BookR: School of Health Core Facilities Booking
PubMed Publications| Keyword search (4,164 papers available) |  |
"Proc Natl Acad Sci U S A" Category Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes. | Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Pierella Karlusich JJ, Pelletier E, Morlon H, Bowler C, Blanc G | 33419955 BIOLOGY |
| 2 | Increased drought severity tracks warming in the United States' largest river basin. | Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, Littell JS, Gray ST, St George S, Friedman JM, Sauchyn DJ, St-Jacques JM, King J | 32393620 GEOGRAPHY |
| 3 | Late-spring frost risk between 1959 and 2017 decreased in North America but increased in Europe and Asia. | Zohner CM, Mo L, Renner SS, Svenning JC, Vitasse Y, Benito BM, Ordonez A, Baumgarten F, Bastin JF, Sebald V, Reich PB, Liang J, Nabuurs GJ, de-Miguel S, Alberti G, Antón-Fernández C, Balazy R, Brändli UB, Chen HYH, Chisholm C, Cienciala E, Dayanandan S, Fayle TM, Frizzera L, Gianelle D, Jagodzinski AM, Jaroszewicz B, Jucker T, Kepfer-Rojas S, Khan ML, Kim HS, Korjus H, Johannsen VK, Laarmann D, Lang M, Zawila-Niedzwiecki T, Niklaus PA, Paquette A, Pretzsch H, Saikia P, Schall P, Šeben V, Svoboda M, Tikhonova E, Viana H, Zhang C, Zhao X, Crowther TW | 32393624 BIOLOGY |
| 4 | Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities. | Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG | 31848251 BIOLOGY |
| 5 | Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits. | Quintana GR, Mac Cionnaith CE, Pfaus JG | 31796602 CSBN |
| 6 | Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans. | Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ | 29255038 BIOLOGY |
| 7 | Biogenic membranes of the chloroplast in Chlamydomonas reinhardtii. | Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W | 23129655 CSFG |
| 8 | Neural network retuning and neural predictors of learning success associated with cello training | Wollman I; Penhune V; Segado M; Carpentier T; Zatorre RJ; | 29891670 PSYCHOLOGY |
| 9 | Linking plasma formation in grapes to microwave resonances of aqueous dimers. | Khattak HK, Bianucci P, Slepkov AD | 30782800 PHYSICS |
| 10 | mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction | Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R; | 29555746 CSBN |
| 11 | Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa. | Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D | 30201715 CHEMBIOCHEM |
| Title: | mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction | ||||
| Authors: | Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S, Sonenberg N, Cao R | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/29555746/ | ||||
| DOI: | 10.1073/pnas.1721578115 | ||||
| Publication: | Proceedings of the National Academy of Sciences of the United States of America | ||||
| Keywords: | |||||
| PMID: | 29555746 | Category: | Proc Natl Acad Sci U S A | Date Added: | 2019-05-31 |
| Dept Affiliation: |
CSBN
1 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812. 2 Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310. 3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. 4 Department of Mathematics and Statistics, Amherst College, Amherst, MA 01002. 5 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 6 Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 7 Goodman Cancer Research Center, McGill University, Montreal, QC H3A 1A3, Canada. 8 Howard Hughes Medical Institute, McGill University, Montreal, QC H3A 1A3, Canada. 9 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 10 Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455. |
||||
Description: |
Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the adult brain. Here we created a conditional mTOR knockout mouse model to address this question. Using the Cre-LoxP system, the mTOR gene was specifically knocked out in cells expressing Vip (vasoactive intestinal peptide), which represent a major population of interneurons widely distributed in the neocortex, suprachiasmatic nucleus (SCN), olfactory bulb (OB), and other brain regions. Using a combination of biochemical, behavioral, and imaging approaches, we found that mice lacking mTOR in VIP neurons displayed erratic circadian behavior and weakened synchronization among cells in the SCN, the master circadian pacemaker in mammals. Furthermore, we have discovered a critical role for mTOR signaling in mediating olfaction. Odor stimulated mTOR activation in the OB, anterior olfactory nucleus, as well as piriform cortex. Odor-evoked c-Fos responses along the olfactory pathway were abolished in mice lacking mTOR in VIP neurons, which is consistent with reduced olfactory sensitivity in these animals. Together, these results demonstrate that mTOR is a key regulator of SCN circadian clock synchrony and olfaction. |
