Keyword search (4,164 papers available)

"Santosa S" Authored Publications:

Title Authors PubMed ID
1 Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G; 41794383
HKAP
2 The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S; 40831565
SOH
3 Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities? Turner L; Wanasinghe AI; Brunori P; Santosa S; 40533358
SOH
4 Combating childhood overweight and obesity: The role of Olympic Movement and bodily movement Tam BT; Wan K; Santosa S; Cai Z; 39991475
SOH
5 Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation Feola S; Al-Nabelsi L; Tam BT; Near J; Morais JA; Santosa S; 39875595
HKAP
6 Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans Costa DN; Santosa S; Jensen MD; 39869194
SOH
7 Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus Plissonneau C; Santosa S; 39553621
SOH
8 Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S; 39045668
SOH
9 Compensatory health motivations and behaviors scale: Development, evaluation, psychometric properties and a preliminary validation Sedemedes K; Knäuper B; Sadikaj G; Yuan TY; Wrosch C; Santosa S; Alberga AS; Kakinami L; 37804879
SOH
10 Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S; 37194560
PERFORM
11 Understanding the impact of radical changes in diet and the gut microbiota on brain function and structure: rationale and design of the EMBRACE study Ben-Porat T; Alberga A; Audet MC; Belleville S; Cohen TR; Garneau PY; Lavoie KL; Marion P; Mellah S; Pescarus R; Rahme E; Santosa S; Studer AS; Vuckovic D; Woods R; Yousefi R; Bacon SL; 37088645
PERFORM
12 Body-composition phenotypes and their associations with cardiometabolic risks and health behaviours in a representative general US sample Kakinami L; Plummer S; Cohen TR; Santosa S; Murphy J; 36183799
PERFORM
13 Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesity Turner L; Gauthier MF; Lafortune A; Tchernof A; Santosa S; 35927468
PERFORM
14 Editorial: The Effect of Carbohydrate Restriction on Cancer and Metabolic Syndrome Elisia I; Santosa S; Popovich DG; Krystal G; 35237644
HKAP
15 Assessing the Contribution of Traditional Foods to Food Security for the Wapekeka First Nation of Canada Robidoux MA; Winnepetonga D; Santosa S; Haman F; 34310881
HKAP
16 Adiposity and muscle mass phenotyping is not superior to BMI in detecting cardiometabolic risk in a cross-sectional study Kakinami L; Danieles PK; Ajibade K; Santosa S; Murphy J; 34231966
PERFORM
17 Editorial: Advances in Dietary Fat Absorption Nauli AM; Santosa S; Dixon JB; 34168573
HKAP
18 Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids Turner L; Santosa S; 33979430
PERFORM
19 Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity Wang C; Murphy J; Delaney KZ; Khor N; Morais JA; Tsoukas MA; Lowry DE; Mutch DM; Santosa S; 33595419
PERFORM
20 Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity Murphy J; Delaney KZ; Dam V; Tam BT; Khor N; Tsoukas MA; Morais JA; Santosa S; 33179451
PERFORM
21 Methodological considerations for the measurement of arterial stiffness using applanation tonometry Cooke AB; Kuate Defo A; Dasgupta K; Papaioannou TG; Lee J; Morin SN; Murphy J; Santosa S; Daskalopoulou SS; 33031179
PERFORM
22 A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue. Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S 32926866
PERFORM
23 Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity. Tam BT, Murphy J, Khor N, Morais JA, Santosa S 32808657
PERFORM
24 Obesity and ageing: Two sides of the same coin. Tam BT, Morais JA, Santosa S 32020741
PERFORM
25 Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage. Santosa S, Bush NC, Jensen MD 28641384
HKAP
26 Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis. Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S 31131996
PERFORM
27 Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S 25557754
PERFORM
28 The Sexual Dimorphism of Lipid Kinetics in Humans. Santosa S, Jensen MD 26191040
PERFORM
29 From neutrophils to macrophages: differences in regional adipose tissue depots. Dam V, Sikder T, Santosa S 26667065
PERFORM
30 Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia. Santosa S, Bonnes SL, Jensen MD 27003301
PERFORM
31 Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs. Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S 27101759
PERFORM
32 Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression. Murphy J, Moullec G, Santosa S 28081776
PERFORM
33 Regional adiposity and markers of inflammation in pre-school age children. Delaney KZ, Vanstone CA, Weiler HA, Santosa S 30315178
PERFORM
34 Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight Kakinami L; Houle-Johnson SA; Demissie Z; Santosa S; Fulton JE; 30456053
PERFORM

 

Title:Obesity and ageing: Two sides of the same coin.
Authors:Tam BT,  Morais JA,  Santosa S
Link:https://www.ncbi.nlm.nih.gov/pubmed/32020741?dopt=Abstract
DOI:10.1111/obr.12991
Publication:Obesity reviews : an official journal of the International Association for the Study of Obesity
Keywords:age-related diseases;  ageing;  obesity; 
PMID:32020741 Category:Obes Rev Date Added:2020-02-06
Dept Affiliation: PERFORM
1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Quebec, Montreal, Canada.
2 Metabolism, Obesity, and Nutrition Lab, PERFORM Centre, Concordia University, Quebec, Montreal, Canada.
3 Division of Geriatric Medicine and Research Institute, McGill University Health Centre, Quebec, Montreal, Canada.
4 Research Centre, Centre intégré universitarie de santé et de services sociaux du Nord-de-I'Île-de-Montréal, Hôpital du Sacré-Cœur de Monréal (CIUSS-NIM, HSCM), Quebec, Montreal, Canada.

Description:

Obesity and ageing: Two sides of the same coin.

Obes Rev. 2020 Feb 05;:

Authors: Tam BT, Morais JA, Santosa S

Abstract

Conditions and comorbidities of obesity mirror those of ageing and age-related diseases. Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic integrity, impaired mitochondrial function, accumulation of intracellular macromolecules, weakened immunity, shifts in tissue and body composition, and enhanced systemic inflammation. Moreover, it has been shown that obesity reduces life expectancy by 5.8 years in men and 7.1 years in women after the age of 40. Shorter life expectancy could be because obesity holistically accelerates ageing at multiple levels. Besides jeopardizing nuclear DNA and mitochondrial DNA integrity, obesity modifies the DNA methylation pattern, which is associated with epigenetic ageing in different tissues. Additionally, other signs of ageing are seen in individuals with obesity including telomere shortening, systemic inflammation, and functional declines. This review aims to show how obesity and ageing are "two sides of the same coin" through discussing how obesity predisposes an individual to age-related conditions, illness, and disease. We will further demonstrate how the mechanisms that perpetuate the early-onset of chronic diseases in obesity parallel those of ageing.

PMID: 32020741 [PubMed - as supplied by publisher]




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