PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss	Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;	40831565 SOH
2	Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?	Turner L; Wanasinghe AI; Brunori P; Santosa S;	40533358 SOH
3	Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus	Plissonneau C; Santosa S;	39553621 SOH
4	Sex differences in regional adipose tissue depots pose different threats for the development of Type 2 diabetes in males and females	Kerri Z Delaney	34985183 PERFORM
5	Altered immunometabolism in adipose tissue: a major contributor to the ageing process?	Delaney KZ; Gillespie ZE; Murphy J; Wang C;	34159597 PERFORM
6	Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids	Turner L; Santosa S;	33979430 PERFORM
7	Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity	Wang C; Murphy J; Delaney KZ; Khor N; Morais JA; Tsoukas MA; Lowry DE; Mutch DM; Santosa S;	33595419 PERFORM
8	A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue.	Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S	32926866 PERFORM
9	Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.	Tam BT, Murphy J, Khor N, Morais JA, Santosa S	32808657 PERFORM
10	From neutrophils to macrophages: differences in regional adipose tissue depots.	Dam V, Sikder T, Santosa S	26667065 PERFORM
11	Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.	Murphy J, Moullec G, Santosa S	28081776 PERFORM

Title:	Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.
Authors:	Murphy J, Moullec G, Santosa S
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28081776?dopt=Abstract
DOI:	10.1016/j.metabol.2016.09.009
Publication:	Metabolism: clinical and experimental
Keywords:	Adipocyte size; Adipose tissue dysfunction; Obesity; Weight loss;
PMID:	28081776	Category:	Metabolism	Date Added:	2019-04-15
Dept Affiliation:	PERFORM 1 Department of Exercise Science, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5. 2 Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5; École de Santé Publique - Département de Médecine Sociale et Preventive, Université de Montréal, 7101 du Parc Ave., Montreal, Quebec, Canada, H3N 1X9. 3 Department of Exercise Science, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5. Electronic address: s.santosa@concordia.ca.

Description:

Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.

Metabolism. 2017 Feb;67:31-40

Authors: Murphy J, Moullec G, Santosa S

Abstract

AIMS: Enlarged adipocytes are a prime feature of adipose tissue dysfunction, and may be an appropriate target to decrease disease risk in obesity. We aimed to assess the change in adipocyte size in response to lifestyle and surgical weight loss interventions for overweight or obesity; and to explore whether certain participant and intervention characteristics influence this response.

METHODS: We systematically searched MEDLINE, EMBASE, CINAHL and Cochrane electronic databases to identify weight loss studies that quantified adipocyte size before and after the intervention. Using meta-regression analysis, we assessed the independent effects of weight loss, age, sex, adipocyte region, and intervention type (surgical vs. lifestyle) on adipocyte size reduction. We repeated the model as a sensitivity analysis including only the lifestyle interventions.

RESULTS: Thirty-five studies met our eligibility criteria. In our main model, every 1.0% weight loss was associated with a 0.64% reduction in adipocyte size (p=0.003); and adipocytes from the upper body decreased 5% more in size than those in the lower body (p=0.009). These relationships were no longer significant when focusing only on lifestyle interventions. Moreover, age, sex and intervention type did not independently affect adipocyte size reduction in either model.

CONCLUSIONS: Weight loss in obese individuals is consistently associated with a decrease in adipocyte size that is more pronounced in upper-body adipocytes. It remains to be clarified how biological differences and intervention characteristics influence this relationship, and whether it corresponds with reductions in other aspects of adipose tissue dysfunction and disease risk.

PMID: 28081776 [PubMed - indexed for MEDLINE]

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