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Thermotolerance in S. cerevisiae as a model to study extracellular vesicle biology

Author(s): Logan CJ; Staton CC; Oliver JT; Bouffard J; Kazmirchuk TDD; Magi M; Brett CL;

The budding yeast Saccharomyces cerevisiae is a proven model organism for elucidating conserved eukaryotic biology, but to date its extracellular vesicle (EV) biology is understudied. Here, we show yeast transmit information through the extracellular medium that increases survival when confronted with heat stress and demonstrate the EV-enriched samples me ...

Article GUID: 38711329


Exploring patterns in mental health treatment and interests of single adults in the United States: a secondary data analysis

Author(s): Gesselman AN; Kaufman EM; Weeks LYS; Moscovici Z; Bennett-Brown M; Adams OR; Campbell JT; Piazza M; Bhuyan L; Dubé S; Hille JJ; Garcia JR;

Objective: The objective of this study is to examine mental health treatment utilization and interest among the large and growing demographic of single adults in the United States, who face unique societal stressors and pressures that may contribute to their heightened need for mental healthcare. ...

Article GUID: 38711766


Chloroplast biogenesis involves spatial coordination of nuclear and organellar gene expression in Chlamydomonas

Author(s): Sun Y; Bakhtiari S; Valente-Paterno M; Wu Y; Nishimura Y; Shen W; Law C; Dhaliwal J; Dai D; Bui KH; Zerges W;

The localization of translation can direct the polypeptide product to the proper intracellular compartment. Our results reveal translation by cytosolic ribosomes on a domain of the chloroplast envelope in the unicellular green alga Chlamydomonas (Chlamydomonas reinhardtii). We show that this enve ...

Article GUID: 38709497


Soutien des frères et sœurs d’un jeune touché de cancer: soins collaboratifs pour les familles

Author(s): Gélinas-Gagné C; D' Amico M;

id="fra-abstract"> Objectif: Cette étude examine les systèmes de soutien et les besoins des frères et sœurs des jeunes touchés par un cancer, mettant en lumière les défis émotionnels et informationnels auxquels les frères et sœurs sont confrontés. Ce domaine a reçu relativement peu d’attention. Devis et méthodologie: Des entretiens qualitatifs ont été me ...

Article GUID: 38706649


Enhancing sibling support in oncology: Collaborative care for families facing cancer in young people

Author(s): Gélinas-Gagné C; D' Amico M;

Purpose: This study investigates the support systems and needs of siblings of young people with cancer, shedding light on the emotional and informational challenges siblings face. This topic area has had relatively little attention. Design and methods: Qualitative interviews were conducted, and thematic analysis was employed to gain in-depth insights int ...

Article GUID: 38706652


Psychometric Validation of the Gambling Craving Scale in a Treatment-Seeking Sample

Author(s): Battaglia AM; Vedelago L; Coelho SG; Baumgartner C; Schaub MP; Stewart SH; MacKillop J; Hodgins DC; Wardell JD; O' Connor RM; Kim HS; Keough MT;

The Gambling Craving Scale (GACS) is a multifaceted measure of gambling craving. Initial validation work by Young and Wohl (2009) in university student samples showed that the GACS had a three-factor structure capturing dimensions of Desire, Anticipation, and Relief. Despite its potential clinica ...

Article GUID: 38700740


A Multilevel Person-Centered Perspective on the Role of Job Demands and Resources for Employees' Job Engagement and Burnout Profiles

Author(s): Gillet N; Morin AJS; Blais AR;

The present study examined the configurations, or profiles, taken by distinct global and specific facets of job engagement and burnout (by relying on a bifactor operationalization of these constructs) among a nationally representative sample of Canadian Defence employees (n = 13,088; nested within 65 work units). The present study also adopted a multileve ...

Article GUID: 38698872


Synergistic Cathode Design for High-Performance Dual-Salt Magnesium/Lithium-Ion Batteries Using 2D/2D 1T/2H-MoS2@Ti3C2Tx MXene Nanocomposite

Author(s): Rahmatinejad J; Liu X; Raisi B; Ye Z;

Magnesium-ion batteries (MIBs) and dual-salt magnesium/lithium-ion batteries (MLIBs) have emerged as promising contenders for next-generation energy storage. In contrast to lithium metal anode in lithium metal batteries, magnesium metal anode in MIBs and MLIBs presents a safer alternative due to the limited dendrite growth and higher volumetric capacity, ...

Article GUID: 38698578


Simultaneous automated ascertainment of prevalent vertebral fracture and abdominal aortic calcification in clinical practice: role in fracture risk assessment

Author(s): Schousboe JT; Lewis JR; Monchka BA; Reid SB; Davidson MJ; Kimelman D; Jozani MJ; Smith C; Sim M; Gilani SZ; Suter D; Leslie WD;

Whether simultaneous automated ascertainments of prevalent vertebral fracture (auto-PVFx) and abdominal aortic calcification (auto-AAC) on vertebral fracture assessment (VFA) lateral spine bone density (BMD) images jointly predict incident fractures in routine clinical practice is unclear. We est ...

Article GUID: 38699950


Functional and structural characterization of an IclR family transcription factor for the development of dicarboxylic acid biosensors

Author(s): Pham C; Nasr MA; Skarina T; Di Leo R; Kwan DH; Martin VJJ; Stogios PJ; Mahadevan R; Savchenko A;

Prokaryotic transcription factors (TFs) regulate gene expression in response to small molecules, thus representing promising candidates as versatile small molecule-detecting biosensors valuable for synthetic biology applications. The engineering of such biosensors requires thorough in vitro and i ...

Article GUID: 38696354


From wastewater to clean water: Recent advances on the removal of metronidazole, ciprofloxacin, and sulfamethoxazole antibiotics from water through adsorption and advanced oxidation processes (AOPs)

Author(s): Gahrouei AE; Vakili S; Zandifar A; Pourebrahimi S;

Antibiotics released into water sources pose significant risks to both human health and the environment. This comprehensive review meticulously examines the ecotoxicological impacts of three prevalent antibiotics-ciprofloxacin, metronidazole, and sulfamethoxazole-on the ecosystems. Within this framework, our primary focus revolves around the key remediati ...

Article GUID: 38685299


A multidimensional investigation of sleep and biopsychosocial profiles with associated neural signatures

Author(s): Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT;

Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to ident ...

Article GUID: 38659875


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