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Cancer symptom burden negatively affects health-related quality of life in patients undergoing prehabilitation prior to liver resection: results from a 12-week randomized controlled trial

Author(s): Kasvis P; Vigano A; Bui T; Carli F; Kilgour R;

Cancer symptoms negatively affect health-related quality of life (HRQoL) in patients with cancer awaiting liver resection. Prehabilitation maintained HRQoL after surgery. Future studies should test whether relieving cancer symptoms can improve HRQoL.

Article GUID: 37690126


A longitudinal person-centered representation of elementary students' motivation: Do perceptions of parent and teacher achievement goals matter?

Author(s): Nadon L; Morin AJS; Olivier E; Archambault I; Smodis McCune V; Tóth-Király I;

This study utilized a longitudinal person-centered approach to investigate how children's achievement goals combine with the goals held for them by their parents and teachers to form unique achievement goal profiles among a sample of 619 elementary school students (Mage = 9.782; 52.5% female; 79.2% first- and second-generation immigrants) from low SES ...

Article GUID: 37689436


Accounting for the climate benefit of temporary carbon storage in nature

Author(s): Matthews HD; Zickfeld K; Koch A; Luers A;

Nature-based climate solutions can contribute to climate mitigation, but the vulnerability of land carbon to disturbances means that efforts to slow or reverse land carbon loss could result in only temporary storage. The challenge of accounting for temporary storage is a key barrier to the implementation of nature-based climate mitigation strategies. Here ...

Article GUID: 37679349


Functional characterization of fungal lytic polysaccharide monooxygenases for cellulose surface oxidation

Author(s): Mathieu Y; Raji O; Bellemare A; Di Falco M; Nguyen TTM; Viborg AH; Tsang A; Master E; Brumer H;

Background: Microbial lytic polysaccharide monooxygenases (LPMOs) cleave diverse biomass polysaccharides, including cellulose and hemicelluloses, by initial oxidation at C1 or C4 of glycan chains. Within the Carbohydrate-Active Enzymes (CAZy) classification, Auxiliary Activity Family 9 (AA9) comp ...

Article GUID: 37679837


The neurophysiology of closed-loop auditory stimulation in sleep: A magnetoencephalography study

Author(s): Jourde HR; Merlo R; Brooks M; Rowe M; Coffey EBJ;

Closed-loop auditory stimulation (CLAS) is a brain modulation technique in which sounds are timed to enhance or disrupt endogenous neurophysiological events. CLAS of slow oscillation up-states in sleep is becoming a popular tool to study and enhance sleep's functions, as it increases slow oscillations, evokes sleep spindles and enhances memory consoli ...

Article GUID: 37675803


C5-Propynyl modified 2'-fluoroarabinonucleic acids form stable duplexes with RNA that are RNase H competent

Author(s): Pontarelli A; Wilds CJ;

The clinical success of the antisense approach for the treatment of genetic disorders is indisputably the result of chemical modifications along the oligonucleotide (ON) scaffold, which impart desirable properties including high RNA affinity, nuclease stability and improved drug delivery. While effective, many modifications are not capable of eliciting an ...

Article GUID: 37667655


Does social connection mediate the association between neuroticism and cognition? Cross-sectional analysis of the Canadian Longitudinal Study on Aging

Author(s): Bethell J; Andrew MK; Hothi S; Mick P; Morgan D; O' Connell ME; Phillips NA; Stewart S; Walker JD; Wittich W; McGilton KS;

Objectives: This study tested the association between neuroticism and six cognitive measures, and examined the potential mediating roles of social connection (social isolation and loneliness) among middle-aged and older adults. Methods: This cross-sectional study was a secondary analysis of the ...

Article GUID: 37667914


Multi-objective control optimization of isolated bridge using replicator controller and NSGA-II

Author(s): Momeni Z; Bagchi A;

Earthquakes can cause significant damage to constructed structures, leading engineers to design systems that effectively reduce damage and improve real-time vibration control. While base isolation is a commonly used passive method for seismic protection in highway structures, it has limitations such as a lack of immediate adaptation, constrained power dis ...

Article GUID: 37662735


A population-averaged structural connectomic brain atlas dataset from 422 HCP-aging subjects

Author(s): Xiao Y; Gilmore G; Kai J; Lau JC; Peters T; Khan AR;

Population-averaged brain atlases, that are represented in a standard space with anatomical labels, are instrumental tools in neurosurgical planning and the study of neurodegenerative conditions. Traditional brain atlases are primarily derived from anatomical scans and contain limited information regarding the axonal organization of the white matter. With ...

Article GUID: 37663773


Assessment of landfill gas storage and application regarding energy management: A case study in the province of Quebec, Canada

Author(s): Malmir T; Héroux M; Lagos D; Eicker U;

Landfills are extensively applied to dispose of municipal solid wastes in developed and developing countries. Landfill gas generation from biodegradable organic wastes can be collected and converted to energy. When the gas collection system is shutdown, some of this gas can accumulate and be stored inside the landfill. Using the gas storage capacity of th ...

Article GUID: 37659122


CRISPR/Cas9 mediated gene editing of transcription factor ACE1 for enhanced cellulase production in thermophilic fungus Rasamsonia emersonii

Author(s): Singh V; Raheja Y; Basotra N; Sharma G; Tsang A; Chadha BS;

Background: The filamentous fungus Rasamsonia emersonii has immense potential to produce biorefinery relevant thermostable cellulase and hemicellulase enzymes using lignocellulosic biomass. Previously in our lab, a hyper-cellulase producing strain of R. emersonii was developed through classical breeding and system biology approaches. ACE1, a pivotal trans ...

Article GUID: 37658430


Screening non-conventional yeasts for acid tolerance and engineering Pichia occidentalis for production of muconic acid

Author(s): Pyne ME; Bagley JA; Narcross L; Kevvai K; Exley K; Davies M; Wang Q; Whiteway M; Martin VJJ;

Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism's prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is not suited to overproduce many bulk bioproducts, as tox ...

Article GUID: 37652930


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