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PubMed Publications| Keyword search (4,163 papers available) |  |
"Plante I" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats | Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN; | 41372546 PSYCHOLOGY |
| 2 | Activating Group II Metabotropic Glutamate Receptors in the Basolateral Amygdala Inhibits Increases in Reward Seeking Triggered by Discriminative Stimuli in Rats | LeCocq MR; Mainville-Berthiaume A; Laplante I; Samaha AN; | 40341317 CSBN |
| 3 | Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues | Ndiaye NA; Shamleh SA; Casale D; Castaneda-Ouellet S; Laplante I; Robinson MJF; Samaha AN; | 38767684 PSYCHOLOGY |
| 4 | The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer. | Busby M, Hallett MT, Plante I | 29495625 BIOLOGY |
| Title: | Activating Group II Metabotropic Glutamate Receptors in the Basolateral Amygdala Inhibits Increases in Reward Seeking Triggered by Discriminative Stimuli in Rats | ||||
| Authors: | LeCocq MR, Mainville-Berthiaume A, Laplante I, Samaha AN | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40341317/ | ||||
| DOI: | 10.1093/ijnp/pyaf030 | ||||
| Publication: | The international journal of neuropsychopharmacology | ||||
| Keywords: | Appetitive; Conditioned approach; Conditioned stimulus; Pavlovian conditioning; Reinforcement; | ||||
| PMID: | 40341317 | Category: | Date Added: | 2025-05-09 | |
| Dept Affiliation: |
CSBN
1 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. 2 Neural Signaling and Circuitry Research Group (SNC), Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. 3 Center for Biomedical Innovation (CIB), Université de Montréal, Montréal, QC, Canada. 4 Center for Interdisciplinary Research on the Brain and Learning (CIRCA), Université de Montréal, Montréal, QC, Canada. 5 Center for Studies in Behavioural Neurobiology, Concordia University, Montréal, QC, Canada. |
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Description: |
Background: Reward-associated cues guide reward-seeking behaviours. These cues include conditioned stimuli (CSs), which occur following seeking actions and predict reward delivery, and discriminative stimuli (DSs), which occur response-independently and signal that a seeking action will produce reward. Metabotropic group II glutamate (mGlu2/3) receptors in the basolateral amygdala (BLA) modulate CS-guided reward seeking; however, their role in DS effects is unknown. Methods: We developed a procedure to assess DS and CS effects on reward seeking in the same subjects within the same test session. Female and male rats self-administered sucrose where DSs signaled periods of sucrose availability (DS+) and unavailability (DS-). During DS+ trials, active lever presses produced sucrose paired with a CS+. During DS- trials, active lever presses produced a CS- and no sucrose. Across 14 sessions, rats learned to load up on sucrose during DS+ trials and inhibit responding during DS- trials. We then compared the effects of intra-BLA microinfusions of the mGlu2/3 receptor agonist LY379268 on cue-evoked sucrose seeking during a test where the DSs and CSs were presented response-independently, without sucrose. Before testing, rats received intra-BLA microinjections of artificial cerebrospinal fluid (aCSF) or LY379268. Results: Under aCSF, only the DS+ and DS+CS+ combined triggered increases in reward-seeking behaviour. The CS+ alone was ineffective. Intra-BLA LY379268 reduced the sucrose seeking triggered by the DS+ and DS+CS+ combination. Conclusions: Using a new procedure to test reward seeking induced by DSs and CSs, we show that BLA mGlu2/3 receptor activity mediates the conditioned incentive motivational effects of reward-predictive DSs. |
