Keyword search (3,448 papers available)


Comprehensive Analysis of Age- and Sex-Related Expression of the Chaperone Protein Sigma-1R in the Mouse Brain

Author(s): Tarmoun K; Lachance V; Le Corvec V; Bélanger SM; Beaucaire G; Kourrich S;

Sigma-1R (S1R) is a ubiquitously distributed protein highly expressed in the brain and liver. It acts as a ligand-inducible chaperone protein localized at the endoplasmic reticulum. S1R participates in several signaling pathways that oversee diverse cellula...

Article GUID: 39335377
AP-1 contributes to endosomal targeting of ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif

Author(s): Cabana VC; Sénécal AM; Bouchard AY; Kourrich S; Cappadocia L; Lussier MP;

Cellular trafficking between organelles is typically assured by short motifs that contact carrier proteins to transport them to their destination. Ubiquitin E3 ligase RING finger protein 13 (RNF13), a regulator of proliferation, apoptosis, and protein traff...

Article GUID: 39206621
Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells

Author(s): Bagheri H; Friedman H; Hadwen A; Jarweh C; Cooper E; Oprea L; Guerrier C; Khadra A; Collin A; Cohen-Adad J; Young A; Victoriano GM; Swire M;...

Myelin basic protein (Mbp) is essential for both elaboration and maintenance of CNS myelin, and its reduced accumulation results in hypomyelination. How different Mbp mRNA levels affect myelin dime...

Article GUID: 39023138
Acute ethanol disrupts conditioned inhibition in the male rat

Author(s): Germé K; Pfaus JG;

Rationale: Alcohol can disrupt conditioned sexual inhibition (CSI) established by first-order conditioning in male rats. CSI can also be induced using second-order conditioning, during which male rats are trained to associate a neutral odor with a nonrecept...

Article GUID: 38822097
The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks

Author(s): Alvarez MR; Alkaissi H; Rieger AM; Esber GR; Acosta ME; Stephenson SI; Maurice AV; Valencia LMR; Roman CA; Alarcon JM;...

Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a potential activator of...

Article GUID: 38549144
Editorial: Neuroepigenetics and biological mechanisms of stress-induced socio-cognitive changes

Author(s): Daniels WMU; Ajonijebu DC; Olajide OJ;

No abstract available

Article GUID: 38445046
Palatability attributed to alcohol and alcohol-paired flavors

Author(s): Valyear MD; Eustachon NM; Britt JP;

The orosensory features of alcoholic drinks are potent relapse triggers because they acquire incentive properties during consumption, including enhanced palatability. Whether mice similarly perceive alcoholic drinks to be more palatable after repeated consu...

Article GUID: 38430645
Ending the overdose epidemic by ending the war on drug users: Can this work?

Author(s): Leyton M; Krausz RM;

No abstract available

Article GUID: 38383036
Mesocorticolimbic function in cocaine polydrug users: A multimodal study of drug cue reactivity and cognitive regulation

Author(s): Scala SG; Kang MS; Cox SML; Rosa-Neto P; Massarweh G; Leyton M;

Addictions are thought to be fostered by the emergence of poorly regulated mesocorticolimbic responses to drug-related cues. The development and persistence of these responses might be promoted by altered glutamate transmission, including changes to type 5 ...

Article GUID: 38221806
Learning from opioid withdrawal: Effects on striatal dopamine (Commentary on Ahn et al., 2023)

Author(s): Leyton M; Nikolic M;

No abstract available

Article GUID: 38129315
What is Learned Determines How Pavlovian Conditioned Fear is Consolidated in the Brain

Author(s): Leake J; Leidl DM; Lay BPP; Fam JP; Giles MC; Qureshi OA; Westbrook RF; Holmes NM;

Activity in the basolateral amygdala complex (BLA) is needed to encode fears acquired through contact with both innate sources of danger (i.e., things that are painful) and learned sources of danger (e.g., being threatened with a gun). However, within the B...

Article GUID: 37963767
The priming effect of rewarding brain stimulation in rats depends on both the cost and strength of reward but survives blockade of D2-like dopamine receptors

Author(s): Czarina Evangelista

Receipt of an intense reward boosts motivation to work for more of that reward. This phenomenon is called the priming effect of rewards. Using a novel measurement method, we show that the priming effect of rewarding electrical brain stimulation depends on t...

Article GUID: 37752810
Modulation of cue value and the augmentation of heroin seeking in chronically food-restricted male rats under withdrawal

Author(s): Firas Sedki

Food restriction augments drug seeking in abstinent rats. The underlying motivational mechanisms, however, remain unclear. We hypothesized that caloric restriction enhances the incentive value attributed to drug-associated cues and, in turn, augments drug s...

Article GUID: 37714221
NMDA Receptors in the Basolateral Amygdala Complex Are Engaged for Pavlovian Fear Conditioning When an Animal's Predictions about Danger Are in Error

Author(s): Tuval Keidar

It is widely accepted that Pavlovian fear conditioning requires activation of NMDA receptors (NMDARs) in the basolateral amygdala complex (BLA). However, it was recently shown that activation of NMDAR in the BLA is only required for fear conditioning when d...

Article GUID: 37607821
A non-human primate model of cocaine addiction: interpreting associations with increased vs. decreased dopamine function

Author(s): Marco Leyton

No abstract available

Article GUID: 37438420
Blocking μ-opioid receptors attenuates reinstatement of responding to an alcohol-predictive conditioned stimulus through actions in the ventral hippocampus

Author(s): Mandy Rita LeCocq

The µ-opioid system is involved in the reinstatement of responding that is immediately evoked by alcohol-predictive cues. The extent of its involvement in reinstatement observed in a new model that evaluates the delayed effects of re-exposure to alcohol, ho...

Article GUID: 37393348
The standard reconsolidation protocol for auditory fear-conditioning does not account for fear to the test context

Author(s): Jason W Payne

Research on memory reconsolidation has relied heavily on the use of Pavlovian auditory cued-fear conditioning. Here, an auditory cue (CS) is paired with a footshock (US) and the CS is later able to evoke a freezing response when presented alone. Some treatm...

Article GUID: 37347748
Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

Author(s): Véronik Lachance

For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled its necessity for maintaining proper cellular homeostasis through modulation of calcium and lipid exchange between the endoplasmic reticulum (ER) and mitochondria, ER-st...

Article GUID: 36768299
A new circuit underlying the renewal of appetitive Pavlovian responses: Commentary on Brown and Chaudhri (2022)

Author(s): Valyear MD; Britt JP;

No abstract available

Article GUID: 36700576
The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats

Author(s): Meyer C; Schoettner K; Amir S;

Disruption of circadian rhythmicity distorts physiological and psychological processes and has major consequences on health and well-being. A chronic misalignment within the internal time-keeping system modulates alcohol consumption and contributes to stres...

Article GUID: 36620855
Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses

Author(s): Cuesta S; Burdisso P; Segev A; Kourrich S; Sperandio V;

Gut-microbiota membership is associated with diverse neuropsychological outcomes, including substance use disorders (SUDs). Here, we use mice colonized with Citrobacter rodentium or the human ?-Proteobacteria commensal Escherichia coli HS as a model to exam...

Article GUID: 36323315
Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

Author(s): Hansen JY; Markello RD; Tuominen L; Nørgaard M; Kuzmin E; Palomero-Gallagher N; Dagher A; Misic B;...

Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotra...

Article GUID: 36209794
A novel stress-based intervention reduces cigarette use in non-treatment seeking smokers

Author(s): Alexandra Barnabe

Tobacco use is the leading cause of preventable mortality worldwide. Since current smoking cessation aids show only modest efficacy, new interventions are needed. Given the evidence that stress is a potent trigger for smoking, the present randomized clinica...

Article GUID: 36175551
Sexual experience increases oxytocin, but not vasopressin, receptor densities in the medial preoptic area, ventromedial hypothalamus, and central amygdala of male rats

Author(s): Shann Ménard

Oxytocin (OT) and vasopressin (VP) are considered to be principal neurochemical substrates of bonding in monogamous species. We have reported previously that conditioning of a sexual partner preference in male rats resulted in conditioned activation of OT a...

Article GUID: 36041295
Alarm cues and alarmed conspecifics: neural activity during social learning from different cues in Trinidadian guppies

Author(s): Raina Fan

Learning to respond appropriately to novel dangers is often essential to survival and success, but carries risks. Learning about novel threats from others (social learning) can reduce these risks. Many species, including the Trinidadian guppy (Poecilia reti...

Article GUID: 36043284
Acute food deprivation-induced relapse to heroin seeking after short and long punishment-imposed abstinence in male rats

Author(s): Borges C; Inigo F; Quteishat N; Charles J; Ah-Yen E; U S;

Rational: Stress is a major trigger for drug relapse in humans and animal models, even after prolonged abstinence. However, animal models for stress-induced relapse were criticized for the lack of predictive and face validity.
...

Article GUID: 35951079
Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex

Author(s): Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA;

Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex. Reductions in estrogens may alter cognit...

Article GUID: 35939438
CPAP for Cognition in Sleep Apnea and Mild Cognitive Impairment: A Pilot Randomised Cross-Over Trial

Author(s): Hoyos CM; Cross NE; Terpening Z; D' Rozario AL; Yee BJ; LaMonica H; Marshall NS; Grunstein RR; Naismith SL;

No abstract

Article GUID: 35584294
Does stimulant drug-induced sensitization occur in primates?

Author(s): Marco Leyton

No abstract

Article GUID: 35418507
Do stimulant medications produce sensitization in humans?

Author(s): Marco Leyton

No abstract

Article GUID: 35398453
Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons

Author(s): Almey A; Milner TA; Brake WG;

Estrogens affect dopamine-dependent diseases/behavior and have rapid effects on dopamine release and receptor availability in the nucleus accumbens (NAc). Low levels of nuclear estrogen receptor (ER) a and ERß are seen in the NAc, which cannot account for t...

Article GUID: 35397175
Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women

Author(s): Gagne C; Piot A; Brake WG;

Ketamine has been shown to acutely and rapidly ameliorate depression symptoms and suicidality. Given that women suffer from major depression at twice the rate of men, it is important to understand how ketamine works in the female brain. This review explores...

Article GUID: 35115970
In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders

Author(s): Ferraro S; de Zavalia N; Belforte N; Amir S;

Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterised by restrictive patterns of behaviour and alterations in social interaction and communication. Up to 80% of children with ASD exhibit sleep-wake cycle disturbances, empha...

Article GUID: 34650409
Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion

Author(s): D' Amour-Horvat V; Cox SML; Dagher A; Kolivakis T; Jaworska N; Leyton M;

Stimulant drug-paired cues can acquire the ability to activate mesocorticolimbic pathways and lead to new bouts of drug use. Studies in laboratory animals suggest that these effects are augmented by progressively greater drug use histories, impulsive person...

Article GUID: 34463411
All-optical approaches to studying psychiatric disease

Author(s): Lafferty CK; Christinck TD; Britt JP;

Improvements in all-optical means of monitoring and manipulating neural activity have generated new ways of studying psychiatric disease. The combination of calcium imaging techniques with optogenetics to concurrently record and manipulate neural activity h...

Article GUID: 34314828
Ghrelin receptor signalling is not required for glucocorticoid-induced obesity in female mice

Author(s): Silver Z; Abbott-Tate S; Hyland L; Sherratt F; Woodside B; Abizaid A;

Chronic exposure to high circulating glucocorticoid or ghrelin concentrations increases food intake, weight gain and adiposity, suggesting that ghrelin could contribute to the metabolic effects of chronic glucocorticoids. In male mice, however, blocking ghr...

Article GUID: 34060474
Threat perception: Fear and the retrorubal field

Author(s): Bradfield LA; Iordanova MD;

A new study has found that neurons within a structure of the rat midbrain known as the retrorubral field show diverse responses to stimuli that signal different levels of threat, as well as a separate pattern of diverse responses to differentially predicted...

Article GUID: 34033766
Anxiety-like behavior in female mice is modulated by STAT3 signaling in midbrain dopamine neurons

Author(s): Fernandes MF; Lau D; Sharma S; Fulton S;

The central signaling actions of cytokines are mediated by signal transducer and activator of transcription (STAT3). STAT3 activation plays a pivotal role in the behavioral responses to the adiposity hormone leptin, including in midbrain dopamine (DA) neuro...

Article GUID: 33872705
Why did the kitten cross the road? A meditation on positive versus negative reinforcement in addiction.

Author(s): Leyton M

J Psychiatry Neurosci. 2021 Jan 21; 46(1):E184-E185 Authors: Leyton M PMID: 33497168 [PubMed - as supplied by publisher]

Article GUID: 33497168
Neural substrates of appetitive and aversive prediction error.

Author(s): Iordanova MD, Yau JO, McDannald MA, Corbit LH

Prediction error, defined by the discrepancy between real and expected outcomes, lies at the core of associative learning. Behavioural investigations have provided evidence that prediction error up- and down-regulates associative relationships, and allocate...

Article GUID: 33453307
Assessing the role of cortico-thalamic and thalamo-accumbens projections in the augmentation of heroin seeking in chronically food-restricted rats.

Author(s): Chisholm A; Rizzo D; Fortin É; Moman V; Quietshat N; Romano A; Capolicchio T; Shalev U;

Drug addiction is a chronic disorder characterized by compulsive drug seeking and involves repetitive cycles of compulsive drug use, abstinence, and relapse. In both human and animal models of addiction, chronic food restriction increases rates of relapse. ...

Article GUID: 33219004
Adaptive behaviour under conflict: deconstructing extinction, reversal, and active avoidance learning.

Author(s): Manning EE, Bradfield LA, Iordanova MD

In complex environments, organisms must respond adaptively to situations despite conflicting information. Under natural (i.e. non-laboratory) circumstances, it is rare that cues or responses are consistently paired with a single outcome. Inconsistent pairin...

Article GUID: 33035525
Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans.

Author(s): Smart K, Nagano-Saito A, Milella MS, Sakae DY, Favier M, Vigneault E, Louie L, Hamilton A, Ferguson SSG, Rosa-Neto P, Narayanan S, El Mestik...

J Psychiatry Neurosci. 2020 Jun 19;45(4):190162 Authors: Smart K, Nagano-Saito A, Milella MS, Sakae DY, Favier M, Vigneault E, Louie L, Hamilton A, Ferguson SSG, Rosa-Neto P, Narayanan S, El Mesti...

Article GUID: 32559027
Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward.

Author(s): Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P

PLoS One. 2020;15(6):e0226722 Authors: Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P

Article GUID: 32502210
Conditioning of Sexual Interests and Paraphilias in Humans Is Difficult to See, Virtually Impossible to Test, and Probably Exactly How It Happens: A Comment on Hsu and Bailey (2020).

Author(s): Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA

Arch Sex Behav. 2020 May 27;: Authors: Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA PMID: 32462414 [PubMed - as supplied by publisher]

Article GUID: 32462414
mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Author(s): Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl R...

Neuropsychopharmacology. 2020 May 15;: Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, C...

Article GUID: 32413893
Manipulations of sensory experiences during development reveal mechanisms underlying vocal learning biases in zebra finches.

Author(s): James LS, Davies R, Mori C, Wada K, Sakata JT

Dev Neurobiol. 2020 Apr 24;: Authors: James LS, Davies R, Mori C, Wada K, Sakata JT

Article GUID: 32330360
Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior.

Author(s): Lafferty CK, Britt JP

Front Neural Circuits. 2020;14:10 Authors: Lafferty CK, Britt JP

Article GUID: 32269514
Extra-striatal D2/3 receptor availability in youth at risk for addiction.

Author(s): Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Ségu...

Neuropsychopharmacology. 2020 Apr 07;: Authors: Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, S&...

Article GUID: 32259831
Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.

Author(s): Lafferty CK, Yang AK, Mendoza JA, Britt JP

Cell Rep. 2020 Mar 17;30(11):3729-3742.e3 Authors: Lafferty CK, Yang AK, Mendoza JA, Britt JP

Article GUID: 32187545
Cannabis Exposure Enhances Subcortical Control of Nucleus Accumbens Activity.

Author(s): Lafferty CK; Britt JP;

Biol Psychiatry. 2020 04 01; 87(7):592-594 Authors: Lafferty CK, Britt JP PMID: 32164914 [PubMed - indexed for MEDLINE]

Article GUID: 32164914
A self-initiated cue-reward learning procedure for neural recording in rodents.

Author(s): Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

J Neurosci Methods. 2020 Mar 02;:108671 Authors: Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

Article GUID: 32135212
Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.

Author(s): Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Nat Neurosci. 2020 Jan 20;: Authors: Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Article GUID: 31959935
Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats.

Author(s): Khoo SY, Correia V, Uhrig A

Lab Anim. 2020 Jan 10;:23677219894356 Authors: Khoo SY, Correia V, Uhrig A

Article GUID: 31924130
Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development.

Author(s): LeCocq MR, Randall PA, Besheer J, Chaudhri N

Neurotherapeutics. 2020 Jan 02;: Authors: LeCocq MR, Randall PA, Besheer J, Chaudhri N

Article GUID: 31898285
Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits.

Author(s): Quintana GR, Mac Cionnaith CE, Pfaus JG

Proc Natl Acad Sci U S A. 2019 Dec 03;: Authors: Quintana GR, Mac Cionnaith CE, Pfaus JG PMID: 31796602 [PubMed - as supplied by publisher]

Article GUID: 31796602
Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Author(s): Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Biol Psychiatry. 2019 Sep 19;: Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Article GUID: 31699294
Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.

Author(s): Mendoza JA, Lafferty CK, Yang AK, Britt JP

Cell Rep. 2019 Nov 05;29(6):1429-1437.e3 Authors: Mendoza JA, Lafferty CK, Yang AK, Britt JP

Article GUID: 31693885
The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Author(s): Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Neuron. 2019 Aug 26;: Authors: Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Article GUID: 31522764
Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Author(s): Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Front Neurosci. 2019;13:798 Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Article GUID: 31447629
Prefrontal Cortex and Multiparity in Lactation.

Author(s): Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD

Neuroscience. 2019 Aug 19;: Authors: Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD

Article GUID: 31437474
Effect of CS preexposure on the conditioned ejaculatory preference of the male rat: behavioral analyses and neural correlates.

Author(s): Quintana GR, Jackson M, Nasr M, Pfaus JG

Learn Mem. 2018 10;25(10):513-521 Authors: Quintana GR, Jackson M, Nasr M, Pfaus JG

Article GUID: 30224554
First sexual experiences determine the development of conditioned ejaculatory preference in male rats.

Author(s): Quintana GR, Guizar A, Rassi S, Pfaus JG

Learn Mem. 2018 10;25(10):522-532 Authors: Quintana GR, Guizar A, Rassi S, Pfaus JG

Article GUID: 30224555
The priming effect of food persists following blockade of dopamine receptors.

Author(s): Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich ...

Eur J Neurosci. 2019 Jul 27;: Authors: Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumro...

Article GUID: 31350860
Learning to use past evidence in a sophisticated world model.

Author(s): Ahilan S, Solomon RB, Breton YA, Conover K, Niyogi RK, Shizgal P, Dayan P

PLoS Comput Biol. 2019 Jun 24;15(6):e1007093 Authors: Ahilan S, Solomon RB, Breton YA, Conover K, Niyogi RK, Shizgal P, Dayan P

Article GUID: 31233559
Legalizing marijuana.

Author(s): Leyton M

J Psychiatry Neurosci. 2016 Mar;41(2):75-6 Authors: Leyton M PMID: 26898727 [PubMed - indexed for MEDLINE]

Article GUID: 26898727
Cocaine cue-induced dopamine release in the human prefrontal cortex.

Author(s): Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M

J Psychiatry Neurosci. 2016 08;41(5):322-30 Authors: Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M

Article GUID: 26900792
High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.

Author(s): Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Horm Behav. 2016 06;82:56-63 Authors: Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Article GUID: 27154458
Neural correlates of two different types of extinction learning in the amygdala central nucleus.

Author(s): Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Nat Commun. 2016 08 17;7:12330 Authors: Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Article GUID: 27531638
Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.

Author(s): Voyer D, Lévesque D, Rompré PP

Neuropharmacology. 2017 01;112(Pt A):150-163 Authors: Voyer D, Lévesque D, Rompré PP

Article GUID: 27267684
Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation.

Author(s): Fakhoury M, Voyer D, Lévesque D, Rompré PP

Neuroscience. 2016 Oct 15;334:214-225 Authors: Fakhoury M, Voyer D, Lévesque D, Rompré PP

Article GUID: 27514573
Effects of contingent and noncontingent nicotine on lever pressing for liquids and consumption in water-deprived rats.

Author(s): Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Eur J Pharmacol. 2017 Jan 05;794:224-233 Authors: Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Article GUID: 27889434
Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment.

Author(s): Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN

Neuropharmacology. 2017 Sep 01;123:10-21 Authors: Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN

Article GUID: 28522313
Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats.

Author(s): Gavrila AM, Hood S, Robinson B, Amir S

PLoS One. 2017;12(6):e0179370 Authors: Gavrila AM, Hood S, Robinson B, Amir S

Article GUID: 28594962
Dopamine and light: effects on facial emotion recognition.

Author(s): Cawley E, Tippler M, Coupland NJ, Benkelfat C, Boivin DB, Aan Het Rot M, Leyton M

J Psychopharmacol. 2017 09;31(9):1225-1233 Authors: Cawley E, Tippler M, Coupland NJ, Benkelfat C, Boivin DB, Aan Het Rot M, Leyton M

Article GUID: 28633582
Experimental study on pressure response to graded spinal canal compromise in an in vitro burst fracture mode.

Author(s): Bourget-Murray J, Bassi M, Frederick A, Hines J, Jarzem PF

J Craniovertebr Junction Spine. 2017 Apr-Jun;8(2):108-112 Authors: Bourget-Murray J, Bassi M, Frederick A, Hines J, Jarzem PF

Article GUID: 28694593
Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.

Author(s): Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Horm Behav. 2018 01;97:56-66 Authors: Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Article GUID: 29080670
17β-estradiol locally increases phasic dopamine release in the dorsal striatum.

Author(s): Shams WM, Cossette MP, Shizgal P, Brake WG

Neurosci Lett. 2018 02 05;665:29-32 Authors: Shams WM, Cossette MP, Shizgal P, Brake WG

Article GUID: 29175028
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Womens Health (Lond). 2018 Jan-Dec;14:1745506518788970 Authors: Tuiten A, Michiels F, Böcker KB, Höhle D, van Honk J, de Lange RP, van Rooij K, Kessels R, Bloemers J, Gerritsen J, Jansse...

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Chronobiol Int. 2018 09;35(10):1435-1444 Authors: Weinert D, Schöttner K, Meinecke AC, Hauer J

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Reproduction. 2014 May;147(5):743-51 Authors: Ladyman SR, Woodside B

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Front Psychiatry. 2014;5:70 Authors: Heyman GM, Dunn BJ, Mignone J

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The attribution of incentive salience to Pavlovian alcohol cues: a shift from goal-tracking to sign-tracking.

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Front Behav Neurosci. 2015;9:54 Authors: Srey CS, Maddux JM, Chaudhri N

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Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids.

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Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young.

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Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.

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Psychopharmacology (Berl). 2015 Oct;232(20):3773-82 Authors: Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

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The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses.

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Behav Brain Res. 2016 Jan 15;297:345-58 Authors: Cossette MP, Conover K, Shizgal P

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The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder.

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CNS Drugs. 2015 Nov;29(11):915-33 Authors: Kingsberg SA, Clayton AH, Pfaus JG

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The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.

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Front Behav Neurosci. 2015;9:331 Authors: Scardochio T, Trujillo-Pisanty I, Conover K, Shizgal P, Clarke PB

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From genes to chronotypes: the influence of circadian clock genes on our daily patterns of sleep and wakefulness.

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The whole versus the sum of some of the parts: toward resolving the apparent controversy of clitoral versus vaginal orgasms.

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The role of orgasm in the development and shaping of partner preferences.

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Do rats have orgasms?

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Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core.

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Alcohol Clin Exp Res. 2017 03;41(3):608-617 Authors: Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

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Non-Contingent Exposure to Amphetamine in Adolescence Recruits miR-218 to Regulate Dcc Expression in the VTA.

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Pre-treatment EEG signal variability is associated with treatment success in depression.

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Neuroimage Clin. 2018;17:368-377 Authors: Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB

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Adolescent Exposure to Methylphenidate Increases Impulsive Choice Later in Life.

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Front Behav Neurosci. 2017;11:214 Authors: Abbas Z, Sweet A, Hernandez G, Arvanitogiannis A

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Efficacy and Safety of On-Demand Use of 2 Treatments Designed for Different Etiologies of Female Sexual Interest/Arousal Disorder: 3 Randomized Clinical Trials.

Author(s): Tuiten A, van Rooij K, Bloemers J, Eisenegger C, van Honk J, Kessels R, Kingsberg S, Derogatis LR, de Leede L, Gerritsen J, Koppeschaar HPF,...

J Sex Med. 2018 Feb;15(2):201-216 Authors: Tuiten A, van Rooij K, Bloemers J, Eisenegger C, van Honk J, Kessels R, Kingsberg S, Derogatis LR, de Leede L, Gerritsen J, Koppeschaar HPF, Olivier B, E...

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mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Author(s): Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R;...

Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the ...

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Modeling Relapse to Pavlovian Alcohol-Seeking in Rats Using Reinstatement and Spontaneous Recovery Paradigms.

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Alcohol Clin Exp Res. 2018 Sep;42(9):1795-1806 Authors: LeCocq MR, Lahlou S, Chahine M, Padillo LN, Chaudhri N

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Thought control with the dopamine transient.

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Learn Behav. 2018 Oct 18;: Authors: Iordanova MD

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Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

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Cereb Cortex. 2018 Oct 29;: Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

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Effect of GAD1 genotype status on auditory attention and acute nicotine administration in healthy volunteers.

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Hum Psychopharmacol. 2019 Jan;34(1):e2684 Authors: Hadjis E, Hyde M, Choueiry J, Jaworska N, Nelson R, de la Salle S, Smith D, Aidelbaum R, Knott V

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Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex.

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The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Addict Biol. 2019 Jan 09;: Authors: Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

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Author(s): Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1179-1183 Authors: Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

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The serial blocking effect: a testbed for the neural mechanisms of temporal-difference learning.

Author(s): Mahmud A; Petrov P; Esber GR; Iordanova MD;

Temporal-difference (TD) learning models afford the neuroscientist a theory-driven roadmap in the quest for the neural mechanisms of reinforcement learning. The application of these models to understanding the role of phasic midbrain dopaminergic responses ...

Article GUID: 30979910
Title:Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion
Authors:D' Amour-Horvat V,  Cox SML,  Dagher A,  Kolivakis T,  Jaworska N,  Leyton M, 
Link:https://pubmed.ncbi.nlm.nih.gov/34463411/
DOI:10.1111/adb.13094
Category:
PMID:34463411
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, Quebec, Canada.
2 Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
3 Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
4 Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.
5 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
6 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.

Description:

Stimulant drug-paired cues can acquire the ability to activate mesocorticolimbic pathways and lead to new bouts of drug use. Studies in laboratory animals suggest that these effects are augmented by progressively greater drug use histories, impulsive personality traits, and acute drug ingestion. As a preliminary test of these hypotheses in humans, we exposed cocaine users (n = 14) and healthy volunteers (n = 10) to cocaine-related videos during two functional magnetic resonance imaging (fMRI) sessions, once following acute administration of placebo and once following d-amphetamine (0.3 mg/kg, p.o.). Across sessions, cocaine users showed larger cocaine cue-induced responses than healthy controls in the associative striatum and midbrain. Among the cocaine users, larger drug cue-induced responses during the placebo session were correlated with higher Barratt Impulsiveness Scale (BIS-11) nonplanning scores (associative striatum) and greater lifetime use of stimulant drugs (limbic, associative, and sensorimotor striatum). The administration of d-amphetamine did not augment the cue-induced activations, but, in cocaine users, drug cue-induced striatal activations were more widespread following prolonged cocaine cue exposure. Together, these effects of past and present drug use might aggravate the risk for stimulant drug use problems.