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Reciprocal effects of single or repeated exposure to methylphenidate or sex in adult male rats

Author(s): Pallikaras V; Mac Cionnaith CE; Rosales VCF; Arvanitogiannis A; Pfaus JG;

Rationale: Exposure to rewards can alter behavioral reactivity to them. For example, stimulants sensitize locomotor activation, whereas sexual experience sensitizes copulatory behaviors. Moreover, rewards can cross-sensitize one another. Although stimulants are known to cross-sensitize locomotor effects, the evidence for cross-sensitization between stimul ...

Article GUID: 36544054


Polarization and cell-fate decision facilitated by the adaptor Ste50p in Saccharomyces cerevisiae

Author(s): Sharmeen N; Law C; Wu C;

In response to pheromone, many proteins localize on the plasma membrane of yeast cell to reform it into a polarized shmoo structure. The adaptor protein Ste50p, known as a pheromone signal enhancer critical for shmoo polarization, has never been explored systematically for its localization and function in the polarization process. Time-lapse single-cell i ...

Article GUID: 36538537


A biophysical study of tear film lipid layer model membranes

Author(s): Keramatnejad M; DeWolf C;

Tear film lipid layer (TFLL), the final layer of the human tear film is responsible for surface tension reduction while blinking, water evaporation retardation and maintaining the stability of the tear film. The study of the composition-structure-function relationship of TFLL is paramount, as a compromised structure of TFLL leads to the emergence of dry e ...

Article GUID: 36535341


Upconversion Luminescence through Cooperative and Energy-Transfer Mechanisms in Yb3+ -Metal-Organic Frameworks

Author(s): Xie Y; Sun G; Mandl GA; Maurizio SL; Chen J; Capobianco JA; Sun L;

Lanthanide-doped metal-organic frameworks (Ln-MOFs) have versatile luminescence properties, however it is challenging to achieve lanthanide-based upconversion luminescence in these materials. Here, 1,3,5-benzenetricarboxylic acid (BTC) and trivalent Yb3+ ions were used to generate crystalline Yb-BTC MOF 1D-microrods with upconversion luminescence under ne ...

Article GUID: 36437239


Visuo-motor transformations in the intraparietal sulcus mediate the acquisition of endovascular medical skill

Author(s): Paul KI; Mueller K; Rousseau PN; Glathe A; Taatgen NA; Cnossen F; Lanzer P; Villringer A; Steele CJ;

Performing endovascular medical interventions safely and efficiently requires a diverse set of skills that need to be practised in dedicated training sessions. Here, we used multimodal magnetic resonance (MR) imaging to determine the structural and functional plasticity and core skills associated ...

Article GUID: 36529202


Opposites Attract: Electrostatically Driven Loading of Antimicrobial Peptides into Phytoglycogen Nanocarriers

Author(s): Ali DA; Domínguez Mercado L; Findlay BL; Badia A; DeWolf C;

Antimicrobial peptides, such as GL13K, have a high binding selectivity toward bacterial membranes, while not affecting healthy mammalian cells at therapeutic concentrations. However, delivery of these peptides is challenging since they are susceptible to proteolytic hydrolysis and exhibit poor cellular uptake. A protective nanocarrier is thus proposed to ...

Article GUID: 36525622


Author Correction: Motion estimation for large displacements and deformations

Author(s): Chen Q; Poullis C;

No abstract

Article GUID: 36517657


Quantifying imbalanced classification methods for leukemia detection

Author(s): Depto DS; Rizvee MM; Rahman A; Zunair H; Rahman MS; Mahdy MRC;

Uncontrolled proliferation of B-lymphoblast cells is a common characterization of Acute Lymphoblastic Leukemia (ALL). B-lymphoblasts are found in large numbers in peripheral blood in malignant cases. Early detection of the cell in bone marrow is essential as the disease progresses rapidly if left untreated. However, automated classification of the cell is ...

Article GUID: 36516574


A Generalized Framework for Preserving Both Privacy and Utility in Data Outsourcing

Author(s): Xie S; Mohammady M; Wang H; Wang L; Vaidya J; Hong Y;

Property preserving encryption techniques have significantly advanced the utility of encrypted data in various data outsourcing settings (e.g., the cloud). However, while preserving certain properties (e.g., the prefixes or order of the data) in the encrypted data, such encryption schemes are typically limited to specific data types (e.g., prefix-preserve ...

Article GUID: 36506788


Introduction to the shared near infrared spectroscopy format

Author(s): Tucker S; Dubb J; Kura S; von Lühmann A; Franke R; Horschig JM; Powell S; Oostenveld R; Lührs M; Delaire É; Aghajan ZM; Yun H; Yücel MA; Fang Q; Huppert TJ; Frederick BB; Pollonini L; Boas D; Luke R;

Significance: Functional near-infrared spectroscopy (fNIRS) is a popular neuroimaging technique with proliferating hardware platforms, analysis approaches, and software tools. There has not been a standardized file format for storing fNIRS data, which has hindered the sharing of data as well as t ...

Article GUID: 36507152


Editorial: Qualitative pain research: Capturing and integrating cultural, social and linguistic data

Author(s): Najmeh Khalili-Mahani

No abstract available

Article GUID: 36506270


Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells

Author(s): Asadi P; Milev MP; Saint-Dic D; Gamberi C; Sacher M;

Mutations in the Transport and Golgi Organization 2 (TANGO2) gene are associated with intellectual deficit, neurodevelopmental delay and regression. Individuals can also present with an acute metabolic crisis that includes rhabdomyolysis, cardiomyopathy and cardiac arrhythmias, the latter of which are potentially lethal. While preventing metabolic crises ...

Article GUID: 36502486


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