PERFORM Publications

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Title		Authors	PubMed ID
1	Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome	Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G;	41794383 HKAP
2	The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss	Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;	40831565 SOH
3	Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?	Turner L; Wanasinghe AI; Brunori P; Santosa S;	40533358 SOH
4	Combating childhood overweight and obesity: The role of Olympic Movement and bodily movement	Tam BT; Wan K; Santosa S; Cai Z;	39991475 SOH
5	Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation	Feola S; Al-Nabelsi L; Tam BT; Near J; Morais JA; Santosa S;	39875595 HKAP
6	Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans	Costa DN; Santosa S; Jensen MD;	39869194 SOH
7	Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus	Plissonneau C; Santosa S;	39553621 SOH
8	Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region	Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S;	39045668 SOH
9	Compensatory health motivations and behaviors scale: Development, evaluation, psychometric properties and a preliminary validation	Sedemedes K; Knäuper B; Sadikaj G; Yuan TY; Wrosch C; Santosa S; Alberga AS; Kakinami L;	37804879 SOH
10	Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss	Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S;	37194560 PERFORM
11	Understanding the impact of radical changes in diet and the gut microbiota on brain function and structure: rationale and design of the EMBRACE study	Ben-Porat T; Alberga A; Audet MC; Belleville S; Cohen TR; Garneau PY; Lavoie KL; Marion P; Mellah S; Pescarus R; Rahme E; Santosa S; Studer AS; Vuckovic D; Woods R; Yousefi R; Bacon SL;	37088645 PERFORM
12	Body-composition phenotypes and their associations with cardiometabolic risks and health behaviours in a representative general US sample	Kakinami L; Plummer S; Cohen TR; Santosa S; Murphy J;	36183799 PERFORM
13	Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesity	Turner L; Gauthier MF; Lafortune A; Tchernof A; Santosa S;	35927468 PERFORM
14	Editorial: The Effect of Carbohydrate Restriction on Cancer and Metabolic Syndrome	Elisia I; Santosa S; Popovich DG; Krystal G;	35237644 HKAP
15	Assessing the Contribution of Traditional Foods to Food Security for the Wapekeka First Nation of Canada	Robidoux MA; Winnepetonga D; Santosa S; Haman F;	34310881 HKAP
16	Adiposity and muscle mass phenotyping is not superior to BMI in detecting cardiometabolic risk in a cross-sectional study	Kakinami L; Danieles PK; Ajibade K; Santosa S; Murphy J;	34231966 PERFORM
17	Editorial: Advances in Dietary Fat Absorption	Nauli AM; Santosa S; Dixon JB;	34168573 HKAP
18	Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids	Turner L; Santosa S;	33979430 PERFORM
19	Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity	Wang C; Murphy J; Delaney KZ; Khor N; Morais JA; Tsoukas MA; Lowry DE; Mutch DM; Santosa S;	33595419 PERFORM
20	Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity	Murphy J; Delaney KZ; Dam V; Tam BT; Khor N; Tsoukas MA; Morais JA; Santosa S;	33179451 PERFORM
21	Methodological considerations for the measurement of arterial stiffness using applanation tonometry	Cooke AB; Kuate Defo A; Dasgupta K; Papaioannou TG; Lee J; Morin SN; Murphy J; Santosa S; Daskalopoulou SS;	33031179 PERFORM
22	A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue.	Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S	32926866 PERFORM
23	Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.	Tam BT, Murphy J, Khor N, Morais JA, Santosa S	32808657 PERFORM
24	Obesity and ageing: Two sides of the same coin.	Tam BT, Morais JA, Santosa S	32020741 PERFORM
25	Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.	Santosa S, Bush NC, Jensen MD	28641384 HKAP
26	Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis.	Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S	31131996 PERFORM
27	Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles.	Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S	25557754 PERFORM
28	The Sexual Dimorphism of Lipid Kinetics in Humans.	Santosa S, Jensen MD	26191040 PERFORM
29	From neutrophils to macrophages: differences in regional adipose tissue depots.	Dam V, Sikder T, Santosa S	26667065 PERFORM
30	Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia.	Santosa S, Bonnes SL, Jensen MD	27003301 PERFORM
31	Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.	Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S	27101759 PERFORM
32	Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.	Murphy J, Moullec G, Santosa S	28081776 PERFORM
33	Regional adiposity and markers of inflammation in pre-school age children.	Delaney KZ, Vanstone CA, Weiler HA, Santosa S	30315178 PERFORM
34	Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight	Kakinami L; Houle-Johnson SA; Demissie Z; Santosa S; Fulton JE;	30456053 PERFORM

Title:	Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.
Authors:	Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S
Link:	https://www.ncbi.nlm.nih.gov/pubmed/27101759?dopt=Abstract
DOI:	10.1016/j.nutres.2015.12.013
Publication:	Nutrition research (New York, N.Y.)
Keywords:	Body fat; Conjugated linoleic acid; Guinea pig; Hypogonadal; Interleukin-6; Testosterone;
PMID:	27101759	Category:	Nutr Res	Date Added:	2019-04-15
Dept Affiliation:	PERFORM 1 School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, Canada. 2 Department of Exercise Science, Concordia University, Montreal, QC H4B 1R6, Canada; Nutrition, Obesity and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: s.santosa@concordia.ca.

Description:

Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

Nutr Res. 2016 May;36(5):408-17

Authors: Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Abstract

We hypothesize that conjugated linoleic acid (CLA) may be effective in preventing the changes in total and regional body composition and increases in interleukin (IL) 6 that occur as a result of hypogonadism. Male guinea pigs (n = 40, 70- to 72-week retired breeders) were block randomized by weight into 4 groups: (1) sham surgery (SHAM)/control (CTRL) diet, (2) SHAM/conjugated linoleic acid (CLA) diet (1%), (3) orchidectomy (ORX)/CTRL diet, and (4) ORX/CLA diet. Dual-energy x-ray absorptiometry scans were performed at baseline and week 16 to assess body composition. Serum IL-6 was analyzed using an enzyme-linked immune sorbent assay. Fatty acids (FAs) from visceral and subcutaneous adipose tissue were analyzed using gas chromatography. In ORX/CTRL guinea pigs, percent total body fat increased by 6.1%, and percent lean mass decreased by 6.7% over the 16-week treatment period, whereas no changes were observed for either parameter in ORX/CLA guinea pigs. Guinea pigs fed the CLA diet gained less percent total, upper, and lower body fat than those fed the CTRL diet regardless of surgical treatment. Regional adipose tissue FA composition was reflective of dietary FAs. Serum IL-6 concentrations were not different among groups. In this study, we observed that, in male guinea pigs, hypogonadism resulted in increased fat mass and decreased lean mass. In addition, CLA was effective in reducing gains in body fat and maintaining lean mass in both hypogonadal and intact guinea pigs.

PMID: 27101759 [PubMed - indexed for MEDLINE]

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