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Trans-regulatory variant network contributes to missing heritability

Author(s): Pereira V; Kuzmin E;

In a recent Cell Genomics article, Tsouris et al.1 analyze the transcriptomes of a large diallel panel of hybrids from Saccharomyces cerevisiae natural isolates to study cis- and trans-regulatory changes underlying gene expression variation. Vanessa Pereira and Elena Kuzmin discuss the authors' findings and the wider context in missing heritability re ...

Article GUID: 38216282


Alkali-Silica Reactions: Literature Review on the Influence of Moisture and Temperature and the Knowledge Gap

Author(s): Olajide OD; Nokken MR; Sanchez LFM;

The alkali-silica reaction is a universally known destructive mechanism in concrete that can lead to the premature loss of serviceability in affected structures. Quite an enormous number of research studies have been carried out focusing on the mechanisms involved as well as the mitigation and prevention of the reaction. A few in-depth discussions on the ...

Article GUID: 38203865


Janus Micromotors for Photophoretic Motion and Photon Upconversion Applications Using a Single Near-Infrared Wavelength

Author(s): Mena-Giraldo P; Kaur M; Maurizio SL; Mandl GA; Capobianco JA;

External stimuli can trigger changes in temperature, concentration, and momentum between micromotors and the medium, causing their propulsion and enabling them to perform different tasks with improved kinetic efficiencies. Light-activated micromotors are attractive systems that achieve improved motion and have the potential for high spatiotemporal control ...

Article GUID: 38197400


Reciprocal inhibition and competitive hierarchy cause negative biodiversity-ecosystem function relationships

Author(s): D' Andrea R; Khattar G; Koffel T; Frans VF; Bittleston LS; Cuellar-Gempeler C;

The relationship between biodiversity and ecosystem function (BEF) captivates ecologists, but the factors responsible for the direction of this relationship remain unclear. While higher ecosystem functioning at higher biodiversity levels ('positive BEF') is not universal in nature, negative BEF relationships seem puzzlingly rare. Here, we develop ...

Article GUID: 38193391


Mixed-Language Input and Infant Volubility: Friend or Foe?

Author(s): Ruan Y; Byers-Heinlein K; Orena AJ; Polka L;

Language mixing is a common feature of many bilingually-raised children's input. Yet how it is related to their language development remains an open question. The current study investigated mixed-language input indexed by observed (30-second segment) counts and proportions in day-long recordings as well as parent-reported scores, in relation to infant ...

Article GUID: 38187471


Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context

Author(s): Valyear MD; Brown A; Deyab G; Villaruel FR; Lahlou S; Caporicci-Dinucci N; Chaudhri N;

Discrete alcohol cues and contexts are relapse triggers for people with alcohol use disorder exerting particularly powerful control over behaviour when they co-occur. Here, we investigated the neural substrates subserving the capacity for alcohol-associated contexts to elevate responding to an alcohol-predictive conditioned stimulus (CS). Specifically, ra ...

Article GUID: 38185906


Morphological and Habitat Quality of Salmonid Streams and their Relationship with Fish-Based Indices in Aotearoa New Zealand and Ontario (Canada)

Author(s): Foote KJ; Biron PM; Grant JWA;

Habitat degradation is one of the major reasons for freshwater species decline. Hydrogeomorphological processes (such as sediment transport, bank erosion, and flooding) operate at the catchment scale and determine habitat features in river reaches. However, habitat quality indices and restoration for freshwater fish species are often implemented at small ...

Article GUID: 38172273


Deep learning for tooth identification and enumeration in panoramic radiographs

Author(s): Sadr S; Mohammad-Rahimi H; Ghorbanimehr MS; Rokhshad R; Abbasi Z; Soltani P; Moaddabi A; Shahab S; Rohban MH;

Background: Dentists begin the diagnosis by identifying and enumerating teeth. Panoramic radiographs are widely used for tooth identification due to their large field of view and low exposure dose. The automatic numbering of teeth in panoramic radiographs can assist clinicians in avoiding errors. ...

Article GUID: 38169618


Age does matter for hospice care: Health care providers' attitudes toward hospice care in Binzhou, China

Author(s): Yu H; de Medeiros K;

Death is still a taboo subject in China. Consequently, hospice remains a relatively new concept in many parts of China. In addition, China is also a rapidly aging country which will likely impact health care delivery, making hospice a potentially effective addition to current healthcare systems. The goal of this study was to better understand health care ...

Article GUID: 38163963


Erratum: Correction Notice: Single-step Precision Genome Editing in Yeast Using CRISPR-Cas9

Author(s): Akhmetov A; Laurent JM; Gollihar J; Gardner EC; Garge RK; Ellington AD; Kachroo AH; Marcotte EM;

[This corrects the article .].

Article GUID: 38161732


Alternating direction method of multipliers for displacement estimation in ultrasound strain elastography

Author(s): Md Ashikuzzaman

CONCLUSIONS: A novel ultrasonic displacement tracking algorithm named ALTRUIST has been developed. The principal novelty of ALTRUIST is incorporating ADMM for optimizing an L 1 $L1$ -norm regularization-based cost function. ALTRUIST exhibits promising performance in simulation, phantom, and in vivo experiments.

Article GUID: 38159299


Nonsingleton Gaussian type-3 fuzzy system with fractional order NTSMC for path tracking of autonomous cars

Author(s): Taghavifar H; Mohammadzadeh A; Zhang W; Zhang C;

Path-tracking and lane-keeping tasks are critical to guarantee safety and navigation performance considerations for deploying autonomous cars. This paper presents a novel control framework for the path-tracking control of high-speed autonomous cars with structured uncertainties. This study introduces a nonlinear adaptive control system based on a fraction ...

Article GUID: 38160078


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