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PubMed Publications| Keyword search (4,163 papers available) |  |
Concordia Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | Slobodchikova I; Sivakumar R; Rahman MS; Vuckovic D; | 31344861 CBAMS |
| 2 | Evaluation of D10-Leu metabolic labeling coupled with MALDI-MS analysis in studying the response of the yeast proteome to H2O2 challenge | Jiang H; English AM; | 17022625 CBAMS |
| 3 | Reduction and S-nitrosation of the neuropeptide oxytocin: implications for its biological function | Roy JF; Chrétien MN; Woodside B; English AM; | 17692543 CBAMS |
| 4 | Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2 | Buscarlet M; Tessier A; Provost S; Mollica L; Busque L; | 27475703 CBAMS |
| Title: | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | ||||
| Authors: | Slobodchikova I, Sivakumar R, Rahman MS, Vuckovic D | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/31344861/ | ||||
| DOI: | 10.3390/toxins11080433 | ||||
| Publication: | Toxins | ||||
| Keywords: | biomonitoring; glucuronidation; high-resolution mass spectrometry (HRMS); human; metabolism; microsomal incubation; mycotoxins; | ||||
| PMID: | 31344861 | Category: | Toxins (Basel) | Date Added: | 2019-08-07 |
| Dept Affiliation: |
CBAMS
1 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 2 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 3 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. 4 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. |
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Description: |
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to measure metabolites in vivo after exposure and to establish which mycotoxin metabolites should be prioritized for the inclusion during large-scale biomonitoring efforts. The objective of this study was to perform human in vitro microsomal incubations of 17 mycotoxins and systematically characterize all resulting metabolites using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The results obtained were then used to build a comprehensive LC-MS library and expand a validated 17-mycotoxin method for exposure monitoring to screening of additional 188 metabolites, including 100 metabolites reported for the first time. The final method represents one of the most comprehensive LC-HRMS methods for mycotoxin biomonitoring or metabolism/fate studies. |
