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Hypothalamic-pituitary-adrenal axis functioning in offspring of parents with a major affective disorder: a meta-analytic review

Author(s): Serravalle L; Trespalacios F; Ellenbogen MA;

Because the offspring of parents with an affective disorder (OAD) are at high risk for developing mental disorders, and persons with an affective disorder (AD) show dysfunctional hypothalamic-pituitary-adrenal (HPA) axis activity, changes in HPA functioning in OAD might be an etiological risk factor that precedes the development of ADs. The primary aim of ...

Article GUID: 39207496


AP-1 contributes to endosomal targeting of ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif

Author(s): Cabana VC; Sénécal AM; Bouchard AY; Kourrich S; Cappadocia L; Lussier MP;

Cellular trafficking between organelles is typically assured by short motifs that contact carrier proteins to transport them to their destination. Ubiquitin E3 ligase RING finger protein 13 (RNF13), a regulator of proliferation, apoptosis, and protein trafficking, localizes to endolysosomal compartments through the binding of a dileucine motif to clathrin ...

Article GUID: 39206621


Integrated Dynamic Photovoltaic Facade for Enhanced Building Comfort and Energy Efficiency

Author(s): Valinejadshoubi M; Athienitis AK; Bagchi A; Abtahi M;

This simulation study explores the potential of a novel façade design with integrated control system comprising a dynamic photovoltaic (PV) facade integrated with dimming lighting control to enhance the work environment in office buildings and achieve energy-efficient solutions. Parametric modeling using the Grasshopper plug-in for Rhino software 7, coupl ...

Article GUID: 39194442


Integrative approach to mitigate chromium toxicity in soil and enhance antioxidant activities in rice (Oryza sativa L.) using magnesium-iron nanocomposite and Staphylococcus aureus strains

Author(s): Ali MA; Sardar MF; Dar AA; Niaz M; Ali J; Wang Q; Zheng Y; Luo Y; Albasher G; Li F;

Pollutants in soil, particularly chromium (Cr), pose high environmental and health risks due to their persistence, bioavailability, and potential for causing toxicity. Cr impairment in plants act as a deleterious environmental pollutant that enters the food chain and eventually disturbs human health. Current study demonstrated the potential of integrative ...

Article GUID: 39190219


Effects of early midlife ovarian removal on sleep: Polysomnography-measured cortical arousal, homeostatic drive, and spindle characteristics

Author(s): Brown A; Gervais NJ; Gravelsins L; O' Byrne J; Calvo N; Ramana S; Shao Z; Bernardini M; Jacobson M; Rajah MN; Einstein G;

Bilateral salpingo-oophorectomy (BSO; removal of ovaries and fallopian tubes) prior to age 48 is associated with elevated risk for both Alzheimer's disease (AD) and sleep disorders such as insomnia and sleep apnea. In early midlife, individuals with BSO show reduced hippocampal volume, functi ...

Article GUID: 39178647


Searching and reporting in Campbell Collaboration systematic reviews: A systematic assessment of current methods

Author(s): Young S; MacDonald H; Louden D; Ellis UM; Premji Z; Rogers M; Bethel A; Pickup D;

The search methods used in systematic reviews provide the foundation for establishing the body of literature from which conclusions are drawn and recommendations made. Searches should aim to be comprehensive and reporting of search methods should be transparent and reproducible. Campbell Collaboration systematic reviews strive to adhere to the best method ...

Article GUID: 39176233


Behavioural science can improve parenting interventions

Author(s): Ahun MN; Bacon SL;

No abstract available

Article GUID: 39174724


Transcriptional and secretome analysis of Rasamsonia emersonii lytic polysaccharide mono-oxygenases

Author(s): Raheja Y; Singh V; Kumar N; Agrawal D; Sharma G; Di Falco M; Tsang A; Chadha BS;

The current study is the first to describe the temporal and differential transcriptional expression of two lytic polysaccharide monooxygenase (LPMO) genes of Rasamsonia emersonii in response to various carbon sources. The mass spectrometry based secretome analysis of carbohydrate active enzymes (CAZymes) expression in response to different carbon sources ...

Article GUID: 39167166


Cardiometabolic disease risk in relation to objectively measured physical activity, sedentary behaviour in South African adults with knee and hip osteoarthritis

Author(s): Kaoje YS; Mokete L; Dafkin C; Pietrzak J; Sikhauli K; Frimpong E; Meiring RM;

Purpose: This study aimed to investigate the relationship between cardiometabolic disease risk and time spent in device-measured activity behaviours in a cohort of people with advanced osteoarthritis (OA) awaiting joint replacement surgery. Materials and methods: Cardiometabolic risk biomarkers were assessed in people with OA (n = 96; hip n = 38, knee n ...

Article GUID: 39162078


Correction: Measuring what matters to older persons for active living: part II cross-sectional validity evidence for OPAL measure across four countries

Author(s): Mayo NE; Auais M; Barclay R; Branin J; Dawes H; Korfage IJ; Sawchuk K; Tal E; White CL; Ayoubi Z; Ekediegwu E; Mate K; Nadeau L; Duque SR; Kuspinar A;

No abstract available

Article GUID: 39158786


Couples-based health behavior change interventions: A relationship science perspective on the unique opportunities and challenges to improve dyadic health

Author(s): Gouin JP; Dymarski M;

Epidemiological studies indicate that better marital quality is associated with less morbidity and premature mortality. A number of interpersonal processes related to marital quality are also associated with health-relevant surrogate biomarkers across different physiological systems. Despite these replicated correlational findings, few interventions have ...

Article GUID: 39155951


17β-Estradiol reduces inhibitory synaptic currents in entorhinal cortex neurons through G protein-coupled estrogen receptor-1 activation of extracellular signal-regulated kinase

Author(s): Batallán Burrowes AA; Moisan É; Garrone A; Buynack LM; Chapman CA;

Estrogens are believed to modulate cognitive functions in part through the modulation of synaptic transmission in the cortex and hippocampus. Administration of 17ß-estradiol (E2) can rapidly enhance excitatory synaptic transmission in the hippocampus and facilitate excitatory synaptic transmission in rat lateral entorhinal cortex via activation of the G p ...

Article GUID: 39150316


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