Author(s): Hazel K; Singh D; He S; Guertin Z; Husser MC; Helfield B;

CRISPR-Cas9 ribonucleoproteins (RNPs) have been heavily considered for gene therapy due to their high on-target efficiency, rapid activity and lack of insertional mutagenesis relative to other CRISPR-Cas9 delivery formats. Genetic diseases such as hypertrophic cardiomyopathy currently lack effective treatment strategies and are prime targets for CRISPR-Ca ...

Article GUID: 39797397

Author(s): Alasmar Z; Chakravarty MM; Penhune VB; Steele CJ;

The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that indivi ...

Article GUID: 39791308

Author(s): Soucy JP; Belasso CJ; Cai Z; Bezgin G; Stevenson J; Rahmouni N; Tissot C; Lussier FZ; Rosa-Neto P; Rivaz HJ; Benali H;

Background: Tau aggregates in Alzheimer's disease (AD) induce loss of synapses and neurons, leading to cognitive impairment. Predicting tau and neurodegeneration temporal evolution could be used for prognostication and for assessing results of therapeutic trials. Tau PET and MRI volumetry are ...

Article GUID: 39782975

Author(s): Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;

Background: Alzheimer's disease (AD) is thought to result from a complex cascade of events involving several pathological processes. Recent studies have reported alterations in white matter (WM) microstructure in the early phase of AD, but WM remains understudied. We used a multivariate appro ...

Article GUID: 39782998

Author(s): Soucy JP; Belasso CJ; Cai Z; Bezgin G; Stevenson J; Rahmouni N; Tissot C; Lussier FZ; Rosa-Neto P; Rivaz HJ; Benali H;

Background: Tau aggregates in Alzheimer's disease (AD) induce loss of synapses and neurons, leading to cognitive impairment. Predicting tau and neurodegeneration temporal evolution could be used for prognostication and for assessing results of therapeutic trials. Tau PET and MRI volumetry are ...

Article GUID: 39784152

Author(s): Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;

Background: Alzheimer's disease (AD) is thought to result from a complex cascade of events involving several pathological processes. Recent studies have reported alterations in white matter (WM) microstructure in the early phase of AD, but WM remains understudied. We used a multivariate appro ...

Article GUID: 39785351

Author(s): Grant N; Phillips N;

Background: Hearing loss (HL) is a risk factor for dementia that is prevalent in older adults. Altered brain connectivity is present in individuals with HL, individuals with subjective cognitive decline (SCD), and individuals with mild cognitive impairment (MCI). In individuals with HL, altered brain connectivity has been associated with impaired scores o ...

Article GUID: 39785420

Author(s): Cassandre Vielle

Through the lens of preclinical research on substance use disorders (SUD), I propose a reflection aimed at re-evaluating animal models in neuroscience, with a focus on ecological relevance. While rodent models have provided valuable insights into the neurobiology of SUD, the field currently faces a validation crisis, with findings often failing to transla ...

Article GUID: 39777969

Author(s): Rehan S; Phillips NA;

Psychosocial function is associated with cognitive performance cross-sectionally and cognitive decline over time. Using data from the COMPASS-ND study, we examined associations between psychosocial and cognitive function in 126 individuals with mild cognitive impairment, an at-risk group for Alzheimer's disease (AD). Psychosocial function was measured ...

Article GUID: 39773214

Author(s): Romkey ID; Matthews T; Foster N; Dalla Bella S; Penhune VB;

In cognitive science, the sensation of "groove" has been defined as the pleasurable urge to move to music. When listeners rate rhythmic stimuli on derived pleasure and urge to move, ratings on these dimensions are highly correlated. However, recent behavioural and brain imaging work has shown that these two components may be separable. To examine this pot ...

Article GUID: 39774498

Author(s): Leite ML; Comeau P; Zaghwan A; Shen Y; Manso AP;

Objectives: This study aimed to assess the potential of experimental dental resins containing ZnO nanoparticles (ZnO-NPs) for antimicrobial photodynamic therapy (aPDT) as a functional tool for the modulation of cariogenic biofilm in long-term. Methods: Minimum inhibitory and bactericidal concentrations (MIC/MBC) of ZnO-NPs against Streptococcus mutans we ...

Article GUID: 39765362

Author(s): Gao Z; Chen X; Xu J; Yu R; Zhang H; Yang J;

Drowsy driving is a leading cause of commercial vehicle traffic crashes. The trend is to train fatigue detection models using deep neural networks on driver video data, but challenges remain in coarse and incomplete high-level feature extraction and network architecture optimization. This paper pioneers the use of the CLIP (Contrastive Language-Image Pre- ...

Article GUID: 39771685