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PubMed Publications| Keyword search (4,163 papers available) |  |
"Plante I" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats | Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN; | 41372546 PSYCHOLOGY |
| 2 | Activating Group II Metabotropic Glutamate Receptors in the Basolateral Amygdala Inhibits Increases in Reward Seeking Triggered by Discriminative Stimuli in Rats | LeCocq MR; Mainville-Berthiaume A; Laplante I; Samaha AN; | 40341317 CSBN |
| 3 | Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues | Ndiaye NA; Shamleh SA; Casale D; Castaneda-Ouellet S; Laplante I; Robinson MJF; Samaha AN; | 38767684 PSYCHOLOGY |
| 4 | The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer. | Busby M, Hallett MT, Plante I | 29495625 BIOLOGY |
| Title: | Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues | ||||
| Authors: | Ndiaye NA, Shamleh SA, Casale D, Castaneda-Ouellet S, Laplante I, Robinson MJF, Samaha AN | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38767684/ | ||||
| DOI: | 10.1007/s00213-024-06614-9 | ||||
| Publication: | Psychopharmacology | ||||
| Keywords: | Cocaine self-administration; Conditioned reinforcement; Conditioned stimulus; Discriminative stimulus; Intermittent access; Rat; Relapse; | ||||
| PMID: | 38767684 | Category: | Date Added: | 2024-05-20 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montréal, QC, H3C 3J7, Canada. 2 Department of Psychology, Concordia University, Montréal, QC, H3G 1M8, Canada. 3 Department of Psychology, Université de Montréal, Montréal, QC, H3C 3J7, Canada. 4 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-Ville Montréal, Montréal, Québec, H3C 3J7, Canada. 5 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-Ville Montréal, Montréal, Québec, H3C 3J7, Canada. anna.samaha@umontreal.ca. 6 Neural Signaling and Circuitry Research Group (SNC), Faculty of Medicine, Université de Montréal, Montréal, QC, H3C 3J7, Canada. anna.samaha@umontreal.ca. 7 Center for Interdisciplinary Research On the Brain and Learning (CIRCA), Université de Montréal, Montréal, QC, H3C 3J7, Canada. anna.samaha@umontreal.ca. 8 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H3G 1M8, Canada. anna.samaha@umontreal.ca. |
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Description: |
Rationale: When people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include conditioned stimuli (CSs) signaling drug delivery and discriminative stimuli (DSs) signaling drug availability. Compared to CS effects, DS effects are less explored in preclinical studies on cue-induced relapse. Objective: We compared CS and DS effects on reward seeking following abstinence from intermittent-access cocaine (or sucrose) self-administration. Methods: During 15-20 intermittent-access sessions, rats self-administered i.v. cocaine or sucrose pellets paired with a light-tone CS. Cocaine/sucrose was available for 5-min (signalled by a light; DS+) and unavailable for 25 min (signalled by different lighting conditions; DS-), and this cycled for 4 h/session. Following abstinence, we measured cocaine/sucrose seeking under extinction triggered by CS and DS presentation, and instrumental responding reinforced by these cues. Results: Across intermittent-access sessions, rats increased lever pressing for cocaine or sucrose during DS+ periods and decreased responding during DS- periods. On days 2 and 21 of abstinence, only presentation of the DS+ or DS+ and CS combined elicited increased cocaine/sucrose-seeking behaviour (i.e., increased active lever presses). Presenting the DS- alongside the DS+ suppressed the increased cocaine-seeking behaviour otherwise produced by the DS+ . Finally, on day 21 of abstinence, rats showed equivalent levels of lever pressing reinforced by the DS+ , CS and by the DS+ and CS combined, suggesting comparable conditioned reinforcing value. Conclusions: After intermittent self-administration, cocaine-associated DSs and CSs acquire similar conditioned reinforcing properties, but DSs more effectively trigger increases in drug seeking. |
