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Mechanisms of higher-order learning in the amygdala

Authors: Gostolupce DIordanova MDLay BPP


Affiliations

1 Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: mihaela.iordanova@concordia.ca.

Description

Adaptive behaviour is under the potent control of environmental cues. Such cues can acquire value by virtue of their associations with outcomes of motivational significance, be they appetitive or aversive. There are at least two ways through which an environmental cue can acquire value, through first-order and higher-order conditioning. In first-order conditioning, a neutral cue is directly paired with an outcome of motivational significance. In higher-order conditioning, a cue is indirectly associated with motivational events via a directly conditioned first-order stimulus. The present article reviews some of the associations that support learning in first- and higher-order conditioning, as well as the role of the BLA and the molecular mechanisms involved in these two types of learning.


Keywords: Fear conditioningLearningOrbitofrontal cortexPerirhinal cortexRetrosplenial cortexSecond-order conditioningSensory preconditioning


Links

PubMed: https://pubmed.ncbi.nlm.nih.gov/34197867/

DOI: 10.1016/j.bbr.2021.113435