Author(s): Feng Y; Lu H; Whiteway M; Jiang Y;
Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mechanisms of FLC tolerance in Candida species remain to be fully ...
Article GUID: 37918789
Author(s): Laporte N; Hechtman L; Rousseau C; Greenfield B;
No abstract available
Article GUID: 37920538
Author(s): Belasso CJ; Cai Z; Bezgin G; Pascoal T; Stevenson J; Rahmouni N; Tissot C; Lussier F; Rosa-Neto P; Soucy JP; Rivaz H; Benali H;
Background: Alzheimer's disease (AD) diagnosis in its early stages remains difficult with current diagnostic approaches. Though tau neurofibrillary tangles (NFTs) generally follow the stereotypical pattern described by the Braak staging scheme, the network degeneration hypothesis (NDH) has su ...
Article GUID: 37920382
Author(s): Singh K; Hachem-Vermette C; D' Almeida R;
The article addresses the challenges of evaluating energy performance in different neighborhood settings under various energy efficiency measures and proposes a methodology for selecting appropriate solar strategies on a neighborhood scale. The study selects five representative neighborhoods from various climatic zones with different building and street l ...
Article GUID: 37914754
Author(s): Kosik B; Larsen S; Bergdahl A;
Insulin deficiency in type 1 diabetes (T1D) leads to an impairment of glucose metabolism and mitochondrial function. Actovegin is a hemodialysate of calf blood, which has been shown to enhance glucose uptake and cell metabolism in healthy human skeletal muscle. The objectives of this study were to determine the effects of Actovegin on skeletal muscle mito ...
Article GUID: 37913525
Author(s): Wang H; Gao RT; Nguyen NT; Bai J; Ren S; Liu X; Zhang X; Wang L;
Photoelectrochemical (PEC) water splitting is an attractive strategy to convert solar energy to hydrogen. However, the lifetime of PEC devices is restricted by the photocorrosion of semiconductors and the instability of co-catalysts. Herein, we report a feasible in situ inherent cross-linking method for stabilizing semiconductors that uses a CoFe-disperse ...
Article GUID: 37901939
Author(s): Dubé C; Morin AJS; Olivier E; Gilbert W; Tracey D; Craven RG; Maïano C;
This study investigated how the school experiences and personal characteristics of youth with Intellectual Disabilities (ID) contribute to their longitudinal trajectories of anxiety. To this end, we relied on a sample of 390 youth with mild (48.2%) to moderate (51.8%) levels of ID, aged from 11 to 22 (M = 15.70), and recruited in Canada (n = 140) and Aust ...
Article GUID: 37898583
Author(s): Savary P; Lessard JP; Peres-Neto PR;
Dispersal has a key role in shaping spatial patterns of biodiversity, yet its spatial heterogeneity is often overlooked in biodiversity analyses and management strategies. Properly parameterised heterogeneous dispersal networks capture the complex interplay between landscape structure and species-specific dispersal capacities. However, this heterogeneity ...
Article GUID: 37891075
Author(s): Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT;
Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C. albicans can initiate a strong drug tolerance response that allows some cells to ...
Article GUID: 37888959
Author(s): Matthew P Unger
This article examines how images of nature, weather, and topography disclose a politics of recognition (who is visible/invisible) invested in a burgeoning criminal justice milieu, where punishment of wrongdoing became increasingly racialized in British Columbia during the early confederation period of Canada's history. Drawing from archived court docu ...
Article GUID: 37885918
Author(s): Deslauriers F; Gosselin-Boucher V; Léger C; Vieira AM; Bacon SL; Lavoie KL;
Background: The COVID-19 pandemic and its prevention policies have taken a toll on Canadians, and certain subgroups may have been disproportionately affected, including those with non-communicable diseases (NCDs; e.g., heart and lung disease) due to their risk of COVID-19 complications and women due to excess domestic workload associated with traditional ...
Article GUID: 37884921
Author(s): Alberts NM; Gilbert A; Kang G; Okhomina VI; Flynn JS; Hodges J; Hankins JS; Klosky JL;
Pain is a primary symptom of sickle cell disease (SCD) and is often severe and chronic. To treat SCD-related pain, proper assessment of SCD pain among youth, including the degree of concordance or agreement between youth and caregiver reports of pain, is essential but has not yet been adequately evaluated. In this study, 525 youth with SCD and their paren ...
Article GUID: 37878652
