Author(s): Pfaus JG; Antonie RA; Dosa PI; Kim SW;
Rationale: Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the release of prolactin through agonist actions on dopamine (DA) D2 receptors; however, it possesses binding affinity for other DA and 5-HT receptors. Side effects that exacerbate valvular heart disease can occur with high doses ...
Article GUID: 37968530
Author(s): Leake J; Leidl DM; Lay BPP; Fam JP; Giles MC; Qureshi OA; Westbrook RF; Holmes NM;
Activity in the basolateral amygdala complex (BLA) is needed to encode fears acquired through contact with both innate sources of danger (i.e., things that are painful) and learned sources of danger (e.g., being threatened with a gun). However, within the BLA, the molecular processes required to consolidate the two types of fear are not the same: protein ...
Article GUID: 37963767
Author(s): Yang JG; Sun B; Wang Z; Li X; Gao JH; Qian JJ; Li J; Wei WJ; Zhang P; Wang W;
Osteoporosis has a profound influence on public health. First-line bisphosphonates often cause osteonecrosis of the jaw meanwhile inhibiting osteoclasts. Therefore, it is important to develop effective treatments. The results of this study showed that the increased level of NFATc1 m6A methylation caused by zoledronic acid (ZOL), with 4249A as the function ...
Article GUID: 37957146
Author(s): Sandstrom A; Radomsky AS;
Background and objectives: Cognitive theories of obsessive-compulsive disorder (OCD) suggest that dysfunctional beliefs influence symptoms. However, well-established belief domains do not fully explain OCD symptomatology, suggesting other cognitive mechanisms may be involved. An additional belief domain which may play a role in OCD is beliefs about losing ...
Article GUID: 37948951
Author(s): Dunn WB; Kuligowski J; Lewis M; Mosley JD; Schock T; Ulmer Holland C; Zanetti KA; Vuckovic D;
Introduction: The Metabolomics Quality Assurance and Quality Control Consortium (mQACC) organized a workshop during the Metabolomics 2022 conference. Objectives: The goal of the workshop was to disseminate recent findings from mQACC community-engagement efforts and to solicit feedback about a li ...
Article GUID: 37940740
Author(s): Wickens RH; Postuma RB; de Villers-Sidani É; Pelletier A; Blinder S; Gagnon JF; Soucy JP; Montplaisir J; Bedard MA;
No abstract available
Article GUID: 37939636
Author(s): Hou D; Zhan D; Wang L; Hassan IG; Sezer N;
Many factors contribute to the inherent uncertainty of energy consumption modeling in buildings. It is essential to perform a calibration and sensitivity analysis in order to manage these uncertainties. Despite the availability of several calibration methods, they are often deterministic and lack quantified uncertainties. Moreover, the selection of parame ...
Article GUID: 37936825
Author(s): Moezi SA; Sedaghati R; Rakheja S;
In recent years, magnetoactive soft continuum robots (MSCRs) with multimodal locomotion capabilities have emerged for various biomedical applications. Developments in nonlinear dynamic models and effective control methods for MSCRs are deemed vital not only to gain a better understanding of their coupled magneto-mechanical behavior but also to accurately ...
Article GUID: 37932207
Author(s): Iantorno M; Consalvo M;
Character backgrounds are one of many elements players use to customize their protagonists in fantasy computer role-playing games. By documenting the narrative trappings, mechanical benefits, and hierarchical availability of character backgrounds in Arcanum: Of Steamworks and Magick Obscura (2001) and Dragon Age: Origins (2009), this paper considers how r ...
Article GUID: 37928454
Author(s): Lomboni DJ; Ozgun A; de Medeiros TV; Staines W; Naccache R; Woulfe J; Variola F;
Neuronal disorders are characterized by the loss of functional neurons and disrupted neuroanatomical connectivity, severely impacting the quality of life of patients. This study investigates a novel electroconductive nanocomposite consisting of glycine-derived carbon nanodots (GlyCNDs) incorporated into a collagen matrix and validates its beneficial physi ...
Article GUID: 37922888
Author(s): Valikhanova G; Kato Y; Fitzcharles MA; Ware M; Da Costa D; Lowensteyn I; Cheung HS; Grover S;
Background: Medical cannabis (MC) is used by Canadian Veterans to manage a wide range of health issues. However, there is little information comparing the reasons for MC use and its perceived effectiveness between Veterans and non-Veterans. Objects: We compared MC use among a convenience sample ...
Article GUID: 37920683
Author(s): Feng Y; Lu H; Whiteway M; Jiang Y;
Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mechanisms of FLC tolerance in Candida species remain to be fully ...
Article GUID: 37918789
