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Agreement between youth and caregiver report of pain and functioning in pediatric sickle cell disease: PedsQL sickle cell disease module

Author(s): Alberts NM; Gilbert A; Kang G; Okhomina VI; Flynn JS; Hodges J; Hankins JS; Klosky JL;

Pain is a primary symptom of sickle cell disease (SCD) and is often severe and chronic. To treat SCD-related pain, proper assessment of SCD pain among youth, including the degree of concordance or agreement between youth and caregiver reports of pain, is essential but has not yet been adequately evaluated. In this study, 525 youth with SCD and their paren ...

Article GUID: 37878652


Olfaction and reaction: The role of olfactory and hypothalamic investment in the antipredator responses to chemical alarm cues by northern redbelly dace

Author(s): Joyce BJ; Brown GE;

Neuroplasticity enables teleosts to promote or downregulate the growth of their brains regionally. To compensate for the effects of predation pressure, teleosts may alter their brain morphology and behavioral responses to mitigate its impact on individual fitness. High-predation environments often promote specific patterns of brain growth and produce bold ...

Article GUID: 37876646


Dosimetry of [18F]TRACK, the first PET tracer for imaging of TrkB/C receptors in humans

Author(s): Thiel A; Kostikov A; Ahn H; Daoud Y; Soucy JP; Blinder S; Jaworski C; Wängler C; Wängler B; Juengling F; Enger SA; Schirrmacher R;

Background: Reduced expression or impaired signalling of tropomyosin receptor kinases (Trk receptors) are found in a vast spectrum of CNS disorders. [18F]TRACK is the first PET radioligand for TrkB/C with proven in vivo brain penetration and on-target specific signal. Here we report dosimetry dat ...

Article GUID: 37870640


At-home computerized executive-function training to improve cognition and mobility in normal-hearing adults and older hearing aid users: a multi-centre, single-blinded randomized controlled trial

Author(s): Downey R; Gagné N; Mohanathas N; Campos JL; Pichora-Fuller KM; Bherer L; Lussier M; Phillips NA; Wittich W; St-Onge N; Gagné JP; Li K;

Background: Hearing loss predicts cognitive decline and falls risk. It has been argued that degraded hearing makes listening effortful, causing competition for higher-level cognitive resources needed for secondary cognitive or motor tasks. Therefore, executive function training has the potential ...

Article GUID: 37864139


Lactate's behavioral switch in the brain: An in-silico model

Author(s): Soltanzadeh M; Blanchard S; Soucy JP; Benali H;

Emerging evidence emphasizes lactate's involvement in both physiological processes (energy metabolism, memory, etc.) and disease (traumatic brain injury, epilepsy, etc.). Furthermore, the usefulness of mathematical modeling in deciphering underlying dynamics of the brain to investigate lactate roles and mechanisms of action has been well established. ...

Article GUID: 37865309


Cervical muscle morphometry and composition demonstrate prognostic value in degenerative cervical myelopathy outcomes

Author(s): Naghdi N; Elliott JM; Weber MH; Fehlings MG; Fortin M;

Objectives: This study aimed to examine whether preoperative cervical muscle size, composition, and asymmetry from magnetic resonance imaging (MRI) can predict post-operative outcomes in patients with degenerative cervical myelopathy (DCM). Methods: A total of 171 patients with DCM were included. Relative total cross-sectional area (RCSA), functional CSA ...

Article GUID: 37745653


The effects of acute exercise and a nap on heart rate variability and memory in young sedentary adults

Author(s): Mograss M; Frimpong E; Vilcourt F; Chouchou F; Zvionow T; Dang-Vu TT;

Recent evidence suggests that the autonomic nervous system can contribute to memory consolidation during sleep. Whether fluctuations in cardiac autonomic activity during sleep following physical exercise contribute to the process of memory consolidation has not been studied. We assessed the effects of a non-rapid eye movement (NREM) nap following acute ex ...

Article GUID: 37855092


Compensatory health motivations and behaviors scale: Development, evaluation, psychometric properties and a preliminary validation

Author(s): Sedemedes K; Knäuper B; Sadikaj G; Yuan TY; Wrosch C; Santosa S; Alberga AS; Kakinami L;

The "Compensatory Health Beliefs" scale assesses the degree to which one believes that unhealthy behaviours can be compensated through healthier ones. However, no validated scale to assess compensatory weight-related behaviors exists. The study's objective was to develop (Study 1) and validate (Study 2) a questionnaire measuring compensatory health mo ...

Article GUID: 37804879


The essential impact of stress appraisals on work engagement

Author(s): Al Hajj R; Vongas JG; Jamal M; ElMelegy AR;

This paper explains the contradictory findings on the relationship between stress and work engagement by including appraisals as a driving mechanism through which job stressors influence engagement. In doing so, it explores whether stressors categorised as either challenging or hindering can be appraised simultaneously as both. Second, it investigates whe ...

Article GUID: 37851607


Uncertainty about predation risk: a conceptual review

Author(s): Crane AL; Feyten LEA; Preagola AA; Ferrari MCO; Brown GE;

Uncertainty has long been of interest to economists and psychologists and has more recently gained attention among ecologists. In the ecological world, animals must regularly make decisions related to finding resources and avoiding threats. Here, we describe uncertainty as a perceptual phenomenon of decision-makers, and we focus specifically on the functi ...

Article GUID: 37839808


Web-based processing of physiological noise in fMRI: addition of the PhysIO toolbox to CBRAIN

Author(s): Valevicius D; Beck N; Kasper L; Boroday S; Bayer J; Rioux P; Caron B; Adalat R; Evans AC; Khalili-Mahani N;

Neuroimaging research requires sophisticated tools for analyzing complex data, but efficiently leveraging these tools can be a major challenge, especially on large datasets. CBRAIN is a web-based platform designed to simplify the use and accessibility of neuroimaging research tools for large-scal ...

Article GUID: 37841811


How can we apply decision-making theories to wild animal behavior? Predictions arising from dual process theory and Bayesian decision theory

Author(s): Teichroeb JA; Smeltzer EA; Mathur V; Anderson KA; Fowler EJ; Adams FV; Vasey EN; Tamara Kumpan L; Stead SM; Arseneau-Robar TJM;

Our understanding of decision-making processes and cognitive biases is ever increasing, thanks to an accumulation of testable models and a large body of research over the last several decades. The vast majority of this work has been done in humans and laboratory animals because these study subjec ...

Article GUID: 37839050


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