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PubMed Publications| Keyword search (4,163 papers available) |  |
Newest Concordia Publications (of 75):
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor-Dependent Manner | Gholizadeh F; Hajiaghayi M; Rahbari N; Choi JS; Heidt S; Como A; Kazerouni M; Kargar M; Pinard-LaRoche A; Shih SCC; Darlington PJ; | 41928597 SOH |
| 2 | Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner | Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ; | 41906691 SOH |
| 3 | Strengthening and Targeted Rehabilitation for Optimal Neuromuscular Gains for chronic BACK pain (STRONG-BACK): protocol for a randomised controlled trial in participants with primary nociceptive pain drivers | Fortin M; Rosenstein B; Bertrand C; Vaillancourt N; Wright A; Montpetit C; Macedo L; Elliott J; Cook CE; Tousignant-Laflamme Y; Ma J; Pagé MG; Dover G; Dang-Vu TT; Weber MH; | 41876162 SOH |
| 4 | A Fully Virtual Graded Exertion Test Is Safe and Feasible in Symptomatic and Asymptomatic Children With Concussion | Coupal J; Shabanova D; Gagnon I; Grilli L; Beaulieu C; Teel E; | 41816309 SOH |
| 5 | Achilles tendon ultrasound-derived properties of the dominant and non-dominant jumping leg of university basketball athletes: relation with performance, range of motion, and injury | Soontjens O; Busner J; Fortin M; | 41783785 SOH |
| 6 | Exploring correlates of weight bias among university students in diverse programs | Jeanningros A; Côté M; Forouhar V; Aimé A; Lavallière M; Blackburn P; Maïano C; Alberga AS; Baillot A; | 41718586 SOH |
| 7 | Beyond the wound: A scoping review of the psychosocial impact of diabetes-related foot ulcers | Hanlon M; McGuire BE; MacGilchrist C; Kirwan E; Neachtain DN; Dhatariya K; Blanchette V; Durand H; Dragomir A; McIntosh C; | 41721498 SOH |
| 8 | The effect of postoperative rehabilitation on outcomes in patients with degenerative cervical myelopathy (DCM): A systematic review | Montpetit C; Kobaisi A; Lantz JM; Chauhan RV; Anderson DB; Fortin M; | 41693706 SOH |
| 9 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 10 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 11 | The effectiveness of Cognitive behavioral therapy for insomnia on sleep EEG hyperarousal: a multicentric polysomnographic study | Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; | 41688421 SOH |
| 12 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 13 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 14 | Aquatic therapy compared to standard care for chronic low back pain: a randomized controlled trial | Vaillancourt N; Montpetit C; Rosenstein B; Fortin M; | 41527881 SOH |
| 15 | The ELEVATE-LBP consortium: exercise &, evidence to lead effective vital action in translating excellence for low back pain prevention | Sheeran L; McIlroy S; Wong AYL; Anderson DB; Samartzis D; Bogaert L; Domokos B; Spang C; Fortin M; Hodges PW; Bizzini M; Dvorák J; | 41507623 SOH |
| Title: | Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner | ||||
| Authors: | Hajiaghayi M, Gholizadeh F, Rahbari N, Emamnia N, Shih SCC, Darlington PJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41906691/ | ||||
| DOI: | 10.1093/cei/uxag018 | ||||
| Publication: | Clinical and experimental immunology | ||||
| Keywords: | T cell exhaustion; cytotoxic T cells; nebivolol; tumor microenvironment; β; ₂; -adrenergic receptors; | ||||
| PMID: | 41906691 | Category: | Date Added: | 2026-03-30 | |
| Dept Affiliation: |
SOH
1 Department of Biology, School of Health, Concordia University, Montréal, Québec, Canada. 2 Department of Chemical and Materials Engineering, Center for Applied Synthetic Biology, Concordia University, Montréal, Québec, Canada. 3 Department of Electrical and Computer Engineering, School of Health, Concordia University, Montréal, Québec, Canada. 4 Department of Health Kinesiology & Applied Physiology, School of Health, Concordia University, Montréal, Québec, Canada. |
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Description: |
Introduction: Cancers often drive T cells toward an exhausted state characterized by impaired cytotoxicity and upregulation of inhibitory receptors (PD-1, TIM-3, CD38) and transcriptional regulators (TOX, NFATc1). Repeated stimulation in vitro is used to model this process, reflecting chronic antigen exposure in the tumor microenvironment. Stress-derived catecholamines further drive dysfunction through ß-adrenergic receptor (ß-AR) signaling. Here, we examined the impact of nebivolol, an atypical ß1-AR blocker with ß2-biased agonist activity, on T-cell exhaustion and cytotoxicity against breast cancer cells. Methods: Human CD3+ T cells from healthy participants were activated once (early activation) or four times (repeated activation) using CD3/CD28/CD2 T cell activator. Cells were treated in vitro with nebivolol, terbutaline (ß2-agonist), isoproterenol (ß1/ß2-agonist), and metoprolol (ß1-blocker). Exhaustion markers, including PD-1, TIM-3, CD38, and TOX, were measured by flow cytometry and RT-qPCR; NFATc1 by western blot; TNF and IFN-? by ELISA, and cytotoxicity against MCF-7 breast carcinoma cells by co-culture assays. Disruption of the ß2-AR gene (ADRB2) was achieved using CRISPR/Cas9. Results: Nebivolol reduced the proportion of TIM-3+CD38+PD-1+ T cells, downregulated TOX and nuclear NFATc1, and restored ADRB2 expression under repeated activation conditions. Nebivolol enhanced TNF secretion and improved cytotoxicity against MCF-7 cells. In contrast, terbutaline and isoproterenol had no significant effect on exhaustion markers or cytotoxicity. Metoprolol did not inhibit nebivolol's activity, indicating that its effects are not ß1-AR-dependent. Disruption of ADRB2 indicated that nebivolol's anti-exhaustion effects are mediated by ß2-AR. Discussion: These findings show that nebivolol reinvigorates CD4+ and CD8+ T cells following repeated activation, restoring their cytotoxic function against breast cancer cells in vitro. The immunomodulatory activity of Nebivolol is independent of ß1-AR and mediated through ß2-AR, suggesting that biased ß2-AR signaling may represent a potential strategy for modulating T cell exhaustion in the tumor microenvironment. |
