PERFORM Publications

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Title		Authors	PubMed ID
1	Combating childhood overweight and obesity: The role of Olympic Movement and bodily movement	Tam BT; Wan K; Santosa S; Cai Z;	39991475 SOH
2	Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation	Feola S; Al-Nabelsi L; Tam BT; Near J; Morais JA; Santosa S;	39875595 HKAP
3	Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region	Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S;	39045668 SOH
4	Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss	Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S;	37194560 PERFORM
5	Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity	Murphy J; Delaney KZ; Dam V; Tam BT; Khor N; Tsoukas MA; Morais JA; Santosa S;	33179451 PERFORM
6	Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.	Tam BT, Murphy J, Khor N, Morais JA, Santosa S	32808657 PERFORM
7	Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.	Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM	32218464 HKAP
8	Obesity and ageing: Two sides of the same coin.	Tam BT, Morais JA, Santosa S	32020741 PERFORM
9	Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension.	Yu AP, Ugwu FN, Tam BT, Lee PH, Lai CW, Wong CSC, Siu PM	30258404 HKAP

Title:	Obesity and ageing: Two sides of the same coin.
Authors:	Tam BT, Morais JA, Santosa S
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32020741?dopt=Abstract
DOI:	10.1111/obr.12991
Publication:	Obesity reviews : an official journal of the International Association for the Study of Obesity
Keywords:	age-related diseases; ageing; obesity;
PMID:	32020741	Category:	Obes Rev	Date Added:	2020-02-06
Dept Affiliation:	PERFORM 1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Quebec, Montreal, Canada. 2 Metabolism, Obesity, and Nutrition Lab, PERFORM Centre, Concordia University, Quebec, Montreal, Canada. 3 Division of Geriatric Medicine and Research Institute, McGill University Health Centre, Quebec, Montreal, Canada. 4 Research Centre, Centre intégré universitarie de santé et de services sociaux du Nord-de-I'Île-de-Montréal, Hôpital du Sacré-Cœur de Monréal (CIUSS-NIM, HSCM), Quebec, Montreal, Canada.

Description:

Obesity and ageing: Two sides of the same coin.

Obes Rev. 2020 Feb 05;:

Authors: Tam BT, Morais JA, Santosa S

Abstract

Conditions and comorbidities of obesity mirror those of ageing and age-related diseases. Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic integrity, impaired mitochondrial function, accumulation of intracellular macromolecules, weakened immunity, shifts in tissue and body composition, and enhanced systemic inflammation. Moreover, it has been shown that obesity reduces life expectancy by 5.8 years in men and 7.1 years in women after the age of 40. Shorter life expectancy could be because obesity holistically accelerates ageing at multiple levels. Besides jeopardizing nuclear DNA and mitochondrial DNA integrity, obesity modifies the DNA methylation pattern, which is associated with epigenetic ageing in different tissues. Additionally, other signs of ageing are seen in individuals with obesity including telomere shortening, systemic inflammation, and functional declines. This review aims to show how obesity and ageing are "two sides of the same coin" through discussing how obesity predisposes an individual to age-related conditions, illness, and disease. We will further demonstrate how the mechanisms that perpetuate the early-onset of chronic diseases in obesity parallel those of ageing.

PMID: 32020741 [PubMed - as supplied by publisher]

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