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PubMed Publications| Keyword search (4,163 papers available) |  |
"neurodegeneration" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Physical activity may protect myelin via modulation of high-density lipoprotein | Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T; | 39989020 HKAP |
| 2 | Cognitive Speed in Neurodegenerative Disease: Comparing Mean Rate and Inconsistency Within and Across the Alzheimer's and Lewy Body Spectra in the COMPASS-ND Study | Caballero HS; McFall GP; Gee M; MacDonald S; Phillips NA; Fogarty J; Montero-Odasso M; Camicioli R; Dixon RA; | 38875040 PSYCHOLOGY |
| 3 | Empowering Melatonin Therapeutics with Drosophila Models | Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C; | 34698120 BIOLOGY |
| 4 | Insomnia symptom subtypes and manifestations of prodromal neurodegeneration: a population-based study in the CLSA | Yao CW; Pelletier A; Fereshtehnejad SM; Cross N; Dang-Vu T; Postuma RB; | 34314348 PERFORM |
| Title: | Empowering Melatonin Therapeutics with Drosophila Models | ||||
| Authors: | Millet-Boureima C, Ennis CC, Jamison J, McSweeney S, Park A, Gamberi C | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34698120/ | ||||
| DOI: | 10.3390/diseases9040067 | ||||
| Publication: | Diseases (Basel, Switzerland) | ||||
| Keywords: | Drosophila; PKD; longevity; melatonin; neurodegeneration; oxidative stress; | ||||
| PMID: | 34698120 | Category: | Date Added: | 2021-10-26 | |
| Dept Affiliation: |
BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada. 2 Department of Biology, Coastal Carolina University, Conway, SC 29528-6054, USA. |
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Description: |
Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved amongst mammals. Other melatonin-binding proteins exist. Non-receptor-mediated activities involve regulating the mitochondrial function and antioxidant cascade, which are frequently affected by normal aging as well as disease. Several pathologies display diseased or dysfunctional mitochondria, suggesting melatonin may be used therapeutically. Drosophila models have extensively been employed to study disease pathogenesis and discover new drugs. Here, we review the multiple functions of melatonin through the lens of functional conservation and model organism research to empower potential melatonin therapeutics to treat neurodegenerative and renal diseases. |
