Author(s): Lu H, Shrivastava M, Whiteway M, Jiang Y
Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazole, C. albicans has the potential to acquire fluconazole resistance. A promising approach to increase ...
Article GUID: 33587857
Author(s): Lindsay RJ, Mansbach RA, Gnanakaran S, Shen T
The conformational ensemble of intrinsically disordered proteins, such as a-synuclein, are responsible for their function and malfunction. Misfolding of a-synuclein can lead to neurodegenerative diseases, and the ability to study their conformations and those of other intrinsically disordered proteins under varying physiological conditions can be crucial ...
Article GUID: 33581430
Author(s): Almeida H, Palys S, Tsang A, Diallo AB
Fungal secondary metabolites (SMs) are an important source of numerous bioactive compounds largely applied in the pharmaceutical industry, as in the production of antibiotics and anticancer medications. The discovery of novel fungal SMs can potentially benefit human health. Identifying biosynthetic gene clusters (BGCs) involved in the biosynthesis of SMs ...
Article GUID: 33575642
Author(s): Kaminski E, Engelhardt M, Hoff M, Steele C, A Villringer, Ragert P
Skill increase in motor performance can be defined as explicitly measuring task success but also via more implicit measures of movement kinematics. Even though these measures are often related, there is evidence that they represent distinct concepts of learning. In the present study, the effect of multiple tDCS-sessions on both explicit and implicit measu ...
Article GUID: 33564052
Author(s): Elshafei M, Costa DE, Shihab E
Nowadays, Human Activity Recognition (HAR) systems, which use wearables and smart systems, are a part of our daily life. Despite the abundance of literature in the area, little is known about the impact of muscle fatigue on these systems' performance. In this work, we use the biceps concentration curls exercise as an example of a HAR activity to obser ...
Article GUID: 33557239
Author(s): Fekri P, Dargahi J, Zadeh M
Having a trusted and useful system that helps to diminish the risk of medical errors and facilitate the improvement of quality in the medical education is indispensable. Thousands of surgical errors are occurred annually with high adverse event rate, despite inordinate number of devised patients safety initiatives. Inadvertently or otherwise, surgeons pla ...
Article GUID: 33553246
Author(s): Faghy MA, Arena R, Stoner L, Haraf RH, Josephson R, Hills AP, Dixit S, Popovic D, Smith A, Myers J, Bacon SL, Niebauer J, Dourado VZ, Babu AS, Maden-Wilkinson TM, Copeland RJ, Gough LA, Bond S, Stuart K, Bewick T, Ashton REM, HL-PIVOT Ne ...
COVID-19 is one of the biggest health crises that the world has seen. Whilst measures to abate transmission and infection are ongoing, there continues to be growing numbers of patients requiring chronic support, which is already putting a strain on health care systems around the world and which m ...
Article GUID: 33549590
Author(s): da Estrela C; MacNeil S; Gouin JP;
Stress exposure increases risk for depressive symptoms. However, there are substantial individual differences in affective responses to stress. High-frequency heart rate variability (HF-HRV), a marker of vagally-mediated parasympathetic activity, has been conceptualized as a psychophysiological index of emotion regulation that may moderate individuals' ...
Article GUID: 33556470
Author(s): Aardema F, Radomsky AS, Moulding R, Wong SF, Bourguignon L, Giraldo-O'Meara M
In recent years, cognitive-behavioural models of OCD have increasingly recognized the potential role of feared possible selves in the development and maintenance of OCD, while simultaneously re-examining factors that have historically been linked to self-perceptions in OCD. The current article describes the development and validation of a multidimensional ...
Article GUID: 33547834
Author(s): Soffer G, Perry JM, Shih SCC
Optimization of engineered biological systems requires precise control over the rates and timing of gene expression. Optogenetics is used to dynamically control gene expression as an alternative to conventional chemical-based methods since it provides a more convenient interface between digital control software and microbial culture. Here, we describe the ...
Article GUID: 33543619
Author(s): Donkor R, Silva AE, Teske C, Wallis-Duffy M, Johnson AP, Thompson B
We tested the hypothesis that five daily sessions of visual cortex transcranial random noise stimulation would improve contrast sensitivity, crowded and uncrowded visual acuity in adults with amblyopia. Nineteen adults with amblyopia (44.2?±?14.9 years, 10 female) were randomly allocated to active or sham tRNS of the visual cortex (active, n?=?9; sham, n? ...
Article GUID: 33542265
Author(s): Serravalle L; Iacono V; Wilson AL; Orlando MA; Tsekova V; Ellenbogen MA;
The offspring of parents with bipolar disorder (OBD) exhibit elevated rates of psychopathology. However, preventative interventions are lacking. Using a quasi-experimental design with an assessment-only control group, we examined if a 12-week program (entitled Reducing Unwanted Stress in the Home, RUSH) decreases internalizing and externalizing symptoms i ...
Article GUID: 33544277
