PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	Hemodynamic performance and blood damage of the Intra-aortic pumps: A CFD-Based investigation	Aycan O; Park Y; Kadem L;	41863715 ENCS
2	A high-fidelity simulator for evaluation of hemodynamic response during cardiopulmonary resuscitation in hypogravity environments	Lord Z; Andrade C; Leroux L; Kadem L;	41741473 CHEMISTRY
3	Comprehensive review of reinforcement learning for medical ultrasound imaging	Elmekki H; Islam S; Alagha A; Sami H; Spilkin A; Zakeri E; Zanuttini AM; Bentahar J; Kadem L; Xie WF; Pibarot P; Mizouni R; Otrok H; Singh S; Mourad A;	40567264 ENCS
4	Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics	Teimouri K; Darwish A; Saleh W; Ng HD; Kadem L;	40325266 ENCS
5	CACTUS: An open dataset and framework for automated Cardiac Assessment and Classification of Ultrasound images using deep transfer learning	Elmekki H; Alagha A; Sami H; Spilkin A; Zanuttini AM; Zakeri E; Bentahar J; Kadem L; Xie WF; Pibarot P; Mizouni R; Otrok H; Singh S; Mourad A;	40107020 ENCS
6	Numerical investigation of the flow induced by a transcatheter intra-aortic entrainment pump	Park Y; Aycan O; Kadem L;	40014031 ENCS
7	Design, manufacturing, and multi-modal imaging of stereolithography 3D printed flexible intracranial aneurysm phantoms	Yalman A; Jafari A; Léger É; Mastroianni MA; Teimouri K; Savoji H; Collins DL; Kadem L; Xiao Y;	39546636 BIOLOGY
8	Design and validation of an In Vitro test bench for the investigation of cardiopulmonary resuscitation procedure	El-Khoury A; Leroux L; Dupuis Desroches J; Di Labbio G; Kadem L;	39305857 ENCS
9	An Anatomically Shaped Mitral Valve for Hemodynamic Testing	Darwish A; Papolla C; Rieu R; Kadem L;	38228812 ENCS
10	Spectral-Clustering of Lagrangian Trajectory Graphs: Application to Abdominal Aortic Aneurysms	Darwish A; Norouzi S; Kadem L;	34845627 ENCS
11	On Left Ventricle Stroke Work Efficiency in Children with Moderate Aortic Valve Regurgitation or Moderate Aortic Valve Stenosis	Asaadi M; Mawad W; Djebbari A; Keshavardz-Motamed Z; Dahdah N; Kadem L;	34357415 ENCS
12	Response to: "Color Doppler Splay: a New Tool for the Assessment of Valvular Regurgitations?" by Allievi et al	Wiener PC; Friend EJ; Bhargav R; Radhakrishnan K; Kadem L; Pressman GS;	34062241 ENCS
13	Energy loss associated with in-vitro modeling of mitral annular calcification.	Wiener PC, Darwish A, Friend E, Kadem L, Pressman GS	33591991 ENCS
14	Proper Orthogonal Decomposition Analysis of the Flow Downstream of a Dysfunctional Bileaflet Mechanical Aortic Valve.	Darwish A, Di Labbio G, Saleh W, Kadem L	33469847 ENCS
15	Impact of Mitral Regurgitation on the Flow in a Model of a Left Ventricle.	Papolla C, Darwish A, Kadem L, Rieu R	33000444 ENCS
16	Color Doppler Splay: A Clue to the Presence of Significant Mitral Regurgitation.	Wiener PC, Friend EJ, Bhargav R, Radhakrishnan K, Kadem L, Pressman GS	32712051 ENCS
17	Effects of Hemodynamic Conditions and Valve Sizing on Leaflet Bending Stress in Self-Expanding Transcatheter Aortic Valve: An In-vitro Study.	Stanová V, Zenses AS, Thollon L, Kadem L, Barragan P, Rieu R, Pibarot P	31995230 ENCS
18	Experimental Investigation of the Effect of Heart Rate On Flow in the Left Ventricle in Health and Disease -- Aortic Valve Regurgitation.	Di Labbio G, Ben-Assa E, Kadem L	31701119 ENCS
19	Jet collisions and vortex reversal in the human left ventricle.	Di Labbio G, Kadem L	30049450 ENCS
20	Response to letter to the editor: 'Left ventricular flow in the presence of aortic regurgitation'.	Di Labbio G, Kadem L	30871721 ENCS
21	Experimental investigation of the flow downstream of a dysfunctional bileaflet mechanical aortic valve.	Darwish A, Di Labbio G, Saleh W, Smadi O, Kadem L	31066923 ENCS

Title:	Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics
Authors:	Teimouri K, Darwish A, Saleh W, Ng HD, Kadem L
Link:	https://pubmed.ncbi.nlm.nih.gov/40325266/
DOI:	10.1007/s10439-025-03744-9
Publication:	Annals of biomedical engineering
Keywords:	Fluid dynamics; Left ventricle; MitraClip; Mitral regurgitation; Particle image velocimetry;
PMID:	40325266	Category:	Date Added:	2025-05-06
Dept Affiliation:	ENCS 1 Laboratory of Cardiovascular Fluid Dynamics, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC, Canada. kowsar.teimouri@concordia.ca. 2 Laboratory of Cardiovascular Fluid Dynamics, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC, Canada. 3 Mechanical Power Engineering Department, Assiut University, Assiut, 71516, Egypt.

Description:

Purpose: The MitraClip device has emerged as an effective treatment option for patients with mitral regurgitation. However, implementing a MitraClip alters the mitral valve structure and left ventricular flow dynamics. In this study, we experimentally investigate the effects of the MitraClip and the resulting twin pulsed jets on flow dynamics within the left ventricle.

Methods: A custom-made left heart pulse duplicator was utilized, considering three different configurations: (1) a healthy mitral valve; (2) a regurgitant mitral valve; and (3) a repaired mitral valve with a MitraClip device. The flow field within the left ventricle was examined using time-resolved particle image velocimetry across different planes. Of particular interest was the analysis of flow structures, viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle.

Results: The results indicate that mitral valve regurgitation increases both viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle along with a 45% increase in peak velocity compared to the case with a normal mitral valve. Moreover, while mitral valve repair with a MitraClip alters the flow dynamics in the left ventricle, generating twin pulsed jets, it effectively reduces viscous energy dissipation (by 25 and 36% in the lateral and side planes, respectively) and shear stress accumulation compared to the regurgitant valve. However, these improvements do not fully restore the levels observed in a healthy mitral valve.

Conclusion: MitraClip mitigates the adverse effects of mitral regurgitation by restoring key hemodynamic parameters closer to healthy levels, highlighting its potential as a promising treatment.

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