Keyword search (4,164 papers available)

"Tremblay RE" Authored Publications:

Title Authors PubMed ID
1 Trajectories of childhood eating behaviors and their association with internalizing and externalizing symptoms in adolescence Dufour R; Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 40883733
PSYCHOLOGY
2 A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; 39725679
CSBN
3 Childhood hyperactivity, eating behaviours, and executive functions: Their association with the development of eating-disorder symptoms in adolescence Dufour R; Breton É; Morin AJS; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 37833803
PSYCHOLOGY
4 Childhood Overeating and Disordered Eating From Early Adolescence to Young Adulthood: A Longitudinal Study on the Mediating Role of BMI, Victimization and Desire for Thinness Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 37270466
PSYCHOLOGY
5 Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M; 37146008
PSYCHOLOGY
6 Developmental trajectories of eating disorder symptoms: A longitudinal study from early adolescence to young adulthood Breton É; Dufour R; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 35725645
PSYCHOLOGY
7 Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort Watkins-Martin K; Orri M; Pennestri MH; Castellanos-Ryan N; Larose S; Gouin JP; Ouellet-Morin I; Chadi N; Philippe F; Boivin M; Tremblay RE; Côté S; Geoffroy MC; 34496901
PSYCHOLOGY
8 Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood Morneau-Vaillancourt G; Andlauer TFM; Ouellet-Morin I; Paquin S; Brendgen MR; Vitaro F; Gouin JP; Séguin JR; Gagnon É; Cheesman R; Forget-Dubois N; Rouleau GA; Turecki G; Tremblay RE; Côté SM; Dionne G; Boivin M; 34085288
PSYCHOLOGY
9 Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins. Hayward DA, Pomares F, Casey KF, Ismaylova E, Levesque M, Greenlaw K, Vitaro F, Brendgen M, Rénard F, Dionne G, Boivin M, Tremblay RE, Booij L 32881198
PSYCHOLOGY
10 mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M 32413893
CSBN
11 Extra-striatal D2/3 receptor availability in youth at risk for addiction. Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M 32259831
CSBN
12 Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates. Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L 30059826
PSYCHOLOGY
13 Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins. Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L 28032437
PSYCHOLOGY
14 Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity. Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L 28774705
PSYCHOLOGY
15 Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults. Ismaylova E, Di Sante J, Gouin JP, Pomares FB, Vitaro F, Tremblay RE, Booij L 29765312
PSYCHOLOGY
16 Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins. Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L 30089832
PSYCHOLOGY

 

Title:A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography
Authors:Nikolic MCox SMLJaworska NCastellanos-Ryan NDagher AVitaro FBrendgen MParent SBoivin MCôté STremblay RESéguin JRLeyton M
Link:https://pubmed.ncbi.nlm.nih.gov/39725679/
DOI:10.1111/acer.15511
Publication:Alcohol, clinical & experimental research
Keywords:addictionbiomarkerendophenotypereward processing
PMID:39725679 Category: Date Added:2024-12-27
Dept Affiliation: CSBN
1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
2 Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
3 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
4 Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.
5 School of Psychoeducation, Université de Montréal, Montreal, Quebec, Canada.
6 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
7 Azrieli Research Center of the CHU Ste-Justine, Montreal, Quebec, Canada.
8 Department of Psychology, Université de Québec à Montréal, Montreal, Quebec, Canada.
9 Department of Psychology, Université Laval, Quebec, Quebec, Canada.
10 Institute of Genetic, Neurobiological and Social Foundations of Child Development, Tomsk State University, Tomsk, Russia.
11 Department of Social & Preventative Medicine, Université de Montréal, Montreal, Quebec, Canada.
12 Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada.
13 Department of Psychology, Université de Montréal, Montreal, Quebec, Canada.
14 School of Public Health and Sports Science, University College Dublin, Dublin, Ireland.
15 INSERM, U669, Paris, France.
16 Department of Psychiatry and Addictology, Université de Montréal, Montreal, Quebec, Canada.
17 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.

Description:

Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent.

Methods: Young social drinkers (age 18.5 ± 0.6 y.o.) who have been followed since birth were recruited from high- versus low-risk trajectories based on externalizing (EXT) behavioral traits. All had functional magnetic resonance imaging (fMRI) scans to measure mesocorticolimbic responses to alcohol, juice, and water cues (High EXT: 20F/10M; Low EXT: 15F/12M). Most had positron emission tomography (PET) [18F]fallypride scans to measure brain regional dopamine D2 receptor availabilities (n = 47).

Results: Compared with the low EXT group, high EXT participants reported larger subjective responses to the alcohol and juice cues (vs. water). Despite this, a main effect of group was not seen for brain activation responses to the alcohol and juice cues. Instead, low EXT participants exhibited higher mesocorticolimbic activations to alcohol than juice, whereas these activations did not differ in the high EXT group. Across all participants, alcohol (vs. water) blood oxygen level-dependent (BOLD) responses in the striatum and amygdala were associated with midbrain [18F]fallypride BPND values.

Conclusion: Young social drinkers at high versus low risk for substance use disorders did not exhibit larger mesocorticolimbic BOLD activations to alcohol-related cues and their responses poorly differentiated alcohol from juice. These observations raise the possibility that (i) diminished mesocorticolimbic BOLD differentiations between reward-related cues might be a marker of increased risk for substance use disorders, and (ii) previously reported large BOLD responses to drug-related cues in people with substance use disorders might better identify the disease than pre-existing vulnerability.





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