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PubMed Publications| Keyword search (4,163 papers available) |  |
Newest Concordia Publications (of 75):
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor-Dependent Manner | Gholizadeh F; Hajiaghayi M; Rahbari N; Choi JS; Heidt S; Como A; Kazerouni M; Kargar M; Pinard-LaRoche A; Shih SCC; Darlington PJ; | 41928597 SOH |
| 2 | Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner | Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ; | 41906691 SOH |
| 3 | Strengthening and Targeted Rehabilitation for Optimal Neuromuscular Gains for chronic BACK pain (STRONG-BACK): protocol for a randomised controlled trial in participants with primary nociceptive pain drivers | Fortin M; Rosenstein B; Bertrand C; Vaillancourt N; Wright A; Montpetit C; Macedo L; Elliott J; Cook CE; Tousignant-Laflamme Y; Ma J; Pagé MG; Dover G; Dang-Vu TT; Weber MH; | 41876162 SOH |
| 4 | A Fully Virtual Graded Exertion Test Is Safe and Feasible in Symptomatic and Asymptomatic Children With Concussion | Coupal J; Shabanova D; Gagnon I; Grilli L; Beaulieu C; Teel E; | 41816309 SOH |
| 5 | Achilles tendon ultrasound-derived properties of the dominant and non-dominant jumping leg of university basketball athletes: relation with performance, range of motion, and injury | Soontjens O; Busner J; Fortin M; | 41783785 SOH |
| 6 | Exploring correlates of weight bias among university students in diverse programs | Jeanningros A; Côté M; Forouhar V; Aimé A; Lavallière M; Blackburn P; Maïano C; Alberga AS; Baillot A; | 41718586 SOH |
| 7 | Beyond the wound: A scoping review of the psychosocial impact of diabetes-related foot ulcers | Hanlon M; McGuire BE; MacGilchrist C; Kirwan E; Neachtain DN; Dhatariya K; Blanchette V; Durand H; Dragomir A; McIntosh C; | 41721498 SOH |
| 8 | The effect of postoperative rehabilitation on outcomes in patients with degenerative cervical myelopathy (DCM): A systematic review | Montpetit C; Kobaisi A; Lantz JM; Chauhan RV; Anderson DB; Fortin M; | 41693706 SOH |
| 9 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 10 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 11 | The effectiveness of Cognitive behavioral therapy for insomnia on sleep EEG hyperarousal: a multicentric polysomnographic study | Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; | 41688421 SOH |
| 12 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 13 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 14 | Aquatic therapy compared to standard care for chronic low back pain: a randomized controlled trial | Vaillancourt N; Montpetit C; Rosenstein B; Fortin M; | 41527881 SOH |
| 15 | The ELEVATE-LBP consortium: exercise &, evidence to lead effective vital action in translating excellence for low back pain prevention | Sheeran L; McIlroy S; Wong AYL; Anderson DB; Samartzis D; Bogaert L; Domokos B; Spang C; Fortin M; Hodges PW; Bizzini M; Dvorák J; | 41507623 SOH |
| Title: | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | ||||
| Authors: | Sanami S, Rezaei A, Tremblay SA, Potvin-Jutras Z, Sabra D, Intzandt B, Gagnon C, Mainville-Berthiaume A, Wright L, Gayda M, Iglesies-Grau J, Nigam A, Bherer L, Gauthier CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41543005/ | ||||
| DOI: | 10.1177/0271678X251413924 | ||||
| Publication: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism | ||||
| Keywords: | Cerebral blood flow; cerebral metabolic rate of oxygen consumption; dual calibrated functional MRI; oxygen extraction fraction; quantitative susceptibility mapping; | ||||
| PMID: | 41543005 | Category: | Date Added: | 2026-01-16 | |
| Dept Affiliation: |
SOH
1 Department of Physics, Concordia University, Montreal, QC, Canada. 2 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, Canada. 3 School of Health, Concordia University, Montreal, QC, Canada. 4 Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada. 5 BrainLab, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada. 6 Dr. Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada. 7 Department of Psychology, Concordia University, Montreal, QC, Canada. 8 Department of Medicine, Université de Montreal, Montreal, QC, Canada. 9 Department of Nutrition, Université de Montréal, Montreal, QC, Canada. 10 Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada. |
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Description: |
Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain health, particularly higher gray matter volume and perfusion. The brain relies heavily on oxidative metabolism, yet the relationship between cardiorespiratory fitness and brain oxidative metabolism remains underexplored. This study investigated the association between VO2peak and two key cerebral metabolic parameters: the cerebral metabolic rate of oxygen consumption (CMRO2) and oxygen extraction fraction (OEF), which represents the balance between cerebral blood flow (CBF) and CMRO2. Thirty-seven healthy adults aged ?50 underwent maximal cardiopulmonary exercise testing for VO2peak assessment. Neuroimaging included dual calibrated functional MRI (dc-fMRI) and quantitative susceptibility mapping (QSM). Higher VO2peak correlated positively with higher CBF across whole-brain gray matter but showed no relationship with CMRO2. Conversely, higher VO2peak negatively correlated with lower OEF from both dc-fMRI and QSM. These findings suggest that greater cardiorespiratory fitness enhances cerebral perfusion without changing resting metabolic rate in healthy older adults, resulting in a reduced oxygen extraction. These results are consistent with exercise yielding improved vascular-metabolic coupling, which would reduce the likelihood of transient hypoxic episodes. |
