Keyword search (4,163 papers available)

"Tremblay RE" Authored Publications:

Title Authors PubMed ID
1 Trajectories of childhood eating behaviors and their association with internalizing and externalizing symptoms in adolescence Dufour R; Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 40883733
PSYCHOLOGY
2 A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; 39725679
CSBN
3 Childhood hyperactivity, eating behaviours, and executive functions: Their association with the development of eating-disorder symptoms in adolescence Dufour R; Breton É; Morin AJS; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 37833803
PSYCHOLOGY
4 Childhood Overeating and Disordered Eating From Early Adolescence to Young Adulthood: A Longitudinal Study on the Mediating Role of BMI, Victimization and Desire for Thinness Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 37270466
PSYCHOLOGY
5 Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M; 37146008
PSYCHOLOGY
6 Developmental trajectories of eating disorder symptoms: A longitudinal study from early adolescence to young adulthood Breton É; Dufour R; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 35725645
PSYCHOLOGY
7 Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort Watkins-Martin K; Orri M; Pennestri MH; Castellanos-Ryan N; Larose S; Gouin JP; Ouellet-Morin I; Chadi N; Philippe F; Boivin M; Tremblay RE; Côté S; Geoffroy MC; 34496901
PSYCHOLOGY
8 Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood Morneau-Vaillancourt G; Andlauer TFM; Ouellet-Morin I; Paquin S; Brendgen MR; Vitaro F; Gouin JP; Séguin JR; Gagnon É; Cheesman R; Forget-Dubois N; Rouleau GA; Turecki G; Tremblay RE; Côté SM; Dionne G; Boivin M; 34085288
PSYCHOLOGY
9 Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins. Hayward DA, Pomares F, Casey KF, Ismaylova E, Levesque M, Greenlaw K, Vitaro F, Brendgen M, Rénard F, Dionne G, Boivin M, Tremblay RE, Booij L 32881198
PSYCHOLOGY
10 mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M 32413893
CSBN
11 Extra-striatal D2/3 receptor availability in youth at risk for addiction. Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M 32259831
CSBN
12 Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates. Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L 30059826
PSYCHOLOGY
13 Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins. Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L 28032437
PSYCHOLOGY
14 Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity. Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L 28774705
PSYCHOLOGY
15 Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults. Ismaylova E, Di Sante J, Gouin JP, Pomares FB, Vitaro F, Tremblay RE, Booij L 29765312
PSYCHOLOGY
16 Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins. Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L 30089832
PSYCHOLOGY

 

Title:Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.
Authors:Ismaylova E,  Lévesque ML,  Pomares FB,  Szyf M,  Nemoda Z,  Fahim C,  Vitaro F,  Brendgen M,  Dionne G,  Boivin M,  Tremblay RE,  Booij L
Link:https://www.ncbi.nlm.nih.gov/pubmed/30089832?dopt=Abstract
DOI:10.1038/s41398-018-0195-6
Publication:Translational psychiatry
Keywords:
PMID:30089832 Category:Transl Psychiatry Date Added:2019-06-20
Dept Affiliation: PSYCHOLOGY
1 CHU Sainte-Justine Research Centre, Montreal, Canada.
2 Department of Psychiatry, University of Montreal, Montreal, Canada.
3 Department of Psychology, Concordia University, Montreal, Canada.
4 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
5 School of Psychoeducation, University of Montreal, Montreal, Canada.
6 Department of Psychology, University of Quebec à Montreal, Montreal, Canada.
7 School of Psychology, University of Laval, Quebec, Canada.
8 Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Tomsk, Russian Federation.
9 Department of Psychology, University of Montreal, Montreal, Canada.
10 School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
11 CHU Sainte-Justine Research Centre, Montreal, Canada. linda.booij@concordia.ca.
12 Department of Psychiatry, University of Montreal, Montreal, Canada. linda.booij@concordia.ca.
13 Department of Psychology, Concordia University, Montreal, Canada. linda.booij@concordia.ca.

Description:

Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.

Transl Psychiatry. 2018 08 08;8(1):147

Authors: Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Abstract

Several studies have examined associations between peripheral DNA methylation patterns of the serotonin transporter gene (SLC6A4) promoter and symptoms of depression and anxiety. The SLC6A4 promoter methylation has also been associated with frontal-limbic brain responses to negative stimuli. However, it is unclear how much of this association is confounded by DNA sequence variations. We utilized a monozygotic-twin within-pair discordance design, to test whether DNA methylation at specific CpG sites in the SLC6A4 promoter of peripheral cells is associated with greater frontal-limbic brain responses to negative stimuli (sadness and fear), independently of DNA sequence effects. In total 48 pairs of healthy 15-year-old monozygotic twins from the Quebec Newborn Twin Study, followed regularly since birth, underwent functional magnetic resonance imaging while conducting an emotion-processing task. The SLC6A4 promoter methylation level was assessed in saliva samples using pyrosequencing. Relative to the co-twins with lower SLC6A4 promoter methylation levels, twins with higher peripheral SLC6A4 methylation levels showed greater orbitofrontal cortical (OFC) activity and left amygdala-anterior cingulate cortex (ACC) and left amygdala-right OFC connectivity in response to sadness as well as greater ACC-left amygdala and ACC-left insula connectivity in response to fearful stimuli. By utilising a monozygotic-twin design, we provided evidence that associations between peripheral SLC6A4 promoter methylation and frontal-limbic brain responses to negative stimuli are, in part, independent of DNA sequence variations. Although causality cannot be determined here, SLC6A4 promoter methylation may be one of the mechanisms underlying how environmental factors influence the serotonin system, potentially affecting emotional processing through frontal-limbic areas.

PMID: 30089832 [PubMed - indexed for MEDLINE]




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