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State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis.

Author(s): Tremblay SA, Chapman CA, Courtemanche R

Front Syst Neurosci. 2019;13:60 Authors: Tremblay SA, Chapman CA, Courtemanche R

Article GUID: 31736718
Gap Junction Modulation of Low-Frequency Oscillations in the Cerebellar Granule Cell Layer.

Author(s): Robinson JC, Chapman CA, Courtemanche R

Cerebellum. 2017 08;16(4):802-811 Authors: Robinson JC, Chapman CA, Courtemanche R

Article GUID: 28421552
Basal Ganglia: Striosomes and the Link between Motivation and Action.

Author(s): Courtemanche R, Cammalleri A

Curr Biol. 2019 Jan 21;29(2):R62-R65 Authors: Courtemanche R, Cammalleri A

Article GUID: 30668951
Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.

Author(s): Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Front Syst Neurosci. 2014;8:145 Authors: Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Article GUID: 25309348
Kinematics and muscle activation patterns during a maximal voluntary rate activity in healthy elderly and young adults.

Author(s): Chadnova E, St-Onge N, Courtemanche R, Kilgour RD

Aging Clin Exp Res. 2017 Oct;29(5):1001-1011 Authors: Chadnova E, St-Onge N, Courtemanche R, Kilgour RD

Article GUID: 27909885
Title:Gap Junction Modulation of Low-Frequency Oscillations in the Cerebellar Granule Cell Layer.
Authors:Robinson JC,  Chapman CA,  Courtemanche R
Link:https://www.ncbi.nlm.nih.gov/pubmed/28421552?dopt=Abstract
Category:Cerebellum
PMID:28421552
Dept Affiliation: HKAP
1 Department of Exercise Science, and the FRQS Groupe de Recherche en Neurobiologie Comportementale (CSBN), Concordia University, SP-165-03, 7141 Sherbrooke Street West, Montreal, QC, H4B 1R6, Canada.
2 Department of Psychology, and the FRQS Groupe de Recherche en Neurobiologie Comportementale (CSBN), Concordia University, Montreal, Canada.
3 Department of Exercise Science, and the FRQS Groupe de Recherche en Neurobiologie Comportementale (CSBN), Concordia University, SP-165-03, 7141 Sherbrooke Street West, Montreal, QC, H4B 1R6, Canada. richard.courtemanche@concordia.ca.

Description:

Gap Junction Modulation of Low-Frequency Oscillations in the Cerebellar Granule Cell Layer.

Cerebellum. 2017 08;16(4):802-811

Authors: Robinson JC, Chapman CA, Courtemanche R

Abstract

Local field potential (LFP) oscillations in the granule cell layer (GCL) of the cerebellar cortex have been identified previously in the awake rat and monkey during immobility. These low-frequency oscillations are thought to be generated through local circuit interactions between Golgi cells and granule cells within the GCL. Golgi cells display rhythmic firing and pacemaking properties, and also are electrically coupled through gap junctions within the GCL. Here, we tested if gap junctions in the rat cerebellar cortex contribute to the generation of LFP oscillations in the GCL. We recorded LFP oscillations under urethane anesthesia, and examined the effects of local infusion of gap junction blockers on 5-15 Hz oscillations. Local infusion of the gap junction blockers carbenoxolone and mefloquine resulted in significant decreases in the power of oscillations over a 30-min period, but the power of oscillations was unchanged in control experiments following vehicle injections. In addition, infusion of gap junction blockers had no significant effect on multi-unit activity, suggesting that the attenuation of low-frequency oscillations was likely due to reductions in electrical coupling rather than a decreased excitability within the granule cell layer. Our results indicate that electrical coupling among the Golgi cell networks in the cerebellar cortex contributes to the local circuit mechanisms that promote the occurrence of GCL LFP slow oscillations in the anesthetized rat.

PMID: 28421552 [PubMed - indexed for MEDLINE]