Author(s): Ayan S; Rotaru AM; Kaye EG; Juneau G; Das S; Wilds CJ; Beharry AA;
Fluorescent chemosensors offer a direct means of measuring enzyme activity for cancer diagnosis, predicting drug resistance, and aiding in the discovery of new anticancer drugs. O6-methylguanine DNA methyltransferase (MGMT) is a predictor of resistance towards anticancer alkylating agents such as temozolomide. Using the fluorescent molecular rotor, 9-(2-c ...
Article GUID: 38502038
Author(s): Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK;
Smart nanoassemblies degradable through the cleavage of acid-labile linkages have attracted significant attention because of their biological relevance found in tumor tissues. Despite their high potential to achieve controlled/enhanced drug release, a systematic understanding of structural factors that affect their pH sensitivity remains challenging, part ...
Article GUID: 38499007
Author(s): Joshani A; Mirzaei Y; Barber A; Balind K; Gobeil C; Gélinas Y;
The biogeochemical cycles of iron and organic carbon (OC) are closely interconnected in terrestrial and aquatic systems. In ocean waters, the concentration of reactive Fe is tightly controlled by soluble organic ligands. In soils, Fe stabilizes OC by forming aggregates that shield OC from degradation. In lake sediments however, the role of Fe in the prese ...
Article GUID: 38499107
Author(s): Alavi S; Mohammadimoghaddam S; Najmabadi H; Maghsoudlou S;
In this report, we describe a 6-year-old girl with a medical history of pallor, mild icterus, anemia, blood transfusion and abnormal hemoglobin variant analysis on capillary electrophoresis. She was referred for further analysis. DNA sequencing of the proband revealed a de novo mutation in Codon 88 (CTG > CCG) of the ß-globin gene (HBB: c.266T > C) in a h ...
Article GUID: 38500334
Author(s): Singh Z; Chiong JD; Kamal S; Majewski MB;
Dye-sensitized photoelectrodes may be used as heterogeneous components for fuel-forming reactions in photoelectrochemical cells. There has been increasing interest in developing Earth-abundant cheaper photosensitizers based on first-row transition metals. We describe here the synthesis, characterization, and study of the ground and excited state propertie ...
Article GUID: 38497406
Author(s): Lafay A; Adrien E; Lonardo Burr SD; Douglas H; Provost-Larocque K; Xu C; LeFevre JA; Maloney EA; Osana HP; Skwarchuk SL; Wylie J;
Transcoding is the process of translating between spoken and written numbers, and it is correlated with other mathematical skills. In the present study, we investigated the link between French number writing of 49 students in the third grade (aged 7-9 years) and their language skills. Transcoding ...
Article GUID: 37129448
Author(s): Sun Y; Wang C;
The work presented in this paper is in the area of brain tumor detection. We propose a fast detection system with 3D MRI scans of Flair modality. It performs 2 functions, predicting the gray level distribution and location distribution of the pixels in the tumor regions and generating tumor masks with pixel-wise precision. To facilitate 3D data analysis a ...
Article GUID: 38493601
Author(s): Bietar K; Chu S; Mandl G; Zhang E; Chabaytah N; Sabelli R; Capobianco JA; Stochaj U;
Lanthanide-doped upconverting nanoparticles (UCNPs) are ideal candidates for use in biomedicine. The interaction of nanomaterials with biological systems determines whether they are suitable for use in living cells. In-depth knowledge of the nano-bio interactions is therefore a pre-requisite for the development of biomedical applications. The current stud ...
Article GUID: 38495986
Author(s): Sidorenkov AV; Borokhovski EF;
In this article, we attempt to integrate and further develop conceptual ideas about functions of small groups and the informal subgroups that arise within them in relation to their respective members, namely, the functions of: (1) creating possibilities for realizing individual goals and meeting individual needs; (2) providing protection from external and ...
Article GUID: 38492193
Author(s): Islam M; Zunair H; Mohammed N;
Crafting effective deep learning models for medical image analysis is a complex task, particularly in cases where the medical image dataset lacks significant inter-class variation. This challenge is further aggravated when employing such datasets to generate synthetic images using generative adversarial networks (GANs), as the output of GANs heavily relie ...
Article GUID: 38492455
Author(s): Mokhtarinia H; Alimohammadi B; Sadeghi-Yarandi M; Torabi-Gudarzi S; Soltanzadeh A; Nikbakht N;
Background: Work-related musculoskeletal disorders (WRMSDs) is a multi-factorial disorder in most occupational setting and it has increased significantly in recent years. Objective: This study aimed to investigate the relationship between physical, cognitive, and environmental factors of ergonom ...
Article GUID: 38489202
Author(s): Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ;
Multivariate approaches have recently gained in popularity to address the physiological unspecificity of neuroimaging metrics and to better characterize the complexity of biological processes underlying behavior. However, commonly used approaches are biased by the intrinsic associations between variables, or they are computationally expensive and may be m ...
Article GUID: 38463982
