Reset filters

Search publications


Search by keyword
List by department / centre / faculty

No publications found.

 

Cytotoxicity and Genotoxicity of Azobenzene-Based Polymeric Nanocarriers for Phototriggered Drug Release and Biomedical Applications

Author(s): Londoño-Berrío M; Pérez-Buitrago S; Ortiz-Trujillo IC; Hoyos-Palacio LM; Orozco LY; López L; Zárate-Triviño DG; Capobianco JA; Mena-Giraldo P;

Drug nanoencapsulation increases the availability, pharmacokinetics, and concentration efficiency for therapeutic regimes. Azobenzene light-responsive molecules experience a hydrophobicity change from a polar to an apolar tendency by trans-cis photoisomerization upon UV irradiation. Polymeric pho ...

Article GUID: 35956634


Modeling hormonal contraception in female rats: a framework for studies in behavioral neurobiology

Author(s): Lacasse JM; Gomez-Perales E; Brake WG;

Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices for designing a model of HC in female rats. We outline specific methodological considerations regard ...

Article GUID: 35952797


Acute food deprivation-induced relapse to heroin seeking after short and long punishment-imposed abstinence in male rats

Author(s): Borges C; Inigo F; Quteishat N; Charles J; Ah-Yen E; U S;

Rational: Stress is a major trigger for drug relapse in humans and animal models, even after prolonged abstinence. However, animal models for stress-induced relapse were criticized for the lack of predictive and face validity.
Objectives: Here we investigated the effect of acute food deprivation stress in a novel str ...

Article GUID: 35951079


Mastering the Relationship between the Body and the Brain? The Case of a Female Master Athlete

Author(s): Saillant K; Intzandt B; Bérubé B; Sanami S; Gauthier C; Bherer L;

Background: Physical inactivity significantly increases risk of cardiovascular diseases, which are highly prevalent in aging. Conversely, higher levels of physical activity in aging have been associated with benefits for physical and cognitive health and is hypothesized to prevent and reduce development of cardiovascular risk factors. However, those older ...

Article GUID: 35950796


Two Chemical Engineers Look at the COVID-19 Pandemic

Author(s): De Visscher A; Pinheiro Patrício PC;

Chemical engineering involves a skill set that is transferrable to a broad range of other areas. A case in point is the work that is being done by chemical engineers to better understand and fight the COVID-19 epidemic. In this study, we consider a problem that has eluded the COVID-19 research community, which is nevertheless very tractable with a chemica ...

Article GUID: 35942051


Community-led risk analysis of direct-to-consumer whole-genome sequencing

Author(s): Samlali K; Thornbury M; Venter A;

Direct-to-consumer (DTC) genetic testing is cheaper and more accessible than ever before. What is generally hidden from the consumer is the intention to combine, reuse, and resell this genetic information as powerful datasets. This financial gain is creating a competitive DTC market, reducing the price of whole genome sequencing (WGS) down to USD 299. Ent ...

Article GUID: 35939839


Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex

Author(s): Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA;

Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex. Reductions in estrogens may alter cognition by reducing the function of cholinergic inputs to both the hippocampus and entorhinal cortex. In ...

Article GUID: 35939438


Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast

Author(s): Leonov A; Feldman R; Piano A; Arlia-Ciommo A; Junio JAB; Orfanos E; Tafakori T; Lutchman V; Mohammad K; Elsaser S; Orfali S; Rajen H; Titorenko VI;

We propose a hypothesis of a mechanism linking cellular aging to cellular quiescence in chronologically aging budding yeast. Our hypothesis posits that this mechanism integrates four different processes, all of which are initiated after yeast cells cultured in a medium initially containing glucos ...

Article GUID: 35937500


Experimental chambers Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

Rationale and objective: Learning to inhibit acquired fear responses is fundamental to adaptive behavior. Two procedures that support such learning are extinction and overexpectation. In extinction, an expected outcome is omitted, whereas in overexpectation two individually trained cues are presented in compound to induce an expectation of a greater outco ...

Article GUID: 35932299


Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesity

Author(s): Turner L; Gauthier MF; Lafortune A; Tchernof A; Santosa S;

Background: The timing of obesity onset and age have been shown to affect the risk of obesity-related comorbidities, although the impact of each of these factors on markers of adipose tissue function remains unclear. Objective: The aim of this study was to determine whether differences in regional adipose tissue characteristics vary with age and age of o ...

Article GUID: 35927468


Assessing effects of predator density and diversity on neophobia in Trinidadian guppies

Author(s): Feyten LEA; Demers EEM; Ramnarine IW; Brown GE;

Neophobic predator avoidance, where prey actively avoid novel stimuli, is thought to allow prey to cope with the inability to predict predation risk (i.e. uncertainty) while reducing the costs associated with learning. Recent studies suggest that neophobia is elicited as a response to unpredictable and elevated mean predation risk, and is linked to experi ...

Article GUID: 35907447


Exploring weight bias internalization in pregnancy

Author(s): Nagpal TS; Salas XR; Vallis M; Piccinini-Vallis H; Alberga AS; Bell RC; da Silva DF; Davenport MH; Gaudet L; Rodriguez ACI; Liu RH; Myre M; Nerenberg K; Nutter S; Russell-Mayhew S; Souza SCS; Vilhan C; Adamo KB;

Background: Recent research has shown that pregnant individuals experience weight stigma throughout gestation, including negative comments and judgement associated with gestational weight gain (GWG). Weight bias internalization (WBI) is often a result of exposure to weight stigma and is detriment ...

Article GUID: 35906530


<   Page 147 / 355   >