Keyword search (4,164 papers available)

"Proc Natl Acad Sci U S A" Category Publications:

Title Authors PubMed ID
1 Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes. Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Pierella Karlusich JJ, Pelletier E, Morlon H, Bowler C, Blanc G 33419955
BIOLOGY
2 Increased drought severity tracks warming in the United States' largest river basin. Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, Littell JS, Gray ST, St George S, Friedman JM, Sauchyn DJ, St-Jacques JM, King J 32393620
GEOGRAPHY
3 Late-spring frost risk between 1959 and 2017 decreased in North America but increased in Europe and Asia. Zohner CM, Mo L, Renner SS, Svenning JC, Vitasse Y, Benito BM, Ordonez A, Baumgarten F, Bastin JF, Sebald V, Reich PB, Liang J, Nabuurs GJ, de-Miguel S, Alberti G, Antón-Fernández C, Balazy R, Brändli UB, Chen HYH, Chisholm C, Cienciala E, Dayanandan S, Fayle TM, Frizzera L, Gianelle D, Jagodzinski AM, Jaroszewicz B, Jucker T, Kepfer-Rojas S, Khan ML, Kim HS, Korjus H, Johannsen VK, Laarmann D, Lang M, Zawila-Niedzwiecki T, Niklaus PA, Paquette A, Pretzsch H, Saikia P, Schall P, Šeben V, Svoboda M, Tikhonova E, Viana H, Zhang C, Zhao X, Crowther TW 32393624
BIOLOGY
4 Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities. Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG 31848251
BIOLOGY
5 Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits. Quintana GR, Mac Cionnaith CE, Pfaus JG 31796602
CSBN
6 Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans. Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ 29255038
BIOLOGY
7 Biogenic membranes of the chloroplast in Chlamydomonas reinhardtii. Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W 23129655
CSFG
8 Neural network retuning and neural predictors of learning success associated with cello training Wollman I; Penhune V; Segado M; Carpentier T; Zatorre RJ; 29891670
PSYCHOLOGY
9 Linking plasma formation in grapes to microwave resonances of aqueous dimers. Khattak HK, Bianucci P, Slepkov AD 30782800
PHYSICS
10 mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R; 29555746
CSBN
11 Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa. Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D 30201715
CHEMBIOCHEM

 

Title:Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.
Authors:Martins DMcKay GSampathkumar GKhakimova MEnglish AMNguyen D
Link:https://www.ncbi.nlm.nih.gov/pubmed/30201715?dopt=Abstract
Publication:
Keywords:
PMID:30201715 Category:Proc Natl Acad Sci U S A Date Added:2019-05-31
Dept Affiliation: CHEMBIOCHEM
1 Department of Microbiology and Immunology, McGill University, Montreal, QC H3A OG4, Canada.
2 Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
3 Department of Chemistry and Biochemistry, Concordia University, Montreal, QC H3G 1M8, Canada.
4 Department of Microbiology and Immunology, McGill University, Montreal, QC H3A OG4, Canada; dao.nguyen@mcgill.ca.
5 Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Description:

Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.

Proc Natl Acad Sci U S A. 2018 09 25;115(39):9797-9802

Authors: Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D

Abstract

Metabolically quiescent bacteria represent a large proportion of those in natural and host environments, and they are often refractory to antibiotic treatment. Such drug tolerance is also observed in the laboratory during stationary phase, when bacteria face stress and starvation-induced growth arrest. Tolerance requires (p)ppGpp signaling, which mediates the stress and starvation stringent response (SR), but the downstream effectors that confer tolerance are unclear. We previously demonstrated that the SR is linked to increased antioxidant defenses in Pseudomonas aeruginosa We now demonstrate that superoxide dismutase (SOD) activity is a key factor in SR-mediated multidrug tolerance in stationary-phase P. aeruginosa Inactivation of the SR leads to loss of SOD activity and decreased multidrug tolerance during stationary phase. Genetic or chemical complementation of SOD activity of the ?relA spoT mutant (?SR) is sufficient to restore antibiotic tolerance to WT levels. Remarkably, we observe high membrane permeability and increased drug internalization upon ablation of SOD activity. Combined, our results highlight an unprecedented mode of SR-mediated multidrug tolerance in stationary-phase P. aeruginosa and suggest that inhibition of SOD activity may potentiate current antibiotics.

PMID: 30201715 [PubMed - indexed for MEDLINE]





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