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17β-Estradiol reduces inhibitory synaptic currents in entorhinal cortex neurons through G protein-coupled estrogen receptor-1 activation of extracellular signal-regulated kinase

Author(s): Batallán Burrowes AA; Moisan É; Garrone A; Buynack LM; Chapman CA;

Estrogens are believed to modulate cognitive functions in part through the modulation of synaptic transmission in the cortex and hippocampus. Administration of 17ß-estradiol (E2) can rapidly enhance excitatory synaptic transmission in the hippocampus and facilitate excitatory synaptic transmission in rat lateral entorhinal cortex via activation of the G p ...

Article GUID: 39150316


A Follow-up Geospatial Analysis and Probabilistic Human Health Risk Assessment of Methylmercury in Fish in Eeyou Istchee (Québec, Canada)

Author(s): Krupa A; Turner SE; Liberda EN; Tsuji LJS; Moriarity RJ;

The Cree Peoples of the Eeyou Istchee territory (northern Québec, Canada) rely on fish as a part of their traditional and contemporary diet. Fish is a culturally significant food and a source of nutrients, but it is also the main pathway of methylmercury (MeHg) exposure for humans. Significant hydroelectric developments in this territory are responsible f ...

Article GUID: 39147182


EEG-based study of design creativity: a review on research design, experiments, and analysis

Author(s): Zangeneh Soroush M; Zeng Y;

Brain dynamics associated with design creativity tasks are largely unexplored. Despite significant strides, there is a limited understanding of the brain-behavior during design creation tasks. The objective of this paper is to review the concepts of creativity and design creativity as well as their differences, and to explore the brain dynamics associated ...

Article GUID: 39148896


Relational conflicts during COVID-19: Impact of loss and reduction of employment due to prevention measures and the influence of sex and stress (in the iCARE study)

Author(s): Tremblay N; Leger C; Deslauriers F; Hébert-Auger L; Gosselin-Boucher V; Bacon SL; Dialufuma MV; Lavoie KL;

This study explored the association between pandemic-related loss/reduction of employment, sex, COVID-19-related stress and relational conflicts. A sample of 5103 Canadians from the iCARE study were recruited through an online polling firm between October 29, 2020, and March 23, 2021. Logistic re ...

Article GUID: 39148311


Identifying personalized barriers for hypertension self-management from TASKS framework

Author(s): Yang J; Zeng Y; Yang L; Khan N; Singh S; Walker RL; Eastwood R; Quan H;

Objective: Effective management of hypertension requires not only medical intervention but also significant patient self-management. The challenge, however, lies in the diversity of patients' personal barriers to managing their condition. The objective of this research is to identify and categorize personalized barriers to hypertension self-management ...

Article GUID: 39143621


From data to action in flood forecasting leveraging graph neural networks and digital twin visualization

Author(s): Roudbari NS; Punekar SR; Patterson Z; Eicker U; Poullis C;

Forecasting floods encompasses significant complexity due to the nonlinear nature of hydrological systems, which involve intricate interactions among precipitation, landscapes, river systems, and hydrological networks. Recent efforts in hydrology have aimed at predicting water flow, floods, and quality, yet most methodologies overlook the influence of adj ...

Article GUID: 39127785


Impact of Stimulation Frequency on Verbal Fluency Following Bilateral Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease

Author(s): Busteed L; García-Sánchez C; Pascual-Sedano B; Grunden N; Gironell A; Kulisevsky J; Pagonabarraga J;

Objective: The effects of stimulation frequency on verbal fluency (VF) following subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) are not well understood. The present study examines the impact stimulation frequency has on VF following bilateral STN-DBS in PD. ...

Article GUID: 39127889


The relationship between workplace justice and self-evaluated nonfatal occupational accidents among healthcare employees in Taiwan: An observational study

Author(s): Hsieh CM; Chen S; Peng TT; Chen PH; Chen A; Chen CJ;

The relationship between workplace justice and nonfatal occupational accidents in a single-payer healthcare system has rarely been explored. As countries strive to achieve and sustain universal health coverage, healthcare workers' occupational safety and health require greater concerns. We used the data from a national survey conducted on randomly sam ...

Article GUID: 39121330


Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials

Author(s): Gotfried MH; Auerbach SH; Dang-Vu TT; Mishima K; Kumar D; Moline M; Malhotra M;

Background: Insomnia is more common as people age. Several common hypnotics used to treat insomnia often do not adequately alleviate sleep issues in older adults and may be associated with negative residual effects such as an increased risk of falls, cognitive impairment, automobile accidents, and lack of response to auditory stimuli. The objective of the ...

Article GUID: 39120786


An Ecological Approach to Conceptual Thinking in Material Engagement

Author(s): Alessandroni N; Malafouris L; Gallagher S;

Although post-cognitivist approaches have shaken the status quo by emphasising the dynamic interactions among the brain, the body, and the environment in cognition, mainstream psychological theories continue to view concepts as primarily representational or skull-bound mental phenomena. As a result, the dynamics of action and the possible impact of materi ...

Article GUID: 39118997


Investigating the kinetics of marine and terrestrial organic carbon incorporation and degradation in coastal bulk sediment and water settings through isotopic lenses

Author(s): Mirzaei Y; Gélinas Y;

Coastal sediments are the main deposition center for allochthonous and autochthonous organic carbon (OC). The discharge of terrestrial biomass, anthropogenic activities, oceanic primary productivity, and natural events contribute to this carbon pool. The OC buried in sediments undergoes alteration through physical, biological and chemical processes, becom ...

Article GUID: 39117203


Minor-Attracted Men's Lived Experiences of Romantic Attraction

Author(s): Levitan JA; Martijn FM; Santaguida M; Seto MC;

Studies of minor-attracted persons have mainly focused on their sexual attractions, and little is known about their romantic attractions. This online qualitative survey study collected 74 self-identified minor-attracted men's anonymous accounts of romantic attraction to minors. Using reflexive thematic analysis, three themes were identified and interp ...

Article GUID: 39118553


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