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State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis.

Author(s): Tremblay SA, Chapman CA, Courtemanche R

Front Syst Neurosci. 2019;13:60 Authors: Tremblay SA, Chapman CA, Courtemanche R

Article GUID: 31736718
Gap Junction Modulation of Low-Frequency Oscillations in the Cerebellar Granule Cell Layer.

Author(s): Robinson JC, Chapman CA, Courtemanche R

Cerebellum. 2017 08;16(4):802-811 Authors: Robinson JC, Chapman CA, Courtemanche R

Article GUID: 28421552
Basal Ganglia: Striosomes and the Link between Motivation and Action.

Author(s): Courtemanche R, Cammalleri A

Curr Biol. 2019 Jan 21;29(2):R62-R65 Authors: Courtemanche R, Cammalleri A

Article GUID: 30668951
Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.

Author(s): Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Front Syst Neurosci. 2014;8:145 Authors: Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Article GUID: 25309348
Kinematics and muscle activation patterns during a maximal voluntary rate activity in healthy elderly and young adults.

Author(s): Chadnova E, St-Onge N, Courtemanche R, Kilgour RD

Aging Clin Exp Res. 2017 Oct;29(5):1001-1011 Authors: Chadnova E, St-Onge N, Courtemanche R, Kilgour RD

Article GUID: 27909885
Title:State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis.
Authors:Tremblay SA,  Chapman CA,  Courtemanche R
Link:https://www.ncbi.nlm.nih.gov/pubmed/31736718?dopt=Abstract
DOI:10.3389/fnsys.2019.00060
Category:Front Syst Neurosci
PMID:31736718
Dept Affiliation: HKAP
1 Department of Health, Kinesiology, and Applied Physiology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
2 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.

Description:

State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis.

Front Syst Neurosci. 2019;13:60

Authors: Tremblay SA, Chapman CA, Courtemanche R

Abstract

The cerebellum is involved in sensorimotor, cognitive, and emotional functions through cerebello-cerebral connectivity. Cerebellar neurostimulation thus likely affects cortical circuits, as has been shown in studies using cerebellar stimulation to treat neurological disorders through modulation of frontal EEG oscillations. Here we studied the effects of different frequencies of cerebellar stimulation on oscillations and coherence in the cerebellum and prefrontal cortex in the urethane-anesthetized rat. Local field potentials were recorded in the right lateral cerebellum (Crus I/II) and bilaterally in the prefrontal cortex (frontal association area, FrA) in adult male Sprague-Dawley rats. Stimulation was delivered to the cerebellar vermis (lobule VII) using single pulses (0.2 Hz for 60 s), or repeated pulses at 1 Hz (30 s), 5 Hz (10 s), 25 Hz (2 s), and 50 Hz (1 s). Effects of stimulation were influenced by the initial state of EEG activity which varies over time during urethane-anesthesia; 1 Hz stimulation was more effective when delivered during the slow-wave state (Stage 1), while stimulation with single-pulse, 25, and 50 Hz showed stronger effects during the activated state (Stage 2). Single-pulses resulted in increases in oscillatory power in the delta and theta bands for the cerebellum, and in frequencies up to 80 Hz in cortical sites. 1 Hz stimulation induced a decrease in 0-30 Hz activity and increased activity in the 30-200 Hz range, in the right FrA. 5 Hz stimulation reduced power in high frequencies in Stage 1 and induced mixed effects during Stage 2.25 Hz stimulation increased cortical power at low frequencies during Stage 2, and increased power in higher frequency bands during Stage 1. Stimulation at 50 Hz increased delta-band power in all recording sites, with the strongest and most rapid effects in the cerebellum. 25 and 50 Hz stimulation also induced state-dependent effects on cerebello-cortical and cortico-cortical coherence at high frequencies. Cerebellar stimulation can therefore entrain field potential activity in the FrA and drive synchronization of cerebello-cortical and cortico-cortical networks in a frequency-dependent manner. These effects highlight the role of the cerebellar vermis in modulating large-scale synchronization of neural networks in non-motor frontal cortex.

PMID: 31736718 [PubMed]