | 35316041 |
| Dept Affiliation: | CHEMBIOCHEM
1 Department of Biology, Centre for Applied Synthetic Biology, and Centre for Structural and Functional Genomics, Concordia University, Montréal, Quebec H4B 1R6, Canada. 2 PROTEO, Quebec Network for Research on Protein Function, Structure, and Engineering, Québec City, Quebec G1 V 0A6, Canada. 3 Department of Chemistry and Biochemistry, Concordia University, Montréal, Quebec H4B 1R6, Canada. |
Description: |
Allosteric transcription factor (aTF) biosensors are valuable tools for engineering microbes toward a multitude of applications in metabolic engineering, biotechnology, and synthetic biology. One of the challenges toward constructing functional and diverse biosensors in engineered microbes is the limited toolbox of identified and characterized aTFs. To overcome this, extensive bioprospecting of aTFs from sequencing databases, as well as aTF ligand-specificity engineering are essential in order to realize their full potential as biosensors for novel applications. In this work, using the TetR-family repressor CmeR from Campylobacter jejuni, we construct aTF genetic circuits that function as salicylate biosensors in the model organisms Escherichia coli and Saccharomyces cerevisiae. In addition to salicylate, we demonstrate the responsiveness of CmeR-regulated promoters to multiple aromatic and indole inducers. This relaxed ligand specificity of CmeR makes it a useful tool for detecting molecules in many metabolic engineering applications, as well as a good target for directed evolution to engineer proteins that are able to detect new and diverse chemistries. |
