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PubMed Publications| Keyword search (4,163 papers available) |  |
"neurodegeneration" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Physical activity may protect myelin via modulation of high-density lipoprotein | Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T; | 39989020 HKAP |
| 2 | Cognitive Speed in Neurodegenerative Disease: Comparing Mean Rate and Inconsistency Within and Across the Alzheimer's and Lewy Body Spectra in the COMPASS-ND Study | Caballero HS; McFall GP; Gee M; MacDonald S; Phillips NA; Fogarty J; Montero-Odasso M; Camicioli R; Dixon RA; | 38875040 PSYCHOLOGY |
| 3 | Empowering Melatonin Therapeutics with Drosophila Models | Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C; | 34698120 BIOLOGY |
| 4 | Insomnia symptom subtypes and manifestations of prodromal neurodegeneration: a population-based study in the CLSA | Yao CW; Pelletier A; Fereshtehnejad SM; Cross N; Dang-Vu T; Postuma RB; | 34314348 PERFORM |
| Title: | Insomnia symptom subtypes and manifestations of prodromal neurodegeneration: a population-based study in the CLSA | ||||
| Authors: | Yao CW, Pelletier A, Fereshtehnejad SM, Cross N, Dang-Vu T, Postuma RB | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34314348/ | ||||
| DOI: | 10.5664/jcsm.9562 | ||||
| Publication: | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | ||||
| Keywords: | dementia; insomnia; movement disorder; neurodegeneration; | ||||
| PMID: | 34314348 | Category: | Date Added: | 2021-07-27 | |
| Dept Affiliation: |
PERFORM
1 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada. 2 Research Institute of the McGill University Health Centre, Montreal, QC, Canada. 3 Research center of the Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada. 4 Division of Neurology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. 5 Institut Universitaire de Gériatrie de Montréal and CRIUGM, CIUSSS du Centre-Sud-de-l'Île-de-Montréal, Montreal, QC, Canada. 6 PERFORM Centre, Center for Studies in Behavioral Neurobiology, Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada. 7 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. |
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Description: |
Study objectives: To identify the association between insomnia symptoms and signs of prodromal neurodegeneration, including an analysis of potential differences between sleep-onset and sleep-maintenance insomnia. Methods: We included those aged 45-85 years, living in one of 10 Canadian provinces in between 2012-2015 (at the baseline), recruited via three population-based sampling methods. Insomnia symptoms were assessed using questions adapted/modified from the Pittsburgh Sleep Quality Index. A panel of potential prodromal neurodegenerative markers including self-reported symptoms and objective gait motor, cognitive, and autonomic variables were assessed cross-sectionally. We compared those who endorsed insomnia symptoms =3 times per week to controls, adjusting for age, sex and education via logistic regression. Results: Overall, 2,051/30,097 people screened positive for sleep-onset insomnia alone and 4,333 for sleep-maintenance insomnia alone, while 2,371 endorsed both subtypes. On objective gait tests, participants with sleep-onset insomnia, but not sleep-maintenance insomnia, had worse balance (OR = 1.33[1.16,1.52]) and slower gait speed (OR = 1.52[1.34,1.73]). Although participants with any insomnia subtype endorsed more motor symptoms, these were more severe in those with sleep-onset insomnia (OR onset vs. maintenance = 1.13 [1.07,1.18]). On objective cognitive tests, those with sleep-maintenance insomnia scored normally. However, participants with sleep-onset insomnia performed worse on tests of verbal fluency (OR = 1.24[1.06,1.43]) immediate memory (OR = 1.23[1.08,1.41]), and prospective memory task (OR = 1.29[1.11,1.50]). The sleep-onset insomnia group also had lower heart rate variability (OR = 1.23[1.07,1.43]). Secondary analyses found generally similar results in young vs. older age of insomnia development. Conclusions: Compared to maintenance insomnia, those with sleep-onset insomnia have more motor, cognitive and autonomic signs/symptoms. When evaluating neurodegenerative risk, differentiating insomnia subtypes may increase precision. |
