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The β2-adrenergic receptor agonist terbutaline upregulates T helper-17 cells in a protein kinase A-dependent manner

Author(s): Carvajal Gonczi CM; Hajiaghayi M; Gholizadeh F; Xavier Soares MA; Touma F; Lopez Naranjo C; Rios AJ; Pozzebon C; Daigneault T; Burchell-Reyes K; Darlington PJ;

Background: T helper 17 (Th17) cells produce IL-17A cytokine and can exacerbate autoimmune diseases and asthma. The ß2 adrenergic receptor is a g protein-coupled receptor that induces cAMP second messenger pathways. We tested the hypothesis that terbutaline, a ß2-adrenergic receptor-specific agon ...

Article GUID: 37438188


Infrared Thermography-A Novel Tool for Monitoring Fracture Healing: A Critically Appraised Topic With Evidence-Based Recommendations for Clinical Practice

Author(s): Castonguay T; Dover G;

Clinical scenario: Stress fractures are one of the most common injuries in athletes. Unfortunately, they are hard to diagnose, require multiple radiology exams and follow-up which leads to more exposure to radiation and an increase in cost. Stress fractures that are mismanaged can lead to serious complications and poorer outcomes for the athlete. During t ...

Article GUID: 37433522


Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

Author(s): Mansur A; Joseph R; Kim ES; Jean-Beltran PM; Udeshi ND; Pearce C; Jiang H; Iwase R; Milev MP; Almousa HA; McNamara E; Widrick J; Perez C; Ravenscroft G; Sacher M; Cole PA; Carr SA; Gupta VA;

Ubiquitin-proteasome system (UPS) dysfunction is associated with the pathology of a wide range of human diseases, including myopathies and muscular atrophy. However, the mechanistic understanding of specific components of the regulation of protein turnover during development and disease progressi ...

Article GUID: 37432316


Childhood Maltreatment in Patients Undergoing Bariatric Surgery: Implications for Weight Loss, Depression and Eating Behavior

Author(s): Ben-Porat T; Bacon SL; Woods R; Fortin A; Lavoie KL;

We aimed to explore the relationships between childhood maltreatment and changes in weight, depressive symptoms and eating behavior post-bariatric surgery (BS). Participants (n = 111, 85% females) were evaluated pre-surgery, and at 6 months (6 M) and 12 months (12 M) post-BS. History of maltreatment was assessed at baseline (Childhood Trauma Questionnaire ...

Article GUID: 37432188


Inpatient Care Utilization Following Mobile Crisis Response Encounters Among Racial/Ethnic Minoritized Youth

Author(s): Lui JHL; Chen BC; Benson LA; Lin YR; Ruiz A; Lau AS;

Objective: There has been an increase in youth psychiatric emergencies and psychiatric inpatient hospitalizations in recent years. Mobile crisis responses (MCR) services offer an opportunity to meet acute youth mental health needs in the community and provide linkage to care. However, an understanding of MCR encounters as a care pathway is needed, includi ...

Article GUID: 37422107


Transformer-based hand gesture recognition from instantaneous to fused neural decomposition of high-density EMG signals

Author(s): Montazerin M; Rahimian E; Naderkhani F; Atashzar SF; Yanushkevich S; Mohammadi A;

Designing efficient and labor-saving prosthetic hands requires powerful hand gesture recognition algorithms that can achieve high accuracy with limited complexity and latency. In this context, the paper proposes a Compact Transformer-based Hand Gesture Recognition framework referred to as [Formula: see text], which employs a vision transformer network to ...

Article GUID: 37419881


Identifying priority questions regarding rapid systematic reviews' methods: protocol for an eDelphi study

Author(s): Vieira AM; Szczepanik G; de Waure C; Tricco AC; Oliver S; Stojanovic J; Ribeiro PAB; Pollock D; Akl EA; Lavis J; Kuchenmuller T; Bragge P; Langer L; Bacon S;

Introduction: Rapid systematic reviews (RRs) have the potential to provide timely information to decision-makers, thus directly impacting healthcare. However, consensus regarding the most efficient approaches to performing RRs and the presence of several unaddressed methodological issues pose cha ...

Article GUID: 37419644


Alzheimer's early detection in post-acute COVID-19 syndrome: a systematic review and expert consensus on preclinical assessments

Author(s): Vandersteen C; Plonka A; Manera V; Sawchuk K; Lafontaine C; Galery K; Rouaud O; Bengaied N; Launay C; Guérin O; Robert P; Allali G; Beauchet O; Gros A;

Introduction: The risk of developing Alzheimer's disease (AD) in older adults increasingly is being discussed in the literature on Post-Acute COVID-19 Syndrome (PACS). Remote digital Assessments for Preclinical AD (RAPAs) are becoming more important in screening for early AD, and should alway ...

Article GUID: 37416323


Assessment of the infiltration of water-in-oil emulsion into soil after spill incidents

Author(s): Qu Z; An C; Yue R; Bi H; Zhao S;

The issue of inland oil spills exerts an adverse impact on environmental and ecological health. Many cases are concerned with water-in-oil emulsions, especially in the oil production and transport system. To understand the contamination and take an efficient response work after spill, this study investigated the infiltration behavior of water-in-oil emuls ...

Article GUID: 37414189


Assessing pragmatics in early childhood with the Language Use Inventory across seven languages

Author(s): Pesco D; O' Neill DK;

The Language Use Inventory (LUI) is a parent-report measure of the pragmatic functions of young children's language, standardized and norm-referenced in English (Canada) for children aged 18-47 months. The unique focus of the LUI, along with its appeal to parents, reliability and validity, and usefulness in both research and clinical contexts has prom ...

Article GUID: 37408974


Dynamic networks differentiate the language ability of children with cochlear implants

Author(s): Koirala N; Deroche MLD; Wolfe J; Neumann S; Bien AG; Doan D; Goldbeck M; Muthuraman M; Gracco VL;

Background: Cochlear implantation (CI) in prelingually deafened children has been shown to be an effective intervention for developing language and reading skill. However, there is a substantial proportion of the children receiving CI who struggle with language and reading. The current study-one ...

Article GUID: 37409105


The more they hear the more they learn? Using data from bilinguals to test models of early lexical development

Author(s): Sander-Montant A; López Pérez M; Byers-Heinlein K;

Children have an early ability to learn and comprehend words, a skill that develops as they age. A critical question remains regarding what drives this development. Maturation-based theories emphasise cognitive maturity as a driver of comprehension, while accumulator theories emphasise children's accumulation of language experience over time. In this ...

Article GUID: 37402336


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