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Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles.

Author(s): Kilin V, Campargue G, Fureraj I, Sakong S, Sabri T, Riporto F, Vieren A, Mugnier Y, Mas C, Staedler D, Collins JM, Bonacina L, Vogel A, Capobianco JA, Wolf JP

ACS Nano. 2020 Apr 16;: Authors: Kilin V, Campargue G, Fureraj I, Sakong S, Sabri T, Riporto F, Vieren A, Mugnier Y, Mas C, Staedler D, Collins JM, Bonacina L, Vogel A, Capobianco JA, Wolf JP

Article GUID: 32282184
Optically Stimulated Nanodosimeters with High Storage Capacity.

Author(s): Van der Heggen D, Cooper DR, Tesson M, Joos JJ, Seuntjens J, Capobianco JA, Smet PF

Nanomaterials (Basel). 2019 Aug 05;9(8): Authors: Van der Heggen D, Cooper DR, Tesson M, Joos JJ, Seuntjens J, Capobianco JA, Smet PF

Article GUID: 31387200
Heme nitrosylation of deoxyhemoglobin by s-nitrosoglutathione requires copper.

Author(s): Romeo AA, Capobianco JA, English AM

J Biol Chem. 2002 Jul 05;277(27):24135-41 Authors: Romeo AA, Capobianco JA, English AM

Article GUID: 11970954
Superoxide dismutase targets NO from GSNO to Cysbeta93 of oxyhemoglobin in concentrated but not dilute solutions of the protein.

Author(s): Romeo AA, Capobianco JA, English AM

J Am Chem Soc. 2003 Nov 26;125(47):14370-8 Authors: Romeo AA, Capobianco JA, English AM

Article GUID: 14624585
Intrinsic Time-Tunable Emissions in Core-Shell Upconverting Nanoparticle Systems.

Author(s): Tessitore G, Maurizio SL, Sabri T, Capobianco JA

Angew Chem Int Ed Engl. 2019 Jun 04;: Authors: Tessitore G, Maurizio SL, Sabri T, Capobianco JA

Article GUID: 31161694
Counting the Photons: Determining the Absolute Storage Capacity of Persistent Phosphors.

Author(s): Van der Heggen D, Joos JJ, Rodríguez Burbano DC, Capobianco JA, Smet PF

Materials (Basel). 2017 Jul 28;10(8): Authors: Van der Heggen D, Joos JJ, Rodríguez Burbano DC, Capobianco JA, Smet PF

Article GUID: 28773228
Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.

Author(s): Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

ACS Appl Mater Interfaces. 2018 Feb 07;10(5):4910-4920 Authors: Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

Article GUID: 29336139
A NIR-responsive azobenzene-based supramolecular hydrogel using upconverting nanoparticles.

Author(s): Mandl GA, Rojas-Gutierrez PA, Capobianco JA

Chem Commun (Camb). 2018 Jun 05;54(46):5847-5850 Authors: Mandl GA, Rojas-Gutierrez PA, Capobianco JA

Article GUID: 29726556
Dual Activity of Rose Bengal Functionalized to Albumin-Coated Lanthanide-Doped Upconverting Nanoparticles: Targeting and Photodynamic Therapy.

Author(s): Sabri T, Pawelek PD, Capobianco JA

ACS Appl Mater Interfaces. 2018 Aug 15;10(32):26947-26953 Authors: Sabri T, Pawelek PD, Capobianco JA

Article GUID: 30028124
Perspective: lanthanide-doped upconverting nanoparticles.

Author(s): Mandl GA, Cooper DR, Hirsch T, Seuntjens J, Capobianco JA

Methods Appl Fluoresc. 2019 Jan 21;7(1):012004 Authors: Mandl GA, Cooper DR, Hirsch T, Seuntjens J, Capobianco JA

Article GUID: 30572318
Recent insights into upconverting nanoparticles: spectroscopy, modeling, and routes to improved luminescence.

Author(s): Tessitore G, Mandl GA, Brik MG, Park W, Capobianco JA

Nanoscale. 2019 May 23;: Authors: Tessitore G, Mandl GA, Brik MG, Park W, Capobianco JA

Article GUID: 31120083
Title:Superoxide dismutase targets NO from GSNO to Cysbeta93 of oxyhemoglobin in concentrated but not dilute solutions of the protein.
Authors:Romeo AA,  Capobianco JA,  English AM
Link:https://www.ncbi.nlm.nih.gov/pubmed/14624585?dopt=Abstract
DOI:10.1021/ja0289752
Category:J Am Chem Soc
PMID:14624585
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, 1455 de Maisonneuve Boulevard West, Montreal, Quebec, Canada H3G 1M8.

Description:

Superoxide dismutase targets NO from GSNO to Cysbeta93 of oxyhemoglobin in concentrated but not dilute solutions of the protein.

J Am Chem Soc. 2003 Nov 26;125(47):14370-8

Authors: Romeo AA, Capobianco JA, English AM

Abstract

The role of hemoglobin (Hb) in transmitting the vasodilatory property of NO throughout the vascular system is of much current interest. NO exchange between Hb and low-molecular-weight nitrosothiols such as S-nitrosoglutathione (GSNO) has been speculated and reported in vitro. Previously, we reported that NO delivery from GSNO to Cysbeta93 of human oxyHb is prevented in the presence of the Cu chelators, neocuproine, and DTPA.(1) In the present work, 5 mM solutions of commercial human Hb were found by ICP-MS to contain approximately 20 microM Cu and Zn, suggesting the presence of Cu,Zn-superoxide dismutase (CuZnSOD), which was confirmed by Western blotting. SOD activity measurements were consistent with the presence of approximately 20 microM CuZnSOD monomer in 5 mM Hb solutions, which is the physiological concentrations of these proteins in the red blood cell. Incubation of 3.75 mM oxyHb (15 mM heme; 7.5 mM Cysbeta93) with 3.75 or 7.5 mM GSNO gave rise to 50% or 100% S-nitrosation, respectively, of Cysbeta93 as monitored by FTIR nu(SH) absorption, whereas excess GSNO over Cysbeta93 converted oxyHb to metHb due to the reaction, oxyHb + NO<==>metHb + NO(3)(-). Removal of CuZnSOD by anion-exchange chromatography yielded an oxyHb sample that was unreactive toward GSNO, and replacement with bovine CuZnSOD restored reactivity. Addition of 1 microM GSNO (Cysbeta93/GSNO = 1) to solutions diluted 10(4)-fold from physiological concentrations of oxyHb and CuZnSOD resulted largely in metHb formation. Thus, this work reports the following key findings: CuZnSOD is an efficient catalyst of NO transfer between GSNO and Cysbeta93 of oxyHb; metHb is not detected in oxyHb/GSNO incubates containing close to the physiological concentration (5 mM) of Hb and CuZnSOD when the Cysbeta93/GSNO molar ratio is 0.5 to 1.0, but metHb is detected when the total Hb concentration is low micromolar. These results suggest that erythrocyte CuZnSOD may play a critical role in preserving the biological activity of NO by targeting it from GSNO to Cysbeta93 of oxyHb rather than to its oxyheme.

PMID: 14624585 [PubMed - indexed for MEDLINE]