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The PREVENT-AD cohort: Accelerating Alzheimer s disease research and treatment in Canada and beyond

Author(s): Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Fajardo Valdez A; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Stri ...

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now be ...

Article GUID: 41020412


Comparative Advances in Sulfide and Halide Electrolytes for Commercialization of All-Solid-State Lithium Batteries

Author(s): Bouguern MD; Ningappa NG; Vishweswariah K; Kumar M R A; Kanno R; Zaghib K;

All-solid-state lithium batteries (ASSBs) outperform lithium-ion batteries (LIBs) in safety, energy density, and thermal stability. Their performance depends on high ionic conductivity, chemical/physical stability, and scalable manufacture of solid electrolytes (SEs). This study compares sulfide- and halide-based SEs, two promising next-generation energy ...

Article GUID: 41017218


Anion Exchange Ionomer Binders for Alkaline Fuel Cells

Author(s): Gowling AC; Meek KM;

Anion exchange ionomer (AEI) binders are critical to the performance of alkaline electrochemical devices (i.e., fuel cells, electrolyzers, and batteries), as they facilitate ion transport, provide structural integrity, and improve the overall performance and lifespan of these devices. These binders not only ensure ion transport but also provide mechanical ...

Article GUID: 41010197


Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles

Author(s): Rattray GF; Jourde HR; Baillet S; Coffey EBJ;

Subcortical brain regions like the thalamus are integral to numerous sensory and cognitive functions. Magnetoencephalography (MEG) enables the study of widespread brain networks with high temporal resolution, but the degree to which deep sources like the thalamus can be resolved remains unclear. Functional connectivity methods may enhance differentiation, ...

Article GUID: 41002111


Single-Atom Catalyst with Optimized Ni Content in a Flexible Zn-Air Battery Operated at a Wide Temperature Range

Author(s): Coello-Mauleón C; Ramos-Castillo CM; Arredondo-Espínola A; Álvarez-Contreras L; Guerra-Balcázar M; Chen N; Deng S; Arjona N;

Flexible and safe energy storage systems are critical for the advancement of wearable and portable electronics. Although lithium-ion batteries dominate the market, their reliance on flammable electrolytes and rigid structures limits their use in flexible applications. Herein, we report the develo ...

Article GUID: 41003649


Prevalence and characteristics of neuropathic pain in adolescent survivors of childhood cancer

Author(s): Mesaroli G; Olaizola S; Nair A; Nishat F; Pizzo A; Nathan PC; Alberts NM; Stinson JN;

Purpose: Neuropathic pain (NP) in individuals with cancer can arise from the cancer itself or its treatments. The prevalence of NP has been estimated in children living with cancer; however, the prevalence in adolescent survivorship is unknown. The aims of this study were to estimate the prevalence of NP among adolescent survivors of childhood cancer and ...

Article GUID: 40999274


Open-space microfluidics as a tool to study signaling dynamics

Author(s): Proulx M; Clapperton-Richard P; Potvin-Trottier L; Piekny A; Gervais T;

The temporal dynamics of cell signaling are a crucial way for cells to regulate their transcriptional targets and consequently may heavily influence cell responses. Improving our understanding of signaling dynamics is important for drug treatments targeting specific signaling pathways. However, studying signaling dynamics requires multiplexed, time-sensit ...

Article GUID: 40995884


Enhancement of syngas production via plastic gasification in low-concentration CO sub 2 /sub by using spent lithium-ion batteries-derived black mass

Author(s): Cho DW; Han HJ; Hwang JH; Ahn Y; Yu H;

This study investigates the thermochemical and co-thermochemical conversion of black mass (BM), derived from spent lithium-ion batteries, with and without polyethylene (PE) under various atmospheric conditions (N2, 25 % CO2, and 99.999 % CO2) at temperatures ranging from 700 °C to 900 °C. In an inert N2 environment, gas emissions were minimal, while signi ...

Article GUID: 40992313


An active bifunctional natural dye for stable all-solid-state organic batteries

Author(s): Yu Q; Hu Y; Deng S; Shakouri M; Chen J; Martins V; Nie HY; Huang Y; Zhao Y; Zaghib K; Sham TK; Li X;

Sustainable and cost-effective organic electrode materials are promising for next-generation lithium-ion batteries but are hindered by severe shuttle effects. While all-solid-state batteries offer a potential solution, chemical and mechanical incompatibility between organic electrode materials an ...

Article GUID: 40993135


Modeling CH sub 3 /sub SOH-aromatic complexes to probe cysteine sulfenic acid-aromatic interactions in proteins

Author(s): Orabi EA; English AM;

Cysteine sulfenic acid (CysOH), formed on oxidation of Cys residues, is an intermediate in the catalytic cycles of numerous antioxidant enzymes and participates in oxidative-stress sensing and redox signaling. Proteins control CysOH reactivity in part by its interactions with aromatic residues. To characterize such interactions, we performed extensive ab ...

Article GUID: 40994121


Reliability of Comprehensive Facial Soft Tissue Landmark Detection and Analysis Using Frontal View Photographs

Author(s): Hassanzadeh-Samani S; Pirayesh Z; Motie P; Ghorbanimehr MS; Farzan A; Mohammad-Rahimi H; Behnaz M; Motamedian SR;

Background: Facial soft tissue analysis plays a vital role in orthodontics, orthognathic surgeries, and forensic anthropology. This study aimed to determine a standardized midline to assess the reliability of symmetry analysis in frontal view photographs. Additionally, it evaluated the consistenc ...

Article GUID: 40975629


A dataset from a coordinated multi-site laboratory study investigating the Hue-Heat-Hypothesis

Author(s): Bavaresco M; Cureau RJ; Pigliautile I; Barna E; Deme Belafi Z; Belussi L; Chinazzo G; Chiucchiù A; Danza L; Deng Z; Dong B; Gapski NH; Garlet L; Gnecco VM; Guo X; Pilehchi Ha P; Karimian H; Lamberts R; Liu S; da Costa Loeser B; Massucci ...

Understanding cross-modal environmental perception is essential for improving occupant well-being and human-centric building design. This paper presents an open-access, multi-site database developed under the IEA-EBC Annex 79 project to test the Hue-Heat Hypothesis (HHH), which hypothesizes that ...

Article GUID: 40973711


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