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PubMed Publications| Keyword search (4,163 papers available) |  |
"Liu-Ambrose T" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment | Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T; | 41929984 HKAP |
| 2 | Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial | Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC; | 41795685 HKAP |
| 3 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 4 | Intra-individual variability in cognitive performance predicts falls in older adults with chronic stroke | Dimri V; Davis JC; Boa Sorte Silva NC; Balbim GM; Eng JJ; Liu-Ambrose T; | 41474479 HKAP |
| 5 | Dementia Care Research and Psychosocial Factors | Mancor E; Montero-Odasso M; Bherer L; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Li K; | 41448628 CONCORDIA |
| 6 | Clinical Manifestations | Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L; | 41447475 CONCORDIA |
| 7 | Developing Topics | Silva NCBS; Stein RG; Gu Y; Hsu CL; Tam RC; Salluzzi M; McCreary CR; Alkeridy WA; Lam K; MacKay AL; Kolind S; Cossette B; Griffith LE; Hogan DB; McMillan JM; Raina P; Smith EE; Liu-Ambrose T; | 41434542 CONCORDIA |
| 8 | Public Health | Silva NCBS; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy WA; Kramer AF; Liu-Ambrose T; | 41435075 CONCORDIA |
| 9 | Public Health | Pieruccini-Faria F; Son S; Liu-Ambrose T; Burhan AM; Almeida QJ; Middleton LE; Li K; Fraser S; Bherer L; Montero-Odasso M; | 41435121 CONCORDIA |
| 10 | Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial | Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M; | 40966614 SOH |
| 11 | 24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment | Balbim GM; Boa Sorte Silva NC; Falck RS; Kramer AF; Voss MW; Liu-Ambrose T; | 40693459 HKAP |
| 12 | Physical activity may protect myelin via modulation of high-density lipoprotein | Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T; | 39989020 HKAP |
| 13 | Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial | Montero-Odasso M; Zou G; Speechley M; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li KZH; Fraser S; Pieruccini-Faria F; Berryman N; Lussier M; Shoemaker JK; Son S; Bherer L; | 37471089 PERFORM |
| 14 | Guidelines for Gait Assessments in the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Cullen S, Montero-Odasso M, Bherer L, Almeida Q, Fraser S, Muir-Hunter S, Li K, Liu-Ambrose T, McGibbon CA, McIlroy W, Middleton LE, Sarquis-Adamson Y, Beauchet O, McFadyen BJ, Morais JA, Camicioli R, Canadian Gait and Cognition Network | 29977431 ENCS |
| 15 | SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment. | Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini-Faria F, Shoemaker K, Speechley M, Vasudev A, Zou GY, Berryman N, Lussier M, Vanderhaeghe L, Bherer L | 29661156 PERFORM |
| 16 | Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network | 30101279 PERFORM |
| 17 | Brain gray matter volume associations with gait speed and related structural covariance networks in cognitively healthy individuals and in patients with mild cognitive impairment: A cross-sectional study. | Beauchet O, Montembeault M, Barden JM, Szturm T, Bherer L, Liu-Ambrose T, Chester VL, Li K, Helbostad JL, Allali G, Canadian Gait Consortium | 31075383 PSYCHOLOGY |
| 18 | A review of the effects of physical activity and exercise on cognitive and brain functions in older adults. | Bherer L, Erickson KI, Liu-Ambrose T | 24102028 PERFORM |
| 19 | Physical exercise and brain functions in older adults. | Bherer L, Erickson KI, Liu-Ambrose T | 24163767 PERFORM |
| 20 | Anti-Dementia Drugs, Gait Performance and Mental Imagery of Gait: A Non-Randomized Open-Label Trial. | Beauchet O, Barden J, Liu-Ambrose T, Chester VL, Annweiler C, Szturm T, Grenier S, Léonard G, Bherer L, Allali G, Canadian Gait Consortium | 27568453 PERFORM |
| 21 | Association Between Falls and Brain Subvolumes: Results from a Cross-Sectional Analysis in Healthy Older Adults. | Beauchet O, Launay CP, Barden J, Liu-Ambrose T, Chester VL, Szturm T, Grenier S, Léonard G, Bherer L, Annweiler C, Helbostad JL, Verghese J, Allali G, Biomathics and Canadian Gait Consortium | 27785698 PERFORM |
| Title: | Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial | ||||
| Authors: | Pieruccini-Faria F, Son S, Zou G, Almeida QJ, Middleton LE, Bray NW, Lussier M, Shoemaker JK, Speechley M, Liu-Ambrose T, Burhan AM, Camicioli R, Li KZH, Fraser S, Berryman N, Bherer L, Montero-Odasso M | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40966614/ | ||||
| DOI: | 10.1093/ageing/afaf242 | ||||
| Publication: | Age and ageing | ||||
| Keywords: | Falls; Mild Cognitive Impairment; cognitive; exercises; gait; older people; training; vitamin D; | ||||
| PMID: | 40966614 | Category: | Date Added: | 2025-09-18 | |
| Dept Affiliation: |
SOH
1 Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. 2 Parkwood Institute, Gait and Brain Laboratory, London, Ontario, Canada. 3 Western University, Schulich School of Medicine and Dentistry, Department of Epidemiology and Biostatistics, London, Ontario, Canada. 4 Alimentiv Inc., London, Ontario, Canada. 5 Carespace Health and Wellness Neurodegeneration Clinics, Waterloo, Ontario, Canada. 6 Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada. 7 Schlegel-UW Research Institute for Aging, Waterloo, Ontario, Canada. 8 Recovery and Performance Laboratory, Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada. 9 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Université de Montréal, Montreal, Quebec, Canada. 10 École de Réadaptation, Faculté de Médecine, Université de Montréal, Montreal, Québec, Canada. 11 School of Kinesiology, University of Western Ontario, London, Ontario, Canada. 12 Department of Epidemiology and Biostatistics, and Schulich Interfaculty Program in Public Health, Western University, London, Ontario, Canada. 13 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada. 14 Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada. 15 Centre for Aging SMART at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada. 16 Ontario Shores Centre for Mental Health Sciences, Whitby, Ontario, Canada. 17 Department of Psychiatry, Temerity Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. 18 Department of Medicine and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada. 19 Department of Psychology, Concordia University, Montréal, Québec, Canada. 20 Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada. 21 Département des Sciences de l'Activité Physique, Université du Québec à Montréal, Montréal, Québec, Canada. 22 Institut national du sport du Québec, Montréal, Québec, Canada. 23 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada. 24 Centre de Recherche, Institut de Cardiologie de Montréal, Montréal, Québec, Canada. 25 Département de Médecine, Université de Montréal, Montréal, Québec, Canada. |
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Description: |
Background: Older adults with mild cognitive impairment (MCI) have a higher risk of gait impairments and falls; yet, the effects of multimodal interventions, including combinations of exercises with cognitive training, on improving their mobility remain unclear. Objectives: To investigate the synergistic effects of aerobic-resistance exercise combined with cognitive training, with or without vitamin D supplementation, on gait performance and falls risk in older adults with MCI. Methods: The effect of 20 weeks of aerobic-resistance exercise, cognitive training, and Vitamin D supplementation (10 000 IU 3×/week) on gait and falls in older adults with MCI was evaluated in the SYNERGIC trial, using a fractional factorial design. Assessments were conducted at baseline, 6-month endpoint (after intervention) and 12-month endpoint (follow-up). Eligible participants were between the ages of 65 and 84 years with MCI enrolled from 19 September 2016 to 7 April 2020. Main outcomes of interest for gait performance were gait speed and gait variability changes, whilst for falls were incidental falls and incidental injurious falls. Results: Amongst 161 participants, the four exercise-based arms improved gait speed (+7.5 cm/s, P < .001) and reduced falls (incidence rate ratios (IRR) = 0.65, 95% confidence interval (CI): 0.32-1.42, P = .25) and injurious falls (IRR = 0.38, 95% CI: 0.15-1.05, P = .05) at 6-month endpoint. Falls reduction reached statistical significance (IRR = 0.28, 95% CI: 0.13-0.64, P = .002) at 12-month endpoint. Exercises combined with cognitive training showed the greatest gains in gait speed at 6-month endpoint (P < .001) and in reducing falls at 12-month endpoint (IRR = 0.24, 95% CI: 0.05-0.77, P = .02) compared to the control. Vitamin D did not enhance outcomes and increased gait variability, a marker of instability. Conclusion: Aerobic-resistance exercise combined with sequential computerised cognitive training improved gait performance at 6 months and decreased the risk of falls and injuries at 12 months in older adults with MCI. The addition of vitamin D did not produce benefits. |
