Author(s): Asadi P; Milev MP; Saint-Dic D; Gamberi C; Sacher M;

Mutations in the Transport and Golgi Organization 2 (TANGO2) gene are associated with intellectual deficit, neurodevelopmental delay and regression. Individuals can also present with an acute metabolic crisis that includes rhabdomyolysis, cardiomyopathy and cardiac arrhythmias, the latter of which are potentially lethal. While preventing metabolic crises ...

Article GUID: 36502486

Author(s): Costes JM; Bonnaire C;

Free-to-Play games (F2P) have spread widely all over the world in recent years. The current economic model for these games is based on microtransactions, where gamers can purchase additional items or services inside the game. The aim of the present study was (1) to describe the profiles and gaming patterns of F2P gamers, and (2) to compare F2P gamers who ...

Article GUID: 36497782

Author(s): Brown A; Villaruel FR; Chaudhri N;

Extinction is a fundamental form of inhibitory learning that is important for adapting to changing environmental contingencies. While numerous studies have investigated the neural correlates of extinction using Pavlovian fear conditioning and appetitive operant reward-seeking procedures, less is known about the neural circuitry mediating the extinction of ...

Article GUID: 36496079

Author(s): Loose T; Geoffroy MC; Orri M; Chadi N; Scardera S; Booij L; Breton E; Tremblay R; Boivin M; Coté S;

Objectives: The COVID-19 pandemic has been associated with increased mental health problems. We investigated (1) associations between disordered eating in adolescence and mental health problems after one year of the pandemic and (2) the mechanisms explaining associations. Method: We analyzed dat ...

Article GUID: 36482144

Author(s): Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y;

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy to avoid FLC resistance and eliminate the ...

Article GUID: 36475771

Author(s): Zhao H; Karppi J; Nguyen TTM; Bellemare A; Tsang A; Master E; Tenkanen M;

Background: The Carbohydrate-Active enZymes (CAZy) auxiliary activity family 3 (AA3) comprises flavin adenine dinucleotide-dependent (FAD) oxidoreductases from the glucose-methanol-choline (GMC) family, which play auxiliary roles in lignocellulose conversion. The AA3 subfamily 1 predominantly consists of cellobiose dehydrogenases (CDHs) that typically com ...

Article GUID: 36476312

Author(s): Price P; Laurie A; Plant E; Chandra K; Pishe T; Brunt K;

Objectives: Significant heterogeneity exists internationally in the airway devices used in the pre-hospital setting during cardiac arrest. This study evaluated the first-pass success (FPS) rate of two supraglottic airways (SGAs) used by paramedics during out-of-hospital cardiac arrest: the King LTS-D and the i-gel. Methods: By examining 2,680 patient car ...

Article GUID: 36475129

Author(s): Ali MMM; Shams SI; Elsaadany M; Gagnon G; Wu K;

Graphene-based microwave devices have enabled reconfigurability, thus paving the way to the realization of flexible wireless terahertz systems with featured performances. Despite great progress in the development of graphene-based terahertz devices in the literature, high insertion loss and wide tunable range are still significant challenges at such high ...

Article GUID: 36473883

Author(s): Ren C; Haghighat F; Feng Z; Kumar P; Cao SJ;

Infectious diseases (e.g., coronavirus disease 2019) dramatically impact human life, economy and social development. Exploring the low-cost and energy-saving approaches is essential in removing infectious virus particles from indoors, such as in classrooms. The application of air purification devices, such as negative ion generators (ionizers), gains popu ...

Article GUID: 36474607

Author(s): He S; Rucker DD;

Uncertainty is an inherent part of consumers' environment. A large literature in marketing and related disciplines has found a positive relationship between uncertainty and information search: as consumers' uncertainty about a brand, product, or service increases, so does their inclination to seek out and engage with information. In contrast to th ...

Article GUID: 36471868

Author(s): Heyman HM; Alberts NM; Rees M; Puri L; Frett MJ; Anghelescu DL;

Adolescents with sickle cell disease (SCD) have been shown to have pain-related sequelae following COVID-19 infection. In this case series, we discuss five adolescents with SCD and SARS-CoV-2 infection who subsequently developed complex pain circumstances manifested as: (1) increased frequency of acute care visits or admissions for pain; (2) new onset chr ...

Article GUID: 36467817

Author(s): Zhang Y; Malaval F; Lehmann A; Deroche MLD;

There is an increasing interest in the field of audiology and speech communication to measure the effort that it takes to listen in noisy environments, with obvious implications for populations suffering from hearing loss. Pupillometry offers one avenue to make progress in this enterprise but important methodological questions remain to be addressed befor ...

Article GUID: 36459511